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公开(公告)号：US08900877B2
公开(公告)日：2014-12-02
申请号：US13459469
申请日：2012-04-30
Applicant: Steve Jia Chang Yu , Jesus Ching , Phillip You Fai Lee , David Hsiang Hu
Inventor： Steve Jia Chang Yu , Jesus Ching , Phillip You Fai Lee , David Hsiang Hu
IPC: G01N1/00 , G01N31/00 , G01N33/00 , G01N35/00 , G01N35/08 , G01N35/02 , C12M1/00 , B01L3/00 , F16K3/00
CPC classification number: C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
Abstract translation: 描述了用于处理样本的并行处理系统。 在一个实施例中，并行处理系统包括用于控制托盘电机驱动系统的仪器接口并行控制器，闭环加热器控制和检测系统，磁性粒子传递系统，试剂释放系统，试剂预混泵送系统 和洗涤缓冲液泵送系统。
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2.发明申请SYSTEMS AND METHODS FOR PRODUCING AN EVAPORATION BARRIER IN A REACTION CHAMBER 审中-公开在反应室中生产蒸发障碍物的系统和方法公开(公告)号：US20120288866A1
公开(公告)日：2012-11-15
申请号：US13469714
申请日：2012-05-11
Applicant: Lynn KOZMA , Maureen FAIRCHILD , Jesus CHING
Inventor： Lynn KOZMA , Maureen FAIRCHILD , Jesus CHING
CPC classification number: B01L7/52 , B01L3/0217 , B01L3/527 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/0647 , B01L2200/142 , B01L2300/0672 , B01L2300/0867 , B01L2300/0877 , B01L2300/161 , B01L2400/043 , B01L2400/0469 , B01L2400/0487 , B01L2400/0672 , G01N21/13 , G01N21/6428 , G01N35/00 , G01N2021/0328
Abstract: The embodiments described herein relate to systems and methods for producing an evaporation barrier in a PCR vial. In some embodiments, beads with a particular distribution in diameters can be used to produce a barrier for reducing the evaporation of liquid PCR samples within the PCR vial. In some embodiments, the beads can be pre-filled in the PCR vial. In use, liquid samples and/or liquid reagents can be introduced in the PCR vial pre-filled with the beads, such that the beads can be driven to the surface of the liquid PCR sample through the buoyancy of the beads.
Abstract translation: 本文描述的实施方案涉及用于在PCR小瓶中产生蒸发屏障的系统和方法。 在一些实施方案中，可以使用直径特定分布的珠粒来产生用于减少PCR小瓶内液体PCR样品蒸发的屏障。 在一些实施方案中，珠可以预先填充在PCR小瓶中。 在使用中，可以将液体样品和/或液体试剂引入预填充珠粒的PCR小瓶中，使得珠可以通过珠的浮力被驱动到液体PCR样品的表面。
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公开(公告)号：US08268603B2
公开(公告)日：2012-09-18
申请号：US11234656
申请日：2005-09-22
Applicant: Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Jesus Ching
Inventor： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Jesus Ching
CPC classification number: B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M47/06
Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
Abstract translation: 用于破坏细胞或病毒的装置包括具有用于保持细胞或病毒的室的容器。 容器包括限定腔室的至少一个柔性壁。 该装置还包括用于冲击柔性壁的外表面的换能器，以在腔室中产生压力波。 该装置还包括用于增加腔室中的压力的压力源。 室的加压确保换能器与柔性壁之间的有效耦合。 该装置还可以包括室中的珠子，用于破裂细胞或病毒。
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公开(公告)号：US08133703B2
公开(公告)日：2012-03-13
申请号：US11262523
申请日：2005-10-27
Applicant: Jesus Ching , Ronald Chang , Douglas Bryan Dority , Jian Ping Zhang , James Jian Quan Wang , Wendy Wingkei Wong , Kendra Lara Paul , Reuel Van Atta
Inventor： Jesus Ching , Ronald Chang , Douglas Bryan Dority , Jian Ping Zhang , James Jian Quan Wang , Wendy Wingkei Wong , Kendra Lara Paul , Reuel Van Atta
IPC: C12P19/34
CPC classification number: G01N21/6428 , B01L3/502 , B01L7/52 , B01L2200/0684 , B01L2300/0654 , B01L2300/0877 , B01L2400/0487 , B01L2400/0644 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q2565/629 , C12Q2563/173 , C12Q2549/119 , C12Q2531/143 , C12Q2537/149
Abstract: The invention is directed to systems, methods, and apparatus for carrying out multi-stage amplification reactions, especially under fluidly closed conditions. In one aspect, methods of the invention are carried out in a fluidly closed reaction system that permits the isolation of a portion of a first (or prior) reaction mixture and its use as a sample or specimen in a second (or subsequent) reaction mixture, thereby substantially avoiding interfering effects that first reaction components may have in the second reaction if both reaction mixtures were simply combined together. In this aspect, systems, methods, and apparatus of the invention may be used with any amplification reaction that permits multiple stages of amplification based on the use of nested primers.
Abstract translation: 本发明涉及用于进行多级扩增反应的系统，方法和装置，特别是在流体封闭的条件下。 在一个方面，本发明的方法在流体封闭的反应体系中进行，其允许分离第一（或先前）反应混合物的一部分，并将其用作第二（或后续）反应混合物中的样品或样品 ，从而基本上避免了如果两个反应混合物简单地组合在一起，第一反应组分可能在第二反应中可能具有干扰效应。 在这方面，本发明的系统，方法和装置可以与基于嵌套引物的使用允许多个扩增阶段的任何扩增反应一起使用。
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公开(公告)号：US08029746B2
公开(公告)日：2011-10-04
申请号：US13044109
申请日：2011-03-09
Applicant: Steve Jia Chang Yu , Jesus Ching , Phillip You Fai Lee , David Hsiang Hu
Inventor： Steve Jia Chang Yu , Jesus Ching , Phillip You Fai Lee , David Hsiang Hu
IPC: B01J19/00
CPC classification number: C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
Abstract translation: 描述了用于处理样本的并行处理系统。 在一个实施例中，并行处理系统包括用于控制托盘电机驱动系统的仪器接口并行控制器，闭环加热器控制和检测系统，磁性粒子传递系统，试剂释放系统，试剂预混泵送系统 和洗涤缓冲液泵送系统。
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Patent Agency Ranking
公开(公告)号：US20110158849A1
公开(公告)日：2011-06-30
申请号：US13044109
申请日：2011-03-09
Applicant: Steve Jia Chang YU , Jesus CHING , Phillip You Fai LEE , David Hsiang HU
Inventor： Steve Jia Chang YU , Jesus CHING , Phillip You Fai LEE , David Hsiang HU
IPC: G01N33/48
CPC classification number: C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
Abstract translation: 描述了用于处理样本的并行处理系统。 在一个实施例中，并行处理系统包括用于控制托盘电机驱动系统的仪器接口并行控制器，闭环加热器控制和检测系统，磁性粒子传递系统，试剂释放系统，试剂预混泵送系统 和洗涤缓冲液泵送系统。
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公开(公告)号：US07910062B2
公开(公告)日：2011-03-22
申请号：US12821446
申请日：2010-06-23
Applicant: Steve Jia Chang Yu , Jesus Ching , Phillip You Fai Lee , David Hsiang Hu
Inventor： Steve Jia Chang Yu , Jesus Ching , Phillip You Fai Lee , David Hsiang Hu
IPC: B01J19/00
CPC classification number: C12Q1/6806 , B01F15/0237 , B01L3/502 , B01L3/502707 , B01L3/502715 , B01L3/523 , B01L3/527 , B01L2200/025 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/0609 , B01L2300/0672 , B01L2300/18 , B01L2400/0478 , C12N15/1013 , G01N35/00871 , G01N35/0098 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/08 , G01N2035/00356 , G01N2035/00366 , G01N2035/00544 , G01N2035/00574 , G01N2035/00801 , G01N2035/00811 , G01N2035/00881 , G01N2035/0091 , G01N2035/0412 , G01N2035/0415 , Y10S436/807 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/25
Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
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公开(公告)号：US20100239471A1
公开(公告)日：2010-09-23
申请号：US12789831
申请日：2010-05-28
Applicant: Jesus Ching , David Hsiang Hu , Steve Jia Chang Yu , Phillip You Fai Lee
Inventor： Jesus Ching , David Hsiang Hu , Steve Jia Chang Yu , Phillip You Fai Lee
IPC: B01J8/00
CPC classification number: C12N15/1013 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F15/06 , B01F2015/0221 , B01F2015/062 , B01F2215/0037 , B01L3/502 , B01L7/00 , B01L2200/026 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/0672 , B01L2300/0867 , B01L2300/0887 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/20 , C12Q1/6806 , G01N1/38 , Y10T137/0402 , Y10T137/0407 , Y10T137/0413 , Y10T137/0419 , Y10T137/0424 , Y10T436/10 , Y10T436/11 , Y10T436/115831 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
Abstract: A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample.
Abstract translation: 本文公开了一种用于制备样品的盒。 盒子包括壳体，其包围用于制备样品的结构和过程。
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公开(公告)号：US07727473B2
公开(公告)日：2010-06-01
申请号：US11582651
申请日：2006-10-17
Applicant: Jesus Ching , David Hsiang Hu , Steve Jia Chang Yu , Phillip You Fai Lee
Inventor： Jesus Ching , David Hsiang Hu , Steve Jia Chang Yu , Phillip You Fai Lee
CPC classification number: C12N15/1013 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F15/06 , B01F2015/0221 , B01F2015/062 , B01F2215/0037 , B01L3/502 , B01L7/00 , B01L2200/026 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/0672 , B01L2300/0867 , B01L2300/0887 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , B03C1/01 , B03C1/286 , B03C2201/18 , B03C2201/20 , C12Q1/6806 , G01N1/38 , Y10T137/0402 , Y10T137/0407 , Y10T137/0413 , Y10T137/0419 , Y10T137/0424 , Y10T436/10 , Y10T436/11 , Y10T436/115831 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
Abstract: A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample.
Abstract translation: 本文公开了一种用于制备样品的盒。 盒子包括壳体，其包围用于制备样品的结构和过程。
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公开(公告)号：US06887693B2
公开(公告)日：2005-05-03
申请号：US10006848
申请日：2001-11-07
Applicant: William A. McMillan , Kurt E. Petersen , Lee A. Christel , Ronald Chang , Farzad Pourahmadi , Jesus Ching , Gregory T. A. Kovacs , M. Allen Northrup
Inventor： William A. McMillan , Kurt E. Petersen , Lee A. Christel , Ronald Chang , Farzad Pourahmadi , Jesus Ching , Gregory T. A. Kovacs , M. Allen Northrup
CPC classification number: C12M47/06 , B01L2400/0622 , B01L2400/0644
Abstract: A device for lysing components (e.g., cells, spores, or microorganisms) of a fluid sample comprises a cartridge having a lysing chamber for receiving the sample and having at least one solid phase in the lysing chamber for capturing the sample components to be lysed. An ultrasonic transducer is coupled to a wall of the lysing chamber to transfer ultrasonic energy to the captured sample components.
Abstract translation: 用于裂解流体样品的组分（例如，细胞，孢子或微生物）的装置包括具有用于接收样品并在裂解室中具有至少一个固相以用于捕获要裂解的样品组分的裂解室的筒。 超声换能器耦合到裂解室的壁以将超声能量转移到捕获的样品组分。
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