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14 条记录 (耗时 0.021 秒)

    Precise and thorough background subtraction
    4.
    发明申请
    Precise and thorough background subtraction 有权
    精确和彻底的背景减法

    公开(公告)号：US20100213368A1

    公开(公告)日：2010-08-26

    申请号：US12709474

    申请日：2010-02-20

    申请人： Xin Wang ,  Haiying Zhang

    发明人： Xin Wang ,  Haiying Zhang

    IPC分类号： H01J49/26 ,  H01J49/02

    CPC分类号： H01J49/0036

    摘要： A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.

    摘要翻译： 用于鉴定和表征复杂样品中感兴趣的组分的方法包括将样品及其对照样品进行色谱/高分辨率质谱分析以检测样品的离子。 该方法包括在测试样本数据中围绕每个离子或每组相同离子的指定色谱波动时间和质量精密窗口中定义控制样本数据的部分。 检查对照样品数据的限定部分，并从测试样品中的相应离子中减去最大强度。 从测试样品的结果数据确定感兴趣的组分。 该方法可用于鉴定复合样品中感兴趣组分的分子离子和/或其碎片离子。

    Mass defect filter
    5.
    发明授权
    Mass defect filter 有权
    质量缺陷过滤器

    公开(公告)号：US07381568B2

    公开(公告)日：2008-06-03

    申请号：US10858738

    申请日：2004-06-02

    申请人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

    发明人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

    IPC分类号： G01N24/00

    CPC分类号： H01J49/0027 ,  Y10T436/24

    摘要： A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species. Mass defect values for the detected ions are determined. The method also includes specifying a predetermined range for mass defect values. Detected ions having mass defect values falling outside the specified range are discarded and those with mass defect values falling within the predetermined range are retained. Species of interest are determined from the retained values. The species of interest include drug metabolites or impurities and/or degradants of a known pharmaceutical sample.

    摘要翻译： 用于检测和鉴定生物样品中代谢物的方法包括对样品进行高分辨质谱（MS）分析以检测分子种类的离子。 确定检测离子的质量缺陷值。 该方法还包括指定质量缺陷值的预定范围。 质量缺陷值超出规定范围的检测离子被丢弃，质量缺陷值落在预定范围内的检测离子被保留。 感兴趣的物种是根据保留值确定的。 感兴趣的物种包括已知药物样品的药物代谢物或杂质和/或降解物。

    CATALYST COMPOSITION FOR OLIGOMERIZATION OF ETHYLENE AND PROCESSES OF OLIGOMERIZATION
    10.
    发明申请
    CATALYST COMPOSITION FOR OLIGOMERIZATION OF ETHYLENE AND PROCESSES OF OLIGOMERIZATION 审中-公开
    乙烯低聚化催化剂组合物及其低分子化方法

    公开(公告)号：US20130018214A1

    公开(公告)日：2013-01-17

    申请号：US13637976

    申请日：2011-03-30

    申请人： Mingfang Zheng ,  Weizhen Li ,  Huaijie Wang ,  Jun Liu ,  Haiying Zhang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Jilong Wang ,  Hongfei Wu ,  Yuling Piao ,  Junlong Sui

    发明人： Mingfang Zheng ,  Weizhen Li ,  Huaijie Wang ,  Jun Liu ,  Haiying Zhang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Jilong Wang ,  Hongfei Wu ,  Yuling Piao ,  Junlong Sui

    IPC分类号： B01J31/12 ,  C07C2/26

    CPC分类号： C08F10/02 ,  B01J31/143 ,  B01J31/183 ,  B01J2231/20 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C2/32 ,  C07C2531/14 ,  C07C2531/22 ,  C08F110/02 ,  Y02P20/52 ,  C08F4/7042 ,  C08F2500/02 ,  C07C11/02 ,  C08F210/02

    摘要： The present invention provides a catalyst composition for the ethylene oligomerization, which comprises 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst. The present invention also provides a process for oligomerization of ethylene is provided, wherein a catalyst composition comprising 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst is used, and the molar ratio of aluminum in the cocatalyst to central metal in the main catalyst ranges from 30 to less than 200. According to the present invention, another process for oligomerization of ethylene is also provided, wherein a catalyst composition comprising 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst is used, and the temperature of ethylene oligomerization ranges from −10 to 19° C. According to the present invention, the price of cocatalyst i.e. triethylaluminum, is low, just a fraction of that of methylaluminoxane, the amount of cocatalyst is therefore significantly reduced, with the catalytic activity is still acceptable, thus the cost of ethylene oligomerization is significantly reduced. In view of both the catalytic activity and the cost, the present invention is highly applicable in industry.

    摘要翻译： 本发明提供了一种用于乙烯低聚的催化剂组合物，其包含2-亚氨基-1,10-菲咯啉配位的铁（II），钴（II）或氯化镍（II）作为主要催化剂，三乙基铝作为助催化剂。 本发明还提供了一种乙烯低聚方法，其中包含2-亚氨基-1,10-菲咯啉配位的铁（II），钴（II）或氯化镍（II）作为主要催化剂的催化剂组合物和三乙基铝作为 助催化剂，主催化剂中助催化剂与中心金属之间的铝的摩尔比为30至小于200.根据本发明，还提供了另一种乙烯低聚方法，其中催化剂组合物包含2 - 亚氨基-1,10-菲咯啉配位的铁（II），钴（II）或氯化镍（II）为主催化剂，三乙基铝为助催化剂，乙烯齐聚温度为-10〜19℃。 对于本发明，助催化剂即三乙基铝的价格低，仅仅是甲基铝氧烷的一部分，因此助催化剂的量显着降低，催化活性为 仍然是可接受的，因此乙烯低聚的成本显着降低。 鉴于催化活性和成本两方面，本发明在工业上是高度适用的。