MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME
    6.
    发明申请
    MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME 有权
    医疗装置及其制造方法

    公开(公告)号:US20110027757A1

    公开(公告)日:2011-02-03

    申请号:US12809690

    申请日:2008-12-19

    摘要: An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

    摘要翻译: 本发明的目的是提供具有优异的抗血栓形成和滑动特性的医疗装置,其能够发挥细胞粘附抑制作用。 一种医疗装置,包括:能够形成羟基的基材; 以及在适当位置层叠在基材上的生物相容性材料层,其中通过表面处理在至少所需位置上在基材的表面上形成羟基,同时生物相容性材料层由含有磷酸胆碱基团的聚合物形成 ,并且其中所述基材和所述生物相容性材料层通过分别与所述羟基和所述生物相容性材料共价键合的由二氧化硅形成的粘合剂层连接。

    Medical device and method for producing the same
    7.
    发明授权
    Medical device and method for producing the same 有权
    医疗器械及其制造方法

    公开(公告)号:US09216241B2

    公开(公告)日:2015-12-22

    申请号:US12809690

    申请日:2008-12-19

    摘要: An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

    摘要翻译: 本发明的目的是提供具有优异的抗血栓形成和滑动特性的医疗装置,其能够发挥细胞粘附抑制作用。 一种医疗装置,包括:能够形成羟基的基材; 以及在适当位置层叠在基材上的生物相容性材料层,其中通过表面处理在至少所需位置上在基材的表面上形成羟基,同时生物相容性材料层由含有磷酸胆碱基团的聚合物形成 ,并且其中所述基材和所述生物相容性材料层通过分别与所述羟基和所述生物相容性材料共价键合的由二氧化硅形成的粘合剂层连接。