公开(公告)号：US07253324B1

公开(公告)日：2007-08-07

申请号：US11626225

申请日：2007-01-23

申请人： Muhammed Majeed ,  Samuel Manoharan Thomas ,  Kalyanam Nagabhushanam ,  Sivaprakash Kurumanghat Balakrishnan ,  Subbalakshmi Prakash

发明人： Muhammed Majeed ,  Samuel Manoharan Thomas ,  Kalyanam Nagabhushanam ,  Sivaprakash Kurumanghat Balakrishnan ,  Subbalakshmi Prakash

IPC分类号： C07C37/00

CPC分类号： C07C39/27 ,  C07C37/055 ,  C07C39/14 ,  C07C39/19 ,  C07C39/21 ,  C07C41/26 ,  C07C43/23 ,  C07C51/377 ,  C07C253/30 ,  C07C65/21 ,  C07C255/53 ,  C07C39/24

摘要： Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.

摘要翻译： 通过用氯化铝/ N，N-二甲基苯胺络合物处理，烷氧基芳族化合物方便地脱苄基化成相应的酚类化合物。 芳族聚O-脱甲基是本发明的独特特征。 该方法适用于多酚如白藜芦醇，氧化藜芦醇，Gnetol的制造。

公开(公告)号：US08394852B2

公开(公告)日：2013-03-12

申请号：US12872675

申请日：2010-08-31

申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

IPC分类号： A61K31/34

CPC分类号： C07D307/58 ,  A23L31/00 ,  A23L33/10 ,  A61K31/341

摘要： Optimal compositions of derivatives of 5-methyl-3(2H)-furanone compounds and phenylpropanoid polyketides related to inotilone, that exert biological response modification in health and disease, and their method of preparation, are disclosed. Methods of treating degenerative conditions stemming from over-expression of inducible nitric oxide synthase (iNOS) using these compositions are also disclosed.

摘要翻译： 本发明公开了5-甲基-3（2H） - 呋喃酮化合物和苯丙素类聚酮化合物与艾吐子酮有关的衍生物的最佳组合物，其在健康和疾病中发挥生物反应修饰及其制备方法。 还公开了使用这些组合物治疗由诱导型一氧化氮合酶（iNOS）过表达引起的退行性病症的方法。

公开(公告)号：US07521580B1

公开(公告)日：2009-04-21

申请号：US12032955

申请日：2008-02-18

申请人： Muhammed Majeed ,  Rajinder Kumar Bammi ,  Natarajan Sankaran ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Susmitha Anand ,  Geetha Kanhangad-Gangadharan

发明人： Muhammed Majeed ,  Rajinder Kumar Bammi ,  Natarajan Sankaran ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Susmitha Anand ,  Geetha Kanhangad-Gangadharan

IPC分类号： C07C49/203 ,  C07C49/215 ,  A61K31/12

CPC分类号： C07C49/248 ,  A61K31/12 ,  C07C45/74

摘要： Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered CFTR trafficking and the associated impaired chloride (Cl−) ion transport. Introduction of branched-alkyl groups ortho to the phenolic groups gave rise to clinical compounds with vastly improved trafficking of delF508CFTR and with no cytotoxicity.

摘要翻译： 公开了（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮的新型合成类似物，以及用于其改变的囊性纤维化的治疗应用 CFTR贩运和相关的氯化物（Cl - ）离子迁移。 引入酚基团邻位的支链烷基产生临床化合物，其具有大大改善的delF508CFTR的运输并且没有细胞毒性。

公开(公告)号：US20110054018A1

公开(公告)日：2011-03-03

申请号：US12872675

申请日：2010-08-31

申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

IPC分类号： A61K31/341 ,  C07D307/58 ,  C07D407/10 ,  A61P9/10 ,  A61P25/16 ,  A61P35/00

CPC分类号： C07D307/58 ,  A23L31/00 ,  A23L33/10 ,  A61K31/341

摘要： Optimal compositions of derivatives of 5-methyl-3(2H)-furanone compounds and phenylpropanoid polyketides related to inotilone, that exert biological response modification in health and disease, and their method of preparation, are disclosed. Methods of treating degenerative conditions stemming from over-expression of inducible nitric oxide synthase (iNOS) using these compositions are also disclosed.

摘要翻译： 本发明公开了5-甲基-3（2H） - 呋喃酮化合物和苯丙素类聚酮化合物与艾吐子酮相关的衍生物的最佳组合物，其在健康和疾病中发挥生物反应修饰及其制备方法。 还公开了使用这些组合物治疗由诱导型一氧化氮合酶（iNOS）过表达引起的退行性病症的方法。

公开(公告)号：US20080255377A1

公开(公告)日：2008-10-16

申请号：US11733772

申请日：2007-04-11

申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivaprskash Kurumanghat Balakrishnan ,  Savita Ganjihal ,  Rajendran Ramanujam ,  Rattan Sood ,  Subbalakshmi Prakash

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivaprskash Kurumanghat Balakrishnan ,  Savita Ganjihal ,  Rajendran Ramanujam ,  Rattan Sood ,  Subbalakshmi Prakash

IPC分类号： C07D307/02

CPC分类号： C07D307/22

摘要： A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.

摘要翻译： 描述了（S）-3-氨基 - 四氢呋喃和（R）-3-氨基 - 四氢呋喃的合成的新方法。 该方法适用于取代的手性3-氨基四氢呋喃衍生物。

公开(公告)号：US20060240126A1

公开(公告)日：2006-10-26

申请号：US11164787

申请日：2005-12-06

申请人： Muhammed Majeed ,  Rajinder Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam

发明人： Muhammed Majeed ,  Rajinder Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam

IPC分类号： A61K36/8962 ,  A61K33/04

CPC分类号： A61K31/197 ,  A61K31/198 ,  A61K33/04 ,  A61K36/8962 ,  A61K45/06 ,  A61K2300/00

摘要： The invention discloses selenium enriched garlic compositions that are a safe and efficacious means of providing supplemental amounts of the essential trace mineral nutrient selenium, to humans and animals.

摘要翻译： 本发明公开了富硒大蒜组合物，其是向人类和动物提供补充量的必需痕量矿物质营养硒的安全有效手段。

公开(公告)号：US20050284812A1

公开(公告)日：2005-12-29

申请号：US11215040

申请日：2005-08-31

申请人： Muhammed Majeed ,  Arvind Kumar ,  Kalyanam Nagabhushanam ,  Subbalakshmi Prakash

发明人： Muhammed Majeed ,  Arvind Kumar ,  Kalyanam Nagabhushanam ,  Subbalakshmi Prakash

IPC分类号： A23L1/30 ,  A61K9/00 ,  A61K31/352 ,  A61K45/06 ,  A61K47/40 ,  C07D311/92 ,  B01D11/04

CPC分类号： A61K9/0014 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0019 ,  A61K31/352 ,  A61K45/06 ,  A61K47/40 ,  C07D311/92 ,  Y10S514/909 ,  Y10S514/913 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2250/5112

摘要： Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs and derivatives, up to approximately 6% concentration, are prepared using suitably substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Forskolin are soluble in water only to concentrations of about 0.001%. Such aqueous solutions find applications in topical and systemic use, as pharmaceutical, cosmeceutical, nutraceutical preparations containing diterpenes such as Forskolin and congeners.

公开(公告)号：US20100204340A1

公开(公告)日：2010-08-12

申请号：US12499239

申请日：2009-07-08

申请人： Muhammed Majeed ,  Jeffrey Reinhardt ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Krishnamani Jayaraman

发明人： Muhammed Majeed ,  Jeffrey Reinhardt ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Krishnamani Jayaraman

IPC分类号： A61K31/09 ,  C07C43/243 ,  A61P3/04

CPC分类号： A61K31/09 ,  A61K31/05 ,  C07C39/21 ,  C07C43/23

摘要： A novel, bioavailable and safe stilbenoid 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 with an unexpected enhanced ability to prevent the accumulation of lipids accompanying the terminal differentiation of adipocytes, thereby inhibiting adipogenesis, and nutraceutical and cosmeceutical compositions comprising 3,5-dimethoxy-3,4′-dihydroxystilbene useful for anti-obesity and anti-cellulite therapy, are disclosed. Further the enhanced SIRT-1 activation ability of 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#1 and 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are disclosed. The enhancement of SIRT-1 polypeptide activity of the said compounds is unexpectedly much higher than resveratrol or its natural analog pterostilbene. Sirtuin modulating compositions comprising an orally bioavailable SIRT-1 enhancing compounds (i) 3,5-dimethoxy-3,4′-dihydroxystilbene represented by STR#I and (ii) 2,3′,5′,6-tetrahydroxy-trans-stilbene represented by STR#II are also disclosed. An additional embodiment, also discloses the enhanced anti-Propionibacterium acnes activity of 3,5-dimethoxy-3,4′-dihydroxystilbenes represented by STR#I and compositions thereof.

摘要翻译： 由STR＃1代表的一种新颖，生物可利用和安全的扁桃体3,5-二甲氧基-3,4'-二羟基茋，具有意想不到的增强的防止伴随脂肪细胞末端分化的脂质积聚的能力，从而抑制脂肪形成，以及营养和药妆 公开了包含可用于抗肥胖和抗脂肪团治疗的3,5-二甲氧基-3,4'-二羟基茋的组合物。 另外，公开了由STR＃1代表的3,5-二甲氧基-3,4'-二羟基茋的增强的SIRT-1活化能力和由STR＃II表示的2,3'，5'，6-四羟基 - 反式 - 二苯乙烯。 所述化合物的SIRT-1多肽活性的增强出乎意料地高于白藜芦醇或其天然类似物p芪烯。 包含口服生物可利用的SIRT-1增强化合物（i）由STR＃I表示的3,5-二甲氧基-3,4'-二羟基茋和（ⅱ）2,3'，5'，6-四羟基 - 也公开了由STR＃II代表的二苯乙烯。 另外的实施方案还公开了由STR＃I表示的3,5-二甲氧基-3,4'-二羟基茋的增强的抗丙酸杆菌痤疮活性及其组合物。

公开(公告)号：US08383594B2

公开(公告)日：2013-02-26

申请号：US11835165

申请日：2007-08-07

申请人： Muhammed Majeed ,  Renukeshwar H Chandramouli ,  Kalyanam Nagabhushanam ,  Rattan Sood ,  Subbalakshmi Prakash ,  Susmitha Anand

发明人： Muhammed Majeed ,  Renukeshwar H Chandramouli ,  Kalyanam Nagabhushanam ,  Rattan Sood ,  Subbalakshmi Prakash ,  Susmitha Anand

IPC分类号： A61K38/08 ,  A61K8/64

CPC分类号： A61Q19/08 ,  A61K8/64 ,  A61Q19/00

摘要： The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.

摘要翻译： 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。

公开(公告)号：US20100034762A1

公开(公告)日：2010-02-11

申请号：US12208024

申请日：2008-09-10

申请人： Muhammed Majeed ,  Atul Namdevrao Jadhav ,  Jyotish Shanker Srivastava ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Beena Bhat

发明人： Muhammed Majeed ,  Atul Namdevrao Jadhav ,  Jyotish Shanker Srivastava ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Beena Bhat

IPC分类号： A61Q17/04 ,  C07H17/02 ,  C07C69/76 ,  C07C63/04 ,  C07D311/78 ,  A61P35/00 ,  A61K31/7088 ,  A61K31/235 ,  A61K31/19 ,  A61K31/35

CPC分类号： A61K8/97 ,  A61K8/375 ,  A61K8/60 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/02 ,  C07C67/58 ,  C07D307/33 ,  C07D493/06 ,  C07H13/08 ,  Y02P20/544 ,  C07C69/84

摘要： Improved methods to prepare aqueous extracts of gallic acid esters including 1-O-galloyl-β-D-glucose (β-glucogallin) and other mucic acid gallates from the fruits of Emblica officinalis, wherein enrichment of gallic acid esters is achieved by Supercritical Fluid Extraction (SCFE) procedure, are disclosed. The use of such standardized extracts of gallic acid esters (greater than 40% w/w of gallic acid esters) in the manufacture of medicaments with diverse health benefits, is also disclosed.

摘要翻译： 改进的方法，用于制备没食子酸酯的含水提取物，其中包括从Emblica officinalis的果实中含有1-O-葡萄糖基-β-D-葡萄糖（β-葡萄糖苷）和其他没有酸的粘酸盐，其中富马酸酯的富集通过超临界流体 提取（SCFE）程序。 还公开了在制造具有多种健康益处的药物中使用没食子酸酯（大于40％w / w的没食子酸酯）的标准提取物。