公开(公告)号：US20110054005A1

公开(公告)日：2011-03-03

申请号：US12662904

申请日：2010-05-11

申请人： Yuki Naito ,  Masato Fujino ,  Shinobu Oguchi ,  Yukikazu Natori

发明人： Yuki Naito ,  Masato Fujino ,  Shinobu Oguchi ,  Yukikazu Natori

IPC分类号： A61K31/713 ,  C07H21/00 ,  C12Q1/68 ,  C12N5/071 ,  A61P25/28 ,  A61P25/00 ,  A61P35/00 ,  A61P7/06 ,  A61P35/02 ,  A61P21/00 ,  A61P5/26

CPC分类号： C12N15/111 ,  A61K31/713 ,  A61K48/00 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2330/30

摘要： The present invention provides a polynucleotide that not only has a high RNA interference effect on its target gene, but also has a very small risk of causing RNA interference against a gene unrelated to the target gene. A sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene for RNA interference and, based on the search results, a polynucleotide capable of causing RNAi is designed, synthesized, etc.: (a) The 3′ end base is adenine, thymine, or uracil, (b) The 5′ end base is guanine or cytosine, (c) A 7-base sequence from the 3′ end is rich in one or more types of bases selected from the group consisting of adenine, thymine, and uracil, and (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity.

摘要翻译： 本发明提供了不仅对其靶基因具有高RNA干扰效应，而且对与靶基因无关的基因造成RNA干扰的风险很小的多核苷酸。 从用于RNA干扰的靶基因的碱基序列中搜索符合以下规则（a）至（d）的序列区段，并且基于搜索结果，设计，合成等能够引起RNAi的多核苷酸： （a）3'末端碱基是腺嘌呤，胸腺嘧啶或尿嘧啶，（b）5'末端碱基是鸟嘌呤或胞嘧啶，（c）3'末端的7碱基序列富含一种或多种 选自腺嘌呤，胸腺嘧啶和尿嘧啶的碱基，（d）碱基数在允许RNA干扰发生而不引起细胞毒性的范围内。

公开(公告)号：US20070063285A1

公开(公告)日：2007-03-22

申请号：US11557221

申请日：2006-11-07

申请人： Masato Fujino ,  Soichi Watanabe

发明人： Masato Fujino ,  Soichi Watanabe

IPC分类号： H01L23/62

CPC分类号： H02M3/158 ,  H01L2924/0002 ,  H01L2924/00

摘要： In a power supply apparatus in which a source of a MOSFET is connected to a node of a rectifier diode and a choke coil through a resonance coil, a series circuit including a capacitor and a MOSFET i s connected to a series circuit including the resonance coil and the rectifier diode, and the MOSFET and the MOSFET are driven by PWM control so that the MOSFET and the MOSFET are alternately turned on with a period in which both MOSFETs are turned off, a resistor is connected in parallel with the capacitor, and optionally another diode is connected in series with the resistor.

摘要翻译： 在其中MOSFET的源极通过谐振线圈连接到整流二极管的节点和扼流线圈的电源装置中，包括电容器和MOSFET的串联电路连接到包括谐振线圈和 整流二极管以及MOSFET和MOSFET由PWM控制驱动，使得MOSFET和MOSFET交替导通，其中两个MOSFET关断，电阻器与电容器并联连接， 二极管与电阻串联。

公开(公告)号：US4700015A

公开(公告)日：1987-10-13

申请号：US916393

申请日：1986-10-07

申请人： Yasuaki Saito ,  Tooru Harada ,  Masato Fujino

发明人： Yasuaki Saito ,  Tooru Harada ,  Masato Fujino

IPC分类号： H05K5/02 ,  H05K9/00

CPC分类号： H05K9/0066 ,  H05K5/0247

摘要： An insulating structure for an external terminal of an electronic part is formed of two insulating housing parts abutting along a junction to define an insulating housing for an electronic part. There is an insulating projection on each housing part and projecting outwardly of the housing from the corresponding housing part, each projection having a U-shaped cross-section with the open sides of the projections facing each other with one projection inside the other and the cross-sections telescopingly interfitted. One of the projections has a cross-section extending into the wall of the corresponding housing part from the junction and the other projection has the cross-section projecting from the junction toward the one projection. The wall of one of said housing parts has a first wall portion extending into the end of the corresponding projection where it extends from the housing part, and this wall portion has a recess therein facing toward the projection on the other housing part, and the wall of the other of the housing parts has a second wall portion extending into the end of the corresponding projection where it extends from the housing part and fitting into the recess in said first wall portion. The recess and second wall portion fit tightly around the terminal of the electronic part. A metallic casing around the insulating housing has an opening therein with the edges of the opening abutting the outside surface of the projections. Leakage current from the terminal to the metallic casing must traverse a long path through the compactly arranged projections.

摘要翻译： 用于电子部件的外部端子的绝缘结构由沿着接合部邻接的两个绝缘壳体部分形成，以限定用于电子部件的绝缘壳体。 在每个壳体部分上具有绝缘突起并且从相应的壳体部分向壳体外侧突出，每个突起具有U形横截面，其中突出部的开口侧面彼此面对并具有一个突出部而在另一个内部和十字形 可伸缩的部分。 一个突起具有从接合部延伸到对应的壳体部分的壁的横截面，另一个突起具有从接合部朝向一个突出部突出的横截面。 所述壳体部件之一的壁具有延伸到相应突起的端部的第一壁部分，其中它从壳体部分延伸，并且该壁部分具有面向另一壳体部分上的突起的凹部，并且壁 另一个壳体部分具有延伸到相应突起的端部的第二壁部分，其中它从壳体部分延伸并且装配到所述第一壁部分中的凹部中。 凹部和第二壁部分紧密地配合在电子部件的端子周围。 绝缘壳体周围的金属壳体具有开口，其中开口的边缘邻接突起的外表面。 从端子到金属外壳的泄漏电流必须穿过紧凑布置的突起的长路径。

公开(公告)号：US07545133B2

公开(公告)日：2009-06-09

申请号：US11557221

申请日：2006-11-07

申请人： Masato Fujino ,  Soichi Watanabe

发明人： Masato Fujino ,  Soichi Watanabe

IPC分类号： H02M3/158

CPC分类号： H02M3/158 ,  H01L2924/0002 ,  H01L2924/00

摘要： In a power supply apparatus in which a source of a MOSFET is connected to a node of a rectifier diode and a choke coil through a resonance coil, a series circuit including a capacitor and a MOSFET is connected to a series circuit including the resonance coil and the rectifier diode, and the MOSFET and the MOSFET are driven by PWM control so that the MOSFET and the MOSFET are alternately turned on with a period in which both MOSFETs are turned off, a resistor is connected in parallel with the capacitor, and optionally another diode is connected in series with the resistor.

摘要翻译： 在其中MOSFET的源极通过谐振线圈连接到整流二极管的节点和扼流线圈的电源装置中，包括电容器和MOSFET的串联电路连接到包括谐振线圈和 整流二极管以及MOSFET和MOSFET由PWM控制驱动，使得MOSFET和MOSFET交替导通，其中两个MOSFET关断，电阻器与电容器并联连接， 二极管与电阻串联。

公开(公告)号：US20080113351A1

公开(公告)日：2008-05-15

申请号：US11598052

申请日：2006-11-13

申请人： Yuki Naito ,  Masato Fujino ,  Shinobu Oguchi ,  Yukikazu Natori

发明人： Yuki Naito ,  Masato Fujino ,  Shinobu Oguchi ,  Yukikazu Natori

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/02

CPC分类号： C12N15/111 ,  A61K31/713 ,  A61K48/00 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2330/30

摘要： The present invention provides a polynucleotide that not only has a high RNA interference effect on its target gene, but also has a very small risk of causing RNA interference against a gene unrelated to the target gene. A sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene for RNA interference and, based on the search results, a polynucleotide capable of causing RNAi is designed, synthesized, etc.: (a) The 3′ end base is adenine, thymine, or uracil, (b) The 5′ end base is guanine or cytosine, (c) A 7-base sequence from the 3′ end is rich in one or more types of bases selected from the group consisting of adenine, thymine, and uracil, and (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity.

摘要翻译： 本发明提供了不仅对其靶基因具有高RNA干扰效应，而且对与靶基因无关的基因造成RNA干扰的风险很小的多核苷酸。 从用于RNA干扰的靶基因的碱基序列中搜索符合以下规则（a）至（d）的序列区段，并且基于搜索结果，设计，合成等能够引起RNAi的多核苷酸： （a）3'末端碱基是腺嘌呤，胸腺嘧啶或尿嘧啶，（b）5'末端碱基是鸟嘌呤或胞嘧啶，（c）3'末端的7碱基序列富含一种或多种 选自腺嘌呤，胸腺嘧啶和尿嘧啶的碱基，（d）碱基数在允许RNA干扰发生而不引起细胞毒性的范围内。

公开(公告)号：US6067002A

公开(公告)日：2000-05-23

申请号：US712205

申请日：1996-09-11

申请人： Masato Fujino ,  Hidetoshi Iwatani ,  Kouichi Nitta

发明人： Masato Fujino ,  Hidetoshi Iwatani ,  Kouichi Nitta

IPC分类号： H01F17/00 ,  H01F27/06 ,  H01F27/29 ,  H01F30/00 ,  H01F37/00 ,  H05K1/00 ,  H05K1/14 ,  H05K1/16 ,  H05K1/18 ,  H05K3/34 ,  H05K3/46 ,  H01F5/00 ,  H01F27/28

CPC分类号： H01F17/0013 ,  H01F27/292 ,  H05K1/165 ,  H05K1/0298 ,  H05K1/141 ,  H05K1/16 ,  H05K2201/086 ,  H05K2201/09309 ,  H05K2201/09663 ,  H05K2201/10287 ,  H05K2201/10416 ,  H05K3/3442

摘要： A circuit substrate with a built-in coil has layers comprising respectively a wiring sheet, magnetic material, a flat coil, and magnetic material, which are overlaid. The wiring circuit sheet is made of polyimide, on which a circuit pattern is formed. The magnetic material is formed of a plurality of overlaid amorphous alloy sheets having slits and put together with adhesive. The flat coil may be formed by winding a copper wire covered with insulating film. The coil component, including the magnetic material and the flat coil, and the wiring circuit sheet are adhered to each other with the circuit pattern and the coil component being electrically connected to each other. According to one embodiment of the invention, the circuit substrate comprises a coil component with a flat coil and a pair of magnetic materials sandwiching the flat coil; and at least one wiring circuit sheet on which a circuit pattern is formed, the wiring circuit sheet being adhered to a surface of the coil component with the circuit pattern being electrically connected to the coil component.

摘要翻译： 具有内置线圈的电路基板具有分别包括布线板，磁性材料，扁平线圈和磁性材料的层。 布线电路板由聚酰亚胺制成，其上形成有电路图案。 磁性材料由多个具有狭缝的重叠的非晶态合金板形成，并与粘合剂一起放置在一起。 扁平线圈可以通过缠绕覆盖有绝缘膜的铜线来形成。 包括磁性材料和扁平线圈的线圈部件和布线电路片通过电路图案彼此粘合，并且线圈部件彼此电连接。 根据本发明的一个实施例，电路基板包括具有扁平线圈的线圈部件和夹着扁平线圈的一对磁性材料; 以及形成有电路图案的至少一个布线电路板，所述布线电路片粘接到所述线圈部件的表面，所述电路图形与所述线圈部件电连接。

公开(公告)号：US5463365A

公开(公告)日：1995-10-31

申请号：US146783

申请日：1993-11-02

申请人： Hidetoshi Iwatani ,  Masato Fujino ,  Shinji Matsumoto ,  Choichiro Fujii ,  Masakazu Kazama

发明人： Hidetoshi Iwatani ,  Masato Fujino ,  Shinji Matsumoto ,  Choichiro Fujii ,  Masakazu Kazama

IPC分类号： H01F17/00 ,  H01F17/04 ,  H01F27/29 ,  H01F30/00 ,  H01F27/02 ,  H01F27/30

CPC分类号： H01F27/292 ,  H01F17/0013 ,  H01F17/04 ,  H01F2027/2819

摘要： A coil contains a winding part and a core. The winding part is formed of plural laminated sheets each having a winding pattern. Plural winding patterns are formed on at least one sheet. Each of the winding patterns has a different number of turns, and the winding patterns are formed around the core so as to be coaxial in the same winding direction. The winding patterns formed on the other sheets are connected via a through-hole, and an end of the winding pattern is connected to an input/output portion formed outside of the sheet.

摘要翻译： 线圈包含绕组部分和芯部。 绕组部分由具有卷绕图案的多个层压片形成。 在至少一张纸上形成多个卷绕图案。 每个绕组图案具有不同的匝数，并且缠绕图案形成在芯周围，以在相同的卷绕方向上同轴。 形成在其他片材上的卷绕图案通过通孔连接，卷绕图案的端部连接到形成在片材外部的输入/输出部分。

公开(公告)号：US5386206A

公开(公告)日：1995-01-31

申请号：US955837

申请日：1992-10-02

申请人： Hidetoshi Iwatani ,  Masakazu Kazama ,  Masato Fujino

发明人： Hidetoshi Iwatani ,  Masakazu Kazama ,  Masato Fujino

IPC分类号： H01F17/00 ,  H01F41/04 ,  H05K1/11

CPC分类号： H01F41/046 ,  H01F17/0013

摘要： A layered coil, having high connection reliability, formed by alternately stacking a plurality of coil conductors and insulators. Outlet portions of the of coil conductors are connected with each other without using through holes. The coil conductors are formed on surfaces of insulating sheets so that the outlet portions of the coil conductors project from edges of the insulating sheets. The insulating sheets are stacked so that the outlet portions of the coil conductors can be connected, by spot welding or the like, with each other or with terminals in portions projecting from surfaces of the layered product.

摘要翻译： 通过交替堆叠多个线圈导体和绝缘体形成具有高连接可靠性的分层线圈。 线圈导体的出口部分彼此连接，而不使用通孔。 线圈导体形成在绝缘片的表面上，使得线圈导体的出口部分从绝缘片的边缘突出。 绝缘片层叠，使得线圈导体的出口部分可以通过点焊等彼此连接，或者可以从分层产品的表面突出的部分连接。