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公开(公告)号：US08288416B2
公开(公告)日：2012-10-16
申请号：US12311243
申请日：2007-09-22
申请人： Vijaykumar Jadgishwar Patil , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Deepak Vijaykumar Dekhane , Mohammad Usman Shaikh , Yati Chugh , Rajesh Prabhakar Chavan , Mohammad Alam Jafri
发明人： Vijaykumar Jadgishwar Patil , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Deepak Vijaykumar Dekhane , Mohammad Usman Shaikh , Yati Chugh , Rajesh Prabhakar Chavan , Mohammad Alam Jafri
IPC分类号： A61K31/445 , C07D413/14
CPC分类号： C07D413/10 , C07F9/65583
摘要： The present invention relates to oxazolidinones of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof. The invention also relates to processes for the preparation of the compound of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof, and to pharmaceutical compositions containing the compounds of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof and to methods for treating or preventing microbial infections using the compounds of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof.
摘要翻译： 本发明涉及式I的恶唑烷酮及其药学上可接受的盐，药学上可接受的溶剂化物或其多晶型物。 本发明还涉及制备式I化合物及其药学上可接受的盐，药学上可接受的溶剂合物或多晶型物的方法，以及含有式I化合物及其药学上可接受的盐，药学上可接受的溶剂化物或多晶型物的药物组合物，以及 使用式I化合物及其药学上可接受的盐，药学上可接受的溶剂合物或多晶型物治疗或预防微生物感染的方法。
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公开(公告)号：US20100120721A1
公开(公告)日：2010-05-13
申请号：US12311243
申请日：2007-09-22
申请人： Vijaykumar Jadgishwar Patil , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Deepak Vijaykumar Dekhane , Mohammad Usman Shaikh , Yati Chugh , Rajesh Prabhakar Chavan , Mohammad Alam Jafri
发明人： Vijaykumar Jadgishwar Patil , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Deepak Vijaykumar Dekhane , Mohammad Usman Shaikh , Yati Chugh , Rajesh Prabhakar Chavan , Mohammad Alam Jafri
IPC分类号： A61K31/454 , C07F9/117 , C07D413/14 , C07D413/10 , A61K31/661 , A61P31/04 , A61P31/00
CPC分类号： C07D413/10 , C07F9/65583
摘要： The present invention relates to oxazolidinones of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof. The invention also relates to processes for the preparation of the compound of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof, and to pharmaceutical compositions containing the compounds of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof and to methods for treating or preventing microbial infections using the compounds of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof.
摘要翻译： 本发明涉及式I的恶唑烷酮及其药学上可接受的盐，药学上可接受的溶剂化物或其多晶型物。 本发明还涉及制备式I化合物及其药学上可接受的盐，药学上可接受的溶剂合物或多晶型物的方法，以及含有式I化合物及其药学上可接受的盐，药学上可接受的溶剂化物或多晶型物的药物组合物，以及 使用式I化合物及其药学上可接受的盐，药学上可接受的溶剂合物或多晶型物治疗或预防微生物感染的方法。
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公开(公告)号：US08541420B2
公开(公告)日：2013-09-24
申请号：US13321892
申请日：2010-05-26
IPC分类号： C07D239/24 , C07D403/14 , C07D417/14 , A61K31/443
CPC分类号： C07H17/08
摘要： The invention relates to ketolide compound of Formula-I and the pharmaceutically acceptable salts thereof having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compound of invention.
摘要翻译： 本发明涉及具有抗菌活性的式I的酮内酯化合物及其药学上可接受的盐。 本发明还提供含有本发明化合物的药物组合物以及用本发明化合物治疗或预防微生物感染的方法。
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公开(公告)号：US20120142710A1
公开(公告)日：2012-06-07
申请号：US13321892
申请日：2010-05-26
IPC分类号： A61K31/4439 , A61K31/506 , A61P31/00 , C07D493/04
CPC分类号： C07H17/08
摘要： The invention relates to ketolide compound of Formula-I and the pharmaceutically acceptable salts thereof having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compound of invention.
摘要翻译： 本发明涉及具有抗菌活性的式I的酮内酯化合物及其药学上可接受的盐。 本发明还提供含有本发明化合物的药物组合物以及用本发明化合物治疗或预防微生物感染的方法。
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公开(公告)号：US08097594B2
公开(公告)日：2012-01-17
申请号：US12379539
申请日：2009-02-24
申请人： Milind Dattatraya Sindkhedkar , Vijaya Narayan Desai , Rajesh Maganlal Loriya , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Rajesh Onkardas Bora , Santosh Devidas Diwakar , Ganesh Rajaram Jadhav , Shivaji Sampatrao Pawar
发明人： Milind Dattatraya Sindkhedkar , Vijaya Narayan Desai , Rajesh Maganlal Loriya , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Rajesh Onkardas Bora , Santosh Devidas Diwakar , Ganesh Rajaram Jadhav , Shivaji Sampatrao Pawar
CPC分类号： C07D493/04
摘要： The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel semi-synthetic 11,12-γ lactone macrolides and ketolides having antimicrobial activity, processes for making compounds as well as pharmaceutical compositions containing said compounds as active ingredients and methods of treating microbial infections with the compounds.
摘要翻译： 本发明提供具有抗微生物活性的化合物，其用于预防和治疗由微生物感染引起的疾病。 因此，本发明涉及具有抗微生物活性的新型半合成11,12-γ内酯大环内酯和酮内酯，以及制备化合物的方法以及含有所述化合物作为活性成分的药物组合物以及用该化合物治疗微生物感染的方法。
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公开(公告)号：US20090247478A1
公开(公告)日：2009-10-01
申请号：US12379539
申请日：2009-02-24
申请人： Milind Dattatraya Sindkhedkar , Vijaya Narayan Desai , Rajesh Maganlal Loriya , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Rajesh Onkardas Bora , Santosh Devidas Diwakar , Ganesh Rajaram Jadhav , Shivaji Sampatrao Pawar
发明人： Milind Dattatraya Sindkhedkar , Vijaya Narayan Desai , Rajesh Maganlal Loriya , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Rajesh Onkardas Bora , Santosh Devidas Diwakar , Ganesh Rajaram Jadhav , Shivaji Sampatrao Pawar
IPC分类号： A61K31/7048 , C07H17/08
CPC分类号： C07D493/04
摘要： The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel semi-synthetic 11,12-γ lactone macrolides and ketolides having antimicrobial activity, processes for making compounds as well as pharmaceutical compositions containing said compounds as active ingredients and methods of treating microbial infections with the compounds.
摘要翻译： 本发明提供具有抗微生物活性的化合物，其用于预防和治疗由微生物感染引起的疾病。 因此，本发明涉及具有抗微生物活性的新型半合成的11,12-γ-内酯大环内酯和酮内酯，以及制备化合物的方法以及含有所述化合物作为活性成分的药物组合物以及用该化合物治疗微生物感染的方法。
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公开(公告)号：US09132133B2
公开(公告)日：2015-09-15
申请号：US14609704
申请日：2015-01-30
申请人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： A61K31/439 , A61K31/5377 , C07D471/08 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/529 , A61K31/542 , A61K45/06 , A61K31/43 , A61K31/546
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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公开(公告)号：US20130059774A1
公开(公告)日：2013-03-07
申请号：US13578428
申请日：2010-04-01
IPC分类号： A61K31/546 , A61K31/7048 , A61K31/65 , A61P31/00 , C12N1/10 , A61P31/10 , C12N1/20 , C12N1/14 , C12N1/16 , A61K38/12 , A61P31/04
CPC分类号： A61K31/546 , A61K31/65 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Novel compositions and methods of reducing microbial resistance to antimicrobial agents and treating infections are disclosed. In particular, compositions and methods of inhibiting efflux pump activity, treating infection and methods of enhancing antimicrobial activity of antimicrobial agents are provided.
摘要翻译： 公开了降低微生物对抗微生物剂的抗性和治疗感染的新型组合物和方法。 特别地，提供抑制外排泵活性，治疗感染的组合物和方法以及增强抗微生物剂的抗微生物活性的方法。
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公开(公告)号：US20090275552A1
公开(公告)日：2009-11-05
申请号：US12226525
申请日：2007-04-27
申请人： Mahesh Vithalbhai Patel , Shrikant Vinayak Gupte , Sachin Subhash Bhagwat , Mohammad Alam Jafri , Girish Kumar Jain , Mandar Madhukar Kodgule
发明人： Mahesh Vithalbhai Patel , Shrikant Vinayak Gupte , Sachin Subhash Bhagwat , Mohammad Alam Jafri , Girish Kumar Jain , Mandar Madhukar Kodgule
IPC分类号： A61K31/397
CPC分类号： A61K31/43 , A61K9/0019 , A61K9/0095 , A61K9/1652 , A61K9/2054 , A61K31/546 , A61K2300/00
摘要： The invention relates to an improved therapy for treating resistant bacterial infections caused by extended-spectrum β-lactamase (ESBLs)-producing strains in a warm-blooded animal, adjuvant step down therapy, and pharmaceutical compositions for such therapies. The invention also relates to a method for inhibiting bacterial resistance in ESBLs-producing strains so as to have better control over the therapy; achieve reduced hospital stay and adjuvant step down therapy so as to avoid recrudescence. In particular, the therapy includes antibacterial combination of cefepime with sulbactam via parenteral route, followed by oral third generation cephalosporin with a suitable β lactamase inhibitor.
摘要翻译： 本发明涉及用于治疗由温血动物中的扩展型β-内酰胺酶（ESBL））产生菌株引起的抗性细菌感染的改进疗法，佐剂降解疗法和用于此类疗法的药物组合物。 本发明还涉及一种抑制ESBLs产生菌株细菌耐药性的方法，以便更好地控制治疗; 实现减少住院时间和辅助降压治疗，避免复发。 特别地，该疗法包括通过肠胃外途径将头孢吡肟与舒巴坦的抗菌结合，随后用合适的β-内酰胺酶抑制剂口服第三代头孢菌素。
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公开(公告)号：US10525043B2
公开(公告)日：2020-01-07
申请号：US14111627
申请日：2011-08-01
IPC分类号： A61K31/431 , A61K31/546 , A61K31/43 , A61K31/407
摘要： A pharmaceutical composition comprising antibacterial agent and tazobactam, wherein the ratio of tazobactam to the antibacterial agent in the composition is in the range of from about 0.5 to about 2 gram of tazobactam per gram of the antibacterial agent, are disclosed.
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