公开(公告)号：US20160341725A1

公开(公告)日：2016-11-24

申请号：US15115234

申请日：2014-05-19

申请人： SYSTEM INSTRUMENTS CO., LTD. ,  HIROSAKI UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Kazuyuki Hamada ,  Takeshi Akiba ,  Chikara Ohyama ,  Tohru Yoneyama ,  Yuki Tobisawa ,  Toshifumi Takeuchi

IPC分类号： G01N33/543 ,  G01N21/59 ,  G01N33/573 ,  G01N35/10 ,  G01N35/00 ,  G01N21/03 ,  G01N21/64

CPC分类号： G01N33/54386 ,  B01L3/0275 ,  B01L2300/0609 ,  C12Y304/21077 ,  G01N21/0303 ,  G01N21/59 ,  G01N21/6428 ,  G01N33/573 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/1011 ,  G01N2021/6439 ,  G01N2035/1062 ,  G01N2201/068 ,  G01N2333/96455

摘要： An automatic analyzing apparatus 10 includes a chip rack 11 that stores a pipette chip, a pipette 12 into which a specimen is injected, a conveyance unit that conveys the pipette 12 by parallel translation, a reagent rack 14, a reaction unit 15, a detection unit 16, and a detection block unit 17. The pipette chip stored by the chip rack 11 has a planar structure to directly and optically detect the specimen. The chip rack 11 includes, in a hole that receives the pipette chip, a guide corresponding to the structure of the pipette chip. The pipette 12 sucks or discharges the specimen via the pipette chip mounted onto the tip thereof by a drive of a pump. In the detection unit 16, a measurement is carried out with the pipette chip arranged so that the plane that receives light is vertical to an optical axis.

摘要翻译： 自动分析装置10包括存储移液管芯片的芯片架11，注入试样的移液管12，通过并行平移输送移液管12的输送单元，试剂架14，反应单元15，检测 单元16和检测块单元17.由芯片架11存储的移液管芯片具有直接和光学地检测样本的平面结构。 芯片架11在接收移液管芯片的孔中包括与移液管芯片的结构相对应的引导件。 移液管12通过泵的驱动器通过安装在其尖端上的移液管芯片吸取或排出样品。 在检测单元16中，使用吸液管芯片进行测量，使得接收光的平面垂直于光轴。

公开(公告)号：US10471011B2

公开(公告)日：2019-11-12

申请号：US15532951

申请日：2015-12-04

申请人： Toshifumi Takeuchi ,  Yukiya Kitayama ,  System Instruments Co., Ltd.

发明人： Toshifumi Takeuchi ,  Yukiya Kitayama

IPC分类号： A61K9/14 ,  C08F2/44 ,  A61K47/69 ,  A61K31/704 ,  C08F220/56 ,  A61P35/00 ,  B82Y5/00 ,  A61K9/00

摘要： Provided is a molecular imprint polymer that is capable of acquiring stealth properties through a new mechanism. The molecular imprint polymer according to the present invention, which has a plasma protein recognition sites molecularly imprinted by a plasma protein thereon and contains a constituent derived from a biocompatible monomer, is an in vivo stealth nanoparticle to be used in intravascular delivery. As the plasma protein, albumin is preferred. When carrying a drug thereon, the in vivo stealth nanoparticle according to the present invention is usable as a drug for drug delivery system.

公开(公告)号：US10302638B2

公开(公告)日：2019-05-28

申请号：US15115234

申请日：2014-05-19

申请人： SYSTEM INSTRUMENTS CO., LTD. ,  HIROSAKI UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Kazuyuki Hamada ,  Takeshi Akiba ,  Chikara Ohyama ,  Tohru Yoneyama ,  Yuki Tobisawa ,  Toshifumi Takeuchi

IPC分类号： G01N35/00 ,  G01N35/10 ,  G01N33/543 ,  G01N21/59 ,  G01N21/03 ,  G01N21/64 ,  G01N33/573 ,  B01L9/00

摘要： An automatic analyzing apparatus 10 includes a chip rack 11 that stores a pipette chip, a pipette 12 into which a specimen is injected, a conveyance unit that conveys the pipette 12 by parallel translation, a reagent rack 14, a reaction unit 15, a detection unit 16, and a detection block unit 17. The pipette chip stored by the chip rack 11 has a planar structure to directly and optically detect the specimen. The chip rack 11 includes, in a hole that receives the pipette chip, a guide corresponding to the structure of the pipette chip. The pipette 12 sucks or discharges the specimen via the pipette chip mounted onto the tip thereof by a drive of a pump. In the detection unit 16, a measurement is carried out with the pipette chip arranged so that the plane that receives light is vertical to an optical axis.

公开(公告)号：US20180353897A1

公开(公告)日：2018-12-13

申请号：US15781545

申请日：2016-01-15

申请人： SYSTEM INSTRUMENTS CO., LTD.

发明人： Kiyoshi YAMAMOTO ,  Yoshihisa UJIMA ,  Takeshi AKIBA

IPC分类号： B01D53/22 ,  C01B21/04 ,  F04B49/06 ,  G01F1/20

摘要： A power supply control device of a nitrogen gas generator includes: a pipe having a nitrogen gas inlet for receiving input of nitrogen gas from a nitrogen gas generator that compresses air by a compressor to separate the nitrogen gas from the air, and a nitrogen gas outlet for outputting, to outside, the nitrogen gas received by the nitrogen gas inlet; a pressure gauge that measures pressure inside the pipe; a flowmeter that measures a flow rate of the nitrogen gas flowing inside the pipe; and a control unit that controls supply of power to the compressor and shut-off of the supply of the power in accordance with a measurement result of at least one of the pressure gauge and the flowmeter.

公开(公告)号：US20170100586A1

公开(公告)日：2017-04-13

申请号：US15126879

申请日：2014-07-23

申请人： SYSTEM INSTRUMENTS CO., LTD. ,  The University of Electro-Communications

发明人： Takeshi AKIBA ,  Hiroshi YOKOI

IPC分类号： A61N1/36 ,  A61N1/04 ,  A61H1/02

CPC分类号： A61N1/36003 ,  A61B5/0408 ,  A61B5/1118 ,  A61B5/1124 ,  A61B5/224 ,  A61B2562/0219 ,  A61B2562/0247 ,  A61H1/0237 ,  A61N1/0452 ,  A61N1/32 ,  A61N1/36 ,  A61N1/36014 ,  A63B21/00065 ,  A63B21/06 ,  A63B21/151 ,  A63B21/154 ,  A63B21/4034 ,  A63B21/4045 ,  A63B21/4047 ,  A63B23/03508 ,  A63B23/0405 ,  A63B2213/004 ,  A63B2220/10 ,  A63B2220/30 ,  A63B2220/40 ,  A63B2220/56 ,  A63B2220/803 ,  A63B2220/836 ,  A63B2230/60 ,  G06F19/00 ,  G06F19/3481

摘要： Provided is an electrical stimulation device including a first to fourth electrodes, and an electrical stimulation generation section which supplies an electrical stimulation signal to each of the first to fourth electrodes. The electrical stimulation generation section supplies, to the first and second electrodes, an electrical stimulation signal according to a first stimulation pattern, and supplies, to the third and fourth electrodes, an electrical stimulation signal according to a second stimulation pattern. The first stimulation pattern is set so that an electrical stimulation signal for changing stimulation intensity according to a first waveform is supplied to the first electrode, and an electrical stimulation signal for changing stimulation intensity according to a second waveform is supplied to the second electrode, the second waveform being increased and decreased in conjunction with the first waveform. The second stimulation pattern is set so that an electrical stimulation signal for changing stimulation intensity according to a third waveform is supplied to the third electrode, and an electrical stimulation signal for changing stimulation intensity according to a fourth waveform is supplied to the fourth electrode, the fourth waveform being increased and decreased in conjunction with the third waveform. The electrical stimulation generation section alternately performs electrical stimulation of the first stimulation pattern and electrical stimulation of the second stimulation pattern.

公开(公告)号：US10258794B2

公开(公告)日：2019-04-16

申请号：US15126879

申请日：2014-07-23

申请人： SYSTEM INSTRUMENTS CO., LTD. ,  The University of Electro-Communications

发明人： Takeshi Akiba ,  Hiroshi Yokoi

IPC分类号： A61N1/36 ,  A61H1/02 ,  A61N1/04 ,  A61B5/0408 ,  A61B5/11 ,  A61B5/22 ,  A61N1/32 ,  G06F19/00 ,  A63B21/06 ,  A63B21/00 ,  A63B23/035 ,  A63B23/04

摘要： Provided is an electrical stimulation device including a first to fourth electrodes, and an electrical stimulation generation section which supplies an electrical stimulation signal to each of the first to fourth electrodes. The electrical stimulation generation section supplies, to the first and second electrodes, an electrical stimulation signal according to a first stimulation pattern, and supplies, to the third and fourth electrodes, an electrical stimulation signal according to a second stimulation pattern. The first stimulation pattern is set so that an electrical stimulation signal for changing stimulation intensity according to a first waveform is supplied to the first electrode, and an electrical stimulation signal for changing stimulation intensity according to a second waveform is supplied to the second electrode, the second waveform being increased and decreased in conjunction with the first waveform. The second stimulation pattern is set so that an electrical stimulation signal for changing stimulation intensity according to a third waveform is supplied to the third electrode, and an electrical stimulation signal for changing stimulation intensity according to a fourth waveform is supplied to the fourth electrode, the fourth waveform being increased and decreased in conjunction with the third waveform. The electrical stimulation generation section alternately performs electrical stimulation of the first stimulation pattern and electrical stimulation of the second stimulation pattern.

公开(公告)号：US09952606B2

公开(公告)日：2018-04-24

申请号：US14911116

申请日：2014-07-15

申请人： SYSTEM INSTRUMENTS CO., LTD. ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

发明人： Toshiharu Kuroda ,  Michio Horiuchi ,  Yanbei Zhu ,  Koichi Chiba

IPC分类号： G05D21/00 ,  B01L3/00 ,  G01N21/80 ,  G05D21/02 ,  B05B15/00

CPC分类号： G05D21/00 ,  B01L3/502 ,  B01L2200/14 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2400/0622 ,  B05B15/00 ,  B05B15/55 ,  G01N21/80 ,  G05D21/02

摘要： In an embodiment, control is performed to operate a three-way valve in accordance with a reaching ratio of pH adjustment. When process of certain steps is performed, bubbles of ammonia generated in a nebulizer can be extruded by air so as to be injected from an injection port together with aqua ammonia remaining in the nebulizer. Therefore, the pH adjustment can be performed while a large amount of bubbles of ammonia are prevented from being generated in the nebulizer.

公开(公告)号：US09702850B2

公开(公告)日：2017-07-11

申请号：US14652583

申请日：2013-04-30

申请人： SYSTEM INSTRUMENTS CO., LTD. ,  NIHON UNIVERSITY

发明人： Yoshinori Hatakeyama ,  Yoshihisa Ujima ,  Nobuaki Shimura

IPC分类号： G01N27/453 ,  G01N27/447

CPC分类号： G01N27/44721 ,  G01N27/44704 ,  G01N27/44708 ,  G01N27/44726

摘要： To provide an electrophoresis method and an electrophoresis device which can reduce difficulty in operation while implementing sufficient staining. An electrophoresis device includes a temperature gradient tank, a dispenser, a holder storage cabinet, a photographing unit, a PCR device, a chip rack, a chip disposal box, a DC power unit, a control unit, an arm, and a liquid feeder. A holder and a cassette removably attached to the holder are put on the temperature gradient tank. The control unit controls a carrying device, the arm, the liquid feeder, the temperature gradient tank, an excitation light source and a camera in the photographing unit, and the DC power unit. The control unit prestores a program for executing the control operation in its internal memory.

公开(公告)号：US11987643B2

公开(公告)日：2024-05-21

申请号：US17918042

申请日：2021-03-18

申请人： Hirosaki University ,  System Instruments Co., Ltd.

发明人： Chikara Ohyama ,  Tohru Yoneyama ,  Kazuyuki Hamada

IPC分类号： C07K16/44 ,  G01N33/66

CPC分类号： C07K16/44 ,  G01N33/66 ,  C07K2317/565

摘要： A monoclonal antibody or an antibody fragment thereof is provided, in which the monoclonal antibody or the antibody fragment thereof specifically binds to a sugar chain in which a terminal sialic acid residue is bonded to galactose by an α2,3 bond, and is not dissociated from the sugar chain after the binding to the sugar chain in which the terminal sialic acid residue is bonded to the galactose by the α2,3 bond.α2,3

公开(公告)号：US20240151724A1

公开(公告)日：2024-05-09

申请号：US18281484

申请日：2021-03-18

申请人： HIROSAKI UNIVERSITY ,  SYSTEM INSTRUMENTS Co., Ltd.

发明人： Chikara OHYAMA ,  Tohru YONEYAMA ,  Kazuyuki HAMADA

IPC分类号： G01N33/574 ,  C07K16/44

CPC分类号： G01N33/574 ,  C07K16/44 ,  C07K2317/565 ,  C07K2317/92

摘要： A monoclonal antibody or an antibody fragment thereof is provided which specifically binds to a sugar chain in which a terminal sialic acid residue is bound to galactose with α2,6 linkage, and which does not bind to a sugar chain to which galactose having no sialic acid bound to a terminal is bound.