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公开(公告)号：US11709165B2
公开(公告)日：2023-07-25
申请号：US16611947
申请日：2018-05-10
发明人： Mikio Oka , Eiichi Nakayama , Yoshihiro Ohue , Koji Kurose
IPC分类号： G01N33/68 , A61K39/00 , C07K14/82 , C12N5/0783 , G01N33/574 , A61K38/00 , A61P35/00
CPC分类号： G01N33/6854 , A61K39/001184 , A61P35/00 , C07K14/82 , C12N5/0636 , G01N33/57407 , A61K38/00 , A61K2039/892 , C12N2501/505 , G01N2800/344 , G01N2800/52
摘要： [Object] To provide a novel examination method for a cancer treatment effect, screening method for a peptide for a cancer vaccine, and peptide and composition for inducing an immune response against cancer. [Solving Means] Provided are an examination method for a cancer treatment effect and a screening method for a peptide for a cancer vaccine each including detecting an antibody against a cancer/testis antigen or an anti-p53 antibody in a sample. It is suitable that an anti-XAGE1 antibody (IgG and/or IgA) be detected, or an anti-NY-ESO-1 antibody (IgG) be detected. Also provided are a novel peptide and novel composition for inducing immune responses against cancer.
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公开(公告)号：US20210128008A1
公开(公告)日：2021-05-06
申请号：US17076503
申请日：2020-10-21
发明人： Hiroshi YOSHIHARA , Shigeyoshi KITAMURA , Kazuya NAGASE , Shunji IWATA , Shunichi TAKAGI , Hideki NAKATSUKA
IPC分类号： A61B5/0488
摘要： A muscle relaxation monitoring apparatus includes: a stimulating circuit that stimulates a nerve of a living body; a signal detecting circuit that detects an electric signal generated by a muscle reacting to the stimulation performed by the stimulating circuit; a reaction time calculating circuit that calculates a reaction time which elapses from the stimulation of the nerve by the stimulating circuit until the electric signal is detected by the signal detecting circuit; and a relaxation degree determining circuit that determines a muscle relaxation degree of the living body based on the length of the reaction time calculated by the reaction time calculating circuit.
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公开(公告)号：US20190314072A1
公开(公告)日：2019-10-17
申请号：US16452997
申请日：2019-06-26
发明人： Sadashige Uemura , Ryushi Takayama
摘要： This fixture for securing a bar for funnel chest correction to a chest of a patient, includes: a base member having a length that allows the base member to extend across a plurality of ribs; a pressing member configured to be overlaid on the base member; a protrusion formed on an upper face of the base member; a plurality of screw holes formed in the base member; a plurality of holes formed in the pressing member at positions corresponding to the respective screw holes; and a plurality of screws. The pressing member is overlaid on the base member in a state where two bars are respectively disposed on both sides of the protrusion, and a screw is screwed into any of the screw holes on each of both sides of the protrusion, whereby the two bars are fixed by being sandwiched by the base member and the pressing member.
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公开(公告)号：US20230214970A1
公开(公告)日：2023-07-06
申请号：US18120366
申请日：2023-03-11
发明人： Tetsushi KOIDE , Michihiro HIDE , Yumi AOYAMA
CPC分类号： G06T5/20 , G06T7/11 , G06T5/50 , G06T7/0012 , A61B5/0077 , G06T2207/20021 , G06T2207/20212 , G06T2207/10056 , G06T2207/30088 , A61B5/442
摘要： Local image enhancement processing is executed on an image obtained by imaging a transcription material. The enhanced image is divided into a plurality of patch images and input to a machine learning identifier. The patch images after segmentation output from the machine learning identifier are combined to generate a likelihood map image of skin ridges from the whole image based on a result of the segmentation. Binarization processing is executed on the likelihood map image to generate a binary image. A skin ridge region is extracted based on the binary image to calculate the area of the skin ridge region.
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5.发明公开公开(公告)号：US20240093168A1
公开(公告)日：2024-03-21
申请号：US18260452
申请日：2022-01-04
发明人： Tatsuo ITO , Yurika SHIMIZU
IPC分类号： C12N9/22 , A61K31/40 , A61K31/505 , C12N15/10 , C12N15/11
CPC分类号： C12N9/22 , A61K31/40 , A61K31/505 , C12N15/10 , C12N15/11 , C12N2310/20
摘要： The invention provides a CRISPR-dCas/Cas protein derivative or CRISPR-dCas/Cas protein derivative set derived from a CRISPR-dCas (dead Cas) protein or a CRISPR-Cas protein, as well as a polynucleotide encoding the same, a vector comprising the polynucleotide, a transformant transformed by the vector, a carrier for purifying a target RNA, a method for purifying a target RNA, a method for analyzing an intracellular environment, and a prophylactic or therapeutic agent.
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6.发明申请公开(公告)号：US20210148927A1
公开(公告)日：2021-05-20
申请号：US16611947
申请日：2018-05-10
发明人： Mikio OKA , Eiichi NAKAYAMA , Yoshihiro OHUE , Koji KUROSE
IPC分类号： G01N33/68 , G01N33/574 , C07K14/82 , A61K39/00 , A61P35/00 , C12N5/0783
摘要： [Object] To provide a novel examination method for a cancer treatment effect, screening method fora peptide fora cancer vaccine, and peptide and composition for inducing an immune response against cancer. [Solving Means] Provided are an examination method for a cancer treatment effect and a screening method for a peptide for a cancer vaccine each including detecting an antibody against a cancer/testis antigen or an anti-p53 antibody in a sample. It is suitable that an anti-XAGE1 antibody (IgG and/or IgA) be detected, or an anti-NY-ESO-1 antibody (IgG) be detected. Also provided are a novel peptide and novel composition for inducing immune responses against cancer.
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公开(公告)号：US20230257966A1
公开(公告)日：2023-08-17
申请号：US18006220
申请日：2021-07-27
申请人： HIROSHIMA UNIVERSITY , KAWASAKI GAKUEN EDUCATIONAL FOUNDATION , KOBELCO CONSTRUCTION MACHINERY CO., LTD.
摘要： A hydraulic excavator specifies acceleration data being operation data in an acceleration period of a manipulation target and deceleration data being operation data in a deceleration period of the manipulation target among operation data, calculates, on the basis of the acceleration data and acceleration evaluation data, an acceleration evaluation value indicating a skill of an operator in the acceleration period, calculates, on the basis of the deceleration data and deceleration evaluation data, a deceleration evaluation value indicating a skill of the operator in the deceleration period, determines, on the basis of the acceleration evaluation value and the deceleration evaluation value, a manipulation type of the operator, and outputs support information associated with the manipulation type.
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公开(公告)号：US11703441B2
公开(公告)日：2023-07-18
申请号：US16145824
申请日：2018-09-28
CPC分类号： G01N15/1031 , G01N15/14 , G16H50/20 , G16H50/30 , G01N15/1459 , G01N33/49 , G01N2015/0073 , G01N2015/1006 , G01N2015/1062 , G01N2015/1486
摘要： Disclosed is a method for assisting prediction of onset of cerebral infarction, based on the number of red blood cells contained in a blood sample collected from a subject, comprising the steps of:
calculating an exponent value for the prediction from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method,
comparing the exponent value with a reference range, and
suggesting that the subject develops cerebral infarction when the exponent value is outside the reference range.-
公开(公告)号：US10563199B2
公开(公告)日：2020-02-18
申请号：US15759305
申请日：2016-09-16
IPC分类号： C12N15/113
摘要： There has been a demand for a novel antisense nucleic acid or the like capable of inhibiting myostatin at the mRNA level. The present invention provides a specific antisense oligomer which allows exon 2 skipping in the myostatin gene or induces degradation of mRNA of the myostatin gene.
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公开(公告)号：US20190101483A1
公开(公告)日：2019-04-04
申请号：US16145824
申请日：2018-09-28
摘要： Disclosed is a method for assisting prediction of onset of cerebral infarction, based on the number of red blood cells contained in a blood sample collected from a subject, comprising the steps of:calculating an exponent value for the prediction from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method, comparing the exponent value with a reference range, and suggesting that the subject develops cerebral infarction when the exponent value is outside the reference range.
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