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公开(公告)号：US09672330B2
公开(公告)日：2017-06-06
申请号：US12739335
申请日：2007-10-23
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
CPC分类号： G06F19/703 , G01N33/6848 , H01J49/0027 , H01J49/004
摘要： A product ion spectrum is created on the basis of MS2 analysis data respectively obtained for a parent compound and a metabolite (S1 and S2). Additionally, a neutral loss spectrum, in which the mass of each product ion is replaced with a mass difference between the mass of the product ion and that of a precursor ion, is created (S3). Then, a common peak having the same mass on the neutral loss spectrums of both the parent compound and the metabolite is extracted (S4), and a complementary peak appearing on the product ion spectrum of the metabolite is extracted (S5); this peak appears at a position corresponding to the difference between the mass of the common peak and that of the precursor ion. The ion corresponding to the complementary peak is designated as a precursor ion for the next MS3 analysis (S6), and this MS3 analysis is performed (S7). By a dissociation operation, if a portion common to the parent compound and the metabolite is desorbed in the form of a neutral molecule while a different portion remains in the form of an ion, an MS3 analysis in which the ion of the different portion is used as the precursor ion is performed to obtain structural information of a site of metabolism.
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公开(公告)号：US20130306857A1
公开(公告)日：2013-11-21
申请号：US13981833
申请日：2011-01-31
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
CPC分类号： H01J49/0036 , H01J49/004 , H01J49/022
摘要： A molecular weight is determined from an actually measured mass spectrum of a target substance, and a database search is performed to extract candidates of a chemical structural formula corresponding to the molecular weight (S2, S3). By using an algorithm for predicting a dissociation pattern, product ions to be produced by a dissociating operation are predicted for each candidate of the chemical structural formula (S4). The predicted pattern of the product ions is compared with an actually measured MS2 spectrum, and a degree of similarity representing the degree of matching of the pattern is calculated (S5). When there are a plurality of candidates of the chemical structural formula, the candidates are displayed in order of their degrees of similarity (S6).
摘要翻译： 从实际测定的物质质谱确定分子量，进行数据库检索，以提取与分子量对应的化学结构式的候选物（S2，S3）。 通过使用用于预测解离图案的算法，针对化学结构式的每个候选物（S4）预测通过解离操作产生的产物离子。 将产物离子的预测图案与实际测量的MS2光谱进行比较，并计算表示图案的匹配程度的相似度（S5）。 当存在化学结构式的多个候选者时，以相似度的顺序显示候选（S6）。
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公开(公告)号：US08417466B2
公开(公告)日：2013-04-09
申请号：US12739108
申请日：2007-10-22
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
CPC分类号： G01N27/62 , G06F19/703 , H01J49/0036 , H01J49/004
摘要： A product ion spectrum is created on the basis of MS2 analysis data respectively obtained for a parent compound and a metabolite (S1 and S2). Additionally, a neutral loss spectrum, in which the mass of each product ion is replaced with a mass difference between the mass of the product ion and that of a precursor ion, is created (S3). Then, a common peak having the same mass in both the parent compound and the metabolite is extracted (S4), and a complementary peak appearing at a position corresponding to the difference between the mass of the common peak and that of the precursor ion is extracted (S5); the complementary peak corresponding to a common peak located on the product ion spectrum appears on the neutral loss spectrum, while the complementary peak corresponding to a common peak located on the neutral loss spectrum appears on the product ion spectrum. In the process of displaying the four spectrums in an integrated form, different display colors are assigned to the common peak, complementary peak and other peaks so that the different peaks can be easily distinguished (S6 to S9).
摘要翻译： 基于分别为母体化合物和代谢物获得的MS2分析数据产生产物离子谱（S1和S2）。 另外，产生中性损失谱，其中每个产物离子的质量被产物离子的质量与前体离子的质量之间的质量差代替（S3）。 然后，提取在母体化合物和代谢物中具有相同质量的共同峰（S4），并且提取出现在对应于共峰的质量与前体离子的质量之间的位置处的互补峰 （S5）; 对应于位于产物离子光谱上的共同峰的互补峰出现在中性损失光谱上，而对应于位于中性损失光谱上的共同峰的互补峰出现在产物离子光谱上。 在以集成形式显示四个光谱的过程中，将不同的显示颜色分配给共同的峰值，互补峰值和其他峰值，使得可以容易地区分不同的峰值（S6至S9）。
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公开(公告)号：US08026476B2
公开(公告)日：2011-09-27
申请号：US12307857
申请日：2006-09-21
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
IPC分类号： H01J49/42
CPC分类号： H01J49/0027 , G01N27/62 , H01J49/0081
摘要： When the analyzer provides the mass and composition formula of the product ion, which is probably produced in the process of a dissociation, through the input unit, based on known information, a composition formula list is created in the database. When a product ion is obtained in an MSn analysis, the data processor checks whether or not the ion's mass exists in the composition formula list, and in the case where it does, the composition formula corresponding to the mass is determined. Then, based the mass difference between the precursor ion and product ion or other factors, the precursor ion's composition formula is deduced, and if it is possible to ultimately narrow down the candidates for the target ion's composition formula, the analysis is terminated. Accordingly, if the composition formula list is available, the refinement operation for the candidates for the composition formula can be omitted.
摘要翻译： 当分析仪提供可能在解离过程中产生的产物离子的质量和组成公式时，通过输入单元，基于已知信息，在数据库中创建组成公式列表。 当在MSn分析中获得产物离子时，数据处理器检查组成公式列表中是否存在离子的质量，并且在它的情况下，确定与质量相对应的组成公式。 然后，基于前体离子与产物离子或其他因素的质量差，推导出前体离子的组成式，如果最终可能缩小目标离子组成式的候选物，则终止分析。 因此，如果组合式列表可用，则可以省略用于组成式的候选的细化操作。
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公开(公告)号：US20110192971A1
公开(公告)日：2011-08-11
申请号：US13125545
申请日：2008-10-30
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
IPC分类号： H01J49/40
CPC分类号： H01J49/408
摘要： A variety of ions generated in an ion source are made to fly while bypassing a loop orbit and mass analyzed to create a mass spectrum. Among the peaks appearing on the mass spectrum, peaks complying with predetermined conditions are extracted to determine a plurality of mass ranges to be measured (S1 through S3). Next, the ion selection conditions for the timing when ions should be injected into the loop orbit and on the loop orbit are determined for each mass range. In addition, deviation conditions under which selected ions will not be mixed are determined (S4 and S5). When the second measurement is performed for the same sample, ions are put into the loop orbit and unnecessary ions are removed from the loop orbit in accordance with the ion selection conditions (S6 and S7). Thus, only the ions to be measured are left on the loop orbit with a high mass resolving power. Then, these ions are sequentially deviated from the loop orbit in accordance with the ion deviation conditions, dissociated, and then mass analyzed (S8). In this manner, MS/MS analyses are performed for each of the plurality of ions to be measured to create an MS/MS spectrum (S10).
摘要翻译： 在离子源中产生的各种离子被制成飞行，同时绕过环路轨道并进行质量分析以产生质谱。 在质谱中出现的峰中，提取符合预定条件的峰以确定待测量的多个质量范围（S1至S3）。 接下来，对于每个质量范围确定离子应注入环路轨道和环路轨道的定时的离子选择条件。 此外，确定不混合选定离子的偏差条件（S4和S5）。 当对相同的样品进行第二次测量时，根据离子选择条件将离子放入环轨道中，并从环路轨道中除去不需要的离子（S6和S7）。 因此，只有待测量的离子留在具有高质量分辨能力的环路轨道上。 然后，这些离子根据离子偏离条件依次偏离环路轨道，解离，然后进行质量分析（S8）。 以这种方式，对待测量的多个离子中的每一个执行MS / MS分析以产生MS / MS谱（S10）。
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公开(公告)号：US20110042567A1
公开(公告)日：2011-02-24
申请号：US12933058
申请日：2008-03-17
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
IPC分类号： H01J49/10
CPC分类号： G01N27/62 , H01J49/044 , H01J49/165
摘要： A sample solution containing a sample component is sprayed onto an atmosphere at atmospheric approximately pressure while being applied with electric charge from the tip of a nozzle (1). A sample molecule is released as an ion in a process where charged minute liquid droplets collide with an atmospheric gas and are broken apart, and a solvent is vaporized from the respective liquid droplets. A reflectron (7) in the shape of a half-cut spheroid is arranged in such a manner that a second focal point (F2) is positioned in front of an ion-introducing portion (4) in the spray flow. A discharge electrode (8) is disposed in a position at a first focal point (F1) of the reflectron (7). When pulsed high voltage is applied to the discharge electrode (8), an electric discharge occurs, causing shock waves to be generated. The shock waves reflected on the reflectron (7) are converged on the second focal point (F2). Due to the converged shock waves, the vicinity of the second focal point (F2) rises to a high temperature, and a large pressure is also applied thereto. Therefore, vaporization of a solvent from the respective liquid droplets is further accelerated, allowing an ion to be easily generated. In addition, direct ionization can be expected. This makes it possible to improve ion generation efficiency.
摘要翻译： 将包含样品组分的样品溶液在大气压大气压下喷雾，同时从喷嘴（1）的尖端施加电荷。 在带电的微小液滴与大气气体碰撞并分离开的过程中，样品分子作为离子释放，并且溶剂从各个液滴中汽化。 以半切球体形状的反射镜（7）以这样的方式布置，使得第二焦点（F2）位于喷射流中的离子引入部分（4）的前面。 放电电极（8）设置在反射器（7）的第一焦点（F1）的位置。 当向放电电极（8）施加脉冲高电压时，发生放电，产生冲击波。 在反射镜（7）上反射的冲击波会聚在第二焦点（F2）上。 由于会聚的冲击波，第二焦点（F2）的附近上升到高温，也施加大的压力。 因此，来自各液滴的溶剂的蒸发进一步加速，容易产生离子。 此外，可以预期直接电离。 这使得可以提高离子产生效率。
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公开(公告)号：US20100257829A1
公开(公告)日：2010-10-14
申请号：US12679610
申请日：2008-09-26
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
CPC分类号： C04B35/478 , B01D46/2429 , B01D46/244 , B01D46/247 , B01D2046/2433 , B01D2046/2481 , B01D2046/2485 , B01D2046/2488 , B01D2046/2496 , B01D2279/30 , C04B38/0006 , C04B2111/00793 , C04B2235/3201 , C04B2235/3206 , C04B2235/3234 , C04B2235/3418 , C04B2235/5436 , C04B2235/72 , C04B2235/77 , C04B2235/80 , C04B2235/96 , C04B2235/9607 , Y10T428/131 , Y10T428/24149 , C04B38/0074 , C04B38/067 , C04B38/068
摘要： There are required a honeycomb structure that is excellent in heat resistance and thermal shock resistance and is less likely to undergo thermal decomposition, and also exhibits stable mechanical properties even when subjected to a heat treatment, and a purifying apparatus using the same. The honeycomb structure of the present invention includes a honeycomb structure made from a ceramic body including a crystal of MgTi2O5—Al2TiO5. The purifying apparatus includes a honeycomb structural, and a casing that accommodates the honeycomb structure and has an inlet port and an outlet port, wherein a fluid introduced through the inlet port of the casing is passed through the honeycomb structure and then discharged through the outlet port of the casing.
摘要翻译： 需要具有优异的耐热性和耐热冲击性并且不太可能发生热分解的蜂窝结构体，并且即使在进行热处理时也表现出稳定的机械性能，以及使用该蜂窝结构体的净化装置。 本发明的蜂窝结构体包括由包含MgTi 2 O 5 -Al 2 TiO 5的结晶的陶瓷体制成的蜂窝结构体。 净化装置包括蜂窝结构体和容纳蜂窝结构体并具有入口和出口的壳体，其中通过壳体的入口引入的流体通过蜂窝结构，然后通过出口端口 的套管。
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公开(公告)号：US07474027B2
公开(公告)日：2009-01-06
申请号：US10542375
申请日：2003-01-15
IPC分类号： H02K1/27
CPC分类号： H02K1/276
摘要： A permanent magnet motor 1 includes a rotor in which permanent magnets 31 are fixed. In the rotor 20, the outer peripheral shape of rotor magnetic-pole portions 24 is formed so that, in the circumferentially central portion, the distance from the center of the rotor iron core 21 is longest, and, at the inter-polar space, the distance from the center of the rotor iron core is shortest, and so that the outermost surface of the rotor magnetic-pole portions 24 forms an arc, and given that sheath thickness tc formed by the outer-side surface of each permanent magnet 31 and the outermost surface of each rotor magnetic-pole portion 24 is practically constant, and letting the thickness of the permanent magnets be the magnet thickness tm, then the relation tc/tm≦0.25 is satisfied.
摘要翻译： 永磁电动机1包括固定永磁体31的转子。 在转子20中，转子磁极部24的外周形状形成为在圆周方向的中心部从转子铁芯21的中心的距离最长的位置，在极间空间处， 从转子铁芯的中心的距离最短，转子磁极部分24的最外表面形成一个电弧，并且给定由每个永磁体31的外侧表面形成的护套厚度tc和 每个转子磁极部24的最外表面几乎恒定，并且使永磁体的厚度为磁铁厚度tm，则满足关系式tc / tm <= 0.25。
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公开(公告)号：US07355168B2
公开(公告)日：2008-04-08
申请号：US11353112
申请日：2006-02-14
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
IPC分类号： H01J49/40
CPC分类号： H01J49/282 , H01J49/408
摘要： The present invention provides a time of flight mass spectrometer having an ion optics forming a multi-turn track, which is capable of time-focusing the ions while allowing the multi-turn track to be configured in an unlimited and highly variable manner. In a specific form of the invention, a reflector 9 is provided on the flight path between the position where the ions leave the loop orbit P and the ion detector 10 located outside the loop orbit P, and the condition of the electric field generated by the reflector 9 is appropriately determined. Thus, even if the ions cannot be well time-focused by the ion optics 2 creating the sector-shaped electric fields 4 and 7, it is possible to compensate the time-focusing performance with the reflector 9 to achieve a good performance of time-focusing of the ion throughout the overall system wherein the ions leave the ion source 1 and finally reach the ion detector 10. Thereby, the ions can reach the ion detector 10 at approximately the same time even if the ions having the same mass number have different levels of energy at the moment they leave the ion source 1.
摘要翻译： 本发明提供了具有形成多匝轨道的离子光学器件的飞行时间质谱仪，其能够对离子进行时间聚焦，同时允许多匝轨道以无限和高度可变的方式配置。 在本发明的具体形式中，在离开离开环路轨道P的位置和位于环路轨道P外部的离子检测器10之间的飞行路径上设置反射器9，以及由 反射器9被适当地确定。 因此，即使由离子光学器件2产生的扇形电场4和7不能很好地对离子进行时间聚焦，也可以利用反射体9补偿时间聚焦性能， 将离子聚焦在整个系统中，其中离子离开离子源1并最终到达离子检测器10。 因此，即使具有相同质量数的离子在离开离子源1的时刻具有不同的能量水平，离子也可以在大约相同的时间到达离子检测器10。
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公开(公告)号：US20050151076A1
公开(公告)日：2005-07-14
申请号：US11032002
申请日：2005-01-11
CPC分类号： H01J49/408
摘要： In the mass spectrometer of the present invention, a flight space is provided before the mass analyzer, and the flight space includes a loop orbit on which ions fly repeatedly. While ions fly on the loop orbit repeatedly, ion selecting electrodes placed on the loop orbit selects object ions having a specific mass to charge ratio in such a manner that, for a limited time period when the object ions are flying through the ion selecting electrodes, an appropriate voltage is applied to the ion selecting electrodes to make them continue to fly on the loop orbit, but otherwise to make or let other ions deflect from the loop orbit. If ions having various mass to charge ratios are introduced in the loop orbit almost at the same time, the object ions having the same mass to charge ratio continue to fly on the loop orbit in a band, but ions having mass to charge ratios different from that are separated from the object ions while flying on the loop orbit repeatedly. Even if the difference in the mass to charge ratio is small, the separation becomes large when the number of turns of the flight becomes large. After such a separation is adequately achieved, the ion selecting electrodes can select the object ions with high selectivity, or at high mass resolution. By adding dissociating means, fragment ions originated only from the selected object ions can be analyzed, which enables the identification and structural analysis of the sample at high accuracy.
摘要翻译： 在本发明的质谱仪中，在质量分析器之前提供飞行空间，并且飞行空间包括离子重复飞行的环轨道。 当离子重复地在环路轨道上飞行时，放置在环路轨道上的离子选择电极以这样的方式选择具有特定质荷比的物体离子，使得在物体离子飞过离子选择电极的有限时间段内， 对离子选择电极施加适当的电压使它们继续在环轨道上飞行，而另外使其它离子从环轨道偏转。 如果几乎同时在环路轨道中引入具有各种质荷比的离子，则具有相同质荷比的物体离子在带内的环路轨道上继续飞行，但质量与电荷比的离子不同于 它们与物体离子分离，同时在环路轨道上重复飞行。 即使质荷比的差小，当飞行匝数变大时，分离也变大。 在这种分离充分实现之后，离子选择电极可以以高选择性或高质量分辨率选择目标离子。 通过添加解离手段，可以分析仅从所选择的对象离子产生的碎片离子，这使得能够高精度地鉴定和结构分析样品。
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