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    MORPHINAN DERIVATIVE
    2.
    发明申请
    MORPHINAN DERIVATIVE 审中-公开

    公开(公告)号：US20180057493A1

    公开(公告)日：2018-03-01

    申请号：US15558026

    申请日：2016-03-17

    申请人： UNIVERSITY OF TSUKUBA ,  SCHOOL JURIDICAL PERSON KITASATO INSTITUTE ,  NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY ,  NIPPON CHEMIPHAR CO., LTD.

    发明人： Hiroshi NAGASE ,  Hideaki FUJII ,  Akiyoshi SAITOH ,  Eriko NAKATA ,  Masaaki HIROSE ,  Isao OOI ,  Kohei HAYASHIDA

    IPC分类号： C07D471/08

    CPC分类号： C07D471/08 ,  A61K31/485

    摘要： A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(═O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.

    DEVICE FOR CELL OR TISSUE CRYOPRESERVATION BY VITRIFICATION
    5.
    发明申请
    DEVICE FOR CELL OR TISSUE CRYOPRESERVATION BY VITRIFICATION 审中-公开
    用于细胞或组织的装置通过维修进行CRYOPRESERVATION

    公开(公告)号：US20160235056A1

    公开(公告)日：2016-08-18

    申请号：US15025571

    申请日：2014-10-17

    申请人： SCHOOL JURIDICAL PERSON KITASATO INSTITUTE ,  MITSUBISHI PAPER MILLS LIMITED

    发明人： Kenji Momozawa ,  Atsushi Matsuzawa ,  Katsumitsu Susaki

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0268 ,  C12M45/22

    摘要： Provided is a device for vitrification-based cryopreservation which enables easy and reliable vitrification freezing of cells or tissues. The device of the present invention for cell or tissue cryopreservation by vitrification has a porous structure made of a material having a refractive index of 1.45 or less as a vitrification solution absorber.

    摘要翻译： 提供了一种用于基于玻璃化的冷冻保存装置，其能够容易且可靠地玻璃化冷冻细胞或组织。 用于通过玻璃化进行细胞或组织冷冻保存的本发明的装置具有由折射率为1.45以下的材料制成的多孔结构作为玻璃化溶液吸收体。

    Fat thickness estimating device, fat thickness estimating system, fat thickness measuring method, and program
    7.
    发明授权
    Fat thickness estimating device, fat thickness estimating system, fat thickness measuring method, and program 有权

    公开(公告)号：US10786176B2

    公开(公告)日：2020-09-29

    申请号：US15123341

    申请日：2015-03-06

    申请人： SCHOOL JURIDICAL PERSON KITASATO INSTITUTE

    发明人： Satoru Nebuya

    IPC分类号： A61B5/053 ,  A61B5/107 ,  A61B5/00

    摘要： A fat thickness estimating device includes a storage unit that stores information indicating relationship between fat thickness and ratio of bioelectrical impedance in a first condition and bioelectrical impedance in a second condition, a measured impedance value acquiring unit configured to acquire a measured impedance value in the first condition of a target living body and a measured impedance value in the second condition of the target living body, and an estimation unit configured to calculate a fat thickness value in the target living body based on the information and a ratio of the measured impedance value in the first condition and the measured impedance value in the second condition.

    EIT measurement device, EIT measurement method and program
    9.
    发明授权
    EIT measurement device, EIT measurement method and program 有权

    公开(公告)号：US10285618B2

    公开(公告)日：2019-05-14

    申请号：US14901445

    申请日：2014-07-01

    申请人： SCHOOL JURIDICAL PERSON KITASATO INSTITUTE

    发明人： Satoru Nebuya ,  So Hifumi

    IPC分类号： A61B5/00 ,  A61B5/053 ,  A61B5/107

    摘要： An electrical impedance tomography (EIT) measurement device (1) includes a measurement belt (10) to which a plurality of electrode pads arranged in a row and a plurality of strain gauges arranged in parallel to the plurality of electrode pads are integrally adhered and configured to be used after being wrapped around a portion (X) serving as a measurement target of a living body, an EIT measurement control unit configured to acquire a tomographic image of the portion (X) serving as the measurement target while applying a current to the plurality of electrode pads and acquiring a voltage signal generated between the electrode pads, and a contour estimation unit configured to estimate a contour shape of the portion serving as the measurement target and a size of the contour shape on the basis of curvature data acquired via the strain gauge.

    Method and system for determining power of intraocular lens to be inserted
    10.
    发明授权
    Method and system for determining power of intraocular lens to be inserted 有权
    用于确定要插入的眼内透镜的功率的方法和系统

    公开(公告)号：US09380933B2

    公开(公告)日：2016-07-05

    申请号：US14564754

    申请日：2014-12-09

    申请人： SCHOOL JURIDICAL PERSON KITASATO INSTITUTE

    发明人： Shuntaro Tsunehiro

    IPC分类号： A61B3/00 ,  A61B3/10 ,  A61F2/16

    CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61F2/145 ,  A61F2/16

    摘要： The present invention accurately predicts postoperative intraocular lens position on the basis of a shape image of the crystalline lens obtained by an optical interference tomographic imaging device. This makes it possible to reduce the postoperative refractive error and determine the power of the intraocular lens. The present invention comprises: a step for finding by computer the equatorial position, which is the site of maximum diameter in the crystalline lens, from the morphology of the crystalline lens obtained from a tomographic image of the patients eye generated by the optical interference tomographic imaging device; and a step for estimating the position of the intraocular lens from the equatorial position thus found.

    摘要翻译： 本发明基于通过光学干涉断层成像装置获得的晶状体的形状图像来准确地预测术后眼内透镜位置。 这使得可以减少术后屈光不正并确定眼内透镜的功率。 本发明包括：通过计算机发现赤道位置，该晶体位置是晶状体中最大直径的位置，从由光学干涉层析成像产生的患者眼睛的断层图像获得的晶状体的形态 设备; 以及用于从所发现的赤道位置估计眼内透镜的位置的步骤。