公开(公告)号：US20080044692A1

公开(公告)日：2008-02-21

申请号：US11761016

申请日：2007-06-11

Applicant: MANFRED REETZ ,  MARCO LOPEZ

Inventor： MANFRED REETZ ,  MARCO LOPEZ

IPC: H01M8/00 ,  B01J23/00 ,  B01J23/02 ,  B01J23/40 ,  B01J23/42 ,  B01J23/745 ,  B01J23/75 ,  B01J27/10 ,  B01J27/20

CPC classification number: H01M4/921 ,  B01J21/18 ,  B01J23/40 ,  B01J23/626 ,  B01J23/6525 ,  B01J35/0013 ,  B01J37/0211 ,  H01M4/8605

Abstract: The invention relates to heterogeneous catalysts which are particularly easy to produce. Said heterogeneous catalysts are generated by immobilizing preformed monometallic or multimetallic metal oxide particles in situ on an oxidic or non-oxidic carrier, wherefore metal oxide colloids which are stabilized by hydroxide ions and immobilized on carriers contained in the suspension are generated from conventional, water-soluble metal salts by means of hydrolysis and condensation. The inventive method makes it possible to produce fuel cell catalysts, for example.

Abstract translation: 本发明涉及特别容易生产的多相催化剂。 所述非均相催化剂通过将预制的单金属或多金属氧化物颗粒原位固定在氧化或非氧化载体上而产生，因此由常规的水溶性聚合物产生由氢氧根离子稳定并固定在悬浮液中的载体上的金属氧化物胶体， 通过水解和缩合可溶性金属盐。 本发明的方法使得可以制备例如燃料电池催化剂。

公开(公告)号：US20060224002A1

公开(公告)日：2006-10-05

申请号：US11382760

申请日：2006-05-11

Applicant: Manfred Reetz ,  Andreas Meiswinkel ,  Gerlinde Mehler

Inventor： Manfred Reetz ,  Andreas Meiswinkel ,  Gerlinde Mehler

IPC: C07F9/30 ,  C07F9/80

CPC classification number: C07F15/008 ,  B01J31/185 ,  B01J31/1855 ,  B01J31/186 ,  B01J31/2234 ,  B01J31/2295 ,  B01J2231/32 ,  B01J2231/321 ,  B01J2231/641 ,  B01J2531/16 ,  B01J2531/80 ,  B01J2531/822 ,  C07C45/505 ,  C07F9/657154 ,  C07F9/65746 ,  C07F15/0073

Abstract: The invention claims chiral di- and triphosphites of general formulas (I) or (II), which are bridged by suitable groups. The claimed compounds can be used in asymmetric transition metal catalysis and as chiral transition metal catalysts.

Abstract translation: 本发明要求通过合适的基团桥连的通式（I）或（II）的手性二 - 和三亚磷酸酯。 所要求保护的化合物可用于不对称过渡金属催化剂和手性过渡金属催化剂。

公开(公告)号：US20050148464A1

公开(公告)日：2005-07-07

申请号：US10507764

申请日：2003-02-25

Applicant: Manfred Reetz ,  Marco Lopez

Inventor： Manfred Reetz ,  Marco Lopez

IPC: B01J37/03 ,  B01J21/18 ,  B01J23/40 ,  B01J23/42 ,  B01J23/46 ,  B01J23/62 ,  B01J23/652 ,  B01J35/00 ,  B01J37/02 ,  B01J37/16 ,  B01J37/18 ,  H01M4/86 ,  H01M4/88 ,  H01M4/90 ,  H01M4/92 ,  H01M4/96 ,  H01M8/10

CPC classification number: H01M4/921 ,  B01J21/18 ,  B01J23/40 ,  B01J23/626 ,  B01J23/6525 ,  B01J35/0013 ,  B01J37/0211 ,  H01M4/8605

Abstract: The invention relates to heterogeneous catalysts which are particularly easy to produce. Said heterogeneous catalysts are generated by immobilizing preformed monometallic or multimetallic metal oxide particles in situ on an oxidic or non-oxidic carrier, wherefore metal oxide colloids which are stabilized by hydroxide ions and immobilized on carriers contained in the suspension are generated from conventional, water-soluble metal salts by means of hydrolysis and condensation. The inventive method makes it possible to produce fuel cell catalysts, for example.

Abstract translation: 本发明涉及特别容易生产的多相催化剂。 所述非均相催化剂通过将预制的单金属或多金属氧化物颗粒原位固定在氧化或非氧化载体上而产生，因此由常规的水溶性聚合物产生由氢氧根离子稳定并固定在悬浮液中的载体上的金属氧化物胶体， 通过水解和缩合可溶性金属盐。 本发明的方法使得可以制备例如燃料电池催化剂。

公开(公告)号：US09061963B2

公开(公告)日：2015-06-23

申请号：US14111217

申请日：2012-04-03

Applicant: Manfred Reetz ,  Gerlinde Mehler

Inventor： Manfred Reetz ,  Gerlinde Mehler

IPC: C07D215/38 ,  C07D217/22 ,  C07D295/033 ,  C07D213/74 ,  C07C209/10 ,  C07B43/04

CPC classification number: C07C209/10 ,  C07B43/04 ,  C07D213/74 ,  C07D215/38 ,  C07D217/22 ,  C07D295/033

Abstract: A process is described for preparing aromatic and heteroaromatic amines of the general formula (I) Ar—NR1R2, in which an aromatic compound with the general formula (II) Ar—X is reacted in the presence of a catalyst with an amine of the general formula (III) H—NR1R2 and a base, wherein the catalyst is selected from transition metal complexes having one or more ligands with the general formula (IV).

Abstract translation: 描述了用于制备通式（I）Ar-NR1R2的芳族和杂芳族胺的方法，其中通式（II）Ar-X的芳族化合物在催化剂存在下与一般的胺反应 式（III）H-NR1R2和碱，其中催化剂选自具有一个或多个具有通式（IV）的配体的过渡金属配合物。

公开(公告)号：US20140213785A1

公开(公告)日：2014-07-31

申请号：US14111217

申请日：2012-04-03

Applicant: Manfred Reetz ,  Gerlinde Mehler

Inventor： Manfred Reetz ,  Gerlinde Mehler

IPC: C07C209/10 ,  C07D217/22 ,  C07D215/38 ,  C07D295/033 ,  C07D213/74

CPC classification number: C07C209/10 ,  C07B43/04 ,  C07D213/74 ,  C07D215/38 ,  C07D217/22 ,  C07D295/033

Abstract: A process is described for preparing aromatic and heteroaromatic amines of the general formula (I) Ar—NR1R2, in which an aromatic compound with the general formula (II) Ar—X is reacted in the presence of a catalyst with an amine of the general formula (III) H—NR1R2 and a base, wherein the catalyst is selected from transition metal complexes having one or more ligands with the general formula (IV).

Abstract translation: 描述了用于制备通式（I）Ar-NR1R2的芳族和杂芳族胺的方法，其中通式（II）Ar-X的芳族化合物在催化剂存在下与一般的胺反应 式（III）H-NR1R2和碱，其中催化剂选自具有一个或多个具有通式（IV）的配体的过渡金属配合物。

公开(公告)号：US20060014981A1

公开(公告)日：2006-01-19

申请号：US10530818

申请日：2003-09-26

Applicant: Manfred Reetz ,  Thorsten Sell ,  Andreas Meiswinkel ,  Gerlinde Mehler

Inventor： Manfred Reetz ,  Thorsten Sell ,  Andreas Meiswinkel ,  Gerlinde Mehler

IPC: C07F15/04 ,  C07F9/547

CPC classification number: B01J31/185 ,  B01J23/464 ,  B01J31/1845 ,  B01J31/1855 ,  B01J31/1865 ,  B01J31/187 ,  B01J31/24 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/321 ,  B01J2231/323 ,  B01J2231/325 ,  B01J2231/326 ,  B01J2231/327 ,  B01J2231/342 ,  B01J2231/348 ,  B01J2231/4211 ,  B01J2231/4238 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/641 ,  B01J2231/72 ,  B01J2531/0266 ,  B01J2531/80 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  C07B53/00 ,  C07C67/303 ,  C07C231/12 ,  C07F9/46 ,  C07F9/5022 ,  C07F9/52 ,  C07F9/6568 ,  C07F9/65683 ,  C07F9/65742 ,  C07F9/65744 ,  C07F9/65842 ,  C07F9/65844 ,  C07F9/65848 ,  Y10S502/506 ,  C07C69/34 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18

Abstract: The invention relates to certain chiral transition metal catalysts, to the metal of which at least two structurally different monophosphorus ligands are bonded, at least one of said monophosphorus ligands being chiral. Said chiral transition metal catalysts are suitable as catalysts for use in asymmetric transition metal-catalyzed reactions, providing better enantioselectivities than in cases where only one structurally defined ligand is used.

Abstract translation: 本发明涉及某些手性过渡金属催化剂，其至少两个结构不同的单磷配体键合的金属，所述单磷配体中的至少一个是手性的。 所述手性过渡金属催化剂适合用作不对称过渡金属催化反应的催化剂，与仅使用一种结构限定的配体的情况相比，提供更好的对映选择性。

公开(公告)号：US20050153358A1

公开(公告)日：2005-07-14

申请号：US10506144

申请日：2003-02-22

Applicant: Manfred Reetz ,  Patrick Tielmann ,  Andreas Eipper ,  Richard Mynott

Inventor： Manfred Reetz ,  Patrick Tielmann ,  Andreas Eipper ,  Richard Mynott

IPC: G01N24/08 ,  C07C27/02 ,  C07C31/12 ,  C07C33/20 ,  C07C69/013 ,  C07C69/145 ,  G01N37/00 ,  G01R33/30 ,  G01R33/46 ,  G01N33/53 ,  G01N33/543

CPC classification number: G01R33/46

Abstract: The invention relates to a high-throughput screening method based on NMR spectroscopy for determining the enantioselectivity of reactions which show an asymmetric course. The reactions can be caused by chiral catalysts, agents, or biocatalysts such that said products can be evaluated regarding the enantioselectivity thereof. In one embodiment, isotope-marked pseudo-enantiomers or pseudo-prochiral substrates are used such that the enantioselectivity can be quantified by integrating the NMR signals of the respective substrates and/or products. The use of an automated setup of devices, including microtiter plates, robots, and high-throughput NMR devices, is decisive for the high-throughput process. In a second embodiment of the invention, the automated setup of devices is used to detect in a quantitative manner the products and/or educts that have been derivatized with enantiomer-pure agents in the form of diastereomers. At least 1000 ee determinations can be done per day with accuracy of at least ±5 percent in both embodiments.

Abstract translation: 本发明涉及一种基于NMR光谱的高通量筛选方法，用于测定显示非对称过程的反应的对映体选择性。 反应可以由手性催化剂，试剂或生物催化剂引起，使得可以评价所述产物的对映体选择性。 在一个实施方案中，使用同位素标记的假对映异构体或假前手性底物，使得对映体选择性可以通过对各个底物和/或产物的NMR信号进行积分来定量。 使用自动设置装置，包括微量滴定板，机器人和高通量NMR装置对于高通量过程是决定性的。 在本发明的第二个实施方案中，设备的自动设置用于以定量方式检测已经以非对映异构体形式的对映异构体纯试剂衍生化的产物和/或离子。 在两个实施方案中，至少可以进行1000次ee测定，其准确度至少为±5％。