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1.发明授权Method for enzymatically preparing peptides for use in improvement of brain function 有权用于酶促制备用于改善脑功能的肽的方法公开(公告)号：US09523109B2
公开(公告)日：2016-12-20
申请号：US13495581
申请日：2012-06-13
申请人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
发明人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
IPC分类号： C12P21/06 , A61P25/00 , A61K38/01 , A61K38/10 , A61K38/17 , C07K14/47 , A23C9/12 , A23C9/13 , A23J3/32 , A23J3/34
CPC分类号： C12P21/06 , A23C9/1209 , A23C9/1307 , A23J3/325 , A23J3/344 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/018 , A61K38/10 , A61K38/1709 , C07K14/4732 , C12Y304/15 , C12Y304/15001 , C12Y304/15004 , C12Y304/16 , C12Y304/17 , C12Y304/17001 , C12Y304/21019 , Y02P20/52 , A23V2200/322 , A23V2250/55
摘要： The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.
摘要翻译： 本发明提供了一种制备用于改善脑功能的肽的方法，包括用包含蛋白酶的酶催化剂水解乳酪蛋白以产生水解产物，其包含：（i）由SEQ ID NO：1所示氨基酸序列组成的肽或 其变体; （ii）由SEQ ID NO：2所示的氨基酸序列或其变体构成的肽; 或（iii）（i）和（ii）的肽的混合物，其中各肽的产率为2％以上，混合物的总产量为10％以上。 本发明还提供了含有水解产物的食品或饮料或药物组合物。
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2.发明授权Composition for improving brain function and method for improving brain function 有权用于改善脑功能的组合物和改善脑功能的方法公开(公告)号：US08916524B2
公开(公告)日：2014-12-23
申请号：US13233922
申请日：2011-09-15
申请人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
CPC分类号： A61K38/07 , A61K9/0053 , A61K38/018 , A61K38/08 , C07K5/101 , C07K5/1016 , C07K7/06
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
摘要翻译： 本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。 本发明是一种用于改善脑功能的组合物，其包含作为活性成分的X-Pro-Pro-Y或其盐，其中X表示Val，Ile或Asn-Ile，Y表示Phe或Leu。
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3.发明申请PROCESS FOR PREPARING CASEIN-DERIVED PEPTIDES BY FERMENTATION OF LACTIC ACID BACTERIA 审中-公开通过发酵乳酸杆菌制备壳衍生肽的方法公开(公告)号：US20120328735A1
公开(公告)日：2012-12-27
申请号：US13495677
申请日：2012-06-13
申请人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
发明人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
CPC分类号： A23J3/343 , A23J3/10 , A23L2/66 , A23L33/17 , A23L33/18 , A23V2002/00 , C07K7/08 , C07K14/4732 , C12P21/06 , A23V2200/322 , A23V2250/5424 , A23V2250/55
摘要： The present invention relates to a method for preparing a casein-derived peptide by fermentation of a lactic acid bacterium. The present invention also relates to a composition containing the peptide, and a method for preparing a functional food.
摘要翻译： 本发明涉及通过乳酸菌发酵制备酪蛋白衍生肽的方法。 本发明还涉及含有该肽的组合物及其制备功能性食品的方法。
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4.发明申请COMPOSITION FOR IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION 有权用于改善脑功能的组合物和用于改善脑功能的方法公开(公告)号：US20120277160A1
公开(公告)日：2012-11-01
申请号：US13532394
申请日：2012-06-25
申请人： Kazuhito OHSAWA , Naoto UCHIDA , Kohji OHKI , Hiroaki GOTO
发明人： Kazuhito OHSAWA , Naoto UCHIDA , Kohji OHKI , Hiroaki GOTO
摘要： Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same.
摘要翻译： 提供了可以以低剂量口服摄取的用于改善脑功能的组合物及其方法。 用于改善脑功能的组合物含有作为活性成分的X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu- Y（其中X为零或表示Ile或Asn-Ile; Y为无或表示Val-Met），X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y X缺失或表示Thr-Gln-Thr-Pro，Pro-Leu-Thr-Gln-Thr-Pro，Leu-Thr-Gln-Thr-Pro或Pro; Y为缺失或代表Val-Met） 盐相同。 改善脑功能的方法包括施用所述肽或其相同的盐。
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5.发明申请COMPOSITION FOR IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION 有权用于改善脑功能的组合物和用于改善脑功能的方法公开(公告)号：US20120083451A1
公开(公告)日：2012-04-05
申请号：US13233922
申请日：2011-09-15
申请人： Kazuhito OHSAWA , Naoto Uchida , Kohji Ohki
发明人： Kazuhito OHSAWA , Naoto Uchida , Kohji Ohki
CPC分类号： A61K38/07 , A61K9/0053 , A61K38/018 , A61K38/08 , C07K5/101 , C07K5/1016 , C07K7/06
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
摘要翻译： 本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。 本发明是一种用于改善脑功能的组合物，其包含作为活性成分的X-Pro-Pro-Y或其盐，其中X表示Val，Ile或Asn-Ile，Y表示Phe或Leu。
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公开(公告)号：US5043422A
公开(公告)日：1991-08-27
申请号：US547809
申请日：1990-07-02
申请人： Kohji Ohki , Kazuyoshi Ikuta , Kazutaka Ohmura , Shiro Kato
发明人： Kohji Ohki , Kazuyoshi Ikuta , Kazutaka Ohmura , Shiro Kato
CPC分类号： C07K14/70514 , A61K38/00 , Y02P20/55
摘要： A peptide having anti-HIV activity consists of an amino acid chain represented by Asn-Phe-Pro-Leu-Ile-Ile-Lys-Asn-Leu-Lys-Ile-Glu-Asp-Ser-Asp-Thr-Tyr-Ile-Cys-Glu-Val-Glu-Asp-Gln-Lys-Glu. The Cys underlined in the above amino acid chain may be replaced by Phe, Ser, Cys.sup.Acm or Cys.sup.Bzl.
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公开(公告)号：US09067972B2
公开(公告)日：2015-06-30
申请号：US12874610
申请日：2010-09-02
申请人： Kazuhito Ohsawa , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
CPC分类号： C07K5/101 , A61K38/00 , C07K5/0808 , C07K5/1016 , C07K7/06
摘要： The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-lle-Pro-Pro-Leu, lle-Pro-Pro-Leu, lle-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr.
摘要翻译： 本发明提供适合于口服摄取，具有皮肤老化抑制活性，胶原产生促进活性，表皮转换促进活性和皮肤细胞增殖效果的肽和组合物。 本发明还提供了具有皮肤老化抑制活性，胶原产生促进活性和皮肤细胞增殖促进活性的药物和功能性食品。 本发明提供包含至少一种Asn-Lle-Pro-Pro-Leu肽，lle-Pro-Pro-Leu，lle-Pro-Pro，Pro-Val-Val-Val-Pro-Pro，Val- Pro-Pro-Phe，Val-Pro-Pro，Phe-Pro-Pro-Gln和Leu-Pro-Pro-Thr。
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8.发明授权Composition for improving brain function and method for improving brain function 有权用于改善脑功能的组合物和改善脑功能的方法公开(公告)号：US08343925B2
公开(公告)日：2013-01-01
申请号：US12890174
申请日：2010-09-24
申请人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
CPC分类号： A61K38/06
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, Xaa-Pro-Pro (wherein Xaa represents Ile, Leu or Ser).
摘要翻译： 本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。 本发明是用于改善脑功能的组合物，该组合物包含作为活性成分的Xaa-Pro-Pro（其中Xaa表示Ile，Leu或Ser）。
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公开(公告)号：US20120058947A1
公开(公告)日：2012-03-08
申请号：US13293993
申请日：2011-11-10
申请人： Tatsuhiko HIROTA , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
发明人： Tatsuhiko HIROTA , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
CPC分类号： A61K38/06 , A23L33/18 , A23V2002/00 , A23V2200/326 , A23V2250/0654 , A23V2250/064 , A23V2200/32 , A23V2250/0626
摘要： The present invention provides an agent having a suppressive action against the thickening of the heart wall, a prophylactic agent for heart failure containing the above described agent, and functional foods expected to have a prophylactic effect for heart failure. The agent for suppressing heart wall thickening comprises Xaa Pro Pro as an active ingredient.
摘要翻译： 本发明提供对心脏壁增厚具有抑制作用的药剂，含有上述药剂的心力衰竭预防剂和预期具有预防心力衰竭作用的功能性食品。 用于抑制心脏壁增厚的药剂包括Xaa Pro Pro作为活性成分。
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10.发明申请COMPOSITION FOR REGULATING AUTONOMIC NERVOUS ACTIVITY AND METHOD FOR REGULATING AUTONOMIC NERVE 审中-公开用于调节自发性神经活性的组合物和用于调节自主神经的方法公开(公告)号：US20120015882A1
公开(公告)日：2012-01-19
申请号：US13245449
申请日：2011-09-26
申请人： Naoto Uchida , Kazuhito Ohsawa , Kohji Ohki , Yasunori Nakamura , Hidehiko Baba
发明人： Naoto Uchida , Kazuhito Ohsawa , Kohji Ohki , Yasunori Nakamura , Hidehiko Baba
CPC分类号： A61K38/05
摘要： The present invention provides an orally ingestible composition and a method for regulating an autonomic nervous activity. In particular, the present invention provides an orally ingestible composition capable of suppressing an increase in a sympathetic nervous activity, and an orally ingestible composition capable of promoting a parasympathetic nervous activity. The present invention is a composition for regulating an autonomic nervous activity, comprising, as an active ingredient, Tyr-Pro or a salt thereof.
摘要翻译： 本发明提供口服摄取组合物和调节自主神经活性的方法。 特别地，本发明提供能够抑制交感神经活性增加的口服摄取性组合物和能够促进副交感神经活动的口服摄取性组合物。 本发明是用于调节自主神经活性的组合物，其包含Tyr-Pro或其盐作为活性成分。
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