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1.发明申请公开(公告)号：US20100172801A1
公开(公告)日：2010-07-08
申请号：US12688346
申请日：2010-01-15
申请人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
发明人： Michael J. Pugia , James A. Profitt , Hai-Hang Kuo , Gert Blankenstein , Ralf-Peter Peters , Lloyd S. Schulman
IPC分类号： G01N30/00 , G01N33/487
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
摘要： Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air.
摘要翻译： 通过在含有干支持试剂的区域中提供结构特征来改进用微流体装置获得的分析结果，其结构特征以预定均匀的方式引导样品流过该区域并促进空气吹扫。
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2.发明授权Method and apparatus for splitting of specimens into multiple channels of a microfluidic device 有权将样品分离成微流体装置的多个通道的方法和装置公开(公告)号：US07125711B2
公开(公告)日：2006-10-24
申请号：US10326157
申请日：2002-12-19
CPC分类号： B01L3/5027 , B01L3/5025 , B01L3/50273 , B01L2200/0605 , B01L2200/0684 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N35/00069 , G01N2035/00158 , G01N2035/00237 , G01N2035/1034
摘要： A microliter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved by capillary forces into one or more metering wells which define the amount of the sample to be analyzed in subsequent steps. The defined amount of the sample is transferred from the metering wells to one or more conditioning and reagent wells for measuring the amount of an analyte contained in each metered amount of the sample.
摘要翻译： 在使用离心和毛细管力的装置中分析微升液体样品，特别是生物样品。 样品通过毛细管力移动到一个或多个计量孔中，其限定在后续步骤中要分析的样品的量。 将定义的样品量从计量孔转移到一个或多个调理和试剂孔，以测量每个计量量的样品中所含的分析物的量。
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3.发明申请公开(公告)号：US20080257754A1
公开(公告)日：2008-10-23
申请号：US12102631
申请日：2008-04-14
IPC分类号： G01N27/26
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0806 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0478 , B01L2400/0487 , B01L2400/0688 , B01L2400/086
摘要： A microfluidic device for analyzing biological samples is provided with a sample inlet section including an inlet port, a capillary passageway communication with the inlet port and with an inlet chamber. The inlet chamber includes means for uniformly distributing the sample liquid across the inlet chamber and purging the air initially contained therein.
摘要翻译： 用于分析生物样品的微流体装置设置有样品入口部分，其包括入口端口，与入口端口的毛细通道连通和入口室。 入口室包括用于均匀地分布样品液体穿过入口室并净化最初容纳在其中的空气的装置。
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4.发明授权公开(公告)号：US07094354B2
公开(公告)日：2006-08-22
申请号：US10326156
申请日：2002-12-19
IPC分类号： G01N9/30
CPC分类号： B01L3/502753 , B01D21/262 , B01D2221/10 , B01L3/502723 , B01L2200/0668 , B01L2300/0816 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/088 , G01N33/491 , Y10T436/111666
摘要： A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has been transferred into a separation chamber with the application of centrifugal force of less than about five times gravity. With the application of greater force measurement of hematocrit is possible.
摘要翻译： 微流体装置提供液体样品中的颗粒的分离，特别是将全血样品分离成其组分用于进一步分析。 在血液样品转移到分离室中后，在几分钟内分离成红细胞和血浆，其应用的离心力小于约5倍重力。 随着应用更大的力测量血细胞比容是可能的。
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5.发明申请METHOD AND APPARATUS FOR PRECISE TRANSFER AND MANIPULATION OF FLUIDS BY CENTRIFUGAL AND OR CAPILLARY FORCES 有权通过离心和毛细血管的精确转运和控制流体的方法和装置公开(公告)号：US20090004059A1
公开(公告)日：2009-01-01
申请号：US12205965
申请日：2008-09-08
IPC分类号： B01J19/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/10 , B01L2300/0645 , B01L2300/0861 , B01L2300/165 , B01L2400/0406 , B01L2400/06 , B01L2400/0688 , F04B19/006 , Y10T436/2575
摘要： A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.
摘要翻译： 在使用离心和毛细管力的装置中分析微升液体样品，特别是生物样品。 通过互连的毛细管通道将样品移动通过一个或多个排列在小扁平芯片内的样品阱。 通道可以是疏水的或亲水的，并且可以包括疏水或亲水的毛细管停止。
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6.发明授权Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces 有权用于通过离心和/或毛细作用力精确地转移和操纵流体的装置公开(公告)号：US08337775B2
公开(公告)日：2012-12-25
申请号：US12205965
申请日：2008-09-08
IPC分类号： G01N33/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/10 , B01L2300/0645 , B01L2300/0861 , B01L2300/165 , B01L2400/0406 , B01L2400/06 , B01L2400/0688 , F04B19/006 , Y10T436/2575
摘要： A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.
摘要翻译： 在使用离心和毛细管力的装置中分析微升液体样品，特别是生物样品。 通过互连的毛细管通道将样品移动通过一个或多个排列在小扁平芯片内的样品阱。 通道可以是疏水的或亲水的，并且可以包括疏水或亲水的毛细管停止。
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7.发明授权Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces 有权用于通过离心和/或毛细管力精确地转移和操纵流体的方法和装置公开(公告)号：US07459127B2
公开(公告)日：2008-12-02
申请号：US10082415
申请日：2002-02-26
IPC分类号： G01N33/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/10 , B01L2300/0645 , B01L2300/0861 , B01L2300/165 , B01L2400/0406 , B01L2400/06 , B01L2400/0688 , F04B19/006 , Y10T436/2575
摘要： A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.
摘要翻译： 在使用离心和毛细管力的装置中分析微升液体样品，特别是生物样品。 通过互连的毛细管通道将样品移动通过一个或多个排列在小扁平芯片内的样品阱。 通道可以是疏水的或亲水的，并且可以包括疏水或亲水的毛细管停止。
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公开(公告)号：US20110011781A1
公开(公告)日：2011-01-20
申请号：US12867335
申请日：2009-02-26
CPC分类号： B01L3/502753 , B01D29/014 , B01D29/05 , B01D61/18 , B01D63/08 , B01D63/087 , B01D63/088 , B01D2201/0415 , B01D2201/44 , B01L3/502715 , B01L2300/0681 , B01L2300/0864 , B01L2400/0406 , G01N33/491
摘要： The invention relates to an apparatus for separating blood, more particularly an apparatus (1) for absorbing blood (19) and separating blood components, e.g. blood plasma, as a sample liquid (2). Said apparatus (1) comprises a feeding device (13) for absorbing the blood (2), a device (15) for separating blood components as a sample liquid (2), a duct which preferably absorbs the sample liquid (2) exclusively by means of capillary forces, and a device for filling the duct (3) with sample liquid (2) in an inlet or feeding zone (18) of the duct (3). The separating device (15), in particular a membrane, is curved, especially convexly shaped, and the apex of said curved, especially convex shape projects into the filling device.
摘要翻译： 本发明涉及一种用于分离血液的装置，更具体地说，涉及用于吸收血液（19）并分离血液成分的装置（1）。 血浆，作为样品液体（2）。 所述装置（1）包括用于吸收血液（2）的供给装置（13），用于分离作为样品液体（2）的血液成分的装置（15），优选地通过以下方式吸收样品液体 以及用于在管道（3）的入口或进料区（18）中用样品液体（2）填充管道（3）的装置。 分离装置（15），特别是膜是弯曲的，特别是凸形的，并且所述弯曲的，特别是凸形的顶点突出到填充装置中。
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公开(公告)号：US07731907B2
公开(公告)日：2010-06-08
申请号：US11279030
申请日：2006-04-07
申请人： Ilse Ballhorn , Gert Blankenstein , Ralf-Peter Peters , Birgit Mueller-Chorus , Michael Schlueter
发明人： Ilse Ballhorn , Gert Blankenstein , Ralf-Peter Peters , Birgit Mueller-Chorus , Michael Schlueter
IPC分类号： B01L3/02
CPC分类号： B01F13/0059 , B01L3/5025 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2300/0806 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , Y10T436/25375 , Y10T436/2575
摘要： A device and a process for testing a sample liquid in which especially the ELISA process can be carried out very easily, rapidly and with high precision. To do this, a sample liquid and a dilution liquid are each supplied to several metering chambers of different volumes, so that the sample liquid can be diluted into assigned reaction chambers in one dilution step in different dilution ratios. Different liquids can be supplied in succession to the reaction chambers by means of a common receiving chamber. The liquids are transferred from the reaction chambers into the assigned test chambers to stop the detection reaction.
摘要翻译： 用于测试样品液体的装置和方法，其中特别是可以非常容易，快速和高精度地进行ELISA过程。 为此，将样品液体和稀释液分别供给到不同体积的多个计量室，使得样品液体可以以不同稀释比在一个稀释步骤中稀释成指定的反应室。 可以通过公共接收室连续地向反应室提供不同的液体。 液体从反应室转移到指定的测试室中以停止检测反应。
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10.发明申请Device for Collecting Blood and Separating Blood Constituents, Method for Separating Blood Constituents and Use of Said Device 有权用于收集血液和分离血液成分的装置，分离血液成分的方法和所述装置的使用公开(公告)号：US20070269893A1
公开(公告)日：2007-11-22
申请号：US11569999
申请日：2005-06-03
CPC分类号： B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0621 , B01L2200/0684 , B01L2300/0654 , B01L2300/0681 , B01L2300/0825 , B01L2300/0864 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/084 , B01L2400/086 , B01L2400/088 , Y10T436/25375
摘要： The invention relates to a device and a method for collecting blood and separating blood plasma as a liquid sample, by means of a canal that absorbs the liquid sample by capillary forces. The aim of the invention is to obtain a uniform filling of the canal with the liquid sample and an effective separation. To achieve this, deaeration takes place in a transverse direction to the main filling direction or to the longitudinal direction of the canal, immediately downstream of a separation device in an inlet region of the canal.
摘要翻译： 本发明涉及一种用于收集血液并分离作为液体样品的血浆的装置和方法，借助于通过毛细管力吸收液体样品的管道。 本发明的目的是获得用液体样品均匀填充管道并进行有效分离。 为了实现这一点，在运河入口区域的分离装置的紧下游处，沿着主填充方向或管道的纵向在横向上进行脱气。
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