摘要:
An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.
摘要:
An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.
摘要:
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a method for producing a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要:
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要:
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
摘要:
A device monitoring apparatus includes a sensor and a stopping unit. The sensor is configured to detect at least either smoke generation or ignition in a module included in an electronic device, based on at least one of a relative intensity of light generated in the module and a temperature of each module. The stopping unit is installed in the module and configured to stop an operation of the module in response to the at least one of the smoke generation and the ignition being detected by the sensor.
摘要:
A PDP-driving semiconductor integrated circuit includes a plurality of PDP drivers each for converting an input signal into a high-voltage pulse having an amplitude greater than that of the input signal and outputting the high-voltage pulse. The PDP-driving semiconductor integrated circuit has a function of performing sequential operation in which the PDP drivers operate at different timings and sequentially output the high-voltage pulses and a function of performing simultaneous operation in which the PDP drivers operate at the same timing and output the high-voltage pulses at a time. In each of the sequential operation and the simultaneous operation, at least one of the speed of change in voltage level of the high-voltage pulse from a low level to a high level and the speed of change in voltage level of the high-voltage pulse from the high level to the low level is controlled.
摘要:
A head-up display apparatus allows an occupant of a vehicle to visually perceive a virtual image of an image light reflected by a windshield after passing through a cylindrical lens. The cylindrical lens is inclined against the image light to thereby reflect outside light not to reach an eye range of the occupant. The cylindrical lens is placed in a light guide portion such that (i) an action axis direction for an optical action and (ii) a horizontal direction in the display image agree with each other. Of the cylindrical lens, an inclination angle and installation depth are so set that light incident at an angle equal to or greater than an interception upper-limit incident angle and reflected by a pass-through side of the cylindrical lens does not arrive at the eye range of the occupant.
摘要:
A device for detecting a state of a discharged liquid droplet includes a plurality of nozzles which is arranged in a width direction of a recording medium orthogonal to a feeding direction of the recording medium to discharge a liquid droplet toward the recording medium, a light emitter which is provided on one side of the recording medium in the width direction orthogonal to the feeding direction of the recording medium, and a light receiver which is provided on the other side of the recording medium in the width direction, wherein the light emitter includes a light-emitting element, a condenser lens which condenses light from the light-emitting element to emit as a light beam, and an aperture stop member including an aperture opening through which the light beam passes.
摘要:
A scan driving circuit includes: a shift register section receiving a scan data signal and a scan clock signal; a plurality of pulse width control circuits each receiving an output signal from the shift register section and a negative pulse width control signal to output a signal whose pulse width is controlled based on the negative pulse width control signal; a blanking section receiving the output signals from the plurality of pulse width control circuits and a blanking signal; and a plurality of high voltage output sections for amplifying the output signals from the plurality of pulse width control circuits, which are received via the blanking section, to successively output negative pulses each having a controlled pulse width to the scanning electrodes.