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    Skin Equivalent Culture
    1.
    发明申请
    Skin Equivalent Culture 有权
    皮肤等效文化

    公开(公告)号：US20100203135A1

    公开(公告)日：2010-08-12

    申请号：US11886113

    申请日：2006-03-14

    申请人： Paul Kemp ,  David Shering ,  Andrew Shering ,  Penny Johnson ,  Damian Marshall

    发明人： Paul Kemp ,  David Shering ,  Andrew Shering ,  Penny Johnson ,  Damian Marshall

    IPC分类号： A61K9/14 ,  C07K14/78 ,  A61K38/39 ,  C07D233/74 ,  C07D307/62 ,  C07C53/128 ,  C07K7/64 ,  C07D213/80 ,  C07D281/10 ,  C07C255/43 ,  A61P17/02 ,  C12P21/02

    CPC分类号： C12N5/0698 ,  A61L27/20 ,  A61L27/225 ,  A61L27/24 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3886 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/60 ,  C12N2500/25 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2501/11 ,  C12N2501/15 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/56

    摘要： Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses. In particular, a method of forming a connective tissue equivalent, comprising the steps of: (i) incubating collagen-producing cells in or on a support matrix; (ii) inducing and/or enhancing collagen production by the collagen-producing cells to form a collagenous construct and degradation and replacement of the support matrix; (iii) freeze-drying the construct; and (iv) re-populating the freeze-dried construct with collagen-producing cells and/or epithelial cells and/or endothelial cells and/or mesenchymal cells, thereby forming a connective tissue equivalent, wherein: (a) the collagen-producing cells are substantially fibroblasts; for example human neonatal dermal fibroblasts; (b) the support matrix is a provisional support matrix in which the support matrix is a fibrin matrix, for example formed by thrombin-mediated polymerisation of fibrinogen; and (c) as a result of the collagen production by the collagen-producing cells the provisional fibrin support matrix is digested by the cells and is replaced by collagen, thereby essentially replacing the provisional fibrin matrix with a collagen matrix synthesised in situ by the cells.

    摘要翻译： 形成软结缔组织组合物如皮肤当量的方法，通过方法制备的组合物及其用途。 特别地，形成结缔组织当量的方法，包括以下步骤：（i）在载体基质中或载体上孵育胶原产生细胞; （ii）诱导和/或增强胶原产生细胞的胶原产生以形成胶原构建物并降解和置换支持基质; （iii）冷冻干燥该构造体; 和（iv）用胶原产生细胞和/或上皮细胞和/或内皮细胞和/或间充质细胞重新填充冷冻干燥的构建体，从而形成结缔组织当量，其中：（a）胶原产生细胞 基本上是成纤维细胞; 例如人类新生儿真皮成纤维细胞; （b）载体基质是临时支持基质，其中载体基质是纤维蛋白基质，例如通过凝血酶介导的纤维蛋白原聚合形成; 和（c）作为胶原蛋白产生细胞产生胶原的结果，临床纤维蛋白载体基质被细胞消化并被胶原替代，从而基本上用由细胞原位合成的胶原基质代替临时纤维蛋白基质 。

    Skin equivalent culture
    3.
    发明授权
    Skin equivalent culture 有权
    皮肤等效文化

    公开(公告)号：US08114670B2

    公开(公告)日：2012-02-14

    申请号：US11886113

    申请日：2006-03-14

    申请人： Paul Kemp ,  David Shering ,  Andrew Shering, legal representative ,  Penny Johnson ,  Damian Marshall

    发明人： Paul Kemp ,  David Shering ,  Penny Johnson ,  Damian Marshall

    IPC分类号： C12N5/00 ,  G01N33/53 ,  A01N63/00 ,  A61K9/14

    CPC分类号： C12N5/0698 ,  A61L27/20 ,  A61L27/225 ,  A61L27/24 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3886 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/60 ,  C12N2500/25 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2501/11 ,  C12N2501/15 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/56

    摘要： Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses. In particular, a method of forming a connective tissue equivalent, comprising the steps of: (i) incubating collagen-producing cells in or on a support matrix; (ii) inducing and/or enhancing collagen production by the collagen-producing cells to form a collagenous construct and degradation and replacement of the support matrix; (iii) freeze-drying the construct; and (iv) re-populating the freeze-dried construct with collagen-producing cells and/or epithelial cells and/or endothelial cells and/or mesenchymal cells, thereby forming a connective tissue equivalent, wherein: (a) the collagen-producing cells are substantially fibroblasts; for example human neonatal dermal fibroblasts; (b) the support matrix is a provisional support matrix in which the support matrix is a fibrin matrix, for example formed by thrombin-mediated polymerisation of fibrinogen; and (c) as a result of the collagen production by the collagen-producing cells the provisional fibrin support matrix is digested by the cells and is replaced by collagen, thereby essentially replacing the provisional fibrin matrix with a collagen matrix synthesised in situ by the cells.

    摘要翻译： 形成软结缔组织组合物如皮肤当量的方法，通过方法制备的组合物及其用途。 特别地，形成结缔组织当量的方法，包括以下步骤：（i）在载体基质中或载体上孵育胶原产生细胞; （ii）诱导和/或增强胶原产生细胞的胶原产生以形成胶原构建物并降解和置换支持基质; （iii）冷冻干燥该构造体; 和（iv）用胶原产生细胞和/或上皮细胞和/或内皮细胞和/或间充质细胞重新填充冷冻干燥的构建体，从而形成结缔组织当量，其中：（a）胶原产生细胞 基本上是成纤维细胞; 例如人类新生儿真皮成纤维细胞; （b）载体基质是临时支持基质，其中载体基质是纤维蛋白基质，例如通过凝血酶介导的纤维蛋白原聚合形成; 和（c）作为胶原蛋白产生细胞产生胶原的结果，临床纤维蛋白载体基质被细胞消化并被胶原替代，从而基本上用由细胞原位合成的胶原基质代替临时纤维蛋白基质 。

    NEURONAL STEM CELL DIFFERENTIATION
    8.
    发明申请
    NEURONAL STEM CELL DIFFERENTIATION 审中-公开
    神经干细胞分化

    公开(公告)号：US20160257930A1

    公开(公告)日：2016-09-08

    申请号：US15029164

    申请日：2014-10-13

    申请人： Paul KEMP ,  Nicholas ALLEN

    发明人： Paul Kemp ,  Nicholas Allen

    IPC分类号： C12N5/0793

    CPC分类号： C12N5/0619 ,  C12N2500/14 ,  C12N2500/38 ,  C12N2501/01 ,  C12N2501/13 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/42 ,  C12N2501/845 ,  C12N2501/999 ,  C12N2506/08

    摘要： The invention relates to at least one novel neural cell differentiation medium for the production of neural cells from at least one precursor cell capable of lineage specific differentiation; a method for neural cell differentiation using said medium; the use of said medium and said method for lineage specific differentiation of at least one precursor cell towards a neural cell fate; and a kit of parts comprising said at least one said neural cell differentiation medium.

    摘要翻译： 本发明涉及至少一种用于从至少一种能够谱系特异性分化的前体细胞产生神经细胞的新型神经细胞分化培养基; 使用所述培养基的神经细胞分化方法; 所述培养基的使用和所述方法用于至少一种前体细胞对神经细胞命运的谱系特异性分化; 以及包含所述至少一种所述神经细胞分化培养基的试剂盒。

    Cell delivery system
    9.
    发明申请
    Cell delivery system 审中-公开

    公开(公告)号：US20070255254A1

    公开(公告)日：2007-11-01

    申请号：US11787340

    申请日：2007-04-16

    申请人： Jane Atkins ,  Michael Leek ,  Paul Kemp ,  Richard Wolowacz ,  Jeffrey Teumer

    发明人： Jane Atkins ,  Michael Leek ,  Paul Kemp ,  Richard Wolowacz ,  Jeffrey Teumer

    IPC分类号： A61K35/36

    CPC分类号： C12N5/0627 ,  A61K35/12 ,  A61K35/36

    摘要： Baldness or hair loss has been treated using pharmaceutical drugs and/or hair transplant surgery. The present invention relates to an improved method for treating baldness. In one aspect, there is provided a method for inducing hair follicle formation in a dermal layer lying beneath an outer skin surface, comprising delivering inductive dermal sheath cells and/or inductive dermal papilla cells directly into the dermal layer using a controlled delivery device. Delivery of the inductive cells need not be into pre-existing pores. Use of a controlled delivery device for the treatment of baldness is a further aspect of the invention.

    Air-bearing center-guiding apparatus and method
    10.
    发明授权
    Air-bearing center-guiding apparatus and method 失效
    空气轴承中心导向装置及方法

    公开(公告)号：US4892243A

    公开(公告)日：1990-01-09

    申请号：US247224

    申请日：1988-09-21

    申请人： Michael Long ,  Thomas W. Palone ,  Paul Kemp

    发明人： Michael Long ,  Thomas W. Palone ,  Paul Kemp

    IPC分类号： B65H20/10 ,  B65H23/02 ,  B65H23/032 ,  B65H23/24

    CPC分类号： B65H23/02 ,  B65H23/032 ,  B65H23/24 ,  B65H2406/111

    摘要： An air-bearing center-guiding apparatus 10 and a method are disclosed for supporting and laterally center-guiding thin flexible webs of paper or plastic under 15 mils in thickness. The apparatus comprises a web support and guide member 22 having an inner surface and an outer web-facing surface. Parallel rows of elongated spaced-apart guide apertures 34 extend longitudinally along edge regions of the web. Each guide aperture 34 is formed from a cylindrical opening in the web support and guide member 22 and extends substantially perpendicular to the web. Within each aperture a flat-sided dowel 60 is mounted to define a flow passage shaped in cross-section like a segment of a circle 62. Each circular-segment guide aperture 34 has a straight side 54 and a curved side 52 for directing a jet of air against the web edge 56. A plurality of the circular-segment guide apertures 34 develop a guiding force for holding lateral movement of the web to plus or minus 0.001 inch (0.0254 mm). A row of web-support apertures 32, separate from the guide apertures 34, is provided between the rows of guide apertures 34 to form an air bearing for supporting the web.

    摘要翻译： 公开了一种空气轴承中心引导装置10和方法，用于支撑和横向中心地引导厚度小于15密耳的纸或塑料的薄柔性幅材。 该装置包括具有内表面和面向外网的表面的腹板支撑件和引导构件22。 细长间隔开的引导孔34的平行排沿腹板的边缘区域纵向延伸。 每个引导孔34由幅材支撑件和引导构件22中的圆柱形开口形成并基本上垂直于幅材延伸。 在每个孔内，平面定位销60被安装以限定如同圆形部分62的横截面形状的流动通道。每个圆形段导向孔34具有直的侧面54和用于引导射流的弯曲侧面52 多个圆形段导向孔34形成用于将幅材的横向运动保持在正或负0.001英寸（0.0254mm）的引导力。 与引导孔34分开的一排腹板支撑孔32设置在引导孔34的行之间，以形成用于支撑腹板的空气轴承。