公开(公告)号：US07250285B2

公开(公告)日：2007-07-31

申请号：US11403784

申请日：2006-04-13

申请人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Michael Arthur Lonetto ,  Richard O Nicholas ,  Robert King Stodola ,  Martin Karl Russel Burnham

发明人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Michael Arthur Lonetto ,  Richard O Nicholas ,  Robert King Stodola ,  Martin Karl Russel Burnham

IPC分类号： C12N1/20 ,  C12N15/00 ,  C07H21/02

CPC分类号： C12N9/1077 ,  A61K38/00 ,  A61K39/00 ,  C07K14/3156 ,  C07K2319/00 ,  C12N9/1205 ,  C12N9/78 ,  C12N9/80 ,  C12Y207/01002

摘要： The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.

摘要翻译： 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。

公开(公告)号：US07176299B2

公开(公告)日：2007-02-13

申请号：US11166905

申请日：2005-06-23

申请人： Michael Terence Black ,  Martin Karl Russell Burnham ,  Jason Craig Fedon ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Michael Arthur Lonetto ,  Richard Oakley Nicholas ,  Leslie Marie Palmer ,  Julie M. Pratt ,  Raymond Winfield Reichard ,  Martin Rosenberg ,  Christopher Michael Traini ,  Judith M. Ward ,  Richard Lloyd Warren

发明人： Michael Terence Black ,  Martin Karl Russell Burnham ,  Jason Craig Fedon ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Michael Arthur Lonetto ,  Richard Oakley Nicholas ,  Leslie Marie Palmer ,  Julie M. Pratt ,  Raymond Winfield Reichard ,  Martin Rosenberg ,  Christopher Michael Traini ,  Judith M. Ward ,  Richard Lloyd Warren

IPC分类号： C07H21/04 ,  C12N1/20 ,  C12N15/00

CPC分类号： C12N9/0036 ,  A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  C07K16/1275 ,  C07K2319/00 ,  C12N9/78 ,  C12N15/52 ,  C12Q1/689 ,  C12Q2600/158 ,  C12Y105/0103 ,  C12Y305/04025

摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

摘要翻译： 本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。

公开(公告)号：US20050245392A1

公开(公告)日：2005-11-03

申请号：US11172880

申请日：2005-07-05

申请人： Markus Holzle ,  Michael Sprague ,  Klaus Harth ,  Martin Schussler ,  Martin Karl ,  Stefan Boneberg

发明人： Markus Holzle ,  Michael Sprague ,  Klaus Harth ,  Martin Schussler ,  Martin Karl ,  Stefan Boneberg

IPC分类号： B01J23/80 ,  B01J33/00 ,  B01J37/14 ,  B01J37/18 ,  C01B3/32 ,  B01J23/50

CPC分类号： B01J37/14 ,  B01J23/80 ,  B01J33/00 ,  B01J37/18 ,  C01B3/326 ,  C01B2203/1052 ,  C01B2203/1064 ,  C01B2203/1076 ,  Y02P20/52

摘要： A methanol reforming catalyst containing passivated copper and zinc oxide and/or alumina can be prepared by (1) precipitating or spray-drying a mixture of catalyst precursor components dissolved or suspended in a diluent in order to form a solid catalyst precursor in the form of powder or granules, (2) calcining and reducing the solid catalyst precursor obtained in stage (1), (3) passivating the reduced catalyst precursor obtained in stage (2) and (4) shaping the passivated catalyst precursor obtained in stage (3) to form the catalyst. A reduction in the volume shrinkage and an increase in the mechanical hardness during operation of the methanol reforming catalyst are achieved by the preparation process.

摘要翻译： 含有钝化铜和氧化锌和/或氧化铝的甲醇重整催化剂可以通过以下步骤制备：（1）将溶解或悬浮在稀释剂中的催化剂前体组分的混合物沉淀或喷雾干燥以形成固体催化剂前体， 粉末或颗粒，（2）煅烧和还原阶段（1）中获得的固体催化剂前体，（3）钝化阶段（2）中获得的还原催化剂前体和（4）成形阶段（3）中获得的钝化催化剂前体， 以形成催化剂。 通过制备方法可以实现甲醇重整催化剂运行时的体积收缩率和机械硬度的增加。

公开(公告)号：US06831381B2

公开(公告)日：2004-12-14

申请号：US09958410

申请日：2002-01-24

申请人： Eckhard Ursel ,  Bruno Droll ,  Walter Haussecker ,  Martin Karl ,  Wolfgang Thomar ,  Stefan Freund ,  Thomas Huck

发明人： Eckhard Ursel ,  Bruno Droll ,  Walter Haussecker ,  Martin Karl ,  Wolfgang Thomar ,  Stefan Freund ,  Thomas Huck

IPC分类号： H02K710

CPC分类号： F16C23/04 ,  F16C35/02 ,  F16C2380/27 ,  F16H1/16 ,  H02K5/148 ,  H02K7/081

摘要： In an electrical drive mechanism, in particular for motor vehicles, having a commutator motor (14) disposed in a housing (10), which commutator motor (14) has a rotor shaft (17) with a commutator (22) non-rotatably supported on it and has a brush holder (30) affixed to the housing (10), and having a bearing (25) disposed in the vicinity of the commutator (22), which bearing has a bearing bush (34) that encloses the rotor shaft (17) with rotary play and a bearing seat (35) that contains the bearing bush (34), in order to achieve a simple embodiment for the bearing (25), a clamping member (37) is formed onto the brush holder (30) of one piece with it, which clamps the bearing bush (34) in a frictionally engaged, axial fashion in the bearing seat (35) formed in the housing (10) (FIG. 1).

公开(公告)号：US06744159B2

公开(公告)日：2004-06-01

申请号：US10129935

申请日：2002-08-05

申请人： Bruno Droll ,  Martin Karl ,  Martin Goedecke

发明人： Bruno Droll ,  Martin Karl ,  Martin Goedecke

IPC分类号： H02K700

CPC分类号： H02K7/00 ,  F16B4/004 ,  F16B17/004 ,  F16B17/006

摘要： An armature of the invention has a component, to be mounted on the shaft, that has a protrusion in the internal diameter; the protrusion engages a knurled feature on the shaft, and the initial stresses can lessen at least in part over the course of time.

摘要翻译： 本发明的电枢具有安装在轴上的具有内径突起的部件， 突起接合轴上的滚花特征，并且初始应力可以至少部分地在一段时间内减小。

公开(公告)号：US06465621B1

公开(公告)日：2002-10-15

申请号：US09631548

申请日：2000-08-03

申请人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Raymond Winfield Reichard ,  Richard O Nicholas ,  Martin Karl Russel Burnham ,  Julie M Pratt ,  Martin Rosenberg ,  Judith M Ward

发明人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Raymond Winfield Reichard ,  Richard O Nicholas ,  Martin Karl Russel Burnham ,  Julie M Pratt ,  Martin Rosenberg ,  Judith M Ward

IPC分类号： C07K1700

CPC分类号： C12N9/78 ,  A61K39/00 ,  C07K14/31 ,  C07K16/1275 ,  C12Y305/04025

摘要： The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.

摘要翻译： 本发明提供了ERA多肽和编码ERA多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用ERA多肽以防止感染，特别是细菌感染的方法。

公开(公告)号：US06399343B1

公开(公告)日：2002-06-04

申请号：US09574912

申请日：2000-05-19

申请人： Sanjoy Biswas ,  James Raymond Brown ,  Martin Karl Russel Burnham ,  Alison Francis Chalker ,  Richard Lloyd Warren ,  Magdalena Zalacain ,  Chi Young So ,  Christopher M Traini ,  David John Holmes ,  Karen Anne Ingraham ,  Thomas B Mathie

发明人： Sanjoy Biswas ,  James Raymond Brown ,  Martin Karl Russel Burnham ,  Alison Francis Chalker ,  Richard Lloyd Warren ,  Magdalena Zalacain ,  Chi Young So ,  Christopher M Traini ,  David John Holmes ,  Karen Anne Ingraham ,  Thomas B Mathie

IPC分类号： C12N900

CPC分类号： C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  Y10S435/885

摘要： The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.

摘要翻译： 本发明提供编码infB多肽的infB多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了在多肽中利用筛选抗菌化合物的方法。

公开(公告)号：US06365159B1

公开(公告)日：2002-04-02

申请号：US09340475

申请日：1999-06-30

申请人： Martin Karl Russel Burnham ,  Daniel Robert Gentry ,  John Edward Hodgson ,  Elizabeth Jane Lawlor

发明人： Martin Karl Russel Burnham ,  Daniel Robert Gentry ,  John Edward Hodgson ,  Elizabeth Jane Lawlor

IPC分类号： A61K3902

CPC分类号： C07K14/31 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51

摘要： spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.

摘要翻译： 披露了spo-rel多肽和编码这种spo-rel的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种spo-rel来治疗感染，特别是细菌感染的方法。 还公开了抗这种害虫的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中spo-rel核酸序列和多肽的存在相关的疾病的诊断测定法。 还公开了用于检测编码relA / spoT基因家族的多核苷酸并用于检测宿主中的多肽的诊断测定法。

公开(公告)号：US06346608B1

公开(公告)日：2002-02-12

申请号：US09621855

申请日：2000-07-24

申请人： Martin Karl Russel Burnham ,  Andrew Fosberry ,  John Hodgson ,  Deborah Jaworski ,  Elizabeth Lawlor ,  Martin Rosenberg ,  Lisa Kathleen Shilling ,  Min Wang ,  Judith Ward

发明人： Martin Karl Russel Burnham ,  Andrew Fosberry ,  John Hodgson ,  Deborah Jaworski ,  Elizabeth Lawlor ,  Martin Rosenberg ,  Lisa Kathleen Shilling ,  Min Wang ,  Judith Ward

IPC分类号： C07K100

CPC分类号： C12N9/14 ,  A61K38/00 ,  A61K48/00 ,  Y10S530/82 ,  Y10S530/825

摘要： The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mecB polypeptides to screen for antibacterial compounds.

摘要翻译： 本发明提供了mecB多肽和编码mecB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用mecB多肽筛选抗菌化合物的方法。

公开(公告)号：US06346392B1

公开(公告)日：2002-02-12

申请号：US08919573

申请日：1997-07-10

申请人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Michael Arthur Lonetto ,  Richard O Nicholas ,  Martin Karl Russel Burnham ,  Robert H Reid, Jr. ,  Phillip N Zarfos

发明人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Michael Arthur Lonetto ,  Richard O Nicholas ,  Martin Karl Russel Burnham ,  Robert H Reid, Jr. ,  Phillip N Zarfos

IPC分类号： C12N1531

CPC分类号： G01N33/68 ,  A61K38/00 ,  A61K39/00 ,  C07K14/3156 ,  C07K2319/00 ,  G01N2333/315

摘要： The invention provides Glutamine Transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Glutamine Transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glutamine Transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.

摘要翻译： 本发明提供谷氨酰胺转运ATP结合蛋白多肽和编码谷氨酰胺转运ATP结合蛋白多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用谷氨酰胺转运ATP结合蛋白多肽筛选抗菌化合物的方法。