公开(公告)号：US09015052B2

公开(公告)日：2015-04-21

申请号：US13499534

申请日：2010-10-12

申请人： Zhibin Lin ,  Guoming Chen ,  Zheng Deng ,  Hao Yuan ,  Jiali Li ,  Ke Peng ,  Kaiwen Liu

发明人： Zhibin Lin ,  Guoming Chen ,  Zheng Deng ,  Hao Yuan ,  Jiali Li ,  Ke Peng ,  Kaiwen Liu

IPC分类号： G10L19/00 ,  H03M7/30 ,  G10L19/038 ,  G10L19/02 ,  H03M7/40

CPC分类号： H03M7/3082 ,  G10L19/0212 ,  G10L19/038 ,  H03M7/3059 ,  H03M7/3068 ,  H03M7/40 ,  H03M7/4018 ,  H03M7/70

摘要： The audio coding method and system of lattice vector quantization is provided in the invention. The method comprises: dividing frequency domain coefficients of an audio signal for which a modified discrete cosine transform (MDCT) has been performed into a plurality of coding sub-bands, and quantizing and coding an amplitude envelope value of each coding sub-band to obtain coded bits of amplitude envelopes; performing bit allocation on each coding sub-band, and performing normalization, quantization and coding respectively on vectors in a low bit coding sub-band with pyramid lattice vector quantization and on vectors in a high bit coding sub-band with sphere lattice vector quantization to obtain coded bits of the frequency domain coefficients; multiplexing and packing the coded bits of the amplitude envelope and the coded bits of the frequency domain coefficients of each coding sub-band, then sending them to a decoding side.

摘要翻译： 在本发明中提供了音频编码方法和格子矢量量化系统。 该方法包括：对已经执行了修正离散余弦变换（MDCT）的音频信号的频域系数进行分解为多个编码子带，并且对每个编码子带的幅度包络值进行量化和编码，以获得 编码位数的幅度包络; 对每个编码子带执行比特分配，并且分别对具有金字塔格子矢量量化的低位编码子带和具有球面格子矢量量化的高比特编码子带中的向量上的向量执行归一化，量化和编码 获得频域系数的编码位; 对每个编码子带的幅度包络的编码比特和频域系数的编码比特进行复用和打包，然后将它们发送到解码侧。

公开(公告)号：US08731910B2

公开(公告)日：2014-05-20

申请号：US13382725

申请日：2010-02-25

申请人： Ming Wu ,  Zhibin Lin ,  Ke Peng ,  Zheng Deng ,  Jing Lu ,  Xiaojun Qiu ,  Jiali Li ,  Guoming Chen ,  Hao Yuan ,  Kaiwen Liu

发明人： Ming Wu ,  Zhibin Lin ,  Ke Peng ,  Zheng Deng ,  Jing Lu ,  Xiaojun Qiu ,  Jiali Li ,  Guoming Chen ,  Hao Yuan ,  Kaiwen Liu

IPC分类号： G10L21/00 ,  G10L19/02 ,  G10L19/00

CPC分类号： G10L19/005 ,  G10L19/0212

摘要： The invention provides a compensation method for audio frame loss in a MDCT domain, the method comprising: when a frame currently lost is a Pth frame, obtaining a set of frequencies to be predicted, and for each frequency in the set, using phases and amplitudes of a plurality of frames before a (P−1)th frame in a MDCT-MDST domain to predict a phase and an amplitude of the Pth frame, and using the predicted phase and amplitude to obtain a MDCT coefficient of the Pth frame at each corresponding frequency; for a frequency outside the set, using MDCT coefficients of a plurality of frames before the Pth frame to calculate a MDCT coefficient value of the Pth frame at the frequency; performing an IMDCT for the MDCT coefficients of the Pth frame to obtain a time domain signal of the Pth frame.

摘要翻译： 本发明提供了一种用于MDCT域中的音频帧丢失的补偿方法，该方法包括：当当前丢失的帧是第P帧时，获得要预测的一组频率，并且对于该组中的每个频率，使用相位和幅度 在MDCT-MDST域中的第（P-1）帧之前的多个帧中预测第P帧的相位和幅度，并且使用预测相位和幅度来获得每帧的第P帧的MDCT系数 相应频率; 对于所述组之外的频率，使用在所述第P帧之前的多个帧的MDCT系数来计算所述频率处的所述第P帧的MDCT系数值; 对第P帧的MDCT系数执行IMDCT以获得第P帧的时域信号。

公开(公告)号：US20120109659A1

公开(公告)日：2012-05-03

申请号：US13382725

申请日：2010-02-25

申请人： Ming Wu ,  Zhibin Lin ,  Ke Peng ,  Zheng Deng ,  Jing Lu ,  Xiaojun Qiu ,  Jiali Li ,  Guoming Chen ,  Hao Yuan ,  Kaiwen Liu

发明人： Ming Wu ,  Zhibin Lin ,  Ke Peng ,  Zheng Deng ,  Jing Lu ,  Xiaojun Qiu ,  Jiali Li ,  Guoming Chen ,  Hao Yuan ,  Kaiwen Liu

IPC分类号： H04B1/66

CPC分类号： G10L19/005 ,  G10L19/0212

摘要： The invention provides a compensation method for audio frame loss in a MDCT domain, the method comprising: when a frame currently lost is a Pth frame, obtaining a set of frequencies to be predicted, and for each frequency in the set, using phases and amplitudes of a plurality of frames before a (P−1)th frame in a MDCT-MDST domain to predict a phase and an amplitude of the Pth frame, and using the predicted phase and amplitude to obtain a MDCT coefficient of the Pth frame at each corresponding frequency; for a frequency outside the set, using MDCT coefficients of a plurality of frames before the Pth frame to calculate a MDCT coefficient value of the Pth frame at the frequency; performing an IMDCT for the MDCT coefficients of the Pth frame to obtain a time domain signal of the Pth frame.

摘要翻译： 本发明提供了一种用于MDCT域中的音频帧丢失的补偿方法，该方法包括：当当前丢失的帧是第P帧时，获得要预测的一组频率，并且对于该组中的每个频率，使用相位和幅度 在MDCT-MDST域中的第（P-1）帧之前的多个帧中预测第P帧的相位和幅度，并且使用预测相位和幅度来获得每帧的第P帧的MDCT系数 相应频率; 对于所述组之外的频率，使用在所述第P帧之前的多个帧的MDCT系数来计算所述频率处的所述第P帧的MDCT系数值; 对第P帧的MDCT系数执行IMDCT以获得第P帧的时域信号。

公开(公告)号：US20110159601A1

公开(公告)日：2011-06-30

申请号：US12961021

申请日：2010-12-06

申请人： Jene A. Golovchenko ,  Jiali Li ,  Derek Stein ,  Marc H. Gershow

发明人： Jene A. Golovchenko ,  Jiali Li ,  Derek Stein ,  Marc H. Gershow

IPC分类号： G01N33/00

CPC分类号： G01N33/50 ,  C12Q1/6811 ,  G01N33/48721 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  C12Q2563/143 ,  C12Q2565/629 ,  C12Q2565/631 ,  C12Q2565/133

摘要： The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

摘要翻译： 本发明的特征在于评估聚合物构象的方法，例如用于确定多种聚合物的构象分布并检测结合或变性事件。 该方法使用聚合物例如核酸穿过的纳米孔。 当聚合物穿过纳米孔时，纳米孔的传输性质的测量产生聚合物构象的数据。

公开(公告)号：US07258838B2

公开(公告)日：2007-08-21

申请号：US10367075

申请日：2003-02-14

申请人： Jiali Li ,  Derek M. Stein ,  Gregor M. Schurmann ,  Gavin M. King ,  Jene Golovchenko ,  Daniel Branton ,  Michael Aziz

发明人： Jiali Li ,  Derek M. Stein ,  Gregor M. Schurmann ,  Gavin M. King ,  Jene Golovchenko ,  Daniel Branton ,  Michael Aziz

IPC分类号： H01L29/00 ,  H01L47/00 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N33/48721 ,  Y10S977/70 ,  Y10S977/701 ,  Y10S977/712 ,  Y10S977/72 ,  Y10S977/762 ,  Y10S977/84 ,  Y10S977/902 ,  Y10S977/92 ,  Y10S977/953 ,  Y10S977/957

摘要： A solid state nanopore device including two or more materials and a method for fabricating the same. The device includes a solid state insulating membrane having an exposed surface, a conductive material disposed on at least a portion of the exposed surface of the solid state membrane, and a nanopore penetrating an area of the conductive material and at least a portion of the solid state membrane. During fabrication a conductive material is applied on a portion of a solid state membrane surface, and a nanopore of a first diameter is formed. When the surface is exposed to an ion beam, material from the membrane and conductive material flows to reduce the diameter of the nanopore. A method for evaluating a polymer molecule using the solid state nanopore device is also described. The device is contacted with the polymer molecule and the molecule is passed through the nanopore, allowing each monomer of the polymer molecule to be monitored.

摘要翻译： 包括两种或多种材料的固体纳米孔装置及其制造方法。 该装置包括具有暴露表面的固态绝缘膜，设置在固态膜的暴露表面的至少一部分上的导电材料，以及穿透导电材料区域的纳米孔和固体的至少一部分 状态膜。 在制造期间，将导电材料施加在固态膜表面的一部分上，并且形成第一直径的纳米孔。 当表面暴露于离子束时，来自膜的材料和导电材料流动以减小纳米孔的直径。 还描述了使用固态纳米孔装置评估聚合物分子的方法。 该装置与聚合物分子接触，分子通过纳米孔，允许监测聚合物分子的每个单体。

公开(公告)号：US08795672B2

公开(公告)日：2014-08-05

申请号：US10779267

申请日：2004-02-13

申请人： Alan L. Epstein ,  Jiali Li ,  Peisheng Hu

发明人： Alan L. Epstein ,  Jiali Li ,  Peisheng Hu

IPC分类号： A61K39/395

CPC分类号： A61K47/48569 ,  A61K38/195 ,  A61K47/6813 ,  A61K47/6849 ,  A61K47/6851 ,  A61K51/1033 ,  A61K51/1045 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/521 ,  C07K14/525 ,  C07K14/535 ,  C07K14/55 ,  C07K14/57 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/82 ,  C07K2319/00

摘要： Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that targets cancer cells or tumors in vivo. The cancer targeting molecule is associated non-covalently or covalently with LEC. The cancer therapeutic agents of the invention are useful for the treatment of cancer in an individual by reducing the size of a tumor or inhibiting the growth of cancer cells in an individual and/or by inhibiting the development of metastasis. The effectiveness of the therapy using the LEC cancer therapeutic agents can be increased by reducing the activity of immunoregulatory T cells and/or by adoptively transferring immune T cells.

摘要翻译： 提供了包含与肝表达趋化因子（LEC）连接的癌靶向分子的癌症治疗剂。 在一个实施方案中，癌靶向分子是在体内靶向癌细胞或肿瘤的抗体。 癌症靶向分子与LEC非共价或共价相关。 本发明的癌症治疗剂可用于通过减少肿瘤的大小或抑制个体中癌细胞的生长和/或通过抑制转移的发展来治疗个体中的癌症。 可以通过降低免疫调节性T细胞的活性和/或通过过继转移免疫T细胞来增加使用LEC癌症治疗剂的治疗的有效性。

公开(公告)号：US08394640B2

公开(公告)日：2013-03-12

申请号：US12961021

申请日：2010-12-06

申请人： Jene A. Golovchenko ,  Jiali Li ,  Derek Stein ,  Marc H. Gershow

发明人： Jene A. Golovchenko ,  Jiali Li ,  Derek Stein ,  Marc H. Gershow

IPC分类号： G01N33/00

CPC分类号： G01N33/50 ,  C12Q1/6811 ,  G01N33/48721 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  C12Q2563/143 ,  C12Q2565/629 ,  C12Q2565/631 ,  C12Q2565/133

摘要： The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

公开(公告)号：US07846738B2

公开(公告)日：2010-12-07

申请号：US10918959

申请日：2004-08-16

申请人： Jene A. Golovchenko ,  Jiali Li ,  Derek Stein ,  Marc H. Gershow

发明人： Jene A. Golovchenko ,  Jiali Li ,  Derek Stein ,  Marc H. Gershow

IPC分类号： G01N33/00

CPC分类号： G01N33/50 ,  C12Q1/6811 ,  G01N33/48721 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  C12Q2563/143 ,  C12Q2565/629 ,  C12Q2565/631 ,  C12Q2565/133

摘要： The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

摘要翻译： 本发明的特征在于评估聚合物构象的方法，例如用于确定多种聚合物的构象分布并检测结合或变性事件。 该方法使用聚合物例如核酸穿过的纳米孔。 当聚合物穿过纳米孔时，纳米孔的传输性质的测量产生聚合物构象的数据。

公开(公告)号：US06464842B1

公开(公告)日：2002-10-15

申请号：US09599137

申请日：2000-06-22

申请人： Jene A. Golovchenko ,  Daniel Branton ,  Derek M. Stein ,  Ciaran J. McMullan ,  Jiali Li

发明人： Jene A. Golovchenko ,  Daniel Branton ,  Derek M. Stein ,  Ciaran J. McMullan ,  Jiali Li

IPC分类号： C23C1434

CPC分类号： B81C99/0065 ,  G01N33/48721

摘要： There is provided controlled fabrication of a solid state structural feature on a solid state structure by exposing the structure to a fabrication process environment the conditions of which are selected to produce a prespecified feature in the structure. A physical detection species is directed toward a designated structure location during process environment exposure of the structure, and the detection species is detected in a trajectory from traversal of the designated structure location, to indicate changing physical dimensions of the prespecified feature. The fabrication process environment is then controlled in response to the physical species detection to fabricate the structural feature. Also provided is a method for controlling a physical dimension of a structural feature or to form a feature by exposing the structure to a flux of ions at a selected structure temperature, the exposure conditions being controlled to cause formation of the feature or to cause at least one physical dimension of the feature to be changed, substantially by transport of material of the structure to the structural feature in response to the ion flux exposure.

摘要翻译： 通过将结构暴露于制造工艺环境中来提供在固态结构上的固态结构特征的受控制造，其制造过程环境被选择以在结构中产生预先指定的特征。 在结构的过程环境暴露期间，物理检测物质指向指定的结构位置，并且在从指定结构位置的遍历的轨迹中检测检测物种，以指示预先指定的特征的变化的物理尺寸。 然后响应于物理物种检测来控制制造工艺环境以制造结构特征。 还提供了一种用于通过在所选择的结构温度下将结构暴露于离子通量来控制结构特征的物理尺寸或形成特征的方法，所述暴露条件被控制以引起特征的形成或至少引起 基本上通过将结构材料转移到响应于离子通量暴露的结构特征而要改变的特征的一个物理尺寸。

公开(公告)号：US10652532B2

公开(公告)日：2020-05-12

申请号：US15448586

申请日：2017-03-02

申请人： Wei Dai ,  Zesen Zhuang ,  Jian Lou ,  Qianzong Chen ,  Jiali Li

发明人： Wei Dai ,  Zesen Zhuang ,  Jian Lou ,  Qianzong Chen ,  Jiali Li

IPC分类号： H04N19/105 ,  H04N19/164 ,  H04N19/114 ,  H04N19/58 ,  H04N21/6373 ,  H04N19/115 ,  H04N19/15 ,  H04N19/172 ,  H04N19/59 ,  H04N19/184

摘要： System and methods of managing reference frame adaptively for video communication under a network are provided. The system adaptively decides the interval between each I frame, the bitrate of the encoded bit steams, and the resolution of the encoded video to achieve quick connection. The system may set the appropriate reference frame(s) for the current frame, manage the reference frame(s) in the DPB to be long/short term reference frame(s) or mark them as unused for reference; mark the current frame to be a long term reference frame, a short term reference frame, unused for reference or skip encoding the current frame; adaptively change the ratio of long term reference frame(s) with respect to the short term reference frame(s) in the DPB; adaptively change the frequency ratio of marking the current frame as long term reference frame and marking the current frame as short term reference frame.