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1.发明申请公开(公告)号：US20190025277A1
公开(公告)日：2019-01-24
申请号：US16138658
申请日：2018-09-21
发明人： Amit MELLER , Meni WANUNU
IPC分类号： G01N33/487 , C12Q1/6869
摘要： Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproductibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.
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2.发明授权公开(公告)号：US09903820B2
公开(公告)日：2018-02-27
申请号：US14815727
申请日：2015-07-31
发明人： Amit Meller , Meni Wanunu
IPC分类号： G01N25/18 , G01N21/64 , B82Y15/00 , G01N33/487 , C12Q1/68
CPC分类号： G01N21/6428 , B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N2021/6439 , Y10T428/2982 , Y10T436/143333 , C12Q2521/543 , C12Q2565/631
摘要： Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly ceased, and (2) self-assembly under voltage driven electrolyte flow, in which 5 nm nanopore may be coated. Applications of chemically modified nanopore are provided including, the detection of biopolymers such as DNA and RNA, immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.
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公开(公告)号：US20160033471A1
公开(公告)日：2016-02-04
申请号：US14775217
申请日：2014-03-14
发明人： Amit MELLER , Nicolas Di FIORI
IPC分类号： G01N33/487 , G01N21/63 , G01N27/49
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N21/63 , G01N27/49 , G01N2201/06113 , C12Q2565/631
摘要： Optoelectronic control of solid-state nanopores and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. Methods for controlling the translocation speed of biopolymers through solid-state nanopores and methods for unblocking clogged pores by illuminating nanopores are described.
摘要翻译： 固态纳米孔的光电子控制及其应用。 纳米孔是非常敏感的单分子传感器。 电子束已被用于制备具有亚纳米分辨率的薄固态膜中的合成纳米孔。 描述了通过固态纳米孔控制生物聚合物的转运速度的方法以及通过照射纳米孔解除堵塞的孔的方法。
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公开(公告)号：US08758949B2
公开(公告)日：2014-06-24
申请号：US13632672
申请日：2012-10-01
发明人： Uday B. Pal , Srikanth Gopalan
CPC分类号： C25B9/14 , C01B3/50 , C01B2203/0495 , C25B1/06 , H01M4/8621 , H01M4/90 , H01M4/9041 , H01M8/1246 , H01M8/186 , H01M2004/8684 , Y02E60/366 , Y02E60/525 , Y02E60/528 , Y02P70/56
摘要： A reversible electrochemical system includes a first electrode comprising liquid silver metal and a second electrode, said first and second electrodes separated by a oxygen ion-conducting solid electrolyte; a conduit for directing a first reactive material across the second electrode; and a conduit for contacting second reactive material with the first liquid silver electrode, wherein the cell is capable of steam electrolysis when the polarity of the electrodes is selected such that the liquid silver is an anode and the cell is capable of electrical energy generation when the polarity of the electrodes is selected such that the liquid silver is a cathode.
摘要翻译： 可逆电化学系统包括包含液态银金属和第二电极的第一电极，所述第一和第二电极由氧离子导电固体电解质分离; 用于引导第一反应性材料穿过第二电极的导管; 以及用于使第二反应性材料与第一液体银电极接触的导管，其中当选择电极的极性使得电池能够进行蒸汽电解，使得液体银是阳极，并且当电池能够产生电能时 选择电极的极性使得液体银是阴极。
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公开(公告)号：US20130026032A1
公开(公告)日：2013-01-31
申请号：US13632672
申请日：2012-10-01
发明人： Uday B. PAL , Srikanth GOPALAN
IPC分类号： C25B9/14
CPC分类号： C25B9/14 , C01B3/50 , C01B2203/0495 , C25B1/06 , H01M4/8621 , H01M4/90 , H01M4/9041 , H01M8/1246 , H01M8/186 , H01M2004/8684 , Y02E60/366 , Y02E60/525 , Y02E60/528 , Y02P70/56
摘要： A reversible electrochemical system includes a first electrode comprising liquid silver metal and a second electrode, said first and second electrodes separated by a oxygen ion-conducting solid electrolyte; a conduit for directing a first reactive material across the second electrode; and a conduit for contacting second reactive material with the first liquid silver electrode, wherein the cell is capable of steam electrolysis when the polarity of the electrodes is selected such that the liquid silver is an anode and the cell is capable of electrical energy generation when the polarity of the electrodes is selected such that the liquid silver is a cathode.
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公开(公告)号：US20040169245A1
公开(公告)日：2004-09-02
申请号：US10790403
申请日：2004-03-01
发明人： M. Selim Unlu , Matthew K. Emsley
IPC分类号： H01L021/8242
CPC分类号： H01L31/0392 , H01L31/02327 , H01L31/03921 , H01L31/056 , Y02E10/52 , Y10S438/977
摘要： A silicon wafer having a distributed Bragg reflector buried within it. The buried reflector provides a high efficiency, readily and accurately manufactured reflector with a body of silicon. A photodetector using the buried layer to form a resonant cavity enhancement of the silicon's basic quantum efficiencies and selectivity is provided. The DBR is created by bonding of two or more substrates together at a silicon oxide interface or an oxide-oxide interface. In the former, an hydrogen implant is used to cleave silicon just above the bond line. In the latter, the bonding is at the oxide layers.
摘要翻译： 具有埋在其中的分布式布拉格反射镜的硅晶片。 掩埋反射器提供了高效率，容易且准确地制造的具有硅体的反射器。 提供了使用掩埋层形成谐振腔增强硅的基本量子效率和选择性的光电探测器。 DBR通过在氧化硅界面或氧化物 - 氧化物界面处将两个或更多个衬底结合在一起而产生。 在前者中，氢注入用于在接合线上方切割硅。 在后者中，键合在氧化物层。
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公开(公告)号：US20030059785A1
公开(公告)日：2003-03-27
申请号：US10034736
申请日：2001-12-27
IPC分类号： C12Q001/68 , C12Q001/70 , G01N033/567 , C12P021/06
CPC分类号： C07D207/404 , A61K38/00 , A61K41/0042 , C07C205/45 , C07C205/57 , C07D311/16 , C07D405/12 , C07D495/04 , C07H19/04 , C07H21/00 , C07K1/1077 , C07K1/13 , C12P21/00 , C12Q1/68 , G01N33/532 , G01N33/582
摘要： The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing machinery. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. The invention also comprises proteins prepared using misaminoacylated tRNAs which can be utilized in pharmaceutical compositions for the treatment of diseases and disorders in humans and other mammals, and kits which may be used for the detection of diseases and disorders.
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公开(公告)号：US20030029452A1
公开(公告)日：2003-02-13
申请号：US10123059
申请日：2002-04-12
IPC分类号： A61M016/00
CPC分类号： A61M16/024 , A61M2230/40
摘要： A system and method for ventilating a lung in a living being by varying the peak inspiratory pressure. The peak inspiratory pressure may deviate about a mean that is chosen to correspond with a knee in a pressure-volume curve of the lung.
摘要翻译： 通过改变吸气峰值压力来使生活中的肺通气的系统和方法。 吸气峰值的峰值可能偏离在肺的压力 - 体积曲线中与膝盖相对应的平均值。
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公开(公告)号：US10925975B2
公开(公告)日：2021-02-23
申请号：US16252927
申请日：2019-01-21
发明人： Orian Shirihai , Mark Grinstaff , Jialiu Zeng
摘要： In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
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公开(公告)号：US20180023211A1
公开(公告)日：2018-01-25
申请号：US15654152
申请日：2017-07-19
发明人： Uday B. PAL , Soumendra BASU , Paul GASPER , Yanchen LU , Srikanth GOPALAN
CPC分类号： C25D17/10 , C23C14/0021 , C23C14/02 , C23C14/046 , C23C14/083 , C23C14/18 , C23C14/228 , C25D7/006 , H01M4/8853 , H01M4/8867 , H01M4/8882 , H01M4/9066 , H01M2008/1293
摘要： A method of preparing a metal nanoparticle on a surface includes subjecting a metal source to a temperature and a pressure in a carrier gas selected to provide a vapor metal species at a vapor pressure in the range of about 10−4 to about 10−11 atm; contacting the vapor metal species with a heated substrate; and depositing the metal as a nanoparticle on the substrate.
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