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    Modular aerosol delivery system
    3.
    发明授权
    Modular aerosol delivery system 有权
    模块化气溶胶输送系统

    公开(公告)号：US09032953B2

    公开(公告)日：2015-05-19

    申请号：US13397284

    申请日：2012-02-15

    申请人： Adam Meyer ,  James Schmidt ,  Chris Dobson ,  Daniel Engelbreth

    发明人： Adam Meyer ,  James Schmidt ,  Chris Dobson ,  Daniel Engelbreth

    IPC分类号： A61M16/14 ,  A61M15/00 ,  A61M11/00 ,  A61M11/04 ,  A61M16/00

    CPC分类号： A61M15/0086 ,  A61M11/04 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/0088 ,  A61M15/009 ,  A61M16/0078 ,  A61M16/14 ,  A61M16/147

    摘要： An adapter for use in a breathing circuit including a housing with a conduit having a ventilator port adapted to be coupled to a breathing circuit and a patient port adapted to communicate with a patient interface. A medicament container receptacle communicates with the conduit between the ventilator port and the patient port. The receptacle includes a support block having a well shaped to receive a valve stem extending from a container of medicament and an actuator finger extending upwardly in the receptacle adjacent the support block. The actuator finger is adapted to actuate a dose counter coupled to the container.

    摘要翻译： 一种用于呼吸回路的适配器，包括具有导管的壳体，所述导管具有适于联接到呼吸回路的呼吸机端口和适于与患者接口通信的患者端口。 药物容器容器与呼吸机端口和患者口之间的导管连通。 该容器包括一个支撑块，其具有良好的形状以容纳从药物容器延伸的阀杆和在邻近支撑块的容器中向上延伸的致动器指状物。 致动器指状件适于致动耦合到容器的剂量计数器。

    Processes for preparing alkylated aromatic compounds
    5.
    发明授权
    Processes for preparing alkylated aromatic compounds 有权
    制备烷基化芳族化合物的方法

    公开(公告)号：US08609915B2

    公开(公告)日：2013-12-17

    申请号：US13418127

    申请日：2012-03-12

    申请人： Debarshi Majumder ,  Carl John Stevens ,  Robert James Schmidt

    发明人： Debarshi Majumder ,  Carl John Stevens ,  Robert James Schmidt

    IPC分类号： C07C2/66

    CPC分类号： C07C2/66 ,  C07C15/073 ,  C07C15/085

    摘要： Processes for preparing alkylation aromatic compounds are provided herein. In an embodiment, a process for preparing alkylated aromatic compounds includes reacting an aromatic compound and an olefin in a first alkylation reaction in the presence of a first alkylation catalyst to produce a first effluent that includes an alkylated aromatic compound and unreacted aromatic compound. Unreacted aromatic compound from the first effluent and additional olefin are reacted in at least one downstream alkylation reaction in the presence of a second alkylation catalyst to produce a second effluent including the alkylated aromatic compound. A recycle stream including the alkylated aromatic compound is recycled from the second effluent to the at least one downstream alkylation reaction and, optionally, the first alkylation reaction. A ratio of the recycle stream to a total mass flow is greater in the at least one downstream alkylation reaction than in the first alkylation reaction.

    摘要翻译： 本文提供了制备烷基化芳族化合物的方法。 在一个实施方案中，制备烷基化芳族化合物的方法包括在第一烷基化反应中在第一烷基化反应中使芳族化合物和烯烃反应，以产生包含烷基化芳族化合物和未反应芳族化合物的第一流出物。 来自第一流出物和另外的烯烃的未反应的芳族化合物在第二烷基化催化剂的存在下在至少一个下游烷基化反应中反应，以产生包含烷基化芳族化合物的第二流出物。 包括烷基化芳族化合物的再循环流从第二流出物再循环到至少一个下游烷基化反应和任选的第一烷基化反应。 在至少一个下游烷基化反应中，再循环流与总质量流的比例大于在第一烷基化反应中。

    Modular aerosol delivery system
    6.
    发明授权
    Modular aerosol delivery system 有权
    模块化气溶胶输送系统

    公开(公告)号：US08596265B2

    公开(公告)日：2013-12-03

    申请号：US12603700

    申请日：2009-10-22

    申请人： Adam Meyer ,  James Schmidt ,  Chris Dobson ,  Daniel Engelbreth

    发明人： Adam Meyer ,  James Schmidt ,  Chris Dobson ,  Daniel Engelbreth

    IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M16/10

    CPC分类号： A61M15/0086 ,  A61M11/04 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/0088 ,  A61M15/009 ,  A61M16/0078 ,  A61M16/14 ,  A61M16/147

    摘要： In a modular medicament delivery system, a dispenser housing has a support block with a well and an orifice communicating with the well. A first container assembly includes a valve stem shaped to be received by the well in the support block. The first container assembly has a first exterior shape. A second container assembly includes a valve stem shaped to be received by the well in the support block. The second container assembly has a second exterior shape that is different than the first exterior shape. An insert member is adapted for mounting to the dispenser housing in the cavity and defines an interior space shaped to receive the second exterior shape of the second container. Methods of assembling the system, a system kit and a device are also provided. A medication delivery device includes first and second end pieces and a collapsible chamber disposed therebetween.

    摘要翻译： 在模块化药物输送系统中，分配器壳体具有支撑块，其具有孔和与孔连通的孔。 第一容器组件包括形成为被所述支撑块中的井接收的阀杆。 第一容器组件具有第一外部形状。 第二容器组件包括形成为被支撑块中的井接收的阀杆。 第二容器组件具有与第一外部形状不同的第二外部形状。 插入构件适于在空腔中安装到分配器壳体并且限定形状为接收第二容器的第二外部形状的内部空间。 还提供了组装系统，系统套件和设备的方法。 药物输送装置包括第一和第二端部件以及设置在它们之间的可折叠室。

    Aerosol delivery system
    7.
    发明授权
    Aerosol delivery system 有权
    气雾剂输送系统

    公开(公告)号：US08151794B2

    公开(公告)日：2012-04-10

    申请号：US12105881

    申请日：2008-04-18

    申请人： Adam Meyer ,  James Schmidt ,  Martin P. Foley ,  Jerry R. Grychowski

    发明人： Adam Meyer ,  James Schmidt ,  Martin P. Foley ,  Jerry R. Grychowski

    IPC分类号： A61M11/00

    CPC分类号： A61M16/14 ,  A61M15/0015 ,  A61M15/0018 ,  A61M15/0068 ,  A61M15/0086 ,  A61M15/009 ,  A61M16/0003 ,  A61M16/0009 ,  A61M16/0078 ,  A61M16/0084 ,  A61M16/04 ,  A61M16/08 ,  A61M16/0816 ,  A61M16/0833 ,  A61M16/0841 ,  A61M16/085 ,  A61M16/0858 ,  A61M16/208 ,  A61M2016/0027 ,  A61M2205/0233 ,  A61M2205/3331 ,  A61M2205/3368

    摘要： Ventilator circuit aerosol delivery systems used to administer medication to a patient are disclosed. In one implementation, a metered dose inhaler (“MDI”) ventilator assembly may include a housing that defines an interior space, an inhalation port that defines an inhalation passageway in communication with the interior space, an exhalation port that defines an exhalation passageway in communication with the interior space, a patient port that defines a patient passageway in communication with the interior space, and a MDI receptacle positioned on the housing and in communication with the interior space. The MDI receptacle is operative to receive a MDI container and dispense an aerosolized medication within the MID container into the interior space so that during inhalation, an inhalation flow including the aerosolized medication may flow through the inhalation port, the interior space, and the patient port. Conversely, during exhalation, gases, moisture, condensation, and/or mucus expelled from the patient flow through the patient port, the interior space, and the exhalation port.

    摘要翻译： 公开了用于向患者施用药物的呼吸机电路气溶胶输送系统。 在一个实施方案中，计量吸入器（“MDI”）呼吸机组件可以包括限定内部空间的壳体，限定与内部空间连通的吸入通道的吸入口，限定呼吸通道的呼气口 与所述内部空间一起，限定与所述内部空间连通的患者通道的患者口和位于所述外壳上并与所述内部空间连通的MDI容器。 MDI容器操作以接收MDI容器并将MID容器内的雾化药物分配到内部空间中，使得在吸入期间，包括雾化药物的吸入流可以流过吸入口，内部空间和患者口 。 相反，在呼气期间，从患者排出的气体，水分，冷凝物和/或粘液流过患者口，内部空间和呼气口。

    High throughput assays for the proteolytic activities of clostridial neurotoxins
    8.
    发明申请
    High throughput assays for the proteolytic activities of clostridial neurotoxins 失效
    梭菌神经毒素蛋白水解活性的高通量测定

    公开(公告)号：US20050287622A1

    公开(公告)日：2005-12-29

    申请号：US11195098

    申请日：2005-08-02

    申请人： James Schmidt ,  Robert Stafford

    发明人： James Schmidt ,  Robert Stafford

    IPC分类号： C07K14/33 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/569 ,  G01N33/68

    CPC分类号： C07K14/33 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/56911 ,  G01N2333/33 ,  Y10S435/842

    摘要： In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or proteins that can serve as FRET substrates and (2) modified peptides or proteins that can serve as immobilized substrates. In both types a fluorescent molecules is present in the substrate, eliminating the requirement for the addition of a fluorigenic reagent. The assays described can be readily adapted for use in automated or robotic systems.

    摘要翻译： 在本申请中描述了用于梭菌神经毒素蛋白水解活性的高通量测定的底物。 描述了两种类型的底物用于梭菌神经毒素的蛋白水解活性的测定：（1）可用作FRET底物的修饰肽或蛋白质，和（2）可用作固定化底物的修饰肽或蛋白质。 在两种类型中，荧光分子存在于底物中，消除了添加荧光试剂的要求。 所描述的测定法可以容易地适用于自动化或机器人系统。

    Deflector for a discharge outlet of a tailings conveyor of an agricultural combine
    9.
    发明申请
    Deflector for a discharge outlet of a tailings conveyor of an agricultural combine 有权
    用于农业组合式尾矿输送机排放口的导流板

    公开(公告)号：US20050020333A1

    公开(公告)日：2005-01-27

    申请号：US10623727

    申请日：2003-07-21

    申请人： Andrew Sahr ,  James Schmidt ,  Denver Yoder

    发明人： Andrew Sahr ,  James Schmidt ,  Denver Yoder

    IPC分类号： A01F12/52 ,  A01F12/46

    CPC分类号： A01F12/52

    摘要： A deflector for a discharge outlet of a tailings conveyor of a harvesting machine for providing tailings dispersal over a sieve of a cleaning system or other location on the harvesting machine, without significantly interfering with crop material flow from a threshing system of the combine and while also preventing entry of crop material from the threshing system into the conveyor outlet.

    摘要翻译： 用于收集机尾矿输送机的排放口的偏转器，用于提供尾矿分散在清洁系统的筛子上或收集机上的其他位置上，而不会显着干扰来自组合机的脱粒系统的作物材料流，同时 防止作物材料从脱粒系统进入输送机出口。