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公开(公告)号：US07288400B2
公开(公告)日：2007-10-30
申请号：US09903410
申请日：2001-07-10
申请人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka , Jay M. Short , Eric J. Mathur
发明人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka , Jay M. Short , Eric J. Mathur
CPC分类号： C12N9/18 , A01K2217/05 , A61K38/00 , C12N9/16 , C12P13/04
摘要： The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及酯酶和编码酯酶的多核苷酸。 此外，还提供了设计新的酯酶方法的方法。 酯酶在增加的pH和温度下具有增加的活性和稳定性。
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公开(公告)号：US06277595B1
公开(公告)日：2001-08-21
申请号：US09196388
申请日：1998-11-19
IPC分类号： C12P2102
CPC分类号： G01N33/5091 , A61K48/00 , C07K14/3156 , C12Q1/689 , G01N33/5008 , G01N33/502 , G01N33/56944 , G01N2333/315
摘要： The invention provides fabZ polypeptides and polynucleotides encoding fabZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabZ polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供编码fabZ多肽的fabZ多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用fabZ多肽筛选抗菌化合物的方法。
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公开(公告)号：US06268188B1
公开(公告)日：2001-07-31
申请号：US09412184
申请日：1999-10-04
IPC分类号： C12P1314
CPC分类号： C12N9/00 , C12N9/1096 , C12N9/16 , C12Y206/01001 , Y10S435/822
摘要： Thermostable transaminase and aminotransferase enzymes derived from various ammonife and aquifex organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
摘要翻译： 公开了衍生自各种氨和生物体的热稳定转氨酶和氨基转移酶。 酶由天然或重组宿主细胞产生，可用于制药，农业和其他工业。
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公开(公告)号：US6013509A
公开(公告)日：2000-01-11
申请号：US69226
申请日：1998-04-27
CPC分类号： C12N9/1096
摘要： Thermostable transaminase and aminotransferase enzymes derived from various ammonifex, aquifex and pyrobaculum organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
摘要翻译： 公开了衍生自各种氨，含水和火腿菌生物体的热稳定转氨酶和氨基转移酶。 酶由天然或重组宿主细胞产生，可用于制药，农业和其他工业。
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公开(公告)号：US5942430A
公开(公告)日：1999-08-24
申请号：US602359
申请日：1996-02-16
申请人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka
发明人： Dan E. Robertson , Dennis Murphy , John Reid , Anthony M. Maffia , Steven Link , Ronald V. Swanson , Patrick V. Warren , Anna Kosmotka
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12P13/02 , C12P13/04
摘要： Esterase enzymes derived from various Staphylothermus, Pyrodictium, Archaeoglobus, Aquifex, M11TL, Thermococcus, Teredinibacter and Sulfolobus organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
摘要翻译： 公开了衍生自各种葡萄球菌，火炬蒿，古细血管，Aquifex，M11TL，Thermococcus，Teredinibacter和Sulfolobus生物体的酯酶。 酶由天然或重组宿主细胞产生，可用于制药，农业和其他工业。
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公开(公告)号：US5876945A
公开(公告)日：1999-03-02
申请号：US759581
申请日：1996-12-05
申请人： Dexter Allan Chisholm , Bruce Aaron Diner , Gail K. Donaldson , Howard Paul Hershey , Douglas Brian Jordan , Xiao Song Tang , Shaojie Wang , Jeffrey T. Trost , Patrick V. Warren
发明人： Dexter Allan Chisholm , Bruce Aaron Diner , Gail K. Donaldson , Howard Paul Hershey , Douglas Brian Jordan , Xiao Song Tang , Shaojie Wang , Jeffrey T. Trost , Patrick V. Warren
CPC分类号： C07H21/00 , C12Q1/37 , G01N33/535
摘要： D1 protease has been isolated from the alga (Scenedesmjus obliquus), wheat, and Synechocystis PCC 6803 and the genes encoding these enzymes have been cloned and sequenced. Native or recombinantly produced enzyme has been used to develop assays to detect herbicidal compositions capable of inhibiting the D1 protease enzyme.
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公开(公告)号：US5814473A
公开(公告)日：1998-09-29
申请号：US599171
申请日：1996-02-09
CPC分类号： C12N9/1096
摘要： Thermostable transaminase and aminotransferase enzymes derived from various ammonifex, aquifex and pyrobaculum organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
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公开(公告)号：US06489139B1
公开(公告)日：2002-12-03
申请号：US09339614
申请日：1999-06-24
IPC分类号： C12N1500
摘要： The invention provides fabZ polypeptides and polynucleotides encoding fabZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabZ polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供编码fabZ多肽的fabZ多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用fabZ多肽筛选抗菌化合物的方法。
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公开(公告)号：US06280990B1
公开(公告)日：2001-08-28
申请号：US09387695
申请日：1999-08-31
IPC分类号： C12P2106
CPC分类号： C12N9/1252 , C07K14/3156
摘要： The invention provides dnaE polypeptides and polynucleotides encoding dnaE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dnaE polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了dnaE多肽和编码dnaE多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用dnaE多肽筛选抗菌化合物的方法。
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公开(公告)号：US5962283A
公开(公告)日：1999-10-05
申请号：US646590
申请日：1996-05-08
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/16 , C12N9/24 , C12N15/00 , C12N15/10 , C12P13/00 , C12P13/04 , C12R1/01 , C12R1/19 , C07H21/04 , C12N1/00
CPC分类号： C12N9/00 , C12N9/1096 , C12N9/16 , C12Y206/01001 , Y10S435/822
摘要： Thermostable transaminase and aminotransferase enzymes derived from various ammonifex, aquifex and pyrobaculum organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
摘要翻译： 公开了衍生自各种氨，含水和火腿菌生物体的热稳定转氨酶和氨基转移酶。 酶由天然或重组宿主细胞产生，可用于制药，农业和其他工业。
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