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公开(公告)号：US20130090268A1
公开(公告)日：2013-04-11
申请号：US13602328
申请日：2012-09-04
Applicant: Paul Ju-sung HUNG , Philip Janmin LEE
Inventor： Paul Ju-sung HUNG , Philip Janmin LEE
IPC: C12M1/00
CPC classification number: C12M23/12 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B29C65/002 , C12M23/16 , C12M29/10 , C12M29/14 , C12M41/00 , C12M41/48 , C12Q1/025 , F16K27/0236 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N33/5008 , G01N33/54366 , G01N2035/00158 , Y10T137/2202
Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
Abstract translation: 公开了一种带阀的微流体装置，微流体细胞培养装置和结合装置的系统。 带阀的微流体装置包括基底，微通道，通过该微通道液体可以在装置内从一个站移动到另一个站;以及气动微型阀，其适于在打开和关闭状态之间切换以控制通过微通道的流体流动。 微型阀由三个柔性膜形成，其中一个柔性膜响应于施加到阀上的气压，另外两个变形以产生更可密封的通道横截面。 细胞培养装置提供阀门以允许将细胞控制加载到装置的个体井中，以及在孔中交换细胞培养组分。
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公开(公告)号：US20080194012A1
公开(公告)日：2008-08-14
申请号：US12019857
申请日：2008-01-25
Applicant: Philip Janmin Lee , Paul Ju-Sung Hung , Narendra Maheshri
Inventor： Philip Janmin Lee , Paul Ju-Sung Hung , Narendra Maheshri
CPC classification number: G01N15/1484 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N33/487 , G01N33/54366 , G01N2015/0065 , G01N2015/1493
Abstract: The method, device, and system relate to particle analysis, and in particular, to a microfluidic device designed for trapping particles for analysis. Particles include beads and cells.
Abstract translation: 该方法，装置和系统涉及颗粒分析，特别涉及设计用于捕获颗粒进行分析的微流体装置。 颗粒包括珠粒和细胞。
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Patent Agency Ranking
公开(公告)号：US09354156B2
公开(公告)日：2016-05-31
申请号：US12019857
申请日：2008-01-25
Applicant: Philip Janmin Lee , Paul Ju-Sung Hung , Narendra Maheshri
Inventor： Philip Janmin Lee , Paul Ju-Sung Hung , Narendra Maheshri
CPC classification number: G01N15/1484 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N33/487 , G01N33/54366 , G01N2015/0065 , G01N2015/1493
Abstract: The method, device, and system relate to particle analysis, and in particular, to a microfluidic device designed for trapping particles for analysis. Particles include beads and cells.
Abstract translation: 该方法，装置和系统涉及颗粒分析，特别涉及设计用于捕获颗粒进行分析的微流体装置。 颗粒包括珠粒和细胞。
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公开(公告)号：US08257964B2
公开(公告)日：2012-09-04
申请号：US11648207
申请日：2006-12-29
Applicant: Paul Ju-Sung Hung , Philip Janmin Lee
Inventor： Paul Ju-Sung Hung , Philip Janmin Lee
IPC: C12M1/34
CPC classification number: C12M23/12 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B29C65/002 , C12M23/16 , C12M29/10 , C12M29/14 , C12M41/00 , C12M41/48 , C12Q1/025 , F16K27/0236 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N33/5008 , G01N33/54366 , G01N2035/00158 , Y10T137/2202
Abstract: Methods for fabricating microfluidics devices, microfluidics cell-culture device and systems having a substrate, a microchannel through which liquid can be moved from one station to another within the device, the fabrication methods using semi-rigid materials during molding that are incorporated into the final device.
Abstract translation: 用于制造微流体装置的方法，微流体细胞培养装置和具有基底的系统，液体可以在装置内从一个站移动到另一个站的微通道，在模制期间使用半刚性材料的制造方法并入最终 设备。
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公开(公告)号：US08709790B2
公开(公告)日：2014-04-29
申请号：US13602331
申请日：2012-09-04
Applicant: Paul Ju-Sung Hung , Philip Janmin Lee
Inventor： Paul Ju-Sung Hung , Philip Janmin Lee
IPC: C12M1/34 , G01N33/543
CPC classification number: C12M23/12 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B29C65/002 , C12M23/16 , C12M29/10 , C12M29/14 , C12M41/00 , C12M41/48 , C12Q1/025 , F16K27/0236 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N33/5008 , G01N33/54366 , G01N2035/00158 , Y10T137/2202
Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
Abstract translation: 公开了一种带阀的微流体装置，微流体细胞培养装置和结合装置的系统。 带阀的微流体装置包括基底，微通道，通过该微通道液体可以在装置内从一个站移动到另一个站;以及气动微型阀，其适于在打开和关闭状态之间切换以控制通过微通道的流体流动。 微型阀由三个柔性膜形成，其中一个柔性膜响应于施加到阀上的气压，另外两个变形以产生更可密封的通道横截面。 细胞培养装置提供阀门以允许将细胞控制加载到装置的个体井中，以及在孔中交换细胞培养组分。
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公开(公告)号：US08673625B2
公开(公告)日：2014-03-18
申请号：US13602328
申请日：2012-09-04
Applicant: Paul Ju-Sung Hung , Philip Janmin Lee
Inventor： Paul Ju-Sung Hung , Philip Janmin Lee
IPC: C12M1/34 , G01N33/543
CPC classification number: C12M23/12 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B29C65/002 , C12M23/16 , C12M29/10 , C12M29/14 , C12M41/00 , C12M41/48 , C12Q1/025 , F16K27/0236 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N33/5008 , G01N33/54366 , G01N2035/00158 , Y10T137/2202
Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
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公开(公告)号：US20130081757A1
公开(公告)日：2013-04-04
申请号：US13602331
申请日：2012-09-04
Applicant: Paul Ju-Sung Hung , Philip Janmin Lee
Inventor： Paul Ju-Sung Hung , Philip Janmin Lee
IPC: B29C65/00
CPC classification number: C12M23/12 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/10 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B29C65/002 , C12M23/16 , C12M29/10 , C12M29/14 , C12M41/00 , C12M41/48 , C12Q1/025 , F16K27/0236 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , G01N33/5008 , G01N33/54366 , G01N2035/00158 , Y10T137/2202
Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
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