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公开(公告)号：US09150318B1
公开(公告)日：2015-10-06
申请号：US12650902
申请日：2009-12-31
Applicant: Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick Owens
Inventor： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick Owens
CPC classification number: B65B55/02 , A61L2/0029 , A61L2/0035 , A61L2/007 , A61L2430/40 , B65B31/02 , B65B55/08 , B65B55/16 , B65B55/22
Abstract: The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.
Abstract translation: 本公开提供了用于制备，灭菌和保存组织的各种方法和组合物。 本公开还具有通过该方法制备的无细胞组织基质。
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公开(公告)号：US08735054B1
公开(公告)日：2014-05-27
申请号：US12348188
申请日：2009-01-02
Applicant: Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick Owens , Mark Hayzlett
Inventor： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick Owens , Mark Hayzlett
IPC: A01N1/00
CPC classification number: A01N1/0294 , A01N1/00 , A01N1/0215
Abstract: The present disclosure provides a variety of methods and compositions (e.g., solutions) useful for making, sterilizing, and preserving tissues (e.g., acellular tissue matrices). The disclosure also features the acellular tissue matrices made by the methods, which matrices can be used for a variety of applications such as, but not limited to, treating an injury to, or repairing, a large number of tissues and/or organs (e.g., e.g., fascia, bones, and/or cartilage) in a mammal (e.g., a human).
Abstract translation: 本公开提供了可用于制备，消毒和保存组织（例如，无细胞组织基质）的各种方法和组合物（例如，溶液）。 本公开还具有通过该方法制备的无细胞组织基质，该基质可用于多种应用，例如但不限于治疗大量组织和/或器官的损伤或修复（例如， 例如筋膜，骨骼和/或软骨）在哺乳动物（例如人）中。
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公开(公告)号：US20110238186A1
公开(公告)日：2011-09-29
申请号：US13070891
申请日：2011-03-24
Applicant: Rick Owens , Wendell Sun , Mike Liu , Yong Mao
Inventor： Rick Owens , Wendell Sun , Mike Liu , Yong Mao
CPC classification number: A61F2/0063 , A61L27/3633 , A61L27/48
Abstract: Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.
Abstract translation: 提供了用于治疗或修复组织或器官缺损或损伤的装置和方法。 该装置可以包括由无细胞组织基质和聚合物产生的组织支架，其具有稳定的三维形状并且引起有限的免疫学或炎症反应。
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公开(公告)号：US08784499B2
公开(公告)日：2014-07-22
申请号：US13070891
申请日：2011-03-24
Applicant: Rick Owens , Wendell Sun , Mike Liu , Yong Mao
Inventor： Rick Owens , Wendell Sun , Mike Liu , Yong Mao
IPC: A61F2/28
CPC classification number: A61F2/0063 , A61L27/3633 , A61L27/48
Abstract: Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.
Abstract translation: 提供了用于治疗或修复组织或器官缺损或损伤的装置和方法。 该装置可以包括由无细胞组织基质和聚合物产生的组织支架，其具有稳定的三维形状并且引起有限的免疫学或炎症反应。
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Patent Agency Ranking
公开(公告)号：US20130028984A1
公开(公告)日：2013-01-31
申请号：US13560362
申请日：2012-07-27
Applicant: Hui Xu , Wenquan Sun , Hua Wan , Rick Owens
Inventor： Hui Xu , Wenquan Sun , Hua Wan , Rick Owens
CPC classification number: A61L27/3604 , A61K31/728 , A61K38/1709 , A61K38/18 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/3683 , A61L27/54 , A61L2300/104 , A61L2300/206 , A61L2300/236 , A61L2300/252 , A61L2300/41 , C08L5/08 , A61K2300/00
Abstract: Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.
Abstract translation: 提供衍生自脱细胞组织的组织填充物。 组织填充剂可以包括当植入体内具有降低的炎症反应的无细胞组织基质。 还提供了用于组织填充剂的制备和治疗用途的方法。
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公开(公告)号：US20050180986A1
公开(公告)日：2005-08-18
申请号：US11102757
申请日：2005-04-11
Applicant: Rebecca Rich , Bernd Kriekemeyer , Rick Owens , Magnus Hook , Barbara Murray , Sreedhar Nallapareddy , George Weinstock
Inventor： Rebecca Rich , Bernd Kriekemeyer , Rick Owens , Magnus Hook , Barbara Murray , Sreedhar Nallapareddy , George Weinstock
IPC: A61K39/02 , C07K16/12 , G01N33/569 , G01N33/554 , C07H21/04 , C12N9/48 , C12P21/06
CPC classification number: G01N33/56938 , A61K39/02 , A61K2039/505 , C07K16/1271 , C07K16/1275 , G01N2333/315
Abstract: A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, contains several 47-residue tandem repeat units between the collagen-binding site and cell wall-associated regions. The Ace protein can be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate.
Abstract translation: 提供了一种与来自肠球菌细菌的Ace的胶原结合MSCRAMM，其与来自金黄色葡萄球菌的胶原结合MSCRAMM的Cna的配体结合区同源，并且可用于抑制肠球菌细菌与细胞外基质蛋白的粘附。 Ace的N-末端区域含有一个区域（残基174-319）或A结构域，在胶原结合位点和细胞壁相关区域之间含有多个47个残基的串联重复单元。 Ace蛋白可用于预防和/或治疗肠球菌感染的方法，此外，针对Ace或其A结构域产生的抗体可用于有效抑制肠球菌细胞与胶原底物的粘附。
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公开(公告)号：US20120040013A1
公开(公告)日：2012-02-16
申请号：US13205899
申请日：2011-08-09
Applicant: Rick Owens , Laura Elmo , Mike Liu , Yong Mao
Inventor： Rick Owens , Laura Elmo , Mike Liu , Yong Mao
Abstract: Methods, mixtures, and kits related to treating tissue are provided. The methods, mixtures, and kits can include an acellular tissue matrix, a polymer, and a solvent and may be capable of producing tissue scaffolds. The tissue scaffolds may be able to form a stable, three-dimensional shape in situ and elicit a limited immunologic or inflammatory response.
Abstract translation: 提供了与治疗组织相关的方法，混合物和试剂盒。 方法，混合物和试剂盒可以包括无细胞组织基质，聚合物和溶剂，并且可以能够产生组织支架。 组织支架可能能够原位形成稳定的三维形状并引起有限的免疫学或炎症反应。
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公开(公告)号：US09089523B2
公开(公告)日：2015-07-28
申请号：US13560362
申请日：2012-07-27
Applicant: Hui Xu , Wenquan Sun , Hua Wan , Rick Owens
Inventor： Hui Xu , Wenquan Sun , Hua Wan , Rick Owens
IPC: A61K35/12 , A61K31/728 , A61K33/38 , A61K35/407 , A61K35/42 , A61K45/06 , A61K38/17 , A61K38/18 , A61L27/20 , A61L27/36 , A61L27/54 , C08L5/08
CPC classification number: A61L27/3604 , A61K31/728 , A61K38/1709 , A61K38/18 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/3683 , A61L27/54 , A61L2300/104 , A61L2300/206 , A61L2300/236 , A61L2300/252 , A61L2300/41 , C08L5/08 , A61K2300/00
Abstract: Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.
Abstract translation: 提供衍生自脱细胞组织的组织填充物。 组织填充剂可以包括当植入体内具有降低的炎症反应的无细胞组织基质。 还提供了用于组织填充剂的制备和治疗用途的方法。
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公开(公告)号：US20130280223A1
公开(公告)日：2013-10-24
申请号：US13865629
申请日：2013-04-18
Applicant: Rick Owens , Zhigang Liu
Inventor： Rick Owens , Zhigang Liu
CPC classification number: A61K35/12 , A61K31/7088 , A61K38/16 , A61K38/4886 , A61K38/50 , A61K45/06 , A61L27/362 , A61L27/3687
Abstract: Disclosed herein are tissue treatment products that have been bound to at least one chelating agent. Also disclosed are tissue treatment products that have been functionalized with at least one metal and/or at least one metal-binding protein. The tissue treatment products can have antimicrobial properties and/or factors that promote or enhance native cell migration, proliferation, and/or revascularization after implantation into a subject. Also disclosed are methods of making and using the tissue treatment products. The tissue treatment products can be implanted into a tissue in need of repair, regeneration, healing, treatment, and/or alteration and can promote or enhance native cell migration, proliferation, and/or revascularization.
Abstract translation: 本文公开了已结合至少一种螯合剂的组织处理产品。 还公开了已经用至少一种金属和/或至少一种金属结合蛋白官能化的组织处理产品。 组织处理产品可具有在植入受试者之后促进或增强天然细胞迁移，增殖和/或血运重建的抗微生物特性和/或因素。 还公开了制备和使用组织处理产品的方法。 组织处理产品可以植入需要修复，再生，愈合，治疗和/或改变的组织中，并可以促进或增强天然细胞迁移，增殖和/或血运重建。
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