公开(公告)号：US20130267708A1

公开(公告)日：2013-10-10

申请号：US13991044

申请日：2011-12-01

申请人： Jun Liu ,  Mingfang Zheng ,  Weizhen Li ,  Haiying Zhang ,  Huaijie Wang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Hongfei Wu ,  Wingjun Xie ,  Chunhong Wu ,  Zhiguang Jia ,  Qi Yanping ,  Jilong Wang

发明人： Jun Liu ,  Mingfang Zheng ,  Weizhen Li ,  Haiying Zhang ,  Huaijie Wang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Hongfei Wu ,  Wingjun Xie ,  Chunhong Wu ,  Zhiguang Jia ,  Qi Yanping ,  Jilong Wang

IPC分类号： C08F110/02

CPC分类号： C08F110/02 ,  B01J31/183 ,  B01J2231/20 ,  B01J2531/0241 ,  B01J2531/842 ,  C07C2/32 ,  C07D213/127 ,  C07D471/04 ,  C07F15/025 ,  C07C11/02

摘要： Provided are a process for preparing an N ortho acyl substituted nitrogen-containing heterocyclic compound and an aminal iron (II) complex thereof, and the use of the complexes obtained by the process in an olefin oligomerization catalyst. The N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is for example 2-acyl-1,10-phenanthroline or 2,6-diacetyl pyridine as shown in formula b, and the N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is produced by a reaction of a precursor thereof in a substituted or unsubstituted nitrobenzene. Preferably the precursor shown in formula I in the present invention is produced by 1,10-phenanthroline reacting with trialkyl aluminum, or a halogenoalkyl aluminum RnAlXm, or a substituted or unsubstituted benzyl lithium 2Li, followed by hydrolysis. The preparation method provided in the present invention has a few synthetic steps, an easy process, a low toxic effect, and reduces the preparation costs of the catalyst, and has a promising outlook in the industrial application.

摘要翻译： 提供了制备N-邻酰基取代的含氮杂环化合物和其亚胺铁（II）络合物的方法，以及通过该方法在烯烃低聚催化剂中获得的络合物的用途。 本发明中的N-邻酰基取代的含氮杂环化合物例如如式b所示的2-酰基-1,10-菲咯啉或2,6-二乙酰基吡啶，并且N-邻酰基取代的含氮杂环化合物 在本发明中通过其前体在取代或未取代的硝基苯中的反应来制备。 优选地，本发明中式I所示的前体是通过与三烷基铝或卤代烷基铝RnAlXm或取代或未取代的苄基锂2Li反应的1,10-菲咯啉然后水解制备的。 本发明提供的制备方法具有几个合成步骤，易操作，低毒性，降低催化剂的制备成本，在工业应用前景看好。

公开(公告)号：US09266982B2

公开(公告)日：2016-02-23

申请号：US13991044

申请日：2011-12-01

申请人： Jun Liu ,  Mingfang Zheng ,  Weizhen Li ,  Haiying Zhang ,  Huaijie Wang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Hongfei Wu ,  Mingjun Xie ,  Chunhong Wu ,  Zhiguang Jia ,  Yanping Qi ,  Jilong Wang

发明人： Jun Liu ,  Mingfang Zheng ,  Weizhen Li ,  Haiying Zhang ,  Huaijie Wang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Hongfei Wu ,  Mingjun Xie ,  Chunhong Wu ,  Zhiguang Jia ,  Yanping Qi ,  Jilong Wang

IPC分类号： C07D471/04 ,  C07D211/70 ,  C07D211/82 ,  C07D213/46 ,  C08F110/02 ,  B01J31/18 ,  C07C2/32 ,  C07D213/127 ,  C07F15/02

CPC分类号： C08F110/02 ,  B01J31/183 ,  B01J2231/20 ,  B01J2531/0241 ,  B01J2531/842 ,  C07C2/32 ,  C07D213/127 ,  C07D471/04 ,  C07F15/025 ,  C07C11/02

摘要： Provided are a process for preparing an N ortho acyl substituted nitrogen-containing heterocyclic compound and an aminal iron (II) complex thereof, and the use of the complexes obtained by the process in an olefin oligomerization catalyst. The N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is for example 2-acyl-1,10-phenanthroline or 2,6-diacetyl pyridine as shown in formula b, and the N ortho acyl substituted nitrogen-containing heterocyclic compound in the present invention is produced by a reaction of a precursor thereof in a substituted or unsubstituted nitrobenzene. Preferably the precursor shown in formula I in the present invention is produced by 1,10-phenanthroline reacting with trialkyl aluminum, or a halogenoalkyl aluminum RnAIXm, or a substituted or unsubstituted benzyl lithium Ph′CH2Li, followed by hydrolysis. The preparation method provided in the present invention has a few synthetic steps, an easy process, a low toxic effect, and reduces the preparation costs of the catalyst, and has a promising outlook in the industrial application.

摘要翻译： 提供了制备N-邻酰基取代的含氮杂环化合物和其亚胺铁（II）络合物的方法，以及通过该方法在烯烃低聚催化剂中获得的络合物的用途。 本发明中的N-邻酰基取代的含氮杂环化合物例如如式b所示的2-酰基-1,10-菲咯啉或2,6-二乙酰基吡啶，并且N-邻酰基取代的含氮杂环化合物 在本发明中通过其前体在取代或未取代的硝基苯中的反应来制备。 优选地，本发明中式I所示的前体是通过与三烷基铝或卤代烷基铝RnAIXm或取代或未取代的苄基锂Ph'CH2Li反应的1,10-菲咯啉然后水解制备的。 本发明提供的制备方法具有几个合成步骤，易操作，低毒性，降低催化剂的制备成本，在工业应用前景看好。

公开(公告)号：US20130018214A1

公开(公告)日：2013-01-17

申请号：US13637976

申请日：2011-03-30

申请人： Mingfang Zheng ,  Weizhen Li ,  Huaijie Wang ,  Jun Liu ,  Haiying Zhang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Jilong Wang ,  Hongfei Wu ,  Yuling Piao ,  Junlong Sui

发明人： Mingfang Zheng ,  Weizhen Li ,  Huaijie Wang ,  Jun Liu ,  Haiying Zhang ,  Yu Zhou ,  Tonglin Li ,  Lan Zhao ,  Jilong Wang ,  Hongfei Wu ,  Yuling Piao ,  Junlong Sui

IPC分类号： B01J31/12 ,  C07C2/26

CPC分类号： C08F10/02 ,  B01J31/143 ,  B01J31/183 ,  B01J2231/20 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C2/32 ,  C07C2531/14 ,  C07C2531/22 ,  C08F110/02 ,  Y02P20/52 ,  C08F4/7042 ,  C08F2500/02 ,  C07C11/02 ,  C08F210/02

摘要： The present invention provides a catalyst composition for the ethylene oligomerization, which comprises 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst. The present invention also provides a process for oligomerization of ethylene is provided, wherein a catalyst composition comprising 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst is used, and the molar ratio of aluminum in the cocatalyst to central metal in the main catalyst ranges from 30 to less than 200. According to the present invention, another process for oligomerization of ethylene is also provided, wherein a catalyst composition comprising 2-imino-1,10-phenanthroline coordinated iron (II), cobalt (II) or nickel (II) chloride as main catalyst and triethylaluminum as cocatalyst is used, and the temperature of ethylene oligomerization ranges from −10 to 19° C. According to the present invention, the price of cocatalyst i.e. triethylaluminum, is low, just a fraction of that of methylaluminoxane, the amount of cocatalyst is therefore significantly reduced, with the catalytic activity is still acceptable, thus the cost of ethylene oligomerization is significantly reduced. In view of both the catalytic activity and the cost, the present invention is highly applicable in industry.

摘要翻译： 本发明提供了一种用于乙烯低聚的催化剂组合物，其包含2-亚氨基-1,10-菲咯啉配位的铁（II），钴（II）或氯化镍（II）作为主要催化剂，三乙基铝作为助催化剂。 本发明还提供了一种乙烯低聚方法，其中包含2-亚氨基-1,10-菲咯啉配位的铁（II），钴（II）或氯化镍（II）作为主要催化剂的催化剂组合物和三乙基铝作为 助催化剂，主催化剂中助催化剂与中心金属之间的铝的摩尔比为30至小于200.根据本发明，还提供了另一种乙烯低聚方法，其中催化剂组合物包含2 - 亚氨基-1,10-菲咯啉配位的铁（II），钴（II）或氯化镍（II）为主催化剂，三乙基铝为助催化剂，乙烯齐聚温度为-10〜19℃。 对于本发明，助催化剂即三乙基铝的价格低，仅仅是甲基铝氧烷的一部分，因此助催化剂的量显着降低，催化活性为 仍然是可接受的，因此乙烯低聚的成本显着降低。 鉴于催化活性和成本两方面，本发明在工业上是高度适用的。

公开(公告)号：USD960228S1

公开(公告)日：2022-08-09

申请号：US29790050

申请日：2021-11-02

申请人： Haiying Zhang

设计人： Haiying Zhang

公开(公告)号：US07381568B2

公开(公告)日：2008-06-03

申请号：US10858738

申请日：2004-06-02

申请人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

发明人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

IPC分类号： G01N24/00

CPC分类号： H01J49/0027 ,  Y10T436/24

摘要： A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species. Mass defect values for the detected ions are determined. The method also includes specifying a predetermined range for mass defect values. Detected ions having mass defect values falling outside the specified range are discarded and those with mass defect values falling within the predetermined range are retained. Species of interest are determined from the retained values. The species of interest include drug metabolites or impurities and/or degradants of a known pharmaceutical sample.

摘要翻译： 用于检测和鉴定生物样品中代谢物的方法包括对样品进行高分辨质谱（MS）分析以检测分子种类的离子。 确定检测离子的质量缺陷值。 该方法还包括指定质量缺陷值的预定范围。 质量缺陷值超出规定范围的检测离子被丢弃，质量缺陷值落在预定范围内的检测离子被保留。 感兴趣的物种是根据保留值确定的。 感兴趣的物种包括已知药物样品的药物代谢物或杂质和/或降解物。

公开(公告)号：USD960227S1

公开(公告)日：2022-08-09

申请号：US29790054

申请日：2021-11-02

申请人： Haiying Zhang

设计人： Haiying Zhang

公开(公告)号：US20120071534A1

公开(公告)日：2012-03-22

申请号：US13319937

申请日：2010-05-26

申请人： Brett B. Busch ,  William C. Stevens, JR. ,  Ellen K. Kick ,  Haiying Zhang ,  Venkataiah Bollu ,  Richard Martin ,  Raju Mohan

发明人： Brett B. Busch ,  William C. Stevens, JR. ,  Ellen K. Kick ,  Haiying Zhang ,  Venkataiah Bollu ,  Richard Martin ,  Raju Mohan

IPC分类号： A61K31/4174 ,  A61P9/10 ,  A61P5/48 ,  A61P19/02 ,  A61P25/00 ,  A61P3/10 ,  A61P3/06 ,  A61P17/06 ,  A61Q19/08 ,  A61P35/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  A61P3/04 ,  A61P27/02 ,  A61P17/00 ,  A61P9/00 ,  A61K8/49 ,  C07D233/64

CPC分类号： C07D233/64

摘要： Compounds, pharmaceutically acceptable salts, isomers, or prodrugs thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

摘要翻译： 公开了本发明的化合物，药学上可接受的盐，异构体或前体药物，其可用作肝脏X受体（LXR）活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。

公开(公告)号：US20100213368A1

公开(公告)日：2010-08-26

申请号：US12709474

申请日：2010-02-20

申请人： Xin Wang ,  Haiying Zhang

发明人： Xin Wang ,  Haiying Zhang

IPC分类号： H01J49/26 ,  H01J49/02

CPC分类号： H01J49/0036

摘要： A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.

摘要翻译： 用于鉴定和表征复杂样品中感兴趣的组分的方法包括将样品及其对照样品进行色谱/高分辨率质谱分析以检测样品的离子。 该方法包括在测试样本数据中围绕每个离子或每组相同离子的指定色谱波动时间和质量精密窗口中定义控制样本数据的部分。 检查对照样品数据的限定部分，并从测试样品中的相应离子中减去最大强度。 从测试样品的结果数据确定感兴趣的组分。 该方法可用于鉴定复合样品中感兴趣组分的分子离子和/或其碎片离子。

公开(公告)号：USD960230S1

公开(公告)日：2022-08-09

申请号：US29790049

申请日：2021-11-02

申请人： Haiying Zhang

设计人： Haiying Zhang

公开(公告)号：US08304719B2

公开(公告)日：2012-11-06

申请号：US12709474

申请日：2010-02-20

申请人： Xin Wang ,  Haiying Zhang

发明人： Xin Wang ,  Haiying Zhang

IPC分类号： H01J49/00

CPC分类号： H01J49/0036

摘要： A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.

摘要翻译： 用于鉴定和表征复杂样品中感兴趣的组分的方法包括将样品及其对照样品进行色谱/高分辨率质谱分析以检测样品的离子。 该方法包括在测试样本数据中围绕每个离子或每组相同离子的指定色谱波动时间和质量精密窗口中定义控制样本数据的部分。 检查对照样品数据的限定部分，并从测试样品中的相应离子中减去最大强度。 从测试样品的结果数据确定感兴趣的组分。 该方法可用于鉴定复合样品中感兴趣组分的分子离子和/或其碎片离子。