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    Disc-like assay chip
    1.
    发明授权
    Disc-like assay chip 有权
    盘状分析芯片

    公开(公告)号：US09005547B2

    公开(公告)日：2015-04-14

    申请号：US13428683

    申请日：2012-03-23

    申请人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

    发明人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

    IPC分类号： B01L3/00 ,  G01N21/07 ,  G01N35/00 ,  G01N21/64

    CPC分类号： G01N33/5302 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5085 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/07 ,  G01N21/6428 ,  G01N35/00069

    摘要： The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.

    摘要翻译： 本发明提供一种盘状测定芯片，更具体地说，本发明提供一种能够有效地清洁存在于流体回路中的被清洁物体的测定芯片，并且可以适当地应用于使用 必须清洁被清洁物体的步骤，例如免疫荧光抗体法，并应用于使用酶反应的检测方法（特别是ELISA法）。 本发明还提供了一种盘状测定芯片，其安装在诸如旋转盘的离心装置上，并且可以通过使用产生的离心力在样品和试剂反应之后通过光学测量对目标物质进行检测或定量 通过离心装置的旋转。

    Disc-shaped analysis chip
    2.
    发明授权
    Disc-shaped analysis chip 有权
    碟形分析芯片

    公开(公告)号：US08900528B2

    公开(公告)日：2014-12-02

    申请号：US13560524

    申请日：2012-07-27

    申请人： Kenji Hamachi ,  Keiji Iwamoto ,  Kazuhiro Oguchi

    发明人： Kenji Hamachi ,  Keiji Iwamoto ,  Kazuhiro Oguchi

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50273 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0409

    摘要： A disc-shaped analysis chip has an internal space. The internal space includes: a first reservoir for accommodating a first liquid; a second reservoir and a third reservoir arranged nearer to an outer peripheral portion of the analysis chip than the first reservoir; a fourth reservoir, a fifth reservoir and a sixth reservoir for accommodating a second liquid, a third liquid and a fourth liquid, respectively, and being arranged nearer to the outer peripheral portion of the analysis chip than the second and the third reservoir; a seventh reservoir arranged nearer to the outer peripheral portion of the analysis chip than the fourth to the sixth reservoir; an eighth reservoir arranged nearer to the outer peripheral portion of the analysis chip than the seventh reservoir; and a first to an eighth flow path for appropriately interconnecting the first to the eighth reservoir.

    摘要翻译： 盘形分析芯片具有内部空间。 内部空间包括：用于容纳第一液体的第一储存器; 第二储存器和第三储存器，布置成比所述第一储存器更靠近所述分析芯片的外周部分; 分别容纳第二液体，第三液体和第四液体的第四储存器，第五储存器和第六储存器，并且布置成比第二和第三储存器更靠近分析芯片的外周部分; 第七容器，布置成比第四至第六储存器更靠近分析芯片的外周部分; 第八储存器，其布置成比所述第七储存器更靠近所述分析芯片的外周部分; 以及用于适当地互连第一至第八贮存器的第一至第八流路。

    DISC-SHAPED ANALYSIS CHIP
    3.
    发明申请
    DISC-SHAPED ANALYSIS CHIP 有权
    DISC型分析芯片

    公开(公告)号：US20130029361A1

    公开(公告)日：2013-01-31

    申请号：US13560524

    申请日：2012-07-27

    申请人： Kenji HAMACHI ,  Keiji IWAMOTO ,  Kazuhiro OGUCHI

    发明人： Kenji HAMACHI ,  Keiji IWAMOTO ,  Kazuhiro OGUCHI

    IPC分类号： C12M1/34 ,  G01N33/558

    CPC分类号： B01L3/50273 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0409

    摘要： A disc-shaped analysis chip has an internal space. The internal space includes: a first reservoir for accommodating a first liquid; a second reservoir and a third reservoir arranged nearer to an outer peripheral portion of the analysis chip than the first reservoir; a fourth reservoir, a fifth reservoir and a sixth reservoir for accommodating a second liquid, a third liquid and a fourth liquid, respectively, and being arranged nearer to the outer peripheral portion of the analysis chip than the second and the third reservoir; a seventh reservoir arranged nearer to the outer peripheral portion of the analysis chip than the fourth to the sixth reservoir; an eighth reservoir arranged nearer to the outer peripheral portion of the analysis chip than the seventh reservoir; and a first to an eighth flow path for appropriately interconnecting the first to the eighth reservoir.

    摘要翻译： 盘形分析芯片具有内部空间。 内部空间包括：用于容纳第一液体的第一储存器; 第二储存器和第三储存器，布置成比所述第一储存器更靠近所述分析芯片的外周部分; 分别容纳第二液体，第三液体和第四液体的第四储存器，第五储存器和第六储存器，并且布置成比第二和第三储存器更靠近分析芯片的外周部分; 第七容器，布置成比第四至第六储存器更靠近分析芯片的外周部分; 第八储存器，其布置成比所述第七储存器更靠近所述分析芯片的外周部分; 以及用于适当地互连第一至第八储存器的第一至第八流路。

    Disc-Like Assay Chip
    4.
    发明申请
    Disc-Like Assay Chip 有权
    盘状分析芯片

    公开(公告)号：US20120244607A1

    公开(公告)日：2012-09-27

    申请号：US13428683

    申请日：2012-03-23

    申请人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

    发明人： Keiji Iwamoto ,  Kazuhiro Oguchi ,  Kenji Hamachi

    IPC分类号： C12M1/40 ,  G01N21/64

    CPC分类号： G01N33/5302 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5085 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/07 ,  G01N21/6428 ,  G01N35/00069

    摘要： The present invention provides a disc-like assay chip, and more specifically, the present invention provides an assay chip which can effectively clean a cleaned object existing in a fluid loop, and can be appropriately applied to a detection method of a reaction system using a step of necessarily cleaning the cleaned object, such as an immunofluorescent antibody method, and applied to a detection method using an enzymatic reaction (especially, an ELISA method). The present invention further provides a disc-like assay chip which is mounted on a centrifugal device such as a rotational disc and can perform detection or quantitation on a target substance through optical measurement after a specimen and a reagent react by use of a centrifugal force generated by rotation of the centrifugal device.

    摘要翻译： 本发明提供一种盘状测定芯片，更具体地说，本发明提供一种能够有效地清洁存在于流体回路中的被清洁物体的测定芯片，并且可以适当地应用于使用 必须清洁被清洁物体的步骤，例如免疫荧光抗体法，并应用于使用酶反应的检测方法（特别是ELISA法）。 本发明还提供了一种盘状测定芯片，其安装在诸如旋转盘的离心装置上，并且可以通过使用产生的离心力在样品和试剂反应之后通过光学测量对目标物质进行检测或定量 通过离心装置的旋转。

    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane
    5.
    发明授权
    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane 失效
    制备3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物和4-酰基四氢吡喃的方法

    公开(公告)号：US07741497B2

    公开(公告)日：2010-06-22

    申请号：US10583473

    申请日：2004-12-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    IPC分类号： C07D309/06

    CPC分类号： C07D309/06

    摘要： The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.

    摘要翻译： 本发明提供一种制备式（1）表示的3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物的方法：其中R 1和R 2可以相同或不同，并且表示基团 其不参与反应，并且R 1和R 2可以键合形成环，并且该环可以含有杂原子，并且R 3表示烃基，其包括使由式（Ⅳ）表示的4-酰基四氢吡喃与 2）：其中R1和R2具有与上述相同的含义，和由式（3）表示的碳酸二酯：其中R 3具有与上述相同的含义，并且两个R 3可以彼此键合形成 在碱的存在下，以及制备4-酰基四氢吡喃的方法。

    Process for Preparing Tetrahydropyran-4-Carboxylic Acid Compound
    6.
    发明申请
    Process for Preparing Tetrahydropyran-4-Carboxylic Acid Compound 审中-公开
    制备四氢吡喃-4-羧酸化合物的方法

    公开(公告)号：US20080306287A1

    公开(公告)日：2008-12-11

    申请号：US11668000

    申请日：2005-11-18

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Taku Nakamura ,  Keiji Iwamoto

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Taku Nakamura ,  Keiji Iwamoto

    IPC分类号： C07D309/08

    CPC分类号： C07D309/08

    摘要： The present invention is to provide a process for preparing tetrahydropyran-4-carboxylic acid represented by the formula (1): which comprises hydrolyzing a 4-cyanotetrahydropyran-4-carboxylic acid compound represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, in the presence of an acid; a process for preparing a tetrahydropyran-4-carboxylic acid ester which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with an alcohol in the presence of an acid; and a process for preparing tetrahydropyran-4-carboxylic acid amide which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with a halogenating agent to prepare tetrahydropyran-4-carboxylic acid halide, and then, reacting an amine compound to the resulting compound.

    摘要翻译： 本发明提供一种制备由式（1）表示的四氢吡喃-4-羧酸的方法：其包括水解由式（2）表示的4-氰基四氢吡喃-4-羧酸化合物：其中R表示氢 原子或烃基，在酸的存在下; 制备四氢吡喃-4-羧酸酯的方法，其包括在酸存在下使由上述式（1）表示的四氢吡喃-4-羧酸与醇反应; 以及制备四氢吡喃-4-羧酸酰胺的方法，其包括使由上述式（1）表示的四氢吡喃-4-羧酸与卤化剂反应以制备四氢吡喃-4-羧酸卤化物，然后使 向所得化合物中加入胺化合物。

    Process for preparing nitrile compound, carboxylic acid compound or carboxylic acid ester compound
    8.
    发明授权
    Process for preparing nitrile compound, carboxylic acid compound or carboxylic acid ester compound 有权
    腈化合物，羧酸化合物或羧酸酯化合物的制备方法

    公开(公告)号：US07300953B2

    公开(公告)日：2007-11-27

    申请号：US10572373

    申请日：2004-09-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    IPC分类号： A61K31/075 ,  C07D309/08

    CPC分类号： C07C253/30 ,  C07C51/00

    摘要： The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.

    摘要翻译： 本发明公开了一种制备由式（2）表示的腈化合物，羧酸化合物或羧酸酯化合物的方法：其中R表示氰基，羧基或酯基，R 1 R 2和R 2各自表示不参与反应的基团，其可以具有取代基，R 1和R 2， SUP>可以彼此组合以形成环，其包括使由式（1）表示的乙酸化合物：其中R，R 1和R 2， 具有与上述相同的含义，在金属催化剂的存在下脱羧。

    Proteins having glucose transporter activity
    9.
    发明授权
    Proteins having glucose transporter activity 失效
    具有葡萄糖转运蛋白活性的蛋白质

    公开(公告)号：US07247705B2

    公开(公告)日：2007-07-24

    申请号：US10451822

    申请日：2001-12-27

    申请人： Keiji Iwamoto ,  Nozomi Katayama ,  Mihoko Kawamura

    发明人： Keiji Iwamoto ,  Nozomi Katayama ,  Mihoko Kawamura

    IPC分类号： C07K14/00 ,  A61K38/17

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides proteins having the Na+/glucose transporter activity, DNAs encoding the proteins, a method of screening for a compound enhancing or inhibiting the activity of the proteins, and compounds obtained by the screening method. The proteins having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, 15 or 26 are useful as a diagnostic marker for a disease such as diabetes. The compounds enhancing or inhibiting the activity of the proteins, obtained the screening method using the proteins, can be used as a prophylactic and/or therapeutic agent for a disease such as diabetes and hyperlipidemia.

    摘要翻译： 本发明提供具有Na + + /葡萄糖转运蛋白活性的蛋白质，编码蛋白质的DNA，筛选增强或抑制蛋白质活性的化合物的方法以及通过筛选方法获得的化合物。 具有与SEQ ID NO：1,5或26所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质可用作糖尿病等疾病的诊断标记物。 获得使用蛋白质的筛选方法增强或抑制蛋白质活性的化合物可用作疾病如糖尿病和高脂血症的预防和/或治疗剂。