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    Nanostructured separation and analysis devices for biological membranes
    2.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE42249E1

    公开(公告)日：2011-03-29

    申请号：US12217114

    申请日：2008-07-01

    申请人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC分类号： B01D21/00

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nonostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the subtrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures. A fluidic device for separating particles according to size is provided including a fluidic channel, and a matrix comprising a plurality of protrusions within the fluidic channel, wherein the device provides a driving force to the particles being separated through the fluidic channel; and wherein a flow of the driving force from between the protrusions is divided unequally into a major flow component and a minor flow component, each component flowing between subsequent protrusions in the matrix, such that the average direction of the major flow component is not parallel to the average direction of the driving force, and, when particles are introduced into the matrix, particles having a size less than a predetermined critical size are transported generally in the average direction of the driving force, and particles having a size at least that of the critical size are transported generally in the average direction of the major flow component, thereby separating the particles according to size. Methods for separating particles including steps of separation based on size and affinity are also provided.

    摘要翻译： 本发明提供一种非结构化装置，其包括其中包括纳入通道的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述缓冲液包含纳米结构，并且其中所述脂质双层包含至少一个膜相关的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。 提供了一种用于根据尺寸分离颗粒的流体装置，包括流体通道和在流体通道内包括多个突起的基体，其中该装置为通过流体通道分离的颗粒提供驱动力; 并且其中来自所述突起之间的驱动力的流动不均匀地分成主流动分量和小流动分量，每个分量在所述基体中的后续突起之间流动，使得主流动分量的平均方向不平行于 驱动力的平均方向，并且当颗粒被引入到基质中时，尺寸小于预定临界尺寸的颗粒通常沿驱动力的平均方向传送，并且尺寸至少大于 临界尺寸通常沿主流体组分的平均方向输送，从而根据尺寸分离颗粒。 还提供了基于尺寸和亲和力分离包括分离步骤的颗粒的方法。

    Nanostructured separation and analysis devices for biological membranes
    3.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE42315E1

    公开(公告)日：2011-05-03

    申请号：US11825298

    申请日：2007-07-05

    申请人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC分类号： B01D15/34

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    Nanostructured separation and analysis devices for biological membranes
    4.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE41762E1

    公开(公告)日：2010-09-28

    申请号：US12215893

    申请日：2008-06-30

    申请人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC分类号： C02F1/00

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    Nanostructured separation and analysis devices for biological membranes
    6.
    发明授权
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：US06913697B2

    公开(公告)日：2005-07-05

    申请号：US10338654

    申请日：2003-01-09

    申请人： Gabriel P. Lopez ,  Steven R. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. Brueck ,  Linnea K. Ista

    IPC分类号： B01D11/00 ,  B01D61/14

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    Nanofluidics for bioseparation and analysis
    9.
    发明授权
    Nanofluidics for bioseparation and analysis 有权
    用于生物分离和分析的纳米流体

    公开(公告)号：US08105471B1

    公开(公告)日：2012-01-31

    申请号：US11184540

    申请日：2005-07-19

    申请人： Sang M. Han ,  Steven R. J. Brueck ,  Cornelius F. Ivory ,  Gabriel P. Lopez ,  Dimiter N. Petsev

    发明人： Sang M. Han ,  Steven R. J. Brueck ,  Cornelius F. Ivory ,  Gabriel P. Lopez ,  Dimiter N. Petsev

    IPC分类号： G01N27/447 ,  G01N27/453

    CPC分类号： G01N27/44752

    摘要： The invention includes nanochannel devices and methods for using such nanochannel devices for separating molecules, ions and biomolecules. The nanochannel devices have at least one nanochannel through which fluid can move, wherein ionic double layers form in the fluid near walls of the nanochannel and those ionic double layers overlap within the nanochannel. Electrical voltage can be applied to the nanochannel to modify an electrostatic potential in the nanochannel and thereby control movement of ions and biomolecules through the nanochannel. The invention also includes arrays and networks of such nanochannel devices.

    摘要翻译： 本发明包括纳米通道装置和使用这种纳米通道装置分离分子，离子和生物分子的方法。 纳米通道装置具有至少一个纳米通道，流体可以通过该纳米通道移动，其中在纳米通道壁附近的流体中形成离子双层，并且那些离子双层在纳米通道内重叠。 可以将电压施加到纳米通道以修改纳米通道中的静电势，从而控制离子和生物分子通过纳米通道的运动。 本发明还包括这种纳米通道装置的阵列和网络。