-
公开(公告)号：US20160257930A1
公开(公告)日：2016-09-08
申请号：US15029164
申请日：2014-10-13
申请人： Paul KEMP , Nicholas ALLEN
发明人： Paul Kemp , Nicholas Allen
IPC分类号： C12N5/0793
CPC分类号： C12N5/0619 , C12N2500/14 , C12N2500/38 , C12N2501/01 , C12N2501/13 , C12N2501/40 , C12N2501/415 , C12N2501/42 , C12N2501/845 , C12N2501/999 , C12N2506/08
摘要： The invention relates to at least one novel neural cell differentiation medium for the production of neural cells from at least one precursor cell capable of lineage specific differentiation; a method for neural cell differentiation using said medium; the use of said medium and said method for lineage specific differentiation of at least one precursor cell towards a neural cell fate; and a kit of parts comprising said at least one said neural cell differentiation medium.
摘要翻译： 本发明涉及至少一种用于从至少一种能够谱系特异性分化的前体细胞产生神经细胞的新型神经细胞分化培养基; 使用所述培养基的神经细胞分化方法; 所述培养基的使用和所述方法用于至少一种前体细胞对神经细胞命运的谱系特异性分化; 以及包含所述至少一种所述神经细胞分化培养基的试剂盒。
-
公开(公告)号：US20070255254A1
公开(公告)日：2007-11-01
申请号：US11787340
申请日：2007-04-16
申请人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
发明人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
IPC分类号： A61K35/36
CPC分类号： C12N5/0627 , A61K35/12 , A61K35/36
摘要： Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.
-
公开(公告)号：US1754364A
公开(公告)日：1930-04-15
申请号：US24609028
申请日：1928-01-11
申请人： PAUL KEMP
发明人： PAUL KEMP
IPC分类号： C22C11/10
CPC分类号： C22C11/10 , Y10S29/022 , Y10T29/49709
-
公开(公告)号：US09526746B2
公开(公告)日：2016-12-27
申请号：US10589227
申请日：2005-02-14
申请人： Paul Kemp , Györgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
发明人： Paul Kemp , Györgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
IPC分类号： A61K35/12 , A61K9/00 , A61P17/02 , A61K35/33 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/60 , G01N33/569 , A61K45/06
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides a wound healing composition comprising living cells such as fibroblasts within a support matrix such as fibrin, in which the cells have a wound healing phenotype, and in which the composition is single layered and has been incubated for up to about 8 days to allow development of the wound healing phenotype. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译： 本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。 在一个方面，本发明提供一种伤口愈合组合物，其包含活细胞，例如载体基质如纤维蛋白中的成纤维细胞，其中细胞具有伤口愈合表型，并且其中组合物是单层的并且已经孵育达 约8天允许发展伤口愈合表型。 本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放性病变。
-
公开(公告)号：US20110086007A1
公开(公告)日：2011-04-14
申请号：US12678957
申请日：2008-09-18
申请人： Paul Kemp , Jeffrey Teumer , Jerry Cooley
发明人： Paul Kemp , Jeffrey Teumer , Jerry Cooley
CPC分类号： A61Q7/00 , A61K8/02 , A61K8/985 , A61K35/12 , C12N5/0627
摘要： The present invention features a method for improving the efficiency of hair formation by follicular cell implantation. The method includes the use of epidermal stimulation (ES) to stimulate keratinocytes in a subject's skin in order to make them more receptive to hair inductive signals originating from implanted follicular cells (e.g. dermal papilla cells, dermal sheath cells, and/or outer root sheath cells).
摘要翻译： 本发明的特征在于通过滤泡细胞植入提高毛发形成效率的方法。 该方法包括使用表皮刺激（ES）刺激受试者的皮肤中的角质形成细胞，以使它们更容易接受来自植入的滤泡细胞（例如真皮乳头细胞，真皮鞘细胞和/或外根鞘）的毛发诱导信号 细胞）。
-
公开(公告)号：US20110027366A1
公开(公告)日：2011-02-03
申请号：US12902710
申请日：2010-10-12
申请人： Paul Kemp , David Shering , Andrew Shering , Penny Johnson , Damian Marshall
发明人： Paul Kemp , David Shering , Andrew Shering , Penny Johnson , Damian Marshall
CPC分类号： C12N5/0698 , A61L27/20 , A61L27/225 , A61L27/24 , A61L27/3687 , A61L27/3691 , A61L27/3804 , A61L27/3839 , A61L27/3886 , A61L27/3895 , A61L27/54 , A61L27/60 , C12N2500/25 , C12N2500/30 , C12N2500/32 , C12N2501/11 , C12N2501/15 , C12N2502/094 , C12N2502/1323 , C12N2533/56
摘要： Disclosed is a method of preparing a collagenous construct comprising casting a support matrix comprising fibrin and viable collagen-producing cells onto a support material, wherein said cells include human dermal fibroblasts, incubating in situ said support matrix in a collagen-inducing medium thereby, inducing or enhancing collagen production by said cells to form a collagenous construct, and degrading said fibrin, and rendering said collagenous construct free of said viable collagen-producing cells.
摘要翻译： 公开了一种制备胶原构建体的方法，包括将包含纤维蛋白和活的产生胶原的细胞的载体基质浇铸到载体材料上，其中所述细胞包括人真皮成纤维细胞，原位培养胶原诱导培养基中的所述载体基质，诱导 或增强所述细胞的胶原产生以形成胶原构建体，并降解所述纤维蛋白，并使所述胶原构建物不含所述活的胶原产生细胞。
-
公开(公告)号：US20080199440A1
公开(公告)日：2008-08-21
申请号：US11915514
申请日：2006-05-25
CPC分类号： A61K8/981 , A61K8/985 , A61K2800/91 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/58 , A61L27/60 , A61Q19/08
摘要： The present invention provides a method for the repair of subcutaneous or dermal tissue in a subject, comprising in one aspect the injection of a suspension of allogeneic dermal fibroblasts into the subject. By injecting a suspension of allogeneic cells, the invention provides, for example, long-term augmentation of the subadjacent tissue without the disadvantages that accompany the preparation and/or use of presently available materials such as autologous fibroblasts cells or collagen. According to a first aspect of the invention there is provided a method for the augmentation of subcutaneous or dermal tissue in a subject, which method comprises the steps of: (i) providing a suspension of allogeneic dermal fibroblasts; and (ii) injecting an effective volume of the suspension into tissue subadjacent to the subcutaneous or dermal tissue so that the tissue is augmented. The method is preferably cosmetic.
摘要翻译： 本发明提供了修复受试者皮下或皮肤组织的方法，其包括在一方面将同种异体真皮成纤维细胞的悬浮液注射入受试者。 通过注射同种异体细胞的悬浮液，本发明提供了例如长期增加下面的组织，而不伴随着制备和/或使用目前可获得的材料如自体成纤维细胞细胞或胶原蛋白的缺点。 根据本发明的第一方面，提供了一种用于增加受试者皮下或皮肤组织的方法，该方法包括以下步骤：（i）提供同种异体真皮成纤维细胞的悬浮液; 和（ii）将有效体积的悬浮液注射到与皮下或皮肤组织相邻的组织中，使得组织被增强。 该方法优选为化妆品。
-
公开(公告)号：US20080193507A1
公开(公告)日：2008-08-14
申请号：US10589150
申请日：2005-02-14
申请人： Paul Kemp , Gyorgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
发明人： Paul Kemp , Gyorgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterised by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3a1 and smooth muscle actin than the housekeeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译： 本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。 一方面，本发明提供伤口愈合组合物，其特征在于表型标记基因如载脂蛋白D，基质金属蛋白酶（2），胶原蛋白3a1和平滑肌肌动蛋白的表达水平高于持家基因核糖体蛋白L32。 本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放病变。
-
公开(公告)号：US20070253939A1
公开(公告)日：2007-11-01
申请号：US11787273
申请日：2007-04-16
申请人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
发明人： Jane Atkins , Michael Leek , Paul Kemp , Richard Wolowacz , Jeffrey Teumer
CPC分类号： C12N5/0627 , A61K35/12 , A61K35/36
摘要： Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.
摘要翻译： 使用药物和/或头发移植手术治疗秃发或脱发。 本发明涉及一种治疗秃发的改进方法。 在一个方面，提供了一种用于在位于外皮表面下面的真皮层中诱导毛囊形成的方法，其包括使用受控输送装置将诱导性皮肤鞘细胞和/或诱导性真皮乳头细胞直接递送到真皮层中。 感应细胞的传送不需要进入预先存在的毛孔。 用于治疗秃发的受控递送装置的使用是本发明的另一方面。
-
公开(公告)号：US20060057542A1
公开(公告)日：2006-03-16
申请号：US11171965
申请日：2005-06-30
申请人： Paul Sharpe , Michael Leek , Paul Kemp , Ewan Campbell
发明人： Paul Sharpe , Michael Leek , Paul Kemp , Ewan Campbell
IPC分类号： A61C5/00
CPC分类号： A61L27/3804 , A61K35/12 , A61L27/3604 , A61L27/3865 , A61L27/3895 , A61L2430/02 , C12N5/0606 , C12N5/0623 , C12N5/0663
摘要： The present invention is based on the discovery that when a tooth primordium is inserted into a mammalian jaw and tooth formation follows, new alveolar bone around the new tooth forms. The present invention is based on the idea of stimulating new tooth formation via the implantation of tooth primordia at selected places in the jaw (e.g. at four points in the molar regions) to result in the formation of bony protuberances which could facilitate denture retention. The teeth may then be removed from the jaw of the patient to leave the new alveolar bone.
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.026 秒)
