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公开(公告)号：US09080188B2
公开(公告)日：2015-07-14
申请号：US13305414
申请日：2011-11-28
申请人： Stephen Picataggio , Robert C. Brown , Jessica R. Kristof , Gena Roy , Prachee Prakash , Stuart A. Underwood , Kevin Watts , Kevin V. Martin
发明人： Stephen Picataggio , Robert C. Brown , Jessica R. Kristof , Gena Roy , Prachee Prakash , Stuart A. Underwood , Kevin Watts , Kevin V. Martin
IPC分类号： C12N1/00 , C12P7/00 , C12P7/64 , C12P7/16 , C12N9/00 , C12N9/02 , C12P21/06 , C07H21/04 , C10L1/02 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12P7/04
CPC分类号： C12P7/16 , C10L1/02 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , Y02E50/343
摘要： This invention describes genes, metabolic pathways, microbial strains and methods to produce methylbutanol and other compounds of interest from renewable feedstocks.
摘要翻译： 本发明描述了可再生原料生产甲基丁醇和其他化合物的基因，代谢途径，微生物菌株和方法。
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公开(公告)号：US20140322780A1
公开(公告)日：2014-10-30
申请号：US13305414
申请日：2011-11-28
申请人： Stephen Picataggio , Robert C. Brown , Jessica R. Kristof , Gena Roy , Prachee Prakash , Stuart A. Underwood , Kevin Watts , Kevin V. Martin
发明人： Stephen Picataggio , Robert C. Brown , Jessica R. Kristof , Gena Roy , Prachee Prakash , Stuart A. Underwood , Kevin Watts , Kevin V. Martin
CPC分类号： C12P7/16 , C10L1/02 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , Y02E50/343
摘要： This invention describes genes, metabolic pathways, microbial strains and methods to produce methylbutanol and other compounds of interest from renewable feedstocks.
摘要翻译： 本发明描述了可再生原料生产甲基丁醇和其他化合物的基因，代谢途径，微生物菌株和方法。
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公开(公告)号：US08343752B2
公开(公告)日：2013-01-01
申请号：US13245780
申请日：2011-09-26
申请人： Stephen Picataggio , Tom Beardslee
发明人： Stephen Picataggio , Tom Beardslee
IPC分类号： C12N1/00 , C12N15/00 , C12N15/74 , C12P21/06 , C12P19/34 , C12P7/46 , C12P7/44 , C07H21/04 , C07K1/00
CPC分类号： C12P7/44 , C12N9/001 , C12N9/0042 , C12N9/0073 , C12Y103/03006 , C12Y602/01001 , C12Y602/01003
摘要： The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.
摘要翻译： 该技术部分地涉及用于生产己二酸的生物学方法和能够进行这种生产的工程微生物。
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公开(公告)号：US08227236B2
公开(公告)日：2012-07-24
申请号：US13045855
申请日：2011-03-11
IPC分类号： C12N1/00
摘要： Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.
摘要翻译： 本文提供了具有增强的发酵活性的遗传修饰的微生物，以及用于制备和使用这些微生物的方法。
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公开(公告)号：US08114641B2
公开(公告)日：2012-02-14
申请号：US12332305
申请日：2008-12-10
申请人： Stephen Picataggio , Robert C. Brown , Jessica R. Kristof , Gena Roy , Prachee Prakash , Stuart A. Underwood , Kevin Watts , Kevin V. Martin
发明人： Stephen Picataggio , Robert C. Brown , Jessica R. Kristof , Gena Roy , Prachee Prakash , Stuart A. Underwood , Kevin Watts , Kevin V. Martin
IPC分类号： C12P7/00 , C12P7/16 , C12P5/02 , C12P21/06 , C12N9/02 , C12N9/00 , C12N1/16 , C10L1/18 , C07H21/04
CPC分类号： C12P7/16 , C10L1/02 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , Y02E50/343
摘要： This invention describes genes, metabolic pathways, microbial strains and methods to produce methyl butanol and other compounds of interest from renewable feedstocks.
摘要翻译： 本发明描述了可再生原料生产甲基丁醇和其他化合物的基因，代谢途径，微生物菌株和方法。
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公开(公告)号：US20070065867A1
公开(公告)日：2007-03-22
申请号：US11541810
申请日：2006-10-02
申请人： Mark Payne , Stephen Picataggio , Amy Hsu , Ramesh Nair , Fernado Valle , Philippe Soucaille , Donald Trimbur
发明人： Mark Payne , Stephen Picataggio , Amy Hsu , Ramesh Nair , Fernado Valle , Philippe Soucaille , Donald Trimbur
摘要： This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful for genetic engineering in microorganisms, especially where multiple genetic insertions are sought.
摘要翻译： 本发明提供了一系列含有限制性内切核酸酶识别位点的低拷贝数质粒，所述限制性内切核酸酶识别位点用于克隆至少三种不同的基因或操纵子，每个侧翼有终止子序列，所述质粒含有不同水平的蛋白质表达的葡萄糖异构酶启动子的变体。 这些材料和方法可用于微生物的遗传工程，特别是在寻求多种遗传插入的情况下。
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公开(公告)号：US20060110806A1
公开(公告)日：2006-05-25
申请号：US11264737
申请日：2005-11-01
申请人： Howard Damude , Peter Gillies , Daniel Macool , Stephen Picataggio , James Ragghianti , John Seip , Zhixiong Xue , Narendra Yadav , Hongxiang Zhang , Quinn Zhu
发明人： Howard Damude , Peter Gillies , Daniel Macool , Stephen Picataggio , James Ragghianti , John Seip , Zhixiong Xue , Narendra Yadav , Hongxiang Zhang , Quinn Zhu
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N1/16 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12N15/746 , C12N15/815 , C12P7/6472 , A23V2250/187 , A23V2200/30
摘要： An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.
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公开(公告)号：US20050147968A1
公开(公告)日：2005-07-07
申请号：US10420587
申请日：2003-04-22
申请人： Mark Payne , Stephen Picataggio , Amy Hsu , Ramesh Nair , Fernado Valle , Philippe Soucaille , Donald Trimbur
发明人： Mark Payne , Stephen Picataggio , Amy Hsu , Ramesh Nair , Fernado Valle , Philippe Soucaille , Donald Trimbur
IPC分类号： C12N15/09 , C12N1/21 , C12N9/90 , C12N15/61 , C12N15/70 , C12P7/18 , C12Q1/68 , C07H21/04 , C12N15/74
摘要： This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful for genetic engineering in microorganisms, especially where multiple genetic insertions are sought.
摘要翻译： 本发明提供了一系列含有限制性内切核酸酶识别位点的低拷贝数质粒，所述限制性内切核酸酶识别位点用于克隆至少三种不同的基因或操纵子，每个侧翼有终止子序列，所述质粒含有不同水平的蛋白质表达的葡萄糖异构酶启动子的变体。 这些材料和方法可用于微生物的遗传工程，特别是在寻求多种遗传插入的情况下。
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公开(公告)号：US5254466A
公开(公告)日：1993-10-19
申请号：US432091
申请日：1989-11-06
CPC分类号： C12R1/74 , C12N15/00 , C12N15/01 , C12N15/815 , C12N15/90 , C12P7/44 , Y10S435/924
摘要： The POX genes of C. tropicalis are disrupted resulting in the complete blockage of the beta-oxidation pathway in the strain. Fermentation of C. tropicalis cells having disrupted genes on alkane, fatty acid and fatty acid ester substrates produces substantially pure dicarboxylic acids in substantially quantitative yield.
摘要翻译： 热带假丝酵母的POX基因被破坏，导致菌株中β-氧化途径的完全阻断。 在烷烃，脂肪酸和脂肪酸酯底物上具有破坏基因的热带假丝酵母细胞的发酵以基本上定量的产率产生基本上纯的二羧酸。
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公开(公告)号：US08778658B2
公开(公告)日：2014-07-15
申请号：US13549076
申请日：2012-07-13
申请人： Stephen Picataggio , Tom Beardslee
发明人： Stephen Picataggio , Tom Beardslee
CPC分类号： C12N15/815 , C12N9/0006 , C12N15/52 , C12P7/44
摘要： The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.
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