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    Sweetness Enhancers Including Rebaudioside A or D
    4.
    发明申请
    Sweetness Enhancers Including Rebaudioside A or D 审中-公开
    甜度增强剂包括雷鲍迪苷A或D

    公开(公告)号：US20120164083A1

    公开(公告)日：2012-06-28

    申请号：US13393942

    申请日：2010-08-31

    申请人： R. Kyle Palmer ,  F. Raymond Salemme

    发明人： R. Kyle Palmer ,  F. Raymond Salemme

    IPC分类号： A23L1/236 ,  A61K8/60 ,  A61Q11/00 ,  A61K47/26

    CPC分类号： A23L2/52 ,  A23K20/10 ,  A23K20/111 ,  A23K20/121 ,  A23K50/40 ,  A23K50/42 ,  A23L2/60 ,  A23L27/33 ,  A23L27/34 ,  A23V2002/00 ,  A23V2200/132 ,  A23V2250/258 ,  A23V2250/262

    摘要： The present invention is directed to the use of rebaudioside A or rebaudioside D in combination with one or more compounds of Formula (I), or a stereoisomer thereof, wherein R2 is rhamnose, and R and R1 are each independently selected from the group consisting of hydrogen, glucose, and beta-sophorose, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables which include a combination of a carbohydrate sweetener, rebaudioside A or rebaudioside D, and one or more compounds of Formula (I), or a stereoisomer thereof.

    摘要翻译： 本发明涉及新蛇菊苷A或莱鲍迪苷D与一种或多种式（I）化合物或其立体异构体的组合的用途，其中R 2是鼠李糖，R 1和R 2各自独立地选自 氢，葡萄糖和β-槐糖，用于增强碳水化合物甜味剂如蔗糖和果糖的甜味。 本发明还涉及包含碳水化合物甜味剂，新蛇菊苷A或莱鲍迪甙D以及一种或多种式（I）化合物或其立体异构体的组合的消耗品。

    Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
    5.
    发明授权
    Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks 有权
    方法，系统和计算机程序产品，用于从库构建块的特征中确定组合图书馆产品的属性

    公开(公告)号：US06834239B2

    公开(公告)日：2004-12-21

    申请号：US09934084

    申请日：2001-08-22

    申请人： Victor S. Lobanov ,  Dimitris K. Agrafiotis ,  F. Raymond Salemme

    发明人： Victor S. Lobanov ,  Dimitris K. Agrafiotis ,  F. Raymond Salemme

    IPC分类号： G06F1900

    CPC分类号： G06N99/005 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/00702 ,  B01J2219/0072 ,  G06N3/02

    摘要： The present invention determines properties of combinatorial library products from features of library building blocks. At least one feature is determined for each building block of a combinatorial library having a plurality of products. A training subset of products is selected from the products, and at least one property is determined for each product of the training subset. A building block set is identified for each product of the training subset, and an input features vector is formed from the features of the identified building blocks for each product of the training subset. A supervised machine learning approach is used to infer a mapping function that transforms the input features vector for each product of the training subset to the corresponding at least one property for each product of the training subset. After the mapping function is inferred, it is used for determining properties of other products of the library from their corresponding input features vectors.

    摘要翻译： 本发明根据图书馆构件的特征确定组合图书馆产品的特性。 为具有多个产品的组合库的每个构建块确定至少一个特征。 从产品中选择产品的训练子集，并确定训练子集的每个产品的至少一个属性。 为训练子集的每个乘积识别构建块集合，并且从训练子集的每个乘积的所识别的构建块的特征形成输入特征向量。 监督机器学习方法被用于推断映射函数，该映射函数将训练子集的每个乘积的输入特征向量变换为训练子集的每个乘积的对应的至少一个属性。 在推测出映射函数之后，它用于从其相应的输入特征向量确定库的其他产品的属性。

    Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
    6.
    发明授权
    Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes 有权
    使用5-（4'-二甲基氨基苯基）-2-（4'-苯基）恶​​唑衍生物荧光染料的配体发育的微板热转移测定

    公开(公告)号：US06569631B1

    公开(公告)日：2003-05-27

    申请号：US09438357

    申请日：1999-11-12

    申请人： Michael W. Pantoliano ,  Eugenio C. Petrella ,  F. Raymond Salemme ,  Barry A. Springer

    发明人： Michael W. Pantoliano ,  Eugenio C. Petrella ,  F. Raymond Salemme ,  Barry A. Springer

    IPC分类号： G01N3353

    CPC分类号： G01N33/582 ,  G01N33/5375

    摘要： The present invention provides a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of unfolding due to a thermal change. The method comprises (a) contacting the target molecule with one molecule of a multiplicity of different molecules, in the presence of a 5-(4″-dimethylaminopheny-2-(4′-phenyl)oxazole derivative dye, in each of a multiplicity of containers; (b) simultaneously heating the multiplicity of containers; (c) measuring the fluorescence in each of the containers; (d) generating thermal unfolding information for the target molecule as a function of temperature for each of the containers; (e) comparing the thermal unfolding information obtained for each of the containers to the thermal unfolding information for the target molecule in the absence of any of the molecules in the multiplicity of different molecules; and (f) ranking the affinities of each of the molecules according to the difference in the thermal unfolding information between the target molecule in each of the containers and the target molecule in the absence of any of the molecules in the multiplicity of different molecules.

    摘要翻译： 本发明提供了一种用于对能够由于热变化而展开的靶分子的多种不同分子的亲和力进行排序的方法。 该方法包括（a）在5-（4“ - 二甲基氨基苯基-2-（4'-苯基）恶​​唑衍生物染料存在下，将目标分子与多个不同分子的一个分子接触， 容器的多样性;（b）同时加热多个容器;（c）测量每个容器中的荧光;（d）作为每个容器的温度的函数产生靶分子的热展开信息;（e ）在不存在多个不同分子中的任何分子的情况下将每个容器获得的热解折叠信息与目标分子的热解折叠信息进行比较;以及（f）根据 在不同分子中多个分子中没有任何分子的情况下，每个容器中的目标分子与靶分子之间的热展开信息的差异。

    Microtiter plate with integral heater
    10.
    发明授权
    Microtiter plate with integral heater 有权
    带有整体加热器的微量滴定板

    公开(公告)号：US06940055B2

    公开(公告)日：2005-09-06

    申请号：US10172993

    申请日：2002-06-18

    申请人： Joseph Kwasnoski ,  F. Raymond Salemme

    发明人： Joseph Kwasnoski ,  F. Raymond Salemme

    IPC分类号： B01L3/00 ,  H05B6/00 ,  H05B6/64

    CPC分类号： B01L3/50851 ,  Y10S435/809

    摘要： A microtiter plate system includes an integral heater. In an embodiment, the integral heater includes a heater plate. In another embodiment, the integral heater includes resistive heater wires positioned beneath and/or between the wells of a microtiter plate. In an embodiment, the microtiter plate system includes optically clear well bottoms that permit sensing and measurement of samples through the optically clear well bottoms. In an implementation, an optically clear heater is positioned beneath the optically clear well bottoms. In an alternative implementation, resistive heater wires are positioned between the wells. In an embodiment, the microtiter plate system includes a microtiter plate lid with an integral heater, which can be implemented using a heater plate, resistive wires, and the like. In an embodiment, the microtiter plate system includes an integral non-contact heater, such as a ferrous plate and/or ferrous particles, powder and/or fibers, which generate heat when subjected to an electromagnetic field. An electromagnetic field can be generated by an inductive coil or the like. In an embodiment, the microtiter plate system includes an integral non-contact heater which generates heat when subjected to microwave radiation from a microwave generator. In an embodiment, the microtiter plate system includes an integral thermostat that maintains a substantially constant temperature in the microtiter plate system.

    摘要翻译： 微量滴定板系统包括一体式加热器。 在一个实施例中，一体式加热器包括加热板。 在另一个实施例中，积分加热器包括位于微量滴定板的孔之下和/或之间的电阻加热丝。 在一个实施方案中，微量滴定板系统包括光学透明的井底，其允许通过光学透明的井底检测和测量样品。 在一个实施方案中，光学透明加热器位于光学透明井底下方。 在替代实施例中，电阻加热器线定位在井之间。 在一个实施方案中，微量滴定板系统包括具有整体加热器的微量滴定板盖，其可以使用加热板，电阻丝等实现。 在一个实施方案中，微量滴定板系统包括一体的非接触式加热器，例如铁质板和/或亚铁颗粒，粉末和/或纤维，其在经受电磁场时产生热量。 可以通过感应线圈等产生电磁场。 在一个实施方案中，微量滴定板系统包括一个整体的非接触式加热器，其在受到来自微波发生器的微波辐射时产生热量。 在一个实施方案中，微量滴定板系统包括在微量滴定板系统中保持基本恒定的温度的整体恒温器。