公开(公告)号：US20240076438A1

公开(公告)日：2024-03-07

申请号：US18364242

申请日：2023-08-02

申请人： Hyalex Orthopaedics, Inc.

发明人： Lampros Kourtis ,  David Myung ,  Daniel Chang ,  Bing Yu ,  Timothy Sun ,  Michael J. Jaasma ,  Vernon Hartdegen

IPC分类号： C08G18/62 ,  A61F2/30 ,  A61K47/32 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61M5/19 ,  B65D85/00 ,  C08G18/32 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/72 ,  C08G81/02 ,  C08L33/08 ,  C08L33/12 ,  C09J4/06 ,  C09J133/14 ,  C09J135/02 ,  F01D5/08 ,  F01D11/00 ,  F01D11/02

CPC分类号： C08G18/6229 ,  A61F2/30 ,  A61K47/32 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/06 ,  A61M5/19 ,  B65D85/70 ,  C08G18/3206 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/6705 ,  C08G18/728 ,  C08G81/024 ,  C08L33/08 ,  C08L33/12 ,  C09J4/06 ,  C09J133/14 ,  C09J135/02 ,  F01D5/082 ,  F01D11/001 ,  F01D11/025 ,  A61B17/56 ,  A61L2300/406 ,  A61L2430/24 ,  F05D2240/57 ,  F05D2260/14

摘要： Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

公开(公告)号：US11771802B2

公开(公告)日：2023-10-03

申请号：US17749699

申请日：2022-05-20

申请人： Hyalex Orthopaedics, Inc.

发明人： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC分类号： A61L27/34 ,  A61L27/48 ,  A61F2/30 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61L27/26 ,  A61L27/18 ,  A61F2/00

CPC分类号： A61L27/34 ,  A61F2/0095 ,  A61F2/3099 ,  A61F2/30756 ,  A61F2/32 ,  A61F2/3804 ,  A61F2/389 ,  A61F2/3872 ,  A61F2/3877 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4261 ,  A61F2/442 ,  A61F2/4405 ,  A61L27/18 ,  A61L27/26 ,  A61L27/48

摘要： The present disclosure pertains to ionic polymer compositions, including semi.- and fully interpenetrating polymer networks, methods of making, such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging, for such articles.

公开(公告)号：US11110200B2

公开(公告)日：2021-09-07

申请号：US17091787

申请日：2020-11-06

申请人： Hyalex Orthopaedics, Inc.

发明人： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC分类号： A61L27/34 ,  A61L27/48 ,  A61F2/30 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61L27/26 ,  A61L27/18 ,  A61F2/00

摘要： The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

公开(公告)号：US10519270B2

公开(公告)日：2019-12-31

申请号：US15668547

申请日：2017-08-03

申请人： Hyalex Orthopaedics, Inc.

发明人： Lampros Kourtis ,  David Myung ,  Daniel Chang ,  Bing Yu ,  Timothy Sun ,  Michael J. Jaasma ,  Vernon Hartdegen

IPC分类号： A61F2/30 ,  A61K47/32 ,  C08G18/62 ,  A61M5/19 ,  B65D85/00 ,  C09J133/14 ,  A61L24/06 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/32 ,  C09J4/06 ,  C09J135/02 ,  A61L24/00 ,  A61L24/04 ,  C08G18/72 ,  C08G81/02 ,  C08L33/08 ,  C08L33/12 ,  F01D5/08 ,  F01D11/00 ,  F01D11/02 ,  A61B17/56

摘要： Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

公开(公告)号：US20200087440A1

公开(公告)日：2020-03-19

申请号：US16688351

申请日：2019-11-19

申请人： Hyalex Orthopaedics, Inc.

发明人： Lampros KOURTIS ,  David MYUNG ,  Daniel CHANG ,  Bing YU ,  Timothy SUN ,  Michael J. JAASMA ,  Vernon HARTDEGEN

IPC分类号： C08G18/62 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/32 ,  C09J4/06 ,  C09J135/02 ,  A61F2/30 ,  A61K47/32 ,  A61M5/19 ,  B65D85/00 ,  C09J133/14 ,  A61L24/06 ,  A61L24/00 ,  A61L24/04 ,  C08G18/72 ,  C08G81/02 ,  C08L33/08 ,  C08L33/12 ,  F01D5/08 ,  F01D11/02 ,  F01D11/00

摘要： Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

公开(公告)号：US20200023098A1

公开(公告)日：2020-01-23

申请号：US16514279

申请日：2019-07-17

申请人： Hyalex Orthopaedics, Inc.

发明人： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC分类号： A61L27/34 ,  A61F2/00 ,  A61F2/30 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61L27/26 ,  A61L27/18 ,  A61L27/48

摘要： The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

公开(公告)号：US20190224367A1

公开(公告)日：2019-07-25

申请号：US16251966

申请日：2019-01-18

申请人： Hyalex Orthopaedics, Inc.

发明人： Lampros Kourtis ,  Iraklis Kourtis ,  Jun Li ,  Gary Li

IPC分类号： A61L27/34 ,  C08L75/04 ,  C08L33/26 ,  C08L101/14 ,  A61L27/26 ,  A61F2/28 ,  A61L27/52 ,  A61F2/42

摘要： IPN compositions and methods of making the same are provided. The IPN compositions can include a water swellable, water permeable IPN or semi-IPN member with a first polymer network including a hydrophobic thermoset or thermoplastic polymer, a second polymer network including a non-ionic polymer, and a third polymer network including an ionic polymer containing sulfonic acid functional groups that are otherwise difficult to form composites with hydrophobic polymers. The IPN compositions can be used in orthopedic implants or in mechanical applications as a bearing material.

公开(公告)号：US20190218386A1

公开(公告)日：2019-07-18

申请号：US16246292

申请日：2019-01-11

申请人： Hyalex Orthopaedics, Inc.

发明人： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC分类号： C08L33/02 ,  C08F220/14 ,  C08G18/48 ,  C08G18/83 ,  C08G77/38 ,  A61F2/30 ,  C08G18/44 ,  C08G18/76 ,  C08L75/06 ,  C08L75/16 ,  C08F236/06 ,  C08F220/06

CPC分类号： C08L33/02 ,  A61F2/30 ,  A61F2/30988 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2/3877 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4261 ,  A61F2/442 ,  A61F2002/30998 ,  A61F2002/4205 ,  A61F2002/4238 ,  A61F2002/4256 ,  A61F2310/00011 ,  A61F2310/00179 ,  C08F220/06 ,  C08F220/14 ,  C08F236/06 ,  C08G18/44 ,  C08G18/4854 ,  C08G18/7671 ,  C08G18/831 ,  C08G18/837 ,  C08G77/38 ,  C08G2270/00 ,  C08L75/04 ,  C08L75/06 ,  C08L75/16 ,  C08L2205/04

摘要： The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

公开(公告)号：US20230414833A1

公开(公告)日：2023-12-28

申请号：US18461116

申请日：2023-09-05

申请人： Hyalex Orthopaedics, Inc.

发明人： Iraklis KOURTIS ,  Jun LI ,  Lampros KOURTIS

IPC分类号： A61L27/34 ,  A61L27/48 ,  A61F2/30 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61L27/26 ,  A61L27/18 ,  A61F2/00

CPC分类号： A61L27/34 ,  A61L27/48 ,  A61F2/30756 ,  A61F2/32 ,  A61F2/3804 ,  A61F2/3872 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/3099 ,  A61F2/389 ,  A61F2/3877 ,  A61F2/4241 ,  A61F2/4405 ,  A61F2/442 ,  A61F2/4261 ,  A61L27/26 ,  A61L27/18 ,  A61F2/0095

摘要： The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

公开(公告)号：US20230000628A1

公开(公告)日：2023-01-05

申请号：US17365135

申请日：2021-07-01

申请人： HYALEX ORTHOPAEDICS, INC.

发明人： Mira Sahney ,  David Myung ,  James Craig Fryman ,  Michael E. Hawkins

IPC分类号： A61F2/30 ,  A61F2/28

摘要： Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.