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    System and method for providing closed loop infusion formulation delivery
    2.
    发明授权
    System and method for providing closed loop infusion formulation delivery 有权
    用于提供闭环输注制剂递送的系统和方法

    公开(公告)号：US08777896B2

    公开(公告)日：2014-07-15

    申请号：US13009519

    申请日：2011-01-19

    申请人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

    发明人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H50/30

    摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

    摘要翻译： 一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。 该算法计算具有比例，导数和基础速率分量的传送量。 可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。 交付量的安全限制可能包含在算法中。 该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。 生物状态由感测装置感测到，该感测装置向控制器提供信号。 所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

    Implantable cardiac device having event recording capability with compression
    10.
    发明授权
    Implantable cardiac device having event recording capability with compression 有权
    具有压缩事件记录能力的可植入心脏装置

    公开(公告)号：US6161043A

    公开(公告)日：2000-12-12

    申请号：US255140

    申请日：1999-02-22

    申请人： Kelly H. McClure ,  Gabriel Mouchawar ,  Timothy J. Starkweather ,  James D. Causey, III

    发明人： Kelly H. McClure ,  Gabriel Mouchawar ,  Timothy J. Starkweather ,  James D. Causey, III

    IPC分类号： A61B5/00 ,  A61N1/365 ,  A61N1/37 ,  A01B5/0452

    CPC分类号： A61B5/0006 ,  A61B5/7232 ,  A61N1/36542 ,  A61N1/3702

    摘要： An implantable cardiac device is disclosed having a converter that provides a digital electrocardiogram signal to a controller which is stored in memory or transmitted via the telemetry circuit in an improved compressed fashion. The improved compression scheme comprises sampling the electrogram signal, transmitting the starting value in an uncompressed format followed by a plurality of delta signals in a compressed format. The delta signals may be determined by subtracting successive signals or by subtracting a predicted value from the current value. In either case, the delta signal is then transmitted in a truncated number of bits, e.g., 2 or 4 bits. When the delta signal is too large to be represented in the compressed number of bits, the controller then provides an indicator signal followed by the delta signal in the uncompressed format. In addition, whenever successive delta signals are below a minimum threshold (e.g., zero), they may be compressed into a count.

    摘要翻译： 公开了一种可植入心脏装置，其具有向控制器提供数字心电图信号的转换器，该控制器存储在存储器中或者以经改进的压缩方式通过遥测电路传输。 改进的压缩方案包括对电描记图信号进行采样，以未压缩格式发送起始值，然后以压缩格式传送多个delta信号。 Δ信号可以通过减去连续信号或从当前值减去预测值来确定。 在任一种情况下，然后以截断的位数（例如2或4位）发送增量信号。 当增量信号太大而不能在压缩位数中表示时，控制器随后以未压缩格式提供指示符信号，后跟增量信号。 此外，每当连续的delta信号低于最小阈值（例如，零）时，它们可以被压缩成计数。