公开(公告)号：US10292658B2

公开(公告)日：2019-05-21

申请号：US15190534

申请日：2016-06-23

Applicant: David A. Borkholder ,  Nicholas J. Conn ,  Masoumeh Haghpanahi

Inventor： David A. Borkholder ,  Nicholas J. Conn ,  Masoumeh Haghpanahi

IPC: A61B5/0402 ,  A61B5/00 ,  A61B5/11 ,  A61B5/0205 ,  A61B5/02 ,  A47K13/24 ,  A61B5/024 ,  A61B5/053 ,  A61B5/01

Abstract: Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.

公开(公告)号：US20240271610A1

公开(公告)日：2024-08-15

申请号：US18108384

申请日：2023-02-10

Applicant: David A. Borkholder ,  Farzad Forouzandeh

Inventor： David A. Borkholder ,  Farzad Forouzandeh

IPC: F16K15/03 ,  F16K15/18

CPC classification number: F04B43/043 ,  F04B19/006

Abstract: A closed leak-free, diffusion-blocking one-way check valve is composed of a substrate having a flow passage through the substrate, the flow passage has a sealing surface between the substrate and a membrane preventing flow through the flow passage. A thin film having internal stress is disposed on the membrane which induces deformation of the membrane biasing the membrane resulting in the sealing surface in a closed orientation. A method for fabrication and pump utilizing the check valve are disclosed.

公开(公告)号：US20190231271A1

公开(公告)日：2019-08-01

申请号：US16377938

申请日：2019-04-08

Applicant: David A. Borkholder ,  Nicholas J. Conn ,  Masoumeh Haghpanahi

Inventor： David A. Borkholder ,  Nicholas J. Conn ,  Masoumeh Haghpanahi

IPC: A61B5/00 ,  A61B5/11 ,  A61B5/0402 ,  A61B5/02 ,  A47K13/24 ,  A61B5/0205

CPC classification number: A61B5/6891 ,  A47K13/24 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/02055 ,  A61B5/02416 ,  A61B5/0402 ,  A61B5/053 ,  A61B5/1102 ,  A61B5/14551 ,  A61B5/4561 ,  A61B5/7246

Abstract: Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.

公开(公告)号：US20170354331A1

公开(公告)日：2017-12-14

申请号：US15527467

申请日：2015-11-17

Applicant: David A. Borkholder ,  Alexander S. Liberson ,  Jeffrey S. Lillie

Inventor： David A. Borkholder ,  Alexander S. Liberson ,  Jeffrey S. Lillie

IPC: A61B5/021 ,  G09B23/28 ,  A61B5/02 ,  G09B23/30 ,  A61B5/0285 ,  A61B5/0295 ,  A61B5/0456

CPC classification number: A61B5/7278 ,  A61B5/02007 ,  A61B5/021 ,  A61B5/02125 ,  A61B5/0285 ,  A61B5/0295 ,  A61B5/0456 ,  G09B23/28 ,  G09B23/288 ,  G09B23/30

Abstract: A noninvasive method for monitoring the blood pressure and arterial compliance of a patient based on measurements of a flow velocity and a pulse wave velocity is described. An embodiment uses a photoplethysmograph and includes a method to monitor the dynamic behavior of the arterial blood flow, coupled with a hemodynamic mathematical model of the arterial blood flow motion in a fully nonlinear vessel. A derived mathematical model creates the patient specific dependence of a blood pressure versus PWV and blood velocity, which allows continuous monitoring of arterial blood pressure.

公开(公告)号：US20120076736A1

公开(公告)日：2012-03-29

申请号：US13234992

申请日：2011-09-16

Applicant: David A. Borkholder

Inventor： David A. Borkholder

IPC: A61K49/00

CPC classification number: G01N33/542 ,  C07K2319/00 ,  C07K2319/20 ,  G01N33/66

Abstract: The present invention relates to an in vivo method of monitoring an analyte in a subject. This method involves providing an expression vector that encodes a biosensor molecule, the biosensor molecule comprising an analyte binding domain and a signal domain. The biosensor molecule produces a signal from the signal domain upon binding of the analyte by the analyte binding domain. The signal is detectable by a non-invasive means. The expression vector is introduced locally into in vivo cells of a subject under conditions effective to express the biosensor molecule in the cells. The signal from the expressed biosensor molecule is detected by a non-invasive means, thereby monitoring the analyte in the subject in vivo.

Abstract translation: 本发明涉及一种监测受试者中分析物的体内方法。 该方法包括提供编码生物传感器分子的表达载体，生物传感器分子包含分析物结合域和信号结构域。 当分析物结合分析物结合域时，生物传感器分子从信号域产生信号。 该信号可通过非侵入性手段检测。 在有效表达细胞内的生物传感器分子的条件下，将表达载体局部引入受试者的体内细胞。 通过非侵入性手段检测来自表达的生物传感器分子的信号，从而在体内监测受试者中的分析物。

公开(公告)号：US20210219924A1

公开(公告)日：2021-07-22

申请号：US17150920

申请日：2021-01-15

Applicant: Alexander S. Liberson ,  Yashar Seyed Vahedein ,  David A. Borkholder

Inventor： Alexander S. Liberson ,  Yashar Seyed Vahedein ,  David A. Borkholder

IPC: A61B5/00 ,  A61B5/029 ,  A61B5/02 ,  A61B5/021 ,  A61B5/0205 ,  G16H50/30

Abstract: An integrated bioinstrumentation system, combining an accurate and robust quasi 1D computational model with experimental peripheral measurements, is designed to extract information on other quantities of interest, for which the direct measurements are not feasible. The system is able to quantify and visualize the distributions of a cardiac output (CO), aortic blood pressure (BP), flow, velocity, and aortic arterial compliance, based on a peripheral analysis of a pulse transit time (PTT) measured at the available peripheral sites. A preliminary calibration stage extracts the arterial properties from simultaneous measurements of a pulse transit time, and an upper arm blood pressure. Obtained transfer functions, linking noninvasive peripheral measurements to the aortic pressure, cardiac output, aortic compliance and others serve to quantify the indicators of cardiac morbidity and mortality.

公开(公告)号：US11035498B2

公开(公告)日：2021-06-15

申请号：US15829565

申请日：2017-12-01

Applicant: Ahmed Alfadhel ,  Meng-Chun Hsu ,  David A. Borkholder

Inventor： Ahmed Alfadhel ,  Meng-Chun Hsu ,  David A. Borkholder

IPC: F16K99/00 ,  B01L3/00 ,  H01F1/00 ,  C01G49/08 ,  H01F1/44

Abstract: A capsule is disclosed which includes a flexible outer shell capable of transforming into an asymmetric shape; an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles, wherein the magnetic particles can move in response to an applied magnetic field. A valve system includes an in-line valve sized to fit within a flow channel including a capsule having a flexible outer shell containing an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles; and a magnetic field source disposed about the exterior wall of the channel.

公开(公告)号：US10292445B2

公开(公告)日：2019-05-21

申请号：US13371202

申请日：2012-02-10

Applicant: David A. Borkholder ,  Werner Fassler ,  Andrew Blair ,  Kim Sherman ,  Derek DeBusschere

Inventor： David A. Borkholder ,  Werner Fassler ,  Andrew Blair ,  Kim Sherman ,  Derek DeBusschere

IPC: A42B3/04 ,  A61B5/11 ,  A61B5/00 ,  G01L5/14 ,  G01P15/08 ,  G16H50/30

Abstract: A dosimetry apparatus includes at least one sensor in a housing, a cover configured to permit compression waves to pass through, the cover is seated over the at least one sensor, and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the at least one sensor; storing the readings with a time and date stamp when obtained; conducting an analysis based on the obtained readings; and outputting at least one of the stored readings or the conducted analysis.

公开(公告)号：US20180269378A1

公开(公告)日：2018-09-20

申请号：US15925166

申请日：2018-03-19

Applicant: David A. Borkholder ,  Jing Ouyang ,  Denis R. Cormier ,  Ahmed Alfadhel

Inventor： David A. Borkholder ,  Jing Ouyang ,  Denis R. Cormier ,  Ahmed Alfadhel

IPC: H01L41/257 ,  B05D7/14 ,  B05D3/14 ,  B05D3/00 ,  C01G25/00 ,  H01L41/187 ,  H01L41/43

CPC classification number: H01L41/257 ,  B05D3/14 ,  B05D3/207 ,  B05D7/14 ,  C01G25/006 ,  H01L41/1876 ,  H01L41/43

Abstract: Material properties are manipulated using rapid pulse application of energy in combination with applied electric or magnetic fields. When sintering, annealing or crystallizing a target film, the pulse repetition cycle can be constrained to ensure material temperature rises above and falls below the Curie temperature before the next energy pulse. This process results in enhanced material properties as compared to traditional techniques having a single, slow temperature excursion and subsequent application of the applied external field.

公开(公告)号：US09339224B2

公开(公告)日：2016-05-17

申请号：US13371183

申请日：2012-02-10

Applicant: David A. Borkholder ,  Gregory T. A. Kovacs ,  Jeffrey Rogers

Inventor： David A. Borkholder ,  Gregory T. A. Kovacs ,  Jeffrey Rogers

IPC: A61B5/103 ,  A61B5/16 ,  A61B5/00 ,  F41H1/02 ,  F41H1/04 ,  F42D5/00 ,  A61B5/11

CPC classification number: A61B5/4064 ,  A61B5/1112 ,  A61B5/165 ,  A61B5/6803 ,  A61B5/7275 ,  A61B5/7282 ,  A61B2562/0219 ,  A61B2562/0247 ,  F41H1/02 ,  F41H1/04 ,  F42D5/00 ,  G06F19/00 ,  Y10T29/49002

Abstract: A dosimetry device includes at least one sensor in a housing and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.

Abstract translation: 剂量测定装置包括壳体中的至少一个传感器和具有存储器的剂量测定处理装置。 剂量测定处理装置耦合到壳体中的至少一个传感器。 剂量测定处理装置被配置为执行存储在存储器中的编程指令，包括：从传感器获得读数; 存储读数; 对存储的读数进行分析以确定伤害风险评估; 并且输出所确定的伤害风险评估或存储的读数的进行分析中的至少一个。