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    MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE
    6.
    发明申请
    MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE 审中-公开
    防止组织粘合的材料和预防联合合同的材料

    公开(公告)号：US20110059176A1

    公开(公告)日：2011-03-10

    申请号：US12744251

    申请日：2008-11-14

    申请人： Toru Moro ,  Kozo Nakamura ,  Hiroshi Kawaguchi ,  Noriyuki Ishiyama ,  Kazuhiko Ishihara ,  Tomohiro Konno ,  Tadashi Ohyama ,  Mizuna Yoshikawa

    发明人： Toru Moro ,  Kozo Nakamura ,  Hiroshi Kawaguchi ,  Noriyuki Ishiyama ,  Kazuhiko Ishihara ,  Tomohiro Konno ,  Tadashi Ohyama ,  Mizuna Yoshikawa

    IPC分类号： A61K9/14 ,  A61P41/00 ,  A61K31/785

    CPC分类号： A61K31/715 ,  A61K31/765 ,  A61K31/80

    摘要： The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.The tissue adhesion prevention material and/or the joint contracture prevention material of the present invention comprise, as the main component, a composition comprising a compound having a polyvalent hydroxyl group and a polymer containing phosphorylcholine groups and phenylboronic acid groups.

    摘要翻译： 本发明提供了一种在外科手术时可以在患病区域制备的组织粘附防止材料，通过在适于温和条件的温和条件下，在包含水作为主要成分的介质中制备具有柔性结构和高溶质渗透性的三维聚合物结构 身体组织成分（即，在常温和常压下）而不进行化学反应或采用诸如加热或光或辐射照射的物理过程。 这使得可以提供能够有效地防止受影响的区域中的组织对周围组织的术后粘附和关节的可动部的挛缩的组织粘合防止材料和接合挛缩防止材料。 本发明的组织粘附防止材料和/或接合挛缩防止材料以包含具有多价羟基的化合物和含有磷酸胆碱基团的聚合物和苯基硼酸基的组成为主要成分。

    OLIGOPEPTIDE SEQUENCE SPECIFICALLY BONDING TO PHENYLBORONIC ACID GROUP
    7.
    发明申请
    OLIGOPEPTIDE SEQUENCE SPECIFICALLY BONDING TO PHENYLBORONIC ACID GROUP 有权
    寡核苷酸序列特异性结合苯乙酸组

    公开(公告)号：US20130344590A1

    公开(公告)日：2013-12-26

    申请号：US13982755

    申请日：2012-01-30

    申请人： Tomohiro Konno ,  Kazuhiko Ishihara ,  Hirokazu Nishida

    发明人： Tomohiro Konno ,  Kazuhiko Ishihara ,  Hirokazu Nishida

    IPC分类号： C07K1/22 ,  C12N9/02

    CPC分类号： C07K1/22 ,  C07K17/06 ,  C07K17/08 ,  C07K17/14 ,  C12N9/0069 ,  G01N33/54353

    摘要： An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.

    摘要翻译： 本发明的目的在于提供作为固定化蛋白质分子的方法，能够控制待固定分子取向的蛋白质固定化方法和方法，而不需要复杂的工艺和化学物质即可稳定地分离 用于固定的组不影响蛋白质的活性和功能。 具体地说，本发明涉及一种用于固定分子的方法，包括通过将包含含羟基的氨基酸的标记肽序列附着在分子上而形成标记分子的步骤; 并使具有苯基硼酸基团的分子与标记分子接触，由具有苯基硼酸基团的分子捕获标记分子。

    Oligopeptide sequence specifically bonding to phenylboronic acid group
    8.
    发明授权
    Oligopeptide sequence specifically bonding to phenylboronic acid group 有权
    特异性结合苯基硼酸基团的寡肽序列

    公开(公告)号：US09175035B2

    公开(公告)日：2015-11-03

    申请号：US13982755

    申请日：2012-01-30

    申请人： Tomohiro Konno ,  Kazuhiko Ishihara ,  Hirokazu Nishida

    发明人： Tomohiro Konno ,  Kazuhiko Ishihara ,  Hirokazu Nishida

    IPC分类号： G01N33/53 ,  A61K39/21 ,  C07K1/22 ,  C07K17/06 ,  C07K17/08 ,  C07K17/14 ,  C12N9/02 ,  G01N33/543

    CPC分类号： C07K1/22 ,  C07K17/06 ,  C07K17/08 ,  C07K17/14 ,  C12N9/0069 ,  G01N33/54353

    摘要： An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.

    摘要翻译： 本发明的目的在于提供作为固定化蛋白质分子的方法，能够控制待固定分子取向的蛋白质固定化方法和方法，而不需要复杂的工艺和化学物质即可稳定地分离 用于固定的组不影响蛋白质的活性和功能。 具体地说，本发明涉及一种用于固定分子的方法，包括通过将包含含羟基的氨基酸的标记肽序列附着在分子上而形成标记分子的步骤; 并使具有苯基硼酸基团的分子与标记分子接触，由具有苯基硼酸基团的分子捕获标记分子。

    CELL-ADHESIVE PHOTOCONTROLLABLE BASE MATERIAL
    9.
    发明申请
    CELL-ADHESIVE PHOTOCONTROLLABLE BASE MATERIAL 审中-公开
    细胞粘合光电材料基材

    公开(公告)号：US20140011960A1

    公开(公告)日：2014-01-09

    申请号：US14002192

    申请日：2012-02-06

    申请人： Tomohiro Konno ,  Kazuhiko Ishihara ,  Batzaya Byambaa ,  Hisashi Sugiyama ,  Satoshi Ozawa

    发明人： Tomohiro Konno ,  Kazuhiko Ishihara ,  Batzaya Byambaa ,  Hisashi Sugiyama ,  Satoshi Ozawa

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0602 ,  C12M25/02 ,  C12M33/00 ,  C12M47/04

    摘要： In analyzing, fractionating, and culturing cells alive, operations can be more simply made in real time and culture can be performed while removing unnecessary cells from cultured cells for purification. Desired cells are also analyzed and fractionated from the cultured cells to increase the purity, recovery rate, and viability of the cells. A cell-adhesive photocontrollable base material is used in which light irradiation causes the bond dissociation of a photolabile group comprising an O-nitrobenzyl skeleton to irreversibly change the surface of the irradiated portion thereof from that of the cell-adhesive material to that of a non-cell-adhesive material. Cell images are detected and analyzed to obtain the positional information of desired cells. Based on this information, areas among cells and a cell-adhesive photocontrollable material are cut by second light irradiation. On the other hand, the surface of the base material is changed from a cell-adhesive one to a non-cell-adhesive one by first light irradiation to produce the detachment between cells and the base material. This enables cells to be analyzed and fractionated alive.

    摘要翻译： 在细胞分析，分离和培养细胞中，可以更简单地进行操作，并且可以在从培养细胞中除去不需要的细胞以进行纯化的同时进行培养。 还对所需的细胞进行分析并从培养的细胞中分离，以提高细胞的纯度，回收率和活力。 使用细胞粘合剂可光控制的基材，其中光照射导致包含O-硝基苄基骨架的光不稳定基团的键解离不可逆地将其照射部分的表面从细胞粘合剂材料的表面改变为非 - - 细胞粘合剂材料。 检测并分析细胞图像以获得所需细胞的位置信息。 基于该信息，通过第二次光照射来切断细胞和细胞粘合剂可光控制材料中的区域。 另一方面，通过第一光照射将基材的表面从电池粘合剂的表面改变为非电池粘合的表面，以产生电池与基材之间的分离。 这使得细胞能够被分析和活化分离。

    Fixing agents, method of fixing substance with the same, and substrate having sustance fixed thereto with the same
    10.
    发明申请
    Fixing agents, method of fixing substance with the same, and substrate having sustance fixed thereto with the same 审中-公开
    定影剂，固定物质的方法以及具有固定剂的固定剂的基材

    公开(公告)号：US20060160089A1

    公开(公告)日：2006-07-20

    申请号：US10551408

    申请日：2004-03-30

    申请人： Yoshihiro Ito ,  Hirokazu Hasuda ,  Tomohiro Konno ,  Kazuhiko Ishihara ,  Tetsuya Yamauchi

    发明人： Yoshihiro Ito ,  Hirokazu Hasuda ,  Tomohiro Konno ,  Kazuhiko Ishihara ,  Tetsuya Yamauchi

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C08G63/48 ,  C12M1/34

    CPC分类号： G01N33/54393

    摘要： An agent for fixing (a) substance(s), which can fix various substances to be fixed on a substrate via covalent bonds and which has an excellent effect for the prevention of non-specific adsorption is disclosed. A polymer containing a plurality of phosphorylcholine groups and photoreactive groups in one molecule is used. The polymer binds to the substrate and to the substance to be fixed via the photoreactive groups, thereby the substance to be fixed is bound to the substrate via covalent bonds through the polymer, and non-specific adsorption is effectively prevented by the phosphorylcholine groups. Further, an agent for fixing (a) substance(s) for fixing the substance on a substrate, comprising a nonionic water-soluble macromolecule having at least 2 photoreactive groups in one molecule was also provided.

    摘要翻译： 公开了一种用于固定（a）物质的试剂，其可以通过共价键固定各种待固定在基材上的物质，并且其具有优异的防止非特异性吸附的效果。 使用在一个分子中含有多个磷酸胆碱基团和光反应基团的聚合物。 聚合物通过光反应基团与基体和待固定的物质结合，通过共聚键将被固定的物质与基底结合，通过磷酸胆碱基团有效地防止非特异性吸附。 此外，还提供了用于将（a）用于将物质固定在基材上的物质（包括在一个分子中具有至少2个光反应性基团的非离子水溶性大分子）的试剂。