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1.发明授权Methods and systems for processing biological specimens utilizing multiple wavelengths 有权用于处理利用多个波长的生物样品的方法和系统公开(公告)号：US08326014B2
公开(公告)日：2012-12-04
申请号：US11864744
申请日：2007-09-28
Applicant: Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
Inventor： Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
IPC: G06K9/00
CPC classification number: G06K9/00147 , G06K9/033 , G06K9/6253
Abstract: Methods, systems and computer readable media for processing one or more biological specimens carried by specimen slides. Images of objects in a specimen are acquired and objects of interest in the acquired images are identified. Additional images of identified objects of interest may be acquired at multiple wavelengths. Cellular features of objects of interest are extracted from images and may be used for classifying the specimen, e.g., as normal or suspicious/abnormal, based a probabilistic model that utilizes the extracted features.
Abstract translation: 方法，系统和计算机可读介质，用于处理标本载玻片携带的一个或多个生物样本。 获取样本中的对象的图像，并且识别获取的图像中的感兴趣对象。 可以在多个波长处获取所识别的感兴趣对象的附加图像。 基于提取的特征的概率模型，从图像中提取感兴趣对象的细胞特征，并且可以将其用于分类样本，例如正常或可疑/异常。
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公开(公告)号：US20070134798A1
公开(公告)日：2007-06-14
申请号：US11297701
申请日：2005-12-08
Applicant: Patric McCormick , James Linder
Inventor： Patric McCormick , James Linder
IPC: G01N1/00
CPC classification number: G01N31/22 , Y10T436/108331 , Y10T436/2525
Abstract: The invention relates to a cell fixative that can be used in the preparation of slides for investigation by microscopy techniques. In particular the present invention provides a cell fixative that contains a light curable mounting medium.
Abstract translation: 本发明涉及可用于制备幻灯片以用于通过显微技术研究的细胞固定剂。 特别地，本发明提供了一种含有可光固化的固定介质的细胞固定剂。
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3.发明申请公开(公告)号：US20060117407A1
公开(公告)日：2006-06-01
申请号：US11071896
申请日：2005-03-02
Applicant: Michael Koziel , Nalini Desai , Kelly Lewis , Vance Kramer , Gregory Warren , Steve Evola , Lyle Crossland , Martha Wright , Ellis Merlin , Karen Launis , Steven Rothstein , Cindy Boyce , John Dawson , Erik Dunder , Gary Pace , Jan Suttie , Nadine Carozzi , Annick De Framond , James Linder , Robert Miller , Bruce Skillings , Alan Mousel , Albert Hornbrook , Christopher Clucas , Moez Meghji , Andreas Tanner , Francis Cassagne , Gilles Pollini , Terry Colbert , Francis Cammack
Inventor： Michael Koziel , Nalini Desai , Kelly Lewis , Vance Kramer , Gregory Warren , Steve Evola , Lyle Crossland , Martha Wright , Ellis Merlin , Karen Launis , Steven Rothstein , Cindy Boyce , John Dawson , Erik Dunder , Gary Pace , Jan Suttie , Nadine Carozzi , Annick De Framond , James Linder , Robert Miller , Bruce Skillings , Alan Mousel , Albert Hornbrook , Christopher Clucas , Moez Meghji , Andreas Tanner , Francis Cassagne , Gilles Pollini , Terry Colbert , Francis Cammack
CPC classification number: C12N9/12 , C07K14/325 , C12N9/88 , C12N15/8286 , Y02A40/162
Abstract: Methods for transformation of maize with nucleic acid sequences of interest are disclosed. The method involves subjecting immature zygotic embryos or Type I callus to high velocity microprojectile bombardment. The method is capable of producing transformed maize lines of commercial importance and their hybrid combinations.
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4.发明申请Novel method for the detection of cancer biomarkers in cervical specimens 审中-公开用于检测宫颈标本中癌症生物标志物的新方法公开(公告)号：US20050136405A1
公开(公告)日：2005-06-23
申请号：US10738018
申请日：2003-12-17
Applicant: James Linder , Brian Lentrichia
Inventor： James Linder , Brian Lentrichia
IPC: G01N33/574 , C12Q1/68
CPC classification number: G01N33/57442 , G01N33/57449
Abstract: The invention provides a method for the assessment of biological markers in a sample of tissue, cells or fluid for the detection a malignant or pre-malignant condition. Aspects of the present invention are particularly useful in screening samples such as cervical smears from women to detect such markers. Identification of a malignant or pre-malignant condition may be followed by appropriate treatment.
Abstract translation: 本发明提供了用于评估组织，细胞或液体样品中用于检测恶性或恶性前病症的生物标志物的方法。 本发明的方面特别可用于筛选来自妇女的子宫颈涂片样品以检测这些标记物。 鉴定恶性或恶性恶性病症之后可以进行适当的治疗。
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公开(公告)号：US09602777B2
公开(公告)日：2017-03-21
申请号：US12768633
申请日：2010-04-27
Applicant: James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
Inventor： James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
CPC classification number: H04N7/18 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N35/00029 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G06K9/00
Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
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Patent Agency Ranking
公开(公告)号：US09083857B2
公开(公告)日：2015-07-14
申请号：US13619381
申请日：2012-09-14
Applicant: James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
Inventor： James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
CPC classification number: H04N7/18 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N35/00029 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G06K9/00
Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
Abstract translation: 公开了分析体液的系统和方法，其中包含血液，骨髓，尿液，阴道组织，上皮组织，肿瘤，精液和唾液等细胞。 该系统和方法利用改进的技术将单层细胞施加到载玻片上并在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微术来提高由光接收装置捕获的图像的质量的系统和方法。
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公开(公告)号：US20130070077A1
公开(公告)日：2013-03-21
申请号：US13619381
申请日：2012-09-14
Applicant: James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
Inventor： James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
CPC classification number: H04N7/18 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N35/00029 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G06K9/00
Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
Abstract translation: 公开了分析体液的系统和方法，其中包含血液，骨髓，尿液，阴道组织，上皮组织，肿瘤，精液和唾液等细胞。 该系统和方法利用改进的技术将单层细胞施加到载玻片上并在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微术来提高由光接收装置捕获的图像的质量的系统和方法。
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公开(公告)号：US20070140543A1
公开(公告)日：2007-06-21
申请号：US11311973
申请日：2005-12-19
Applicant: Peter D'Errico , James Linder , Kam Wong , Peter Albany , David Zahniser
Inventor： Peter D'Errico , James Linder , Kam Wong , Peter Albany , David Zahniser
IPC: G06K9/00
CPC classification number: G01N15/1475 , G01N2015/1488 , G01N2015/1497 , G02B21/365 , G06K9/00134
Abstract: A system for prescreening and reviewing cytological specimens includes an imager for obtaining and processing image data of a specimen slide, which identifies cellular objects of interest in the specimen, calculates object values for the identified objects based on one or more of their respective physical attributes, and selects fields of view of the specimen slide for subsequent review on a review scope, based on the locations of identified objects having object values of greatest relative interest. One or more of the objects may be further selected by the imager for emphasized review, which may include additional presentation for review (whether automatic or conditioned) of the one or more objects, whether in the same or in a different field of view than when the object(s) were originally presented. Emphasized review of selected objects may also or additionally be provided by highlighting or otherwise visually emphasizing the objects when they are presented for viewing on the review scope.
Abstract translation: 用于预筛选和检查细胞学标本的系统包括用于获得和处理标本片的图像数据的成像器，其标识样本中感兴趣的细胞物体，基于它们各自的物理属性中的一个或多个来计算所识别的对象的对象值， 并且基于具有最大相对感兴趣的对象值的被识别对象的位置，在审查范围上选择标本幻灯片的视野以供随后审查。 一个或多个对象可以被成像器进一步选择用于强调审查，其可以包括用于一个或多个对象的另外的呈现（不管是自动的还是调节的），不管是在相同还是在不同的视场中 该对象最初被呈现。 还可以或另外通过突出显示或以其他方式将物体视觉上强调对象在被提供以便在审查范围上观看时，强调对所选对象的审查。
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公开(公告)号：US20060243755A1
公开(公告)日：2006-11-02
申请号：US11400034
申请日：2006-04-07
Applicant: John Hennen , Barry Rauworth , James Linder
Inventor： John Hennen , Barry Rauworth , James Linder
IPC: B67D5/60
CPC classification number: B67D7/0294
Abstract: A fluid dispense system for use with a drum having a drum insert configured to couple with a bung included on a drum, the drum insert having an upper portion and a drum insert down tube extending therefrom into an interior of the drum. The system further having a dispense head configured to couple with the drum insert, the dispense head having first and second conduits, each having a valve assembly, the valve assemblies in operable communication with the drum insert when the dispense head is coupled with the drum insert. When the dispense head is coupled with the drum insert the first and second valve assemblies are effected to an open position enabling fluid to flow through the conduits. When the dispense head is not coupled with the drum insert the first and second valve assemblies are biased to a closed position inhibiting fluid from flowing through the conduits.
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公开(公告)号：US20060235544A1
公开(公告)日：2006-10-19
申请号：US11394331
申请日：2006-03-29
Applicant: Edwin Iversen , Harold Sears , Arthur Dyck , Steven Kunz , Joseph Jacobs , James Linder , Peter Strazdins
Inventor： Edwin Iversen , Harold Sears , Arthur Dyck , Steven Kunz , Joseph Jacobs , James Linder , Peter Strazdins
CPC classification number: A61F2/64 , A61F2/6607 , A61F2/68 , A61F2/72 , A61F2002/5003 , A61F2002/5006 , A61F2002/5033 , A61F2002/6854 , A61F2002/704 , A61F2002/741 , A61F2002/744 , A61F2002/745 , A61F2002/748 , A61F2002/7625
Abstract: A device and system is provided for a prosthetic device having an articulating joint for a leg amputee. The device includes a joint housing forming a chamber, and the chamber has a first opening. A rotary hub can be disposed within the joint housing and configured to act as the articulating joint. One or more vanes can extend outwardly from the rotary hub, and the vane is configured to actuate fluid flow through the first opening.
Abstract translation: 提供了一种用于具有用于腿截肢者的关节连接的假体装置的装置和系统。 该装置包括形成腔室的接头壳体，并且腔室具有第一开口。 旋转轮毂可以设置在接头壳体内并且构造成用作铰接接头。 一个或多个叶片可以从旋转轮毂向外延伸，并且叶片构造成致动通过第一开口的流体流动。
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