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公开(公告)号:US06758828B2
公开(公告)日:2004-07-06
申请号:US10013636
申请日:2001-12-10
申请人: Bruce E. Hammer , Mark J. Conroy
发明人: Bruce E. Hammer , Mark J. Conroy
IPC分类号: A61M300
CPC分类号: A61M1/1678 , A61B2017/00969 , A61K35/00 , A61M25/00
摘要: An apparatus delivers an agent to a treatment region, the apparatus having an outer cannula or lumen that has an internal surface and an external surface, the external surface being substantially smooth to penetrate tissue whereas the distal end is tapered; an inner cannula, or lumen coaxial to the outer cannula, providing a common fluid path (that is the same fluid passes through both the inner cannula and outer cannula) at the distal end with the inner surface of the outer cannula; a source of fluid to be passed through the common fluid path, the source of fluid comprising at least a reservoir of nutrients and/or gases for maintaining cells contained in a lumen coaxial and internal to the inner cannula; a semipermeable membrane comprises the surface of the lumen, thus allowing controlled material transport across the lumen surface; a source of cells or other biologically active material mass flow connected to the proximal lumen so that the cells or other biologically active material can exit the distal portion upon entering the target tissue; and a first flow distributor located at the proximal end of the outer cannula to provide substantially uniform flow through the outer cannula.
摘要翻译: 一种装置将药剂递送到治疗区域,所述装置具有外套管或内腔,其具有内表面和外表面,所述外表面基本上平滑以穿透组织,而远端是锥形的; 与外套管同轴的内插管或腔,在远端处提供与外插管的内表面相同的共同流体路径(即相同的流体穿过内插管和外套管); 要流过公共流体路径的流体源,流体源包括营养物和/或气体的至少一个储存器,用于维持包含在内套管同轴和内部的内腔中的细胞; 半透膜包括内腔的表面,从而允许受控的材料在管腔表面上的输送; 连接到近端内腔的细胞源或其他生物活性物质质量流,使得细胞或其他生物活性物质在进入靶组织时可以离开远侧部分; 以及位于外套管的近端处的第一流量分配器,以提供穿过外套管的基本上均匀的流动。
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公开(公告)号:US08805534B2
公开(公告)日:2014-08-12
申请号:US13264093
申请日:2010-04-28
申请人: James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人: James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
IPC分类号: A61N1/05
CPC分类号: A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要: Grounding of a shield that is located in an implantable medical lead may be done in many ways. The shield may be grounded directly to tissue from the lead body at one or more points along the lead body. The pathway for grounding may be a direct current pathway or be capacitively coupled. The pathway for grounding may utilize an exposed or nearly exposed shield at one or more points along the lead body. A jacket forming the lead body may have an outer layer removed at these points to provide the RF pathway to ground. Alternatively, the jacket may be doped with conductive particles at these points. Metal conductors such as ring electrodes and/or lead anchors may be attached to the lead at one or more points to provide the RF pathway to ground.
摘要翻译: 位于植入式医疗引线中的护罩的接地可以以许多方式进行。 屏蔽件可以沿着引线主体的一个或多个点从引线体直接接地到组织。 用于接地的途径可以是直流电路或电容耦合。 用于接地的路径可以沿着引线主体在一个或多个点处利用暴露或几乎暴露的屏蔽。 形成引线体的护套可以在这些点处具有去除的外层,以将RF通路提供到地面。 或者,夹套可以在这些点处掺杂导电颗粒。 诸如环形电极和/或引线锚的金属导体可以在一个或多个点附接到引线,以将RF通路提供到地。
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公开(公告)号:US08788061B2
公开(公告)日:2014-07-22
申请号:US13265313
申请日:2010-04-27
申请人: Bruce R. Mehdizadeh , Brian T. Stolz , Michael R. Klardie , Michael J. Kern , James M. Olsen , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人: Bruce R. Mehdizadeh , Brian T. Stolz , Michael R. Klardie , Michael J. Kern , James M. Olsen , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
IPC分类号: A61N1/05
CPC分类号: A61N1/056 , A61B90/39 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582
摘要: A shield located within an implantable medical lead may be terminated in various ways at a metal connector. The shield may be terminated by various joints including butt, scarf, lap, or other joints between insulation layers surrounding the lead and an insulation extension. The shield may terminate with a physical and electrical connection to a single metal connector. The shield may terminate with a physical and electrical connection by passing between an overlapping pair of inner and outer metal connectors. The metal connectors may include features such as teeth or threads that penetrate the insulation layers of the lead. The shield may terminate with a physical and electrical connection by exiting a jacket of a lead adjacent to a metal connector and lapping onto the metal connector.
摘要翻译: 位于可植入医疗引线内的护罩可以以各种方式在金属连接器处终止。 屏蔽层可以由围绕引线的绝缘层和绝缘延伸部之间的各种接头(包括对接,围巾,搭接或其他接头)终止。 屏蔽可以通过与单个金属连接器的物理和电连接终止。 屏蔽可以通过在重叠的一对内部和外部金属连接器之间通过物理和电连接终止。 金属连接器可以包括贯穿引线的绝缘层的诸如齿或螺纹的特征。 通过离开与金属连接器相邻的引线的护套并且研磨到金属连接器上,屏蔽件可以通过物理和电连接终止。
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公开(公告)号:US20120046722A1
公开(公告)日:2012-02-23
申请号:US13264067
申请日:2010-04-27
申请人: James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人: James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
CPC分类号: A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要: Implantable medical leads are shielded with a braided shield that surrounds an inner layer of insulation. An outer layer of insulation may also surround the shield. The shield is designed with parameters that limit the passage of radio frequency energy, particularly in the magnetic resonance imaging spectrum, to filars that are surrounded by the inner layer of insulation. The braided shield has a plurality of parameters and corresponding ranges. The parameters include one or more of braid angle, wire size, number of wires wound per direction, number of wires in a bundle, wire spacing in an axial dimension, ultimate tensile strength, cross-sectional wire shape, material, and distance from termination to a nearest electrode. Additional parameters of the lead related to the shielding also include one or more of inner insulation thickness, and outer insulation thickness.
摘要翻译: 可植入的医用引线用围绕绝缘层内层的编织屏蔽屏蔽。 绝缘外层也可围绕屏蔽。 屏蔽设计有限制射频能量通过的参数,特别是在磁共振成像光谱中,由绝缘层内层包围的丝束。 编织屏蔽具有多个参数和相应的范围。 这些参数包括一个或多个编织角度,线径,每个方向缠绕的线数,束中的线数,轴向尺寸的线间距,极限拉伸强度,截面线形状,材料和距离终止 到最近的电极。 与屏蔽相关的引线的附加参数还包括内绝缘厚度和外绝缘厚度中的一个或多个。
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公开(公告)号:US20120035697A1
公开(公告)日:2012-02-09
申请号:US13265098
申请日:2010-04-28
CPC分类号: A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要: Implantable medical leads include a shield that is guarded at a termination by having a first portion and second portion of the shield, where the first portion is between a termination of the shield at the second portion and an inner insulation layer surrounding the filars. The first portion may reduce the coupling of RF energy from the termination of the shield at the second portion to the filars. The first and second portions may be part of a continuous shield, where the first and second portions are separated by an inversion of the shield. The first and second portions may instead be separate pieces. The first portion may be noninverted residing between the termination at the second portion and inner layers, or the first portion may be inverted to create first and second sub-portions. The shield termination at the second portion is between the first and second sub-portions.
摘要翻译: 可植入医疗引线包括通过具有屏蔽件的第一部分和第二部分在端子处被保护的屏蔽件,其中第一部分位于第二部分处的屏蔽件的终端和围绕线圈的内部绝缘层之间。 第一部分可以减少RF能量从第二部分处的屏蔽端接到丝状体的耦合。 第一和第二部分可以是连续屏蔽的一部分,其中第一和第二部分被屏蔽的反转分开。 第一和第二部分可以是分开的部分。 第一部分可以位于第二部分的终端和内层之间,或者第一部分可以被倒置以产生第一和第二子部分。 第二部分处的屏蔽终端位于第一和第二子部分之间。
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公开(公告)号:US20100145183A1
公开(公告)日:2010-06-10
申请号:US12706266
申请日:2010-02-16
申请人: Carl D. Wahlstrand , Mark J. Conroy , John Kast , Erik R. Scott
发明人: Carl D. Wahlstrand , Mark J. Conroy , John Kast , Erik R. Scott
IPC分类号: A61B5/055
CPC分类号: G01R33/56572 , A61B5/055 , A61B34/10 , A61N1/05 , A61N1/0529 , A61N1/0551 , A61N1/08 , A61N1/086 , A61N1/3605 , A61N1/36125 , A61N1/3718 , A61N1/375 , A61N1/3758 , A61N1/378 , G01R33/3875 , H01M2/0217 , H01M2/026 , H01M2/0275 , H01M2/0285 , H01M2/0404 , H01M2/1066 , H01M2/22 , H01M2/263 , H01M2/30 , H01M10/0431 , H01M10/052 , H01M10/0525 , H01M10/0587 , H01M2220/30 , Y10T29/49 , Y10T29/49002
摘要: An implantable medical device includes a housing and a circuit board provided within the housing. The circuit board includes a plurality of electronic components electrically coupled thereto. At least one non-functional component is provided on the circuit board and formed from a material that has an electromagnetic permeability configured to reduce the amount of image distortion caused by at least one of the plurality of electronic components when the device is subject to a magnetic field during an MRI scan.
摘要翻译: 可植入医疗装置包括壳体和设置在壳体内的电路板。 电路板包括与其电耦合的多个电子部件。 至少一个非功能部件设置在电路板上,并且由具有电磁渗透率的材料形成,该材料被配置为当该器件经受磁性时减少由多个电子部件中的至少一个引起的图像失真量 在MRI扫描期间。
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公开(公告)号:US09216286B2
公开(公告)日:2015-12-22
申请号:US13265098
申请日:2010-04-28
CPC分类号: A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要: Implantable medical leads include a shield that is guarded at a termination by having a first portion and second portion of the shield, where the first portion is between a termination of the shield at the second portion and an inner insulation layer surrounding the filars. The first portion may reduce the coupling of RF energy from the termination of the shield at the second portion to the filars. The first and second portions may be part of a continuous shield, where the first and second portions are separated by an inversion of the shield. The first and second portions may instead be separate pieces. The first portion may be noninverted residing between the termination at the second portion and inner layers, or the first portion may be inverted to create first and second sub-portions. The shield termination at the second portion is between the first and second sub-portions.
摘要翻译: 可植入医疗引线包括通过具有屏蔽件的第一部分和第二部分在端子处被保护的屏蔽件,其中第一部分位于第二部分处的屏蔽件的终端和围绕线圈的内部绝缘层之间。 第一部分可以减少RF能量从第二部分处的屏蔽端接到丝状体的耦合。 第一和第二部分可以是连续屏蔽的一部分,其中第一和第二部分被屏蔽的反转分开。 第一和第二部分可以是分开的部分。 第一部分可以位于第二部分的终端和内层之间,或者第一部分可以被倒置以产生第一和第二子部分。 第二部分处的屏蔽终端位于第一和第二子部分之间。
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公开(公告)号:US20120209352A1
公开(公告)日:2012-08-16
申请号:US13398588
申请日:2012-02-16
申请人: John Kast , Carl D. Wahlstrand , Mark J. Conroy , Erik R. Scott
发明人: John Kast , Carl D. Wahlstrand , Mark J. Conroy , Erik R. Scott
CPC分类号: G01R33/56572 , A61B5/055 , A61B34/10 , A61N1/05 , A61N1/0529 , A61N1/0551 , A61N1/08 , A61N1/086 , A61N1/3605 , A61N1/36125 , A61N1/3718 , A61N1/375 , A61N1/3758 , A61N1/378 , G01R33/3875 , H01M2/0217 , H01M2/026 , H01M2/0275 , H01M2/0285 , H01M2/0404 , H01M2/1066 , H01M2/22 , H01M2/263 , H01M2/30 , H01M10/0431 , H01M10/052 , H01M10/0525 , H01M10/0587 , H01M2220/30 , Y10T29/49 , Y10T29/49002
摘要: An implantable medical device includes a housing having a coating selectively provided on only a portion of the housing and a plurality of electronic components provided within an interior space defined by the housing. A first of the electronic components is a charging or telemetry coil and a second of the electronic components is a circuit board. The coating is provided on the housing in a first region near a component of the circuit board and is not provided on the housing in a second region near the charging or telemetry coil. The coating has a magnetic permeability suitable to and is provided in an amount effective to reduce MRI image distortion caused by the component of the circuit board.
摘要翻译: 可植入医疗装置包括壳体,其具有仅选择性地设置在壳体的一部分上的涂层和设置在由壳体限定的内部空间内的多个电子部件。 电子部件中的第一个是充电或遥测线圈,并且第二电子部件是电路板。 涂层在靠近电路板的部件的第一区域中设置在壳体上,并且在充电或遥测线圈附近的第二区域中不设置在壳体上。 该涂层具有适于和提供有效降低由电路板的部件引起的MRI图像失真的量的磁导率。
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公开(公告)号:US20120035696A1
公开(公告)日:2012-02-09
申请号:US13264179
申请日:2010-04-27
申请人: Michael J. Kern , James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham , Brian T. Stolz
发明人: Michael J. Kern , James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham , Brian T. Stolz
CPC分类号: A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要: A shield located within an implantable medical lead may be terminated in various ways. The shield may be terminated by butt, scarf, lap, or other joints between insulation layers surrounding the lead and an insulation extension. For lap joints, a portion of an outer insulation layer may be removed and a replacement outer insulation layer is positioned in place of the removed outer insulation layer, where the replacement layer extends beyond an inner insulation layer and the shield. The replacement layer may also lap onto a portion of the insulation extension. Barbs may be located between the replacement layer and the inner insulation layer or the insulation extension. The shield wires have ends at the termination point that may be folded over individually or may be capped with a ring located within one of the insulation layers of the jacket.
摘要翻译: 位于可植入医疗引线内的护罩可以以各种方式终止。 护罩可以通过对接,围巾,搭接或围绕导线的绝缘层与绝缘延伸部分之间的其他接头来终止。 对于搭接接头,可以去除外部绝缘层的一部分,并且替换外部绝缘层被定位成代替去除的外部绝缘层,其中替换层延伸超出内部绝缘层和屏蔽。 替换层也可以搭接在绝缘延伸部分的一部分上。 倒钩可以位于替换层和内绝缘层之间或绝缘延伸部分之间。 屏蔽线在终止点处具有可以单独折叠的端部,或者可以用位于护套的绝缘层之一内的环来封盖。
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公开(公告)号:US09205253B2
公开(公告)日:2015-12-08
申请号:US13264067
申请日:2010-04-27
申请人: James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
发明人: James M. Olsen , Michael R. Klardie , Richard T. Stone , Chad Q. Cai , Spencer M. Bondhus , Mark J. Conroy , Timothy R. Abraham
CPC分类号: A61N1/08 , A61B90/39 , A61B2090/3966 , A61N1/05 , A61N1/0551 , A61N1/086 , A61N1/3718 , A61N1/3752 , A61N2001/058 , A61N2001/0582 , A61N2001/086 , Y10T29/49016 , Y10T29/49117 , Y10T29/4921 , Y10T29/49227 , Y10T29/49826
摘要: Implantable medical leads are shielded with a braided shield that surrounds an inner layer of insulation. An outer layer of insulation may also surround the shield. The shield is designed with parameters that limit the passage of radio frequency energy, particularly in the magnetic resonance imaging spectrum, to filars that are surrounded by the inner layer of insulation. The braided shield has a plurality of parameters and corresponding ranges. The parameters include one or more of braid angle, wire size, number of wires wound per direction, number of wires in a bundle, wire spacing in an axial dimension, ultimate tensile strength, cross-sectional wire shape, material, and distance from termination to a nearest electrode. Additional parameters of the lead related to the shielding also include one or more of inner insulation thickness, and outer insulation thickness.
摘要翻译: 可植入的医用引线用围绕绝缘层内层的编织屏蔽屏蔽。 绝缘外层也可围绕屏蔽。 屏蔽设计有限制射频能量通过的参数,特别是在磁共振成像光谱中,由绝缘层内层包围的丝束。 编织屏蔽具有多个参数和相应的范围。 这些参数包括一个或多个编织角度,线径,每个方向缠绕的线数,束中的线数,轴向尺寸的线间距,极限拉伸强度,截面线形状,材料和距离终止 到最近的电极。 与屏蔽相关的引线的附加参数还包括内绝缘厚度和外绝缘厚度中的一个或多个。
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