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    System for delivering therapy
    3.
    发明授权
    System for delivering therapy 有权
    治疗系统

    公开(公告)号：US08100900B2

    公开(公告)日：2012-01-24

    申请号：US12119442

    申请日：2008-05-12

    申请人： Friedrich B. Prinz ,  Paul J. Wang ,  Bryant Y Lin ,  Ross Venook

    发明人： Friedrich B. Prinz ,  Paul J. Wang ,  Bryant Y Lin ,  Ross Venook

    IPC分类号： A61B18/14 ,  A61B18/02

    CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/1861

    摘要： The system of the preferred embodiments includes a first rotational element, a second rotational element, and a therapeutic source coupled to the rotational elements. The system permits simultaneous attachment to and movement around a surface of tissue, preferably during an ablation procedure (either during lesion creation or between lesion creation events), or during any other suitable procedure. The therapeutic source functions to translate along the path of tissue and deliver therapy as the first and second rotational elements rotate and roll along the path of tissue. The therapeutic source preferably delivers contiguous doses of therapy along the path of tissue. The system is preferably designed for delivering therapy to tissue and, more specifically, for delivering therapy to cardiac tissue. The system, however, may be alternatively used in any suitable environment and for any suitable reason.

    摘要翻译： 优选实施例的系统包括耦合到旋转元件的第一旋转元件，第二旋转元件和治疗源。 该系统允许同时附着于组织表面并且围绕组织表面移动，优选地在消融过程期间（在损伤创建期间或在损伤创建事件之间）或在任何其它合适的过程期间。 当第一和第二旋转元件沿着组织的路径旋转和滚动时，治疗源用于沿着组织的路径平移并递送治疗。 治疗源优选沿着组织的路径递送连续剂量的治疗。 该系统优选地被设计用于递送治疗组织，更具体地，用于将治疗递送到心脏组织。 然而，该系统可以替代地在任何合适的环境中使用，并且出于任何合适的原因。

    Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization
    5.
    发明授权
    Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization 失效

    公开(公告)号：US07041095B2

    公开(公告)日：2006-05-09

    申请号：US10695110

    申请日：2003-10-28

    申请人： Paul J. Wang ,  Hassan Rastegar

    发明人： Paul J. Wang ,  Hassan Rastegar

    IPC分类号： A61B18/04

    CPC分类号： A61B18/1445 ,  A61B18/1442 ,  A61B2017/2945 ,  A61B2018/0212 ,  A61B2018/0225 ,  A61B2018/0262 ,  A61B2018/1432 ,  A61B2018/1467

    摘要： A medical device, and related method, use epicardial ablators and detectors for intraoperative epicardial approaches to ablation therapy of cardiac conduction pathways. An epicardial gripper is sized to grasp the cardiac circumference or smaller structures on the epicardial surface of the heart. Ablators are disposed on the arms of the gripper for epicardial ablation of cardiac conduction tissue. In another embodiment of the invention, an electrode system includes a flexible, adjustable probe forming a loop for epicardial ablation. Ablators are provided on one or multiple surfaces of the probe for epicardial ablation of cardiac conduction tissue. In yet another embodiment of the invention, an endocardial ablator detection system provides an indicator adjacent an ablator on an endocardial catheter, and a detector on an epicardial probe. The epicardial probe detects signals transmitted by the indicator on the endocardial catheter to localize the position of the endocardial ablator relative to the epicardial surface. The surgeon uses this information for guidance in adjusting the position of the endocardial ablator according to therapeutic objectives of cardiac ablation.

    Aziridine primer for flexographic printing plates
    6.
    发明授权
    Aziridine primer for flexographic printing plates 失效
    用于苯胺印刷版的Aziridine底漆

    公开(公告)号：US5534391A

    公开(公告)日：1996-07-09

    申请号：US189075

    申请日：1994-01-28

    申请人： Paul J. Wang

    发明人： Paul J. Wang

    IPC分类号： B41C1/00 ,  C07D203/08 ,  C08J7/00 ,  C08J7/04 ,  C08L33/04 ,  C08L33/08 ,  C08L53/00 ,  C09D5/00 ,  G03F7/00 ,  G03F7/027 ,  G03F7/095 ,  G03F7/11 ,  G03C1/73

    CPC分类号： G03F7/095 ,  G03F7/11

    摘要： The invention is a flexible plate, suitable for use as a flexographic printing plate, comprising a flexible substrate primed with an aziridine functional material, and, contacting a primed surface of said substrate, a photosensitive layer which comprises a substantially polar acrylate compound, an elastomeric block copolymer, and a photoinitiator. The adhesion between the substrate and the photosensitive layer is strengthened by use of the aziridine functional primer in combination with a substantially polar acrylate compound. In contrast, when acrylate compounds with large nonpolar portions are used, the adhesion tends to be poor. The adhesion is further improved by exposure of the plate to radiation.

    摘要翻译： 本发明是一种柔性板，适合用作柔性版印刷版，其中包括用氮丙啶功能材料制成的柔性基材，以及接触所述基材的底漆表面，感光层，其包含基本上极性的丙烯酸酯化合物，弹性体 嵌段共聚物和光引发剂。 通过使用氮丙啶功能底漆与基本上极性的丙烯酸酯化合物的组合，增强了基材和感光层之间的粘合性。 相反，当使用具有大非极性部分的丙烯酸酯化合物时，粘附性趋于变差。 通过将板暴露于辐射来进一步改善粘附性。

    Method to discriminate arrhythmias in cardiac rhythm management devices
    7.
    发明授权
    Method to discriminate arrhythmias in cardiac rhythm management devices 有权
    辨别心律失常的方法

    公开(公告)号：US08204581B2

    公开(公告)日：2012-06-19

    申请号：US12340772

    申请日：2008-12-22

    申请人： Baharan Kamousi ,  Bryant Lin ,  Paul J Wang

    发明人： Baharan Kamousi ,  Bryant Lin ,  Paul J Wang

    IPC分类号： A61B5/02 ,  A61N1/00

    CPC分类号： A61B5/0464 ,  A61N1/3925 ,  A61N1/3956

    摘要： Techniques for discrimination of heart rhythms in cardiac rhythm management devices include determining a current covariance matrix of multiple electrograms measuring each current heart beat, determining a distance measure between the current covariance matrix and a predetermined covariance matrix of the multiple electrograms measuring at least one different heart beat; and determining whether the heart beat represents ventricular tachycardia based on the distance measure.

    摘要翻译： 在心律管理装置中用于区分心律的技术包括确定测量每个当前心跳的多个电图的当前协方差矩阵，确定当前协方差矩阵与测量至少一个不同心脏的多个电描记图的预定协方差矩阵之间的距离度量 击败; 并且基于距离测量来确定心跳是否表示心室性心动过速。

    Intraluminal delivery of tissue lysing medium
    10.
    发明授权
    Intraluminal delivery of tissue lysing medium 失效
    组织裂解培养基的腔内递送

    公开(公告)号：US6113584A

    公开(公告)日：2000-09-05

    申请号：US335388

    申请日：1999-06-17

    申请人： Tracey A. Morley ,  Paul J. Wang

    发明人： Tracey A. Morley ,  Paul J. Wang

    IPC分类号： A61B17/22 ,  A61B18/02 ,  A61B18/06 ,  A61N1/05 ,  A61M25/00

    CPC分类号： A61B18/06 ,  A61B17/22 ,  A61B18/02 ,  A61B2017/22038 ,  A61B2017/22067 ,  A61B2017/22082 ,  A61B2018/00839 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61M2210/125 ,  A61N2001/0585

    摘要： A method and system for lysing a patient's heart tissue causing or involved with arrhythmia which includes an intravascular catheter with a relatively inelastic occlusion balloon on the distal end of the catheter which is inflated to block an artery or vein of the patient's heart so than when lysing fluid such as an ethanol solution is discharged from the distal port in the catheter the inflated balloon prevents the proximal refluxing of lysing medium into undesirable areas of the patient's heart. The inelastic balloon is configured to be inflated to a diameter of about 0.7 to about 1.3, preferably about 0.8 to about 1.2, times the diameter of the blood vessel in which the balloon is to be inflated so as to effectively occlude the passageway without damaging the wall of the blood vessel. The working length of the balloon is less than about 1.5 cm, preferably less than 0.75 cm.

    摘要翻译： 一种用于裂解引起或参与心律失常的患者心脏组织的方法和系统，其包括在导管的远端上具有相对非弹性闭塞气囊的血管内导管，其被充气以阻塞患者心脏的动脉或静脉，而不是在裂解时 诸如乙醇溶液的流体从导管中的远端口排出，充气气球防止裂解介质的近端回流进入患者心脏的不期望的区域。 非弹性球囊被构造成充气至球囊膨胀的血管的直径的约0.7至约1.3，优选约0.8至约1.2倍的直径，以便有效地闭塞通道而不损伤 血管壁。 球囊的工作长度小于约1.5厘米，优选小于0.75厘米。