公开(公告)号：US08161993B2

公开(公告)日：2012-04-24

申请号：US12236406

申请日：2008-09-23

申请人： Anthony James Ratcliffe

发明人： Anthony James Ratcliffe

IPC分类号： F16K11/10 ,  F16K17/02

CPC分类号： E21B41/0007 ,  E21B43/01 ,  Y10T137/0379 ,  Y10T137/7762

摘要： A subsea system comprises a wellbore within a reservoir, equipment downstream of the wellbore, and a barrier connected to the equipment. The equipment is rated for a maximum pressure that is less than a maximum reservoir pressure and equal to or greater than the maximum reservoir pressure less external hydrostatic pressure experienced by the equipment. The barrier is rated for a maximum pressure that is equal to or greater than the maximum reservoir pressure.

摘要翻译： 海底系统包括储层内的井筒，井筒下游的设备以及连接到设备的障碍物。 设备的额定最大压力小于最大油藏压力，并且等于或大于设备经历的最小油藏压力较小的外部静水压力。 屏障的额定最大压力等于或大于最大储层压力。

公开(公告)号：US06255326B1

公开(公告)日：2001-07-03

申请号：US09239075

申请日：1999-01-27

申请人： Michael John Ashton ,  David Charles Cook ,  Garry Fenton ,  Susan Jacqueline Hills ,  Ian Michael McFarlane ,  Andrew David Morley ,  Malcolm Norman Palfreyman ,  Andrew James Ratcliffe ,  Brian William Sharp ,  Sukanthini Thurairatnam ,  Bernard Yvon Jack Vacher ,  Nigel Vicker

发明人： Michael John Ashton ,  David Charles Cook ,  Garry Fenton ,  Susan Jacqueline Hills ,  Ian Michael McFarlane ,  Andrew David Morley ,  Malcolm Norman Palfreyman ,  Andrew James Ratcliffe ,  Brian William Sharp ,  Sukanthini Thurairatnam ,  Bernard Yvon Jack Vacher ,  Nigel Vicker

IPC分类号： C07D21172

CPC分类号： C07C43/225 ,  C07C45/004 ,  C07C45/292 ,  C07C45/71 ,  C07C47/575 ,  C07C49/84 ,  C07C59/58 ,  C07C59/60 ,  C07C59/62 ,  C07C65/21 ,  C07C65/24 ,  C07C65/26 ,  C07C65/42 ,  C07C69/76 ,  C07C69/92 ,  C07C205/59 ,  C07C217/88 ,  C07C235/56 ,  C07C255/57 ,  C07C255/60 ,  C07C275/34 ,  C07C311/29 ,  C07C311/46 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07D213/50 ,  C07D213/75 ,  C07D213/89 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D275/03 ,  C07D409/12

摘要： This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.

摘要翻译： 本发明涉及通过各种连接与芳基部分连接的用于抑制肿瘤坏死因子的苯基化合物的药物用途。 本发明还涉及含有这些化合物的化合物及其制备方法和药物组合物。 此外，本发明涉及化合物抑制环AMP磷酸二酯酶的药物用途。

公开(公告)号：US08453744B2

公开(公告)日：2013-06-04

申请号：US12621169

申请日：2009-11-18

申请人： John Buss ,  Charles William Donkin ,  Ian Hitchcock ,  William Peter Stuart Bruges ,  Roy Mowatt ,  James Ratcliffe ,  Anthony Webb

发明人： John Buss ,  Charles William Donkin ,  Ian Hitchcock ,  William Peter Stuart Bruges ,  Roy Mowatt ,  James Ratcliffe ,  Anthony Webb

IPC分类号： E21B34/00 ,  E21B34/06

CPC分类号： E21B47/10 ,  E21B33/126

摘要： A modulator is disclosed for creating a pressure pulse in a fluid-filled well. The modulator comprises a tool body on which a plurality of extendable arms are mounted. The arms may be retracted into a stowed position substantially adjacent the tool body, or may be extended to meet the wall of the borehole. The arms are preferably resilient bowsprings that may be flexed outwards from the tool by means of an actuator pushing on at least one end of the springs. A flexible valve sleeve or bag is suspended between the arms and cooperates with a valve mounted adjacent the sleeve on the tool body. The valve sleeve creates a fluid-flow path through the valve, and in operation, the valve closes one end of the valve sleeve to create the pressure pulse. Sealing of the valve sleeve against the wall of the well is a result of the fluid pressure inflating the sleeve against the well wall. As a result, sealing takes place over an extended area of the bag and is dynamically responsive to changes in fluid flow or pressure.

摘要翻译： 公开了用于在流体填充的井中产生压力脉冲的调制器。 调制器包括一个工具主体，多个可伸缩臂安装在该工具主体上。 臂可以缩回到基本上邻近工具主体的收起位置，或者可以延伸以满足钻孔的壁。 臂优选地是弹性弓形，其可以通过推动弹簧的至少一端的致动器从工具向外弯曲。 柔性阀套或袋悬挂在臂之间并与安装在工具主体上的套筒相邻的阀配合。 阀套产生通过阀的流体流动路径，并且在操作中，阀关闭阀套的一端以产生压力脉冲。 将阀套密封在井的壁上是由于流体压力使套筒相对于井壁膨胀的结果。 结果，密封发生在袋的延伸区域上并且动态地响应于流体流动或压力的变化。

公开(公告)号：US20110201630A1

公开(公告)日：2011-08-18

申请号：US13124947

申请日：2009-10-21

申请人： Kerry Jenkins ,  Christopher James Lock ,  Andrew James Ratcliffe

发明人： Kerry Jenkins ,  Christopher James Lock ,  Andrew James Ratcliffe

IPC分类号： C07D495/04 ,  A61K31/52 ,  A61K31/506

CPC分类号： C07D495/04

摘要： A series of heteroaryl-substituted fused pyridine derivatives, in particular heteroaryl-substituted thieno[3,2-6]pyridine derivatives, being selective inhibitors of PO kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

摘要翻译： 一系列杂芳基取代的稠合吡啶衍生物，特别是杂芳基取代的噻吩并[3,2-6]吡啶衍生物，是PO激酶的选择性抑制剂，因此在医学中有益，例如在治疗炎症，自身免疫 ，心血管，神经变性，代谢，肿瘤，伤害性或眼科疾病。

公开(公告)号：US06610700B2

公开(公告)日：2003-08-26

申请号：US09835656

申请日：2001-04-16

申请人： Timothy John Norman ,  John Robert Porter ,  Brian Woodside Hutchinson ,  Andrew James Ratcliffe ,  John Clifford Head ,  Rikki Peter Alexander ,  Barry John Langham ,  Graham John Warrellow ,  Sarah Catherine Archibald ,  Janeen Marsha Linsley

发明人： Timothy John Norman ,  John Robert Porter ,  Brian Woodside Hutchinson ,  Andrew James Ratcliffe ,  John Clifford Head ,  Rikki Peter Alexander ,  Barry John Langham ,  Graham John Warrellow ,  Sarah Catherine Archibald ,  Janeen Marsha Linsley

IPC分类号： A61K31435

CPC分类号： C07D213/81 ,  C07C229/36 ,  C07C2601/10 ,  C07D217/22 ,  C07D471/04

摘要： Enamine derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which Ar1 is an aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an arylene or heteroarylene group and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(Rw) group; Rx is a oxo, thioxo, or imino group; Rw and Rz is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.

摘要翻译： 描述了式（1）的胺衍生物：其中R1是Ar1，其中Ar1是芳族或杂芳基，L2是共价键或连接原子或基团，Ar2是亚芳基或亚杂芳基，Alk是 链-CH 2 -CH（R） - ， - CH = C（R） - ，其中R是羧酸或其衍生物或生物试剂; R 2是氢原子或C 1-6烷基; Cy是脂环族或杂环脂族 环，其中X是N原子或C（Rw）基团; Rx是氧代，硫代或亚氨基; Rw和Rz各自是氢原子或任选的取代基;条件是Cy不是环丁烯二酮基团;并且 盐，溶剂合物，水合物和N-氧化物。化合物能够抑制整联蛋白与其配体的结合，并且可用于预防和治疗免疫或炎性疾病或涉及细胞不适当生长或迁移的病症。

公开(公告)号：US5840724A

公开(公告)日：1998-11-24

申请号：US881888

申请日：1997-06-24

申请人： Garry Fenton ,  Andrew David Morley ,  Malcolm Norman Palfreyman ,  Andrew James Ratcliffe ,  Brian William Sharp ,  Keith Alfred James Stuttle ,  Sukanthini Thurairatnam ,  Bernard Yvon Jack Vacher

发明人： Garry Fenton ,  Andrew David Morley ,  Malcolm Norman Palfreyman ,  Andrew James Ratcliffe ,  Brian William Sharp ,  Keith Alfred James Stuttle ,  Sukanthini Thurairatnam ,  Bernard Yvon Jack Vacher

IPC分类号： C07C43/225 ,  C07C45/00 ,  C07C45/29 ,  C07C45/71 ,  C07C47/575 ,  C07C49/84 ,  C07C59/58 ,  C07C59/60 ,  C07C59/62 ,  C07C65/21 ,  C07C65/24 ,  C07C65/26 ,  C07C65/42 ,  C07C69/76 ,  C07C69/92 ,  C07C205/59 ,  C07C217/88 ,  C07C235/56 ,  C07C255/60 ,  C07C275/34 ,  C07C311/29 ,  C07C311/46 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D213/50 ,  C07D213/75 ,  C07D213/89 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D275/02 ,  C07D275/03 ,  C07D409/12 ,  C07D213/02 ,  A61K31/44

CPC分类号： C07C43/225 ,  C07C205/59 ,  C07C217/88 ,  C07C235/56 ,  C07C255/60 ,  C07C275/34 ,  C07C311/29 ,  C07C311/46 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07C45/004 ,  C07C45/292 ,  C07C45/71 ,  C07C47/575 ,  C07C49/84 ,  C07C59/58 ,  C07C59/60 ,  C07C59/62 ,  C07C65/21 ,  C07C65/24 ,  C07C65/26 ,  C07C65/42 ,  C07C69/76 ,  C07C69/92 ,  C07D213/50 ,  C07D213/75 ,  C07D213/89 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D275/03 ,  C07D409/12 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2102/42

摘要： This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.

公开(公告)号：US08399483B2

公开(公告)日：2013-03-19

申请号：US12809394

申请日：2008-12-17

申请人： Daniel Rees Allen ,  George Martin Buckley ,  Roland Bürli ,  John Richard Davenport ,  Natasha Kinsella ,  Christopher James Lock ,  Christopher Lowe ,  Stephen Robert Mack ,  William Ross Pitt ,  Andrew James Ratcliffe ,  Marianna Dilani Richard ,  Verity Margaret Sabin ,  Andrew Sharpe ,  Laura Jane Tait ,  Graham John Warrellow ,  Sophie Caroline Williams

发明人： Daniel Rees Allen ,  George Martin Buckley ,  Roland Bürli ,  John Richard Davenport ,  Natasha Kinsella ,  Christopher James Lock ,  Christopher Lowe ,  Stephen Robert Mack ,  William Ross Pitt ,  Andrew James Ratcliffe ,  Marianna Dilani Richard ,  Verity Margaret Sabin ,  Andrew Sharpe ,  Laura Jane Tait ,  Graham John Warrellow ,  Sophie Caroline Williams

IPC分类号： A61K31/47

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D473/34 ,  C07D473/36

摘要： A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions, said substituted derivatives having the general formula

摘要翻译： 因此，作为PI3激酶的选择性抑制剂的一系列杂芳基取代的喹喔啉和喹啉衍生物在医学中是有益的，例如在治疗炎性，自身免疫，心血管，神经退行性，代谢性，肿瘤学，伤害性感受性或眼科疾病中，所述 具有通式的取代衍生物

公开(公告)号：US20100071775A1

公开(公告)日：2010-03-25

申请号：US12236406

申请日：2008-09-23

申请人： ANTHONY JAMES RATCLIFFE

发明人： ANTHONY JAMES RATCLIFFE

IPC分类号： F16K17/02

CPC分类号： E21B41/0007 ,  E21B43/01 ,  Y10T137/0379 ,  Y10T137/7762

摘要： A subsea system comprises a wellbore within a reservoir, equipment downstream of the wellbore, and a barrier connected to the equipment. The equipment is rated for a maximum pressure that is less than a maximum reservoir pressure and equal to or greater than the maximum reservoir pressure less external hydrostatic pressure experienced by the equipment. The barrier is rated for a maximum pressure that is equal to or greater than the maximum reservoir pressure.

摘要翻译： 海底系统包括储层内的井筒，井筒下游的设备以及连接到设备的障碍物。 设备的额定最大压力小于最大油藏压力，并且等于或大于设备经历的最小油藏压力较小的外部静水压力。 屏障的额定最大压力等于或大于最大储层压力。

公开(公告)号：US06780874B2

公开(公告)日：2004-08-24

申请号：US10458234

申请日：2003-06-10

申请人： Timothy John Norman ,  John Robert Porter ,  Brian Woodside Hutchinson ,  Andrew James Ratcliffe ,  John Clifford Head ,  Rikki Peter Alexander ,  Barry John Langham ,  Graham John Warrellow ,  Sarah Catherine Archibald ,  Janeen Marsha Linsley

发明人： Timothy John Norman ,  John Robert Porter ,  Brian Woodside Hutchinson ,  Andrew James Ratcliffe ,  John Clifford Head ,  Rikki Peter Alexander ,  Barry John Langham ,  Graham John Warrellow ,  Sarah Catherine Archibald ,  Janeen Marsha Linsley

IPC分类号： A61K31435

CPC分类号： C07D213/81 ,  C07C229/36 ,  C07C2601/10 ,  C07D217/22 ,  C07D471/04

摘要： Enamine derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in, which Ar1 is an aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an arylene or heteroarylene group and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(Rw) group; Rx is a oxo, thioxo, or imino group; Rw and Rz is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.

摘要翻译： 描述式（1）的胺衍生物：其中R 1是Ar 1，Ar 2，Ar 2，其中Ar 1是芳族或杂芳族基团，L 2是 共价键或连接原子或基团，Ar 2是亚芳基或亚杂芳基，Alk是链-CH 2 -CH（R） - ， - CH = C（R） - ，其中R是羧酸或 R 2是氢原子或C 1-6烷基; Cy是其中X是N原子或C（R））基团的脂环族或杂环脂族环; R x是氢原子或C 1-6烷基; 是氧代，硫代或亚氨基; R w和R z各自为氢原子或任选的取代基; 只要Cy不是环丁烯二酮基团; 和其盐，溶剂合物，水合物和N-氧化物。化合物能够抑制整联蛋白与其配体的结合，并且可用于预防和治疗免疫或炎性疾病或涉及不适当生长或迁移的疾病 细胞。

公开(公告)号：US4161503A

公开(公告)日：1979-07-17

申请号：US774201

申请日：1977-03-03

申请人： Stanley C. Foulkes ,  Robert Moore ,  James Ratcliffe ,  James M. Stephenson

发明人： Stanley C. Foulkes ,  Robert Moore ,  James Ratcliffe ,  James M. Stephenson

IPC分类号： B01D39/16 ,  H01M4/76 ,  B29G5/00

CPC分类号： B01D39/1623 ,  B01D39/083 ,  H01M4/765 ,  B01D2239/0464 ,  B01D2239/0478 ,  B01D2239/0695 ,  B01D2239/10 ,  B01D2239/1258

摘要： A method of making a multitubular sheath comprising providing a porous multitubular fabric impregnated with thermoplastic or deformable polymer, continuously feeding the fabric onto an array of parallel metal rods, one tube to each rod, the rods having straight sizing portions, while holding the rods in a fixed position, the rods having substantially the same cross sectional area over the whole of their length, the fabric at least immediately prior to the sizing portions being substantially at ambient temperature, heating the fabric on the sizing portions so as to permit the fabric to conform to the rod, thereafter cooling the fabric on the rods to solidify or the deformable composite material to set to shape and the tubes to become self supporting, feeding the fabric off the ends of the rods and cutting it to the required length.

摘要翻译： 一种制造多管鞘的方法，包括提供浸渍有热塑性或可变形聚合物的多孔多管织物，将织物连续地供给到平行金属棒阵列上，将一根管连接到每个杆，所述杆具有直的上浆部分，同时将杆保持在 固定位置，杆在其整个长度上具有基本相同的横截面积，织物至少在施胶部分之前基本处于环境温度，在织物上加热织物以使织物 然后冷却杆上的织物以固化，或将可变形的复合材料固化成形状，并使管子成为自支撑，将织物从棒的端部上取出并将其切割成所需的长度。