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    Shielded implantable medical lead with guarded termination
    1.
    发明授权
    Shielded implantable medical lead with guarded termination 有权
    屏蔽植入式医用导线，带有防护端接

    公开(公告)号：US09216286B2

    公开(公告)日：2015-12-22

    申请号：US13265098

    申请日：2010-04-28

    申请人： Richard T. Stone ,  Mark J. Conroy ,  Wanzhan Liu ,  Gary W. Salminen

    发明人： Richard T. Stone ,  Mark J. Conroy ,  Wanzhan Liu ,  Gary W. Salminen

    IPC分类号： A61N1/00 ,  A61N1/08 ,  A61N1/05 ,  A61N1/37 ,  A61N1/375 ,  A61M25/01 ,  A61B19/00

    CPC分类号： A61N1/08 ,  A61B90/39 ,  A61B2090/3966 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/3752 ,  A61N2001/058 ,  A61N2001/0582 ,  A61N2001/086 ,  Y10T29/49016 ,  Y10T29/49117 ,  Y10T29/4921 ,  Y10T29/49227 ,  Y10T29/49826

    摘要： Implantable medical leads include a shield that is guarded at a termination by having a first portion and second portion of the shield, where the first portion is between a termination of the shield at the second portion and an inner insulation layer surrounding the filars. The first portion may reduce the coupling of RF energy from the termination of the shield at the second portion to the filars. The first and second portions may be part of a continuous shield, where the first and second portions are separated by an inversion of the shield. The first and second portions may instead be separate pieces. The first portion may be noninverted residing between the termination at the second portion and inner layers, or the first portion may be inverted to create first and second sub-portions. The shield termination at the second portion is between the first and second sub-portions.

    摘要翻译： 可植入医疗引线包括通过具有屏蔽件的第一部分和第二部分在端子处被保护的屏蔽件，其中第一部分位于第二部分处的屏蔽件的终端和围绕线圈的内部绝缘层之间。 第一部分可以减少RF能量从第二部分处的屏蔽端接到丝状体的耦合。 第一和第二部分可以是连续屏蔽的一部分，其中第一和第二部分被屏蔽的反转分开。 第一和第二部分可以是分开的部分。 第一部分可以位于第二部分的终端和内层之间，或者第一部分可以被倒置以产生第一和第二子部分。 第二部分处的屏蔽终端位于第一和第二子部分之间。

    Catheter for cell delivery in tissue
    4.
    发明授权
    Catheter for cell delivery in tissue 有权
    导管用于组织中的细胞传递

    公开(公告)号：US06758828B2

    公开(公告)日：2004-07-06

    申请号：US10013636

    申请日：2001-12-10

    申请人： Bruce E. Hammer ,  Mark J. Conroy

    发明人： Bruce E. Hammer ,  Mark J. Conroy

    IPC分类号： A61M300

    CPC分类号： A61M1/1678 ,  A61B2017/00969 ,  A61K35/00 ,  A61M25/00

    摘要： An apparatus delivers an agent to a treatment region, the apparatus having an outer cannula or lumen that has an internal surface and an external surface, the external surface being substantially smooth to penetrate tissue whereas the distal end is tapered; an inner cannula, or lumen coaxial to the outer cannula, providing a common fluid path (that is the same fluid passes through both the inner cannula and outer cannula) at the distal end with the inner surface of the outer cannula; a source of fluid to be passed through the common fluid path, the source of fluid comprising at least a reservoir of nutrients and/or gases for maintaining cells contained in a lumen coaxial and internal to the inner cannula; a semipermeable membrane comprises the surface of the lumen, thus allowing controlled material transport across the lumen surface; a source of cells or other biologically active material mass flow connected to the proximal lumen so that the cells or other biologically active material can exit the distal portion upon entering the target tissue; and a first flow distributor located at the proximal end of the outer cannula to provide substantially uniform flow through the outer cannula.

    摘要翻译： 一种装置将药剂递送到治疗区域，所述装置具有外套管或内腔，其具有内表面和外表面，所述外表面基本上平滑以穿透组织，而远端是锥形的; 与外套管同轴的内插管或腔，在远端处提供与外插管的内表面相同的共同流体路径（即相同的流体穿过内插管和外套管）; 要流过公共流体路径的流体源，流体源包括营养物和/或气体的至少一个储存器，用于维持包含在内套管同轴和内部的内腔中的细胞; 半透膜包括内腔的表面，从而允许受控的材料在管腔表面上的输送; 连接到近端内腔的细胞源或其他生物活性物质质量流，使得细胞或其他生物活性物质在进入靶组织时可以离开远侧部分; 以及位于外套管的近端处的第一流量分配器，以提供穿过外套管的基本上均匀的流动。