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    Cephem compound having catechol group
    2.
    发明授权
    Cephem compound having catechol group 有权
    具有儿茶酚基的头孢烯化合物

    公开(公告)号：US09145425B2

    公开(公告)日：2015-09-29

    申请号：US13639412

    申请日：2011-04-04

    申请人： Shinya Hisakawa ,  Yasushi Hasegawa ,  Toshiaki Aoki ,  Hiroki Kusano ,  Masayuki Sano ,  Jun Sato ,  Kenji Yamawaki

    发明人： Shinya Hisakawa ,  Yasushi Hasegawa ,  Toshiaki Aoki ,  Hiroki Kusano ,  Masayuki Sano ,  Jun Sato ,  Kenji Yamawaki

    IPC分类号： C07D471/08 ,  C07D501/56 ,  C07D505/24 ,  C07D501/46 ,  C07D519/06

    CPC分类号： C07D505/24 ,  C07D471/08 ,  C07D501/46 ,  C07D501/56 ,  C07D519/06

    摘要： This invention provides Cephem compounds having the formula: or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, a pharmaceutical composition thereof, and a method for treating a bacterial infectious disease with the compound, the ester, the protected compound, the salt, or the solvate thereof, wherein the symbols in the formula are defined in the specification. The compounds exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, preferably beta-lactamase producing Gram negative bacteria, more preferably, multi-drug resistant microbials, in particular, Class B type metallo-beta-lactamase producing Gram negative bacteria, and still preferably extended-spectrum beta-lactamase (ESBL) producing bacteria. The compounds most preferably do not exhibit cross-resistance against known Cephem drugs or Carbapenem drugs.

    摘要翻译： 本发明提供具有下式的Cephem化合物：或酯，7-侧链上的环上的氨基上的被保护的化合物，其药学上可接受的盐或溶剂合物，其药物组合物和 化合物，酯，受保护化合物，盐或其溶剂化物的细菌感染性疾病，其中式中的符号在说明书中定义。 该化合物对各种细菌（包括革兰氏阴性细菌和/或革兰氏阳性细菌，优选β-内酰胺酶产生革兰氏阴性细菌，更优选多药耐药性微生物，特别是B类金属β- 产生革兰氏阴性细菌的内酰胺酶，更优选延长的β-内酰胺酶（ESBL）产生细菌。 该化合物最优选不表现出对已知的Cephem药物或碳青霉烯类药物的抗药性。

    Automobile-Use High Pressure Fuel Injection Accumulator-Distributor and Method of Production of the Same
    5.
    发明申请
    Automobile-Use High Pressure Fuel Injection Accumulator-Distributor and Method of Production of the Same 有权
    汽车用高压燃油喷射蓄能器 - 分配器及其生产方法

    公开(公告)号：US20100095934A1

    公开(公告)日：2010-04-22

    申请号：US11989844

    申请日：2006-07-31

    申请人： Yasushi Hasegawa ,  Ryuichi Honma ,  Yutaka Takagi

    发明人： Yasushi Hasegawa ,  Ryuichi Honma ,  Yutaka Takagi

    IPC分类号： F02M63/00 ,  F02M61/14

    CPC分类号： F02M55/025 ,  F02M55/005 ,  F02M2200/803 ,  F02M2200/8053 ,  F02M2200/8084

    摘要： An automobile-use high pressure fuel injection accumulator-distributor comprised of a body of an automobile-use high pressure fuel injection accumulator-distributor to which pipe attachment holders for attaching fuel distribution pipes for distributing fuel to injection nozzles at an equal pressure are joined by liquid phase diffusion bonding etc., wherein each holder is comprised of a tube part at the pipe side and a partial cone-shaped skirt at the end of the rail body side, each holder skirt has a shape spreading in a partial cone shape toward the joint face end with an angle from the holder tube part side face of 10° or more in a range of a length of 2 mm or more in the holder axial direction at the outer circumference of the end of the holder at the joint face side, the rail body has holder joint position determining guide grooves at its holder joint positions, each guide groove is comprised of a groove inner circumferential wall of a size enabling engagement with a holder joint inner circumference, a groove bottom forming a joint face with the holder, and a groove outer circumferential wall of a partial cone shape bulging out to the inner side parallel to the holder skirt from the groove bottom toward the holder side at a depth of 2 mm or more, and a metal ring is plastically deformed and press-fit into a clearance of 0.5 mm or more between each holder skirt and the groove outer circumferential wall and parallel to the joint face.

    摘要翻译： 一种汽车用高压燃料喷射蓄能器 - 分配器，由汽车用高压燃料喷射蓄能器 - 分配器的主体组成，用于将用于将燃料分配到等压喷嘴的燃料分配管的管附接保持器连接到其上 液相扩散接合等，其中每个保持器由在管侧的管部分和在轨道体侧的端部处的部分锥形裙部组成，每个保持器裙部具有朝向 在保持器轴向方向上，在保持器的端部的外周的接合面侧，在保持器管部侧面10°以上的长度为2mm以上的范围内， 轨道体在其保持器接合位置处具有保持器关节位置确定引导槽，每个引导槽由具有能够与保持器接合部配合的尺寸的槽内周壁 内圆周，形成与保持器的接合面的槽底部，以及从凹槽底部向保持器侧平行于保持器裙部的内侧凸出的部分锥形的凹槽外周壁以2mm的深度 以上，并且金属环塑性变形并且压配合在每个保持器裙部和槽外周壁之间并平行于接合面的0.5mm以上的间隙。

    Fire-Resistant Steel Material Superior in Haz Toughness of Welded Joint and Method of Production of Same
    6.
    发明申请
    Fire-Resistant Steel Material Superior in Haz Toughness of Welded Joint and Method of Production of Same 有权
    焊接接头耐火韧性优良的耐火钢材料及其生产方法

    公开(公告)号：US20090053097A1

    公开(公告)日：2009-02-26

    申请号：US12224253

    申请日：2007-09-20

    申请人： Yasushi Hasegawa ,  Suguru Yoshida ,  Yoshiyuki Watannabe

    发明人： Yasushi Hasegawa ,  Suguru Yoshida ,  Yoshiyuki Watannabe

    IPC分类号： C22C38/22 ,  C22C38/00 ,  C21D8/00

    CPC分类号： C21D8/021 ,  C21D1/54 ,  C21D6/002 ,  C21D9/46 ,  C21D9/50 ,  C21D2211/005 ,  C22C38/001 ,  C22C38/02 ,  C22C38/04 ,  C22C38/24

    摘要： The present invention provides a fire-resistant steel material superior in HAZ toughness of a welded joint which is high in high temperature yield strength at an envisioned fire temperature of 700 to 800° C. and is free of embrittlement of the welded joint even if exposed at this envisioned fire temperature and a method of production of the same, that is, a fire-resistant steel material of a composition containing, by mass %, C: 0.005% to less than 0.03%, Si: 0.01 to 0.50%, Mn: 0.05 to 0.40%, Cr: 1.50 to 5.00%, V: 0.05 to 0.50%, and N: 0.001 to 0.005% and restricted in contents of Ni, Cu, Mo, B, P, S, and O obtained by heating a steel slab to 1150 to 1300° C., then hot working or hot rolling the slab to an end temperature of 880 degrees or more, acceleratedly cooling the worked or rolled steel material under conditions of a cooling rate at a position of the slowest cooling rate of at least 2° C./sec or more, stopping this accelerated cooling at a temperature region where the surface temperature of the steel material becomes 350 to 600° C., and then allowing the material to cool.

    摘要翻译： 本发明提供一种在700-800℃的预期的火焰温度下，在高温屈服强度高的焊接接头的HAZ韧性优异的耐火钢材料，即使暴露于焊接接头也不会发生脆化 在这种预想的耐火温度及其制造方法中，即，以质量％计含有C：0.005〜小于0.03％的Si：0.01〜0.50％的组成的耐火钢材，Mn：0.01〜 ：0.05〜0.40％，Cr：1.50〜5.00％，V：0.05〜0.50％，N：0.001〜0.005％，通过加热得到的Ni，Cu，Mo，B，P，S， 钢板坯坯为1150〜1300℃，然后热轧或热轧板坯至880度以上的终止温度，在冷却速度最慢的位置的条件下，对加工后的钢材进行加速冷却 至少2℃/ sec以上，在表面的温度区域停止加速冷却 钢材的温度变为350〜600℃，然后使材料冷却。

    Turbo chiller, compressor therefor, and control method therefor
    8.
    发明申请
    Turbo chiller, compressor therefor, and control method therefor 有权
    涡轮制冷机，压缩机及其控制方法

    公开(公告)号：US20050144965A1

    公开(公告)日：2005-07-07

    申请号：US11010385

    申请日：2004-12-14

    申请人： Kenji Ueda ,  Yasushi Hasegawa

    发明人： Kenji Ueda ,  Yasushi Hasegawa

    IPC分类号： F04D27/00 ,  F04D27/02 ,  F25B1/04 ,  F25B49/02 ,  F25B49/00 ,  F25B1/00

    CPC分类号： F04D27/0261 ,  F25B1/053 ,  F25B49/025 ,  F25B2600/021 ,  F25B2600/0253 ,  F25B2700/195 ,  F25B2700/197 ,  F25B2700/21161 ,  F25B2700/21172 ,  F25B2700/21173 ,  Y02B30/741

    摘要： A compressor for a turbo chiller that can stably and efficiently operate in various operating states is provided. An aerodynamic feature map showing a rotating stall line at which rotating stall occurs is provided on a map represented by a flow parameter reflecting the volume flow based on the output thermal capacity of the chiller and by a pressure parameter reflecting the head based on the evaporator pressure and the condenser pressure. A minimum rotation speed obtaining unit obtains a minimum rotation speed from the pressure parameter and the rotating stall line on the aerodynamic feature map in the current operating state, and a rotation speed greater than or equal to the minimum rotation speed thus obtained is designated to the inverter.

    摘要翻译： 提供了一种能够在各种操作状态下稳定且有效地操作的涡轮冷冻机的压缩机。 在由映射表示的旋转失速线的空气动力学特征图中提供反映体积流量的流量参数，该流量参数基于冷却器的输出热容量和基于蒸发器压力的反映头部的压力参数 和冷凝器压力。 最小转速获取单元从当前运行状态下的空气动力学特性图上的压力参数和旋转失速线获得最小转速，并将大于或等于所获得的最小转速的转速指定为 逆变器。

    Classification tree based information retrieval scheme
    10.
    发明授权
    Classification tree based information retrieval scheme 失效
    基于分类树的信息检索方案

    公开(公告)号：US06363375B1

    公开(公告)日：2002-03-26

    申请号：US09410146

    申请日：1999-09-30

    申请人： Takashi Hoshino ,  Yasushi Hasegawa ,  Giichi Kishimoto ,  Kinji Kato ,  Tsuyoshi Hayashi

    发明人： Takashi Hoshino ,  Yasushi Hasegawa ,  Giichi Kishimoto ,  Kinji Kato ,  Tsuyoshi Hayashi

    IPC分类号： G06F1730

    CPC分类号： G06F17/30643 ,  Y10S707/99932 ,  Y10S707/99934 ,  Y10S707/99935 ,  Y10S707/99944

    摘要： An information retrieval scheme using classification trees with respect to a plurality of information sources connected to a network is disclosed, where each classification tree having a hierarchical structure defined in terms of entries. In the information retrieval apparatus, classification tree class information for each classification tree class defined among entries constituting each classification tree is managed, where each classification tree class information indicating retrieval condition parameters for each classification tree class. Then, the information retrieval is controlled by receiving from a user a retrieval request indicating a retrieval target entry that was obtained by the user by tracing the classification trees, generating retrieval commands with respect to selected information sources among said plurality of information sources by referring to each classification tree class information corresponding to the retrieval target entry that is managed by the class definition unit, obtaining a retrieval result of a retrieval with respect to the selected information sources using the retrieval commands, and returning the retrieval result to the user.

    摘要翻译： 公开了使用关于连接到网络的多个信息源的分类树的信息检索方案，其中每个分类树具有根据条目定义的分层结构。 在信息检索装置中，对构成每个分类树的条目中定义的每个分类树类的分类树类信息进行管理，其中每个分类树类信息指示每个分类树类的检索条件参数。 然后，通过从用户接收指示由用户通过跟踪分类树获得的检索目标条目的检索请求来控制信息检索，通过参考所述多个信息源中的所选信息源生成关于所选信息源的检索命令 每个分类树类信息对应于由类定义单元管理的检索目标条目，使用检索命令获得关于所选择的信息源的检索的检索结果，并将检索结果返回给用户。