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14 条记录 (耗时 0.036 秒)

    Cephem compound having catechol group
    2.
    发明授权
    Cephem compound having catechol group 有权
    具有儿茶酚基的头孢烯化合物

    公开(公告)号：US09145425B2

    公开(公告)日：2015-09-29

    申请号：US13639412

    申请日：2011-04-04

    申请人： Shinya Hisakawa ,  Yasushi Hasegawa ,  Toshiaki Aoki ,  Hiroki Kusano ,  Masayuki Sano ,  Jun Sato ,  Kenji Yamawaki

    发明人： Shinya Hisakawa ,  Yasushi Hasegawa ,  Toshiaki Aoki ,  Hiroki Kusano ,  Masayuki Sano ,  Jun Sato ,  Kenji Yamawaki

    IPC分类号： C07D471/08 ,  C07D501/56 ,  C07D505/24 ,  C07D501/46 ,  C07D519/06

    CPC分类号： C07D505/24 ,  C07D471/08 ,  C07D501/46 ,  C07D501/56 ,  C07D519/06

    摘要： This invention provides Cephem compounds having the formula: or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, a pharmaceutical composition thereof, and a method for treating a bacterial infectious disease with the compound, the ester, the protected compound, the salt, or the solvate thereof, wherein the symbols in the formula are defined in the specification. The compounds exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, preferably beta-lactamase producing Gram negative bacteria, more preferably, multi-drug resistant microbials, in particular, Class B type metallo-beta-lactamase producing Gram negative bacteria, and still preferably extended-spectrum beta-lactamase (ESBL) producing bacteria. The compounds most preferably do not exhibit cross-resistance against known Cephem drugs or Carbapenem drugs.

    摘要翻译： 本发明提供具有下式的Cephem化合物：或酯，7-侧链上的环上的氨基上的被保护的化合物，其药学上可接受的盐或溶剂合物，其药物组合物和 化合物，酯，受保护化合物，盐或其溶剂化物的细菌感染性疾病，其中式中的符号在说明书中定义。 该化合物对各种细菌（包括革兰氏阴性细菌和/或革兰氏阳性细菌，优选β-内酰胺酶产生革兰氏阴性细菌，更优选多药耐药性微生物，特别是B类金属β- 产生革兰氏阴性细菌的内酰胺酶，更优选延长的β-内酰胺酶（ESBL）产生细菌。 该化合物最优选不表现出对已知的Cephem药物或碳青霉烯类药物的抗药性。

    Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
    3.
    发明授权
    Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same 有权
    用于产生多能干细胞的载体和使用其制备多能干细胞的方法

    公开(公告)号：US08496941B2

    公开(公告)日：2013-07-30

    申请号：US12792580

    申请日：2010-06-02

    申请人： Mahito Nakanishi ,  Ken Nishimura ,  Manami Ohtaka ,  Masayuki Sano

    发明人： Mahito Nakanishi ,  Ken Nishimura ,  Manami Ohtaka ,  Masayuki Sano

    IPC分类号： A61K39/12 ,  A61K39/155 ,  C12N5/00 ,  C12N15/00 ,  C12N15/86

    CPC分类号： C12N5/0696 ,  C12N15/1131 ,  C12N15/86 ,  C12N15/8775 ,  C12N15/8776 ,  C12N2310/14 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2510/00 ,  C12N2760/18843

    摘要： Stem cell reprogramming genes cloned into a single sustained expression-type Sendai viral vector are shown to reprogram differentiated somatic cells into induced pluripotent stem (iPS) cells without integration of vector sequences into the host cell's genome. The genes are transduced into normal differentiated somatic cells via infection with recombinant Sendai virus. After expression of the reprogramming genes and subsequent induction of pluripotency, the vector genome RNA including the reprogramming genes is removed from the cell to establish an iPS cell that is genetically identical to the parent somatic differentiated cell thus reducing the risk of tumorigenic transformation caused by random integration of vector sequences into the host genome. The method promises to provide safe, autologous iPS cells that can be used for human cell replacement and regeneration therapeutic applications.

    摘要翻译： 克隆到单一持续表达型仙台病毒载体中的干细胞重编程基因显示将分化的体细胞重编程为诱导多能干细胞（iPS）细胞，而不将载体序列整合到宿主细胞的基因组中。 通过感染重组仙台病毒将基因转导入正常分化的体细胞。 在重编程基因表达和随后的多能性诱导之后，从细胞中除去包括重编程基因的载体基因组RNA以建立与亲本体细胞分化细胞遗传相同的iPS细胞，从而降低由随机引起的致瘤转化的风险 将载体序列整合到宿主基因组中。 该方法有望提供可用于人类细胞替代和再生治疗应用的安全的自体iPS细胞。

    Fuel cylinder mounting structure in motorcar
    4.
    发明授权
    Fuel cylinder mounting structure in motorcar 失效
    汽车中的油缸安装结构

    公开(公告)号：US5997040A

    公开(公告)日：1999-12-07

    申请号：US841527

    申请日：1997-04-23

    申请人： Masami Fukagawa ,  Masayuki Sano ,  Toshiaki Hitomi ,  Yutaka Kanaguchi

    发明人： Masami Fukagawa ,  Masayuki Sano ,  Toshiaki Hitomi ,  Yutaka Kanaguchi

    IPC分类号： B60K15/01 ,  B60K15/07 ,  B60B3/22 ,  B60K15/10

    CPC分类号： B60K15/07 ,  B60K15/013 ,  B60K2015/0638

    摘要： A fuel cylinder for storing a compressed fuel gas is modularized for mounting and supporting the fuel cylinder easily in a motorcar without reconstructing a conventional car-body and necessitating troublesome fuel pipe arranging work after mounting the fuel cylinder. The modularized fuel cylinder comprises a supporting frame fixed to the fuel cylinder, fuel pipes neighboring the fuel cylinder and a joint box on which the fuel pipes concentrate attached to the supporting frame integrally. The fuel cylinder module is detachably fixed to a car-body side supporting frame provided on a rear floor of the motorcar.

    摘要翻译： 用于存储压缩燃料气体的燃料气缸是模块化的，用于将燃料汽缸容易地安装和支撑在汽车中，而不需要重新构建常规的车体，并且在安装燃料汽缸之后需要麻烦的燃料管道排列工作。 模块化燃料筒包括固定到燃料缸的支撑框架，与燃料缸相邻的燃料管和一个接合盒，燃料管集中在其上一体地附着在支撑框架上。 燃料缸模块可拆卸地固定到设置在汽车后部的车身侧支撑框架上。

    Fuel cylinder mounting structure in motorcar
    5.
    发明授权
    Fuel cylinder mounting structure in motorcar 失效
    汽车中的油缸安装结构

    公开(公告)号：US5924734A

    公开(公告)日：1999-07-20

    申请号：US855718

    申请日：1997-05-08

    申请人： Masami Fukagawa ,  Masayuki Sano

    发明人： Masami Fukagawa ,  Masayuki Sano

    IPC分类号： B60G7/00 ,  B60K15/03 ,  B60K15/063 ,  B60K15/07 ,  B62D25/20 ,  B62D43/04 ,  F02M37/00 ,  B60P3/22

    CPC分类号： B60K15/07 ,  B60K2015/0638

    摘要： A fuel cylinder mounting structure in a motorcar wherein a fuel cylinder can be attached together with suspensions and a spare tire easily so that productivity is improved, the vehicle can be made small and light at a reduction of cost. The fuel cylinder mounting structure comprises a fuel cylinder for storing compressed fuel gas; a chassis frame having a rectangular frame-like shape, supporting the fuel cylinder and attached to a car-body frame from the bottom; suspensions attached to both sides of the chassis frame and modularized with the chassis frame; and a spare tire rack attached to the chassis frame and supporting a spare tire laid down and hung under a rear part of the car-body.

    摘要翻译： 在汽车中的燃料缸安装结构，其中燃料缸可以容易地与悬架和备胎连接在一起，从而提高生产率，可以降低成本，使车辆小型化和轻量化。 燃料缸安装结构包括用于储存压缩燃料气体的燃料缸; 具有矩形框状的底盘框架，支撑燃料缸并从底部附接到车身框架; 悬挂在底盘框架的两侧并与底盘框架模块化; 以及备用轮胎架，其安装在所述底盘框架上，并支撑放置并悬挂在所述车身后部的备用轮胎。

    Cephem compound having pseudo-catechol group
    6.
    发明授权
    Cephem compound having pseudo-catechol group 有权
    具有假儿茶酚基的头孢烯化合物

    公开(公告)号：US08883773B2

    公开(公告)日：2014-11-11

    申请号：US13639427

    申请日：2011-04-04

    申请人： Kenji Yamawaki ,  Hideki Sugimoto ,  Masayuki Sano

    发明人： Kenji Yamawaki ,  Hideki Sugimoto ,  Masayuki Sano

    IPC分类号： A61K31/546 ,  C07D501/46

    CPC分类号： C07D501/46

    摘要： A compound of the formula: wherein X is —N═, —CH═, or the like; W is —CH2— or the like; U is —S— or the like; R1 and R2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; Q is a single bond or the like; R3 is hydrogen or the like; Ring A is a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; each R4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; G is —C(═O)— or the like; D is a single bond, —NH—, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

    摘要翻译： 下式的化合物：其中X为-N =，-CH =等; W是-CH 2 - 等; U是-S-等; R 1和R 2各自独立地为氢，卤素，任选取代的低级烷基等; Q是单键等; R3是氢等; 环A是具有1-3个氮原子的6元芳族杂环基; 每个R 4独立地是氢，卤素等; m为0〜2的整数; G是-C（= O） - 等; D是单键-NH-等; 并且E是环状季铵基团，或酯，在7-侧链上的环上的氨基上的受保护化合物，其药学上可接受的盐或溶剂合物。

    CEPHEM COMPOUND HAVING PSEUDO-CATECHOL GROUP
    10.
    发明申请
    CEPHEM COMPOUND HAVING PSEUDO-CATECHOL GROUP 有权
    具有PSEUDO-CATECHOL集团的CEPHEM化合物

    公开(公告)号：US20130079319A1

    公开(公告)日：2013-03-28

    申请号：US13639427

    申请日：2011-04-04

    申请人： Kenji Yamawaki ,  Hideki Sugimoto ,  Masayuki Sano

    发明人： Kenji Yamawaki ,  Hideki Sugimoto ,  Masayuki Sano

    IPC分类号： C07D501/46

    CPC分类号： C07D501/46

    摘要： A compound of the formula: wherein X is —N═, —CH═, or the like; W is —CH2— or the like; U is —S— or the like; R1 and R2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; Q is a single bond or the like; R3 is hydrogen or the like; Ring A is a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; each R4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; G is —C(═O)— or the like; D is a single bond, —NH—, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

    摘要翻译： 下式的化合物：其中X为-N =，-CH =等; W是-CH 2 - 等; U是-S-等; R 1和R 2各自独立地为氢，卤素，任选取代的低级烷基等; Q是单键等; R3是氢等; 环A是具有1-3个氮原子的6元芳族杂环基; 每个R 4独立地是氢，卤素等; m为0〜2的整数; G是-C（= O） - 等; D是单键-NH-等; 并且E是环状季铵基团，或酯，在7-侧链上的环上的氨基上的受保护化合物，其药学上可接受的盐或溶剂合物。