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1.发明授权Process for treating thrombosis by administering poly-kringle plasminogen activator 失效通过施用聚多克隆纤溶酶原激活剂治疗血栓形成的方法
公开(公告)号：US5045315A
公开(公告)日：1991-09-03
申请号：US601542
申请日：1990-10-23
CPC分类号： C12N9/6456 , C12N15/85 , C07K2319/00
摘要： Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.
摘要翻译： 公开了含有通过重组DNA技术制备的复数个异源多肽三聚体以及编码活化剂的基因，含有这些基因的载体和使用纤溶酶原激活剂作为溶栓剂的方法的混合第三代纤溶酶原激活剂。
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公开(公告)号：US5591823A
公开(公告)日：1997-01-07
申请号：US169813
申请日：1993-12-17
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/16 , A61P37/08 , C07H21/00 , C07K14/11 , C07K14/16 , C12N7/01 , C12N15/08 , C12N15/09 , C12N15/11 , C12N15/32 , C12N15/34 , C12N15/44 , C12P21/02 , G01N33/53 , G01N33/569 , C07K1/00 , A61K39/145 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/40 , C12N2740/16022 , C12N2760/16122
摘要： Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigenic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immunotherapy.
摘要翻译： 提供了嵌合DNA片段，其包括与编码具有5个免疫显性抗原位点的甲型流感病毒的HA表面蛋白基本上相同的核苷酸序列，其中插入与编码外源表位的碱基序列基本相同的核苷酸序列 进入抗原位点的核苷酸序列。 也提供相应的嵌合肽，表达载体和转化的宿主。 这些肽可用于提供针对相应抗原和测试试剂盒的疫苗以检测对这些抗原的暴露。 此外，这些肽或其相应的抗体可用于治疗和预防暴露于这些抗原的表现的方法，包括免疫治疗。
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公开(公告)号：US4997766A
公开(公告)日：1991-03-05
申请号：US436528
申请日：1989-11-14
CPC分类号： C12N9/6456 , C12N15/85 , C07K2319/00
摘要： Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators. Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.
摘要翻译： 通过重组DNA技术制备的含有复数个异源多肽三聚体的混合第三代纤溶酶原激活剂以及编码活化剂的基因。 公开了含有这些基因的载体和使用纤溶酶原激活剂作为溶栓剂的方法。
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公开(公告)号：US4916071A
公开(公告)日：1990-04-10
申请号：US884835
申请日：1986-07-11
IPC分类号： C12N15/09 , A61K20060101 , A61K35/12 , A61K35/74 , A61K38/00 , A61K38/46 , A61K48/00 , A61P7/02 , C07H20060101 , C07H21/04 , C07K20060101 , C07K14/745 , C12N9/48 , C12N9/52 , C12N9/64 , C12N9/72 , C12N15/00 , C12N15/58 , C12R1/19
CPC分类号： C12N9/6456 , C07K2319/00
摘要： Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.
摘要翻译： 公开了包含通过重组DNA技术制备的复数个异源多肽三聚体以及编码活化剂的基因，含有这些基因的载体和使用纤溶酶原激活剂作为溶栓剂的方法的混合第三代纤溶酶原激活剂。
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公开(公告)号：US5047241A
公开(公告)日：1991-09-10
申请号：US140068
申请日：1987-12-31
CPC分类号： C12N9/6459 , C12N15/85 , C12N9/6456 , C12Y304/21069 , A61K38/00 , C07K2319/00
摘要： Tris-Kringle plasminogen activators containing an additional second kringle domain or an additional modified second kringle domain are useful in disrupting blood clots.
摘要翻译： 含有额外的第二kringle结构域或另外修饰的第二kringle结构域的Tris-Kringle纤溶酶原激活物可用于破坏血块。
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公开(公告)号：US5376547A
公开(公告)日：1994-12-27
申请号：US150267
申请日：1988-01-29
IPC分类号： C12N9/64 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/02 , C12N9/72 , C12N15/09 , C12N9/48 , A61K37/547
CPC分类号： C12N9/6456
摘要： Des-epidermal growth factor homologous--plasminogen activators with greatly diminished affinity for liver membranes.
摘要翻译： 去皮表皮生长因子同源纤溶酶原激活剂，对肝膜的亲和力大大降低。
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公开(公告)号：US08481692B2
公开(公告)日：2013-07-09
申请号：US13451631
申请日：2012-04-20
申请人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
发明人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
CPC分类号： C07K14/33 , A61K39/08 , C07K16/1282 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N9/1051 , C12N9/99 , C12N15/74
摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
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8.发明申请COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF 有权关于一种突变型脱落孢子虫毒素的组合物及其方法公开(公告)号：US20120269841A1
公开(公告)日：2012-10-25
申请号：US13451631
申请日：2012-04-20
申请人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
发明人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
CPC分类号： C07K14/33 , A61K39/08 , C07K16/1282 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N9/1051 , C12N9/99 , C12N15/74
摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
摘要翻译： 一方面，本发明涉及包含突变型艰难梭菌毒素A和/或突变型艰难梭菌毒素B的免疫原性组合物。每种突变毒素包括具有至少一个突变的葡糖基转移酶结构域和具有至少一个突变的半胱氨酸蛋白酶结构域 突变，相对于相应的野生型艰难梭菌毒素。 突变毒素还可以包括至少一个化学交联的氨基酸。 在另一方面，本发明涉及结合所述免疫原性组合物的抗体或其结合片段。 在另外的方面，本发明涉及编码前述任何一种的分离的核苷酸序列，以及任何上述组合物的使用方法。
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