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38 条记录 (耗时 0.032 秒)

    INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
    6.
    发明申请
    INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
    用于治疗疾病的组织脱乙酰酶的抑制剂

    公开(公告)号：US20070135438A1

    公开(公告)日：2007-06-14

    申请号：US11608736

    申请日：2006-12-08

    申请人： Joseph Payne ,  Nicholas Smith ,  Shawn Scranton ,  Christian Hassig

    发明人： Joseph Payne ,  Nicholas Smith ,  Shawn Scranton ,  Christian Hassig

    IPC分类号： A61K31/53 ,  A61K31/4965 ,  C07D253/08 ,  A61K31/505

    CPC分类号： C07D213/76 ,  C07D405/12

    摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

    摘要翻译： 本文公开了具有以下结构式的羰基化合物：或其药学上可接受的盐，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，中枢神经系统疾病 使用本发明的化合物，神经变性疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地热病，炎性病症，心血管病症和血管生成在发病机理中发挥作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

    Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
    7.
    发明申请
    Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5 审中-公开
    代谢型谷氨酸受体-5的二芳基取代的吡唑调节剂

    公开(公告)号：US20060194807A1

    公开(公告)日：2006-08-31

    申请号：US10551709

    申请日：2004-03-30

    申请人： Nicholas Cosford ,  Brian Eastman ,  Dehua Huang ,  Nicholas Smith ,  Lida Tehrani ,  Essa Hu

    发明人： Nicholas Cosford ,  Brian Eastman ,  Dehua Huang ,  Nicholas Smith ,  Lida Tehrani ,  Essa Hu

    IPC分类号： A61K31/506 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/4439 ,  C07D403/14

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

    摘要： Novel pyrazole compounds such as compounds of the formula (I): (where A, A1, A2, B, R11, W, X, Y and Z are as defined herein) in which the pyrazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, obesity, drug addiction, drug abuse, drug withdrawal and other diseases.

    摘要翻译： 新的吡唑化合物，例如式（I）的化合物：其中A，A 1，A 2，B，R 11，W ，X，Y和Z如本文所定义），其中吡唑直接被取代，或通过桥取代，其中i）杂芳基部分含有与杂芳基的连接点相邻的N，和ii）另一个杂芳基或芳基环 ，其中至少一个环被另一个环取代，是用于治疗精神病和情绪障碍的mGluR5调节剂，例如精神分裂症，焦虑症，抑郁症，恐慌症和双相情感障碍，以及在 治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律紊乱，肥胖，药物成瘾，药物滥用，戒毒等疾病。

    Skateboard truck mounting apparatus
    10.
    发明授权
    Skateboard truck mounting apparatus 有权

    公开(公告)号：US12042715B2

    公开(公告)日：2024-07-23

    申请号：US17625401

    申请日：2022-01-06

    申请人： Nicholas Smith

    发明人： Nicholas Smith

    IPC分类号： A63C17/01

    CPC分类号： A63C17/017 ,  A63C2203/42

    摘要： A skateboard truck mounting apparatus is provided. The skateboard truck mounting apparatus includes a rigid body, having a first hole and a second hole, where the holes are configured to interface with the holes on a skateboard deck. Both the first hole and the second hole are equipped with self-locking mechanisms.