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    Acellular tissue matrix preservation solution
    3.
    发明授权
    Acellular tissue matrix preservation solution 有权
    无细胞组织基质保存液

    公开(公告)号：US08735054B1

    公开(公告)日：2014-05-27

    申请号：US12348188

    申请日：2009-01-02

    Applicant: Wendell Sun ,  Jerome Connor ,  Qing-Qing Qiu ,  Rick Owens ,  Mark Hayzlett

    Inventor： Wendell Sun ,  Jerome Connor ,  Qing-Qing Qiu ,  Rick Owens ,  Mark Hayzlett

    IPC: A01N1/00

    CPC classification number: A01N1/0294 ,  A01N1/00 ,  A01N1/0215

    Abstract: The present disclosure provides a variety of methods and compositions (e.g., solutions) useful for making, sterilizing, and preserving tissues (e.g., acellular tissue matrices). The disclosure also features the acellular tissue matrices made by the methods, which matrices can be used for a variety of applications such as, but not limited to, treating an injury to, or repairing, a large number of tissues and/or organs (e.g., e.g., fascia, bones, and/or cartilage) in a mammal (e.g., a human).

    Abstract translation: 本公开提供了可用于制备，消毒和保存组织（例如，无细胞组织基质）的各种方法和组合物（例如，溶液）。 本公开还具有通过该方法制备的无细胞组织基质，该基质可用于多种应用，例如但不限于治疗大量组织和/或器官的损伤或修复（例如， 例如筋膜，骨骼和/或软骨）在哺乳动物（例如人）中。

    Bioactive, resorbable scaffolds for tissue engineering
    4.
    发明申请
    Bioactive, resorbable scaffolds for tissue engineering 审中-公开
    生物活性，可吸收的组织工程支架

    公开(公告)号：US20050118236A1

    公开(公告)日：2005-06-02

    申请号：US10721028

    申请日：2003-11-24

    Applicant: Qing-Qing Qiu ,  Charles Cohen ,  Paul Ducheyne

    Inventor： Qing-Qing Qiu ,  Charles Cohen ,  Paul Ducheyne

    IPC: A61B20060101 ,  A61K9/70 ,  A61K45/00 ,  A61L27/10 ,  A61L27/34 ,  A61L27/44 ,  A61L27/56

    CPC classification number: A61L27/446 ,  A61L27/10 ,  A61L27/34 ,  A61L27/56 ,  Y10T442/2525 ,  C08L67/04

    Abstract: Flexible, bioactive glass meshes and scaffolds made therefrom are provided. The meshes comprise interwoven bioactive glass fibers that can be coated with resorbable polymers. Meshes can also be woven from glass fibers and resorbable polymers. Scaffolds can be constructed by a plurality of meshes, which can have varying porosities to create porosity gradients in the scaffold. Methods of making scaffolds are provided which can comprise pulling bioactive glass fibers, winding the fibers, forming the fibers into bundles, coating the fibers with a resorbable polymer, and creating a biaxial weave with the bundles. Soft tissue engineering methods are also provided for creating scaffolds for incubating cells such as fibroblasts and chondroblasts. Meshes and scaffolds are suitable for tissue engineering, such as bone tissue engineering and cartilage tissue engineering.

    Abstract translation: 提供由其制成的柔性，生物活性玻璃网和支架。 网格包括交织的生物活性玻璃纤维，其可以涂覆有可再吸收的聚合物。 网格也可以由玻璃纤维和可再吸收的聚合物编织。 支架可以由多个网孔构成，其可以具有不同的孔隙度以在支架中产生孔隙度梯度。 提供制备支架的方法，其可以包括拉动生物活性玻璃纤维，缠绕纤维，将纤维形成束，用可再吸收的聚合物涂覆纤维，以及用束形成双轴织造。 还提供软组织工程方法用于产生用于孵育细胞如纤维母细胞和软骨细胞的支架。 网格和支架适用于组织工程，如骨组织工程和软骨组织工程。

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