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    Systems, methods, and computer readable media for high frequency contrast imaging and image-guided therapeutics
    1.
    发明授权
    Systems, methods, and computer readable media for high frequency contrast imaging and image-guided therapeutics 有权
    用于高频对比成像和图像引导治疗的系统，方法和计算机可读介质

    公开(公告)号：US09532769B2

    公开(公告)日：2017-01-03

    申请号：US13393500

    申请日：2010-09-07

    申请人： Paul A. Dayton ,  Ryan Gessner ,  Hyunggyun Lee ,  Marc Lukacs ,  Francis Stuart Foster

    发明人： Paul A. Dayton ,  Ryan Gessner ,  Hyunggyun Lee ,  Marc Lukacs ,  Francis Stuart Foster

    IPC分类号： A61B8/00 ,  A61B8/08 ,  A61M37/00

    CPC分类号： A61B8/481 ,  A61M37/0092

    摘要： Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics are disclosed. According to one aspect a method for high frequency contrast imaging and image-guided therapeutics includes: providing ultrasound of a first frequency bandwidth, directed toward the volume to be imaged, the volume containing a carrier having non-linear acoustical properties, wherein the ultrasound of the first frequency bandwidth causes the carrier to generate ultrasound of a second frequency bandwidth that is different from the first frequency bandwidth; receiving, from the volume to be imaged, ultrasound of the second frequency bandwidth; and using the received ultrasound of the second frequency bandwidth to generate an image of the volume to be imaged, wherein the components of the second frequency bandwidth that are detected are of a frequency greater than 20 MHz. According to another aspect, ultrasound at a first frequency bandwidth enables imaging of a target, and ultrasound at a second frequency bandwidth mediates drug or gene delivery to a portion of the target, as guided by the image provided by the first frequency.

    摘要翻译： 公开了用于高频对比成像和图像引导治疗剂的系统，方法和计算机可读介质。 根据一个方面，用于高频对比成像和图像引导治疗的方法包括：提供针对待成像的体积的第一频率带宽的超声波，该体积包含具有非线性声学特性的载体，其中超声波 所述第一频率带宽使所述载波产生与所述第一频带宽度不同的第二频带宽度的超声波; 从要成像的体积中接收第二频带的超声波; 以及使用所接收的所述第二频率带宽的超声波产生要成像的体积的图像，其中所检测的所述第二频率带宽的分量具有大于20MHz的频率。 根据另一方面，在第一频率带宽上的超声使得能够对目标进行成像，并且在由第一频率提供的图像的指导下，以第二频率带宽的超声介导药物或基因递送到目标的一部分。

    METHOD, SYSTEM AND USE FOR THERAPEUTIC ULTRASOUND
    2.
    发明申请
    METHOD, SYSTEM AND USE FOR THERAPEUTIC ULTRASOUND 有权
    方法，系统和治疗超声的使用

    公开(公告)号：US20150148711A1

    公开(公告)日：2015-05-28

    申请号：US14543215

    申请日：2014-11-17

    申请人： Matthew Bujak ,  F. Stuart Foster ,  Michael Hynes

    发明人： Matthew Bujak ,  F. Stuart Foster ,  Michael Hynes

    IPC分类号： A61N7/00 ,  A61F9/007

    CPC分类号： A61N7/00 ,  A61F9/007

    摘要： The described embodiments relate to methods, systems and uses for therapeutic ultrasound, and in particular, to methods, systems and uses for therapeutic ultrasound and contact lenses for treating or alleviating eye conditions. The described embodiments relate to methods, systems and uses that involve an ultrasound device configured for treatment of an eye condition and a contact lens protects ocular tissue of the eye and forms a chamber of air.

    摘要翻译： 所描述的实施例涉及用于治疗性超声的方法，系统和用途，特别涉及用于治疗或减轻眼睛状况的治疗性超声和隐形眼镜的方法，系统和用途。 所描述的实施例涉及涉及被配置用于治疗眼睛状况的超声波装置的方法，系统和用途，并且隐形眼镜保护眼睛的眼组织并形成空气室。

    Method and apparatus for sorting biological cells with a MEMS device
    10.
    发明授权
    Method and apparatus for sorting biological cells with a MEMS device 有权
    用MEMS装置分选生物细胞的方法和装置

    公开(公告)号：US07264972B2

    公开(公告)日：2007-09-04

    申请号：US10978947

    申请日：2004-11-01

    申请人： John Stuart Foster

    发明人： John Stuart Foster

    IPC分类号： G01N1/10 ,  G01N21/64

    CPC分类号： B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0633 ,  B07C5/3425 ,  G01N2015/0288 ,  G01N2021/6482 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25375 ,  Y10T436/2575

    摘要： A micromechanical actuator for sorting hematopoietic stem cells for use in cancer therapies. The actuator operates by diverting cells into one of a number of possible pathways fabricated in the fabrication substrate of the micromechanical actuator, when fluorescence is detected emanating from the cells. The fluorescence results from irradiating the cells with laser light, which excites a fluorescent tag attached to the cell. The micromechanical actuator thereby sorts the cells individually, with an operation rate of 3.3 kHz, however with the massively parallel 1024-fold device described herein, a throughput of 3.3 million events/second is achievable.

    摘要翻译： 用于分选用于癌症治疗的造血干细胞的微机械致动器。 当从细胞发出荧光时，致动器通过将细胞转移到在微机械致动器的制造衬底中制造的许多可能通路中的一个中。 用激光照射细胞产生荧光，激发附着于细胞的荧光标记物。 因此，微机械致动器以3.3kHz的操作速率单独地对单元进行排序，然而通过本文描述的大规模平行的1024倍设备，可实现330万次/秒的吞吐量。