公开(公告)号：US11147899B2

公开(公告)日：2021-10-19

申请号：US14916226

申请日：2014-09-02

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION-RAMBAM

Inventor： Shulamit Levenberg ,  Dana Egozi ,  Jacob Koffler ,  Yulia Shandalov-Levi

IPC: A61L27/18 ,  C12N5/077 ,  A61L27/36 ,  A61L27/56 ,  A61L27/38 ,  C12N5/071

Abstract: The present invention provides an implant which includes: (a) an autologous engineered tissue; and (b) a vasculature, wherein the engineered tissue is a porous scaffold embedded with endothelial cell, a fibroblast, a myoblast, a mesenchymal cell, an adipocyte, or any combination thereof, wherein the vasculature feeds the cells. Further, the invention provides a method for treating a subject afflicted with a large soft tissue defect by implanting the implant of the invention.

公开(公告)号：US20160287577A1

公开(公告)日：2016-10-06

申请号：US15037412

申请日：2014-11-26

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION - RAMBAM ,  THE RAPPAPORT INSTITUTE

Inventor： Asya ROLLS ,  Tamar BEN SHANNAN ,  Hilla AZULAY-DEBBIE ,  Fahed HAKIM ,  Maya SCHILLER ,  Shai SHEN-ORR ,  Elina STAROSVETSKY

IPC: A61K31/48 ,  A61K31/506 ,  A61N2/02 ,  A61K31/428 ,  A61N2/00 ,  A61K31/473 ,  A61K31/4045

CPC classification number: A61K31/48 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/473 ,  A61K31/506 ,  A61N2/006 ,  A61N2/02

Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

Abstract translation: 提供了通过激活或抑制腹侧视野区域（VTA）中的多巴胺能神经元来调节免疫应答的方法。 通过调节自然杀伤细胞，CD8T细胞，CD4T细胞，B细胞，树突状细胞，巨噬细胞，粒细胞或其组合的活性，丰度或丰度来实现调节。

公开(公告)号：US20160193382A1

公开(公告)日：2016-07-07

申请号：US14916226

申请日：2014-09-02

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION-RAMBAM

Inventor： Shulamit LEVENBERG ,  Dana EGOZI ,  Jacob KOFFLER ,  Yulia SHANDALOV-LEVI

IPC: A61L27/18 ,  C12N5/077 ,  A61L27/36 ,  C12N5/071 ,  A61L27/38 ,  A61L27/56

CPC classification number: A61L27/18 ,  A61L27/3625 ,  A61L27/3695 ,  A61L27/3808 ,  A61L27/3886 ,  A61L27/3895 ,  A61L27/56 ,  A61L2300/64 ,  A61L2430/34 ,  C12N5/0658 ,  C12N5/069 ,  C12N2502/13 ,  C12N2502/1335 ,  C12N2533/40 ,  C08L67/04

Abstract: The present invention provides an implant which includes: (a) an autologous engineered tissue; and (b) a vasculature, wherein the engineered tissue is a porous scaffold embedded with endothelial cell, a fibroblast, a myoblast, a mesenchymal cell, an adipocyte, or any combination thereof, wherein the vasculature feeds the cells. Further, the invention provides a method for treating a subject afflicted with a large soft tissue defect by implanting the implant of the invention.

Abstract translation: 本发明提供了一种植入物，其包括：（a）自体工程组织; 和（b）脉管系统，其中所述工程化组织是嵌入有内皮细胞，成纤维细胞，成肌细胞，间充质细胞，脂肪细胞或其任何组合的多孔支架，其中所述脉管系统进料细胞。 此外，本发明提供了一种通过植入本发明的植入物来治疗患有大软组织缺损的受试者的方法。

公开(公告)号：US12201628B2

公开(公告)日：2025-01-21

申请号：US17947509

申请日：2022-09-19

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION—RAMBAM

Inventor： Asya Rolls ,  Tamar Ben Shannan ,  Hilla Azulay-Debbie ,  Fahed Hakim ,  Maya Schiller ,  Shai Shen-Orr ,  Elina Starosvetsky

IPC: A61N2/00 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/473 ,  A61K31/48 ,  A61K31/506 ,  A61N2/02

Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

公开(公告)号：US20230037897A1

公开(公告)日：2023-02-09

申请号：US17947509

申请日：2022-09-19

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION - RAMBAM

Inventor： Asya ROLLS ,  Tamar BEN SHANNAN ,  Hilla AZULAY-DEBBIE ,  Fahed HAKIM ,  Maya SCHILLER ,  Shai SHEN-ORR ,  Elina STAROSVETSKY

IPC: A61K31/48 ,  A61K31/428 ,  A61K31/473 ,  A61K31/506 ,  A61N2/00 ,  A61N2/02 ,  A61K31/404 ,  A61K31/4045

Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

公开(公告)号：US20170202900A1

公开(公告)日：2017-07-20

申请号：US15125340

申请日：2015-03-09

Applicant: HEALTH CORPORATION - RAMBAM MED-TECH LTD.

Inventor： Yona Nadir ,  Benjamin Brenner

IPC: A61K38/00

CPC classification number: A61K38/005 ,  A61K38/57

Abstract: The present invention is directed to peptides derived from certain domains of tissue factor pathway inhibitor (TFPI) for use in the treatment of solid tumors and diseases or disorders associated with abnormal clotting.

公开(公告)号：US11471453B2

公开(公告)日：2022-10-18

申请号：US16834323

申请日：2020-03-30

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION—RAMBAM

Inventor： Asya Rolls ,  Tamar Ben Shannan ,  Hilla Azulay-Debbie ,  Fahed Hakim ,  Maya Schiller ,  Shai Shen-Orr ,  Elina Starosvetsky

IPC: A61N2/00 ,  A61N2/02 ,  A61K31/48 ,  A61K31/428 ,  A61K31/473 ,  A61K31/506 ,  A61K31/404 ,  A61K31/4045

Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

公开(公告)号：US20200246329A1

公开(公告)日：2020-08-06

申请号：US16834323

申请日：2020-03-30

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION - RAMBAM

Inventor： Asya ROLLS ,  Tamar BEN SHANNAN ,  Hilla AZULAY-DEBBIE ,  Fahed HAKIM ,  Maya SCHILLER ,  Shai SHEN-ORR ,  Elina STAROSVETSKY

IPC: A61K31/48 ,  A61K31/428 ,  A61K31/473 ,  A61K31/506 ,  A61N2/00 ,  A61N2/02 ,  A61K31/404 ,  A61K31/4045

Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.

公开(公告)号：US10603315B2

公开(公告)日：2020-03-31

申请号：US15037412

申请日：2014-11-26

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED ,  HEALTH CORPORATION—RAMBAM ,  THE RAPPAPORT INSTITUTE

Inventor： Asya Rolls ,  Tamar Ben Shannan ,  Hilla Azulay-Debbie ,  Fahed Hakim ,  Maya Schiller ,  Shai Shen-Orr ,  Elina Starosvetsky

IPC: A61N2/00 ,  A61N2/02 ,  A61K31/48 ,  A61K31/428 ,  A61K31/473 ,  A61K31/506 ,  A61K31/404 ,  A61K31/4045

Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.