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    Leukemic stem cell markers
    5.
    发明申请
    Leukemic stem cell markers 审中-公开
    白血病干细胞标志物

    公开(公告)号：US20160305945A1

    公开(公告)日：2016-10-20

    申请号：US15102075

    申请日：2014-12-02

    Applicant: Stichting VU-VUmc

    Inventor： Gerrit Johan OSSENKOPPELE ,  Gerrit Jan SCHUURHUIS ,  Wendelien ZEIJLEMAKER

    IPC: G01N33/574 ,  G01N15/14 ,  G01N33/50

    CPC classification number: G01N33/57426 ,  G01N15/14 ,  G01N33/5011 ,  G01N33/5073 ,  G01N33/57492 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2800/52

    Abstract: The present invention relates to a method for identifying Leukemic stem cells (LSC), based on measurement of the presence of a specific set of markers. The invention further relates to a container for use in performing the method. Also provided is application of the method for predicting response to therapy and/or chance of relapse of Acute Myeloid Leukemia, and application of the method in the context of screening for compounds that specifically eradicate Leukemic cells and not benign cells.

    Abstract translation: 本发明涉及一种用于鉴别白血病干细胞（LSC）的方法，该方法是基于特定标记物组的存在的测量。 本发明还涉及一种用于执行该方法的容器。 还提供了预测对急性骨髓性白血病的治疗反应和/或复发机率的方法的应用，以及在筛选特异性根除白血病细胞而不是良性细胞的化合物的上下文中应用该方法。

    Microscopic Imaging Apparatus and Method to Detect a Microscopic Image
    6.
    发明申请
    Microscopic Imaging Apparatus and Method to Detect a Microscopic Image 审中-公开
    显微镜成像设备和检测显微镜图像的方法

    公开(公告)号：US20150234170A1

    公开(公告)日：2015-08-20

    申请号：US14424700

    申请日：2013-08-27

    Applicant: STICHTING VU-VUMC

    Inventor： Stefan Michiel Witte ,  Kjeld Sijbrand Eduard Eikema

    IPC: G02B21/36 ,  G02B21/16 ,  G02B21/06

    CPC classification number: G02B21/367 ,  G02B21/06 ,  G02B21/16 ,  G02B21/365 ,  G03F7/70616

    Abstract: A microscopic imaging apparatus to provide an image of a sample. The apparatus includes an illumination system to provide an illumination beam with radiation; and a sensor constructed and arranged to receive: a first image of a first diffraction pattern created by diffraction of the illumination beam on the sample; and a second image of a second diffraction pattern created by diffraction of the illumination beam on the sample.

    Abstract translation: 一种用于提供样品图像的显微成像装置。 该装置包括用于向辐射提供照明光束的照明系统; 以及传感器，被构造和布置成接收：通过所述样品上的所述照射光束的衍射而产生的第一衍射图案的第一图像; 以及由样品上的照明光束衍射产生的第二衍射图案的第二图像。

    SUTURE DEVICE
    7.
    发明申请
    SUTURE DEVICE 审中-公开
    SUTURE设备

    公开(公告)号：US20140316442A1

    公开(公告)日：2014-10-23

    申请号：US14358136

    申请日：2012-11-16

    Applicant: Stichting VU-VUMC

    Inventor： Rianne Irene Van Loenen ,  Micha Ilan Paalman ,  Alexander Arnold Frederik Adriann Veenhof

    IPC: A61B17/04

    CPC classification number: A61B17/0469 ,  A61B2017/047 ,  A61B2017/0472 ,  F04C2270/0421

    Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.

    Abstract translation: 缝合装置包括在至少插入位置和针转移位置之间相对于壳体纵向移动的针操作装置。 针操作装置包括从壳体的远端延伸到壳体近端或靠近壳体近端的细长操作元件。 连接在操作元件的远端处的针保持器保持两个或更多针，其自由端朝向近端方向。 保持器在至少保护自由端的保护位置与保护装置的非保护位置之间相对于保护装置可移动。 当操作装置移动到转移位置时，在壳体的远端处的针接收装置接收自由端。 在至少插入位置中，保持器和保护装置与壳体纵向隔开以在其间接收组织。

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