-
1.发明公开公开(公告)号：US20240360401A1
公开(公告)日：2024-10-31
申请号：US18287728
申请日：2022-04-21
申请人： ETABLISSEMENT FRANÇAIS DU SANG , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE STRASBOURG , AVIGNON UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE D'AIX MARSEILLE , ECOLE CENTRALE DE MARSEILLE
摘要： The disclosure relates to a method for releasing platelets from megakaryocytes contained in a fluid (F), the method being carried out by means of a system comprising two concentric cylinders, an inner cylinder comprising a cylindrical wall and a hollow outer cylinder located radially external to the inner cylinder, the outer cylinder comprising a cylindrical wall of a base at which the second cylinder is closed, the cylinders being separated by a space devoid of any mechanical parts, the space being intended to receive the fluid (F), the method comprising the following steps: supplying the space with a fluid (F) comprising megakaryocytes, rotating the inner cylinder about its axis, the outer cylinder being stationary, or moving the two cylinders in opposite directions about their axes, so as to generate an at least partially turbulent flow of fluid (F) in the space and obtain a second fluid (F′) enriched in platelets.
-
公开(公告)号：US12115393B2
公开(公告)日：2024-10-15
申请号：US17609542
申请日：2020-05-11
发明人： Ayache Bouakaz , Catherine Belzung
CPC分类号： A61N7/00 , G16H20/30 , A61N2007/0026 , A61N2007/0073 , A61N2007/0078
摘要： The present invention relates the field of ultrasound and neurostimulation. The inventors have shown that using ultrasound neurostimulation with specific parameters provides similar or better effects that fluoxetine administration in depression. Such assessment was made in unpredictable chronic mild stress model in mouse. The proposed use also provides with positive effects in other cases, such as modulating emotion or attenuating anxiety-related behaviours (stress notably).
-
公开(公告)号：US12048693B2
公开(公告)日：2024-07-30
申请号：US16959954
申请日：2019-01-04
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique , Université Côte d'Azur
IPC分类号： A61K31/4706 , A61K39/395 , A61K45/06 , A61P35/00 , A61P35/04 , C07D215/44 , C07K16/28
CPC分类号： A61K31/4706 , A61K39/3955 , A61P35/00 , A61P35/04 , C07D215/44 , A61K45/06 , C07K16/2818 , C07K16/2827
摘要： The present invention relates to a compound of general formula (I), wherein R1 is OCH2CH2OCH3 or OCH3, R′1 is H or OH, R2 is Cl, F, Br or I, with the proviso that when: R1 is OCH2CH2OCH3 then R′1 is H, R1 is OCH3 then R′1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.
-
公开(公告)号：US20240242331A1
公开(公告)日：2024-07-18
申请号：US18563087
申请日：2022-05-25
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE LEON BERARD , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CENTRE HOSPITALIER NATIONAL D'OPHTALMOLOGIE QUINZE-VINGTS
CPC分类号： G06T7/0006 , A61B3/1241 , A61B5/4851 , A61B8/06 , A61B8/488 , G06T7/0012 , G06T2207/30104 , G06T2207/30181
摘要： This computer-implemented method allows assessing the shear elasticity modulus of a flexible tube, such as a blood vessel. In the field of medicine, this allows assessing whether a blood vessel is at risk of breakage or tearing. In the case of an artificial tube to be implanted in a patient's body, this allows verifying that this tube is compatible with the patient's body. The method includes the following further steps: a) obtaining (1002) a first dataset relating to spatiotemporal deformations of the tube; b) detecting and storing (1004) a wall inner surface of the tube and its diameter (D); c) identifying (1006) a number of transverse sections (Sij) of the tube; d) computing (1008) an average particle velocity (Vij) over each section; e) computing (1010) a wave propagation speed (C2) of an antisymmetric wave (W2); f) based on the wave propagation speed (C2) and on the diameter (D), assessing (1012) the shear elasticity modulus (μ) of the tube.
-
公开(公告)号：US20240228546A9
公开(公告)日：2024-07-11
申请号：US18130375
申请日：2023-04-03
申请人： Institut National De La Sante Et De La Recherche Medicale (INSERM) , Centre National De La Recherche Scientifique (CNRS) , Ecole Normale Superieure De Lyon , Universite Claude Bernard Lyon 1
IPC分类号： C07K14/005 , C12N7/00 , C12N9/22 , C12N15/10 , C12N15/113
CPC分类号： C07K14/005 , C12N7/00 , C12N9/22 , C12N15/102 , C12N15/113 , C07K2319/00 , C07K2319/43 , C07K2319/50 , C12N2310/20 , C12N2740/10023 , C12N2740/10042 , C12N2740/13023 , C12N2740/13042 , C12N2800/80
摘要： The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
-
公开(公告)号：US20240197821A1
公开(公告)日：2024-06-20
申请号：US18495355
申请日：2023-10-26
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , Université Paris-Sud
发明人： Joël DORE , Jamila FAIVRE , Nicolas MONIAUX , Christian BRECHOT , Marion DARNAUD
CPC分类号： A61K38/1709 , A23L33/19
摘要： The present disclosure concerns a Reg3α polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for protecting oxygen sensitive gram-positive bacteria, compositions including the polypeptide, and their use. The disclosure shows that increasing concentration of the hReg3α lectin into the gastrointestinal tract (GIT) lumen of hReg3α-transgenic mice induced significant changes in composition of gut microbiota, and dramatically improved host resistance to intestinal inflammation. The Reg3α polypeptide may be used for preventing or treating microbiota-related diseases and/or disorders, including inflammatory bowel disease (IBD), colitis, gastrointestinal infections, irritable bowel syndrome and other gastrointestinal functional diseases, gastrointestinal tract cancer, metabolic syndrome and obesity, diabetes, liver diseases, allergic diseases, neurodegenerative diseases and psychological disorders, and the prevention and treatment methods may also include transferring to said patient fecal microbiota from a human or animal expressing the Reg3α polypeptide.
-
公开(公告)号：US20240182990A1
公开(公告)日：2024-06-06
申请号：US18549058
申请日：2021-03-09
申请人： Etablissement Français du Sang , Université de Montpellier , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , HORIBA ABX SAS
发明人： Chantal FOURNIER-WIRTH , Fanny LEON , Jean-François CANTALOUBE , Jean-Pierre MOLÈS , Elena PINCHON , Aurélien DAYNÈS , Charly MAYRAN
IPC分类号： C12Q1/70 , C12Q1/6804 , C12Q1/6844 , C12Q1/689
CPC分类号： C12Q1/701 , C12Q1/6804 , C12Q1/689 , C12Q1/6844
摘要： The present invention concerns a method for the molecular detection of an infectious agent based on isothermal amplification by recombinase polymerase amplification (RPA) combined with a Magnetic Field-Enhanced Agglutination (MFEA) readout.
-
公开(公告)号：US11905253B2
公开(公告)日：2024-02-20
申请号：US17049680
申请日：2019-04-19
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE RENNES 1 , CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX , INSTITUT BERGONIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE BORDEAUX
IPC分类号： C07D233/64 , A61P37/00 , A61K45/06
CPC分类号： C07D233/64 , A61K45/06 , A61P37/00
摘要： The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLCγ1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells. Thus, the present invention relates to compounds of formula (A) as defined in the present text, to a pharmaceutical composition comprising said compounds in a pharmaceutically acceptable medium and to the use of these compounds and compositions as medicament, in particular for their use in the reduction or treatment of the above-mentioned pathologies, and in particular in the treatment of cancers and autoimmune inflammatory disease such as systemic lupus erythematosus, inflammatory condition and Th17-mediated disease.
-
9.发明公开公开(公告)号：US20230416398A1
公开(公告)日：2023-12-28
申请号：US18321094
申请日：2023-05-22
申请人： OGD2 PHARMA , NANTES UNIVERSITÉ , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT DE CANCEROLOGIE DE L'OUEST
发明人： Stéphane BIRKLE , Julien FLEURENCE , Sébastien FARAJ , Jean-Marc LE DOUSSAL , Denis COCHONNEAU , Mickaël TERME , Brigitte ASSOULINE
IPC分类号： C07K16/30
CPC分类号： C07K16/3084 , C07K2317/24 , C07K2317/565 , C07K2317/622
摘要： Disclosed is a method for delivery of an anti-cancer agent into a cell expressing the OAcGD2 ganglioside by using an antibody recognizing the OAcGD2 ganglioside.
-
公开(公告)号：US11839630B2
公开(公告)日：2023-12-12
申请号：US16766222
申请日：2018-11-14
申请人： ETABLISSEMENT FRANCAIS DU SANG , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE BESANCON , UNIVERSITE DE FRANCHE COMTE
IPC分类号： C12N5/10 , A61K35/17 , A61P35/02 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , C12N15/85
CPC分类号： A61K35/17 , A61P35/02 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70575 , C07K14/70578 , C07K14/7155 , C07K16/2866 , C12N5/10 , C12N15/85 , C07K2317/565 , C07K2317/622 , C07K2319/03 , C07K2319/33
摘要： The present invention is relative to an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody or antibody fragment which includes a anti-IL-1RAP binding domain, polypeptides encoded by this nucleic acid molecule, isolated chimeric antigen receptor (CAR) molecule comprising such an antibody or antibody fragment, a vector comprising a nucleic acid molecule encoding a CAR, as well as a T cell comprising this vector. The present invention is also relative to the use of this T cell (autologous or allogeneic) expressing a CAR molecule to treat a proliferative disease in a mammal.
-
-
-
-
-
-
-
-
-
搜索结果
705 条记录 (耗时 0.051 秒)
