公开(公告)号：US20200023098A1

公开(公告)日：2020-01-23

申请号：US16514279

申请日：2019-07-17

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC: A61L27/34 ,  A61F2/00 ,  A61F2/30 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61L27/26 ,  A61L27/18 ,  A61L27/48

Abstract: The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

公开(公告)号：US20190224367A1

公开(公告)日：2019-07-25

申请号：US16251966

申请日：2019-01-18

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Lampros Kourtis ,  Iraklis Kourtis ,  Jun Li ,  Gary Li

IPC: A61L27/34 ,  C08L75/04 ,  C08L33/26 ,  C08L101/14 ,  A61L27/26 ,  A61F2/28 ,  A61L27/52 ,  A61F2/42

Abstract: IPN compositions and methods of making the same are provided. The IPN compositions can include a water swellable, water permeable IPN or semi-IPN member with a first polymer network including a hydrophobic thermoset or thermoplastic polymer, a second polymer network including a non-ionic polymer, and a third polymer network including an ionic polymer containing sulfonic acid functional groups that are otherwise difficult to form composites with hydrophobic polymers. The IPN compositions can be used in orthopedic implants or in mechanical applications as a bearing material.

公开(公告)号：US20190218386A1

公开(公告)日：2019-07-18

申请号：US16246292

申请日：2019-01-11

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC: C08L33/02 ,  C08F220/14 ,  C08G18/48 ,  C08G18/83 ,  C08G77/38 ,  A61F2/30 ,  C08G18/44 ,  C08G18/76 ,  C08L75/06 ,  C08L75/16 ,  C08F236/06 ,  C08F220/06

CPC classification number: C08L33/02 ,  A61F2/30 ,  A61F2/30988 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2/3877 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4261 ,  A61F2/442 ,  A61F2002/30998 ,  A61F2002/4205 ,  A61F2002/4238 ,  A61F2002/4256 ,  A61F2310/00011 ,  A61F2310/00179 ,  C08F220/06 ,  C08F220/14 ,  C08F236/06 ,  C08G18/44 ,  C08G18/4854 ,  C08G18/7671 ,  C08G18/831 ,  C08G18/837 ,  C08G77/38 ,  C08G2270/00 ,  C08L75/04 ,  C08L75/06 ,  C08L75/16 ,  C08L2205/04

Abstract: The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

公开(公告)号：US20240076438A1

公开(公告)日：2024-03-07

申请号：US18364242

申请日：2023-08-02

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Lampros Kourtis ,  David Myung ,  Daniel Chang ,  Bing Yu ,  Timothy Sun ,  Michael J. Jaasma ,  Vernon Hartdegen

IPC: C08G18/62 ,  A61F2/30 ,  A61K47/32 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61M5/19 ,  B65D85/00 ,  C08G18/32 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/72 ,  C08G81/02 ,  C08L33/08 ,  C08L33/12 ,  C09J4/06 ,  C09J133/14 ,  C09J135/02 ,  F01D5/08 ,  F01D11/00 ,  F01D11/02

CPC classification number: C08G18/6229 ,  A61F2/30 ,  A61K47/32 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/06 ,  A61M5/19 ,  B65D85/70 ,  C08G18/3206 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/6705 ,  C08G18/728 ,  C08G81/024 ,  C08L33/08 ,  C08L33/12 ,  C09J4/06 ,  C09J133/14 ,  C09J135/02 ,  F01D5/082 ,  F01D11/001 ,  F01D11/025 ,  A61B17/56 ,  A61L2300/406 ,  A61L2430/24 ,  F05D2240/57 ,  F05D2260/14

Abstract: Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

公开(公告)号：US11771802B2

公开(公告)日：2023-10-03

申请号：US17749699

申请日：2022-05-20

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC: A61L27/34 ,  A61L27/48 ,  A61F2/30 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61L27/26 ,  A61L27/18 ,  A61F2/00

CPC classification number: A61L27/34 ,  A61F2/0095 ,  A61F2/3099 ,  A61F2/30756 ,  A61F2/32 ,  A61F2/3804 ,  A61F2/389 ,  A61F2/3872 ,  A61F2/3877 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2/4261 ,  A61F2/442 ,  A61F2/4405 ,  A61L27/18 ,  A61L27/26 ,  A61L27/48

Abstract: The present disclosure pertains to ionic polymer compositions, including semi.- and fully interpenetrating polymer networks, methods of making, such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging, for such articles.

公开(公告)号：US11110200B2

公开(公告)日：2021-09-07

申请号：US17091787

申请日：2020-11-06

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Iraklis Kourtis ,  Jun Li ,  Lampros Kourtis

IPC: A61L27/34 ,  A61L27/48 ,  A61F2/30 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61L27/26 ,  A61L27/18 ,  A61F2/00

Abstract: The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

公开(公告)号：US10519270B2

公开(公告)日：2019-12-31

申请号：US15668547

申请日：2017-08-03

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Lampros Kourtis ,  David Myung ,  Daniel Chang ,  Bing Yu ,  Timothy Sun ,  Michael J. Jaasma ,  Vernon Hartdegen

IPC: A61F2/30 ,  A61K47/32 ,  C08G18/62 ,  A61M5/19 ,  B65D85/00 ,  C09J133/14 ,  A61L24/06 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/32 ,  C09J4/06 ,  C09J135/02 ,  A61L24/00 ,  A61L24/04 ,  C08G18/72 ,  C08G81/02 ,  C08L33/08 ,  C08L33/12 ,  F01D5/08 ,  F01D11/00 ,  F01D11/02 ,  A61B17/56

Abstract: Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

公开(公告)号：US10457803B2

公开(公告)日：2019-10-29

申请号：US15394297

申请日：2016-12-29

Applicant: Hyalex Orthopaedics, Inc.

Inventor： David Myung ,  Michael J. Jaasma ,  Lampros Kourtis ,  Jeffrey G. Roberts ,  Vernon Hartdegen

IPC: A61F2/30 ,  C08L33/02 ,  C08G18/48 ,  C08G18/76 ,  C08G18/83 ,  C08L75/06 ,  C08L75/16 ,  C08F220/06 ,  C08F220/14 ,  C08F236/06 ,  C08G18/44 ,  C08G77/38 ,  C08L75/04 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44

Abstract: Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or compositional gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.

公开(公告)号：US09750842B2

公开(公告)日：2017-09-05

申请号：US14877884

申请日：2015-10-07

Applicant: HYALEX ORTHOPAEDICS, INC.

Inventor： Lampros Kourtis ,  David Myung ,  Daniel Chang ,  Bing Yu ,  Timothy Sun ,  Michael J. Jaasma ,  Vernon Hartdegen

IPC: A61L24/06 ,  A61F2/30 ,  A61K47/32 ,  A61M5/19 ,  B65D85/00 ,  C09J133/14 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/32 ,  C09J4/06 ,  C09J135/02 ,  A61L24/00 ,  A61L24/04

CPC classification number: C08G18/6229 ,  A61B17/56 ,  A61F2/30 ,  A61K47/32 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/06 ,  A61L2300/406 ,  A61L2430/24 ,  A61M5/19 ,  B65D85/70 ,  C08G18/3206 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/6705 ,  C08G18/728 ,  C08G81/024 ,  C08L33/08 ,  C08L33/12 ,  C09J4/06 ,  C09J133/14 ,  C09J135/02 ,  C08F2220/343 ,  C08F220/14

Abstract: Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

公开(公告)号：US11015016B2

公开(公告)日：2021-05-25

申请号：US16688351

申请日：2019-11-19

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Lampros Kourtis ,  David Myung ,  Daniel Chang ,  Bing Yu ,  Timothy Sun ,  Michael J. Jaasma ,  Vernon Hartdegen

IPC: A61F2/30 ,  A61K47/32 ,  C08G18/62 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/32 ,  C09J4/06 ,  C09J135/02 ,  C08L33/08 ,  C08L33/12 ,  F01D5/08 ,  F01D11/02 ,  F01D11/00 ,  A61M5/19 ,  B65D85/00 ,  C09J133/14 ,  A61L24/06 ,  A61L24/00 ,  A61L24/04 ,  C08G18/72 ,  C08G81/02 ,  A61B17/56

Abstract: Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.