公开(公告)号：US12070216B2

公开(公告)日：2024-08-27

申请号：US17845700

申请日：2022-06-21

申请人： The Regents of the University of Colorado, a body corporate

发明人： Max Bannister Mitchell ,  Alexander Travis Brown

IPC分类号： A61B17/11 ,  A61M60/148 ,  A61M60/178 ,  A61M60/863

CPC分类号： A61B17/11 ,  A61M60/148 ,  A61M60/178 ,  A61M60/863 ,  A61B2017/1107 ,  A61M2205/0216

摘要： An implantable anastomotic assembly, which is configured to be attached to cardiovascular tissue, includes a connection interface, a plurality of outer plates, and a plurality of connectors configured to extend between and interconnect the connection interface and the plurality of outer plates, respectively, according to various embodiments. The connection interface is separate from and non-contiguous with the plurality of outer plates, according to various embodiments.

公开(公告)号：US20240245049A1

公开(公告)日：2024-07-25

申请号：US18627309

申请日：2024-04-04

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Marc MATHIAS ,  Kang LI ,  Miguel FLORES BELLVER ,  Silvia APARICIO DOMINGO ,  Conan CHEN ,  Valeria CANTO-SOLER

IPC分类号： A01N1/02 ,  A61F9/00 ,  A61K35/30

CPC分类号： A01N1/0263 ,  A61F9/0017 ,  A61K35/30

摘要： A cell transplant carrier including a carrier plate and a carrier housing. The carrier plate includes a body and one or more chambers defined in the body. Each of the one or more chambers is configured to receive a cell transplant and is shaped to cause the cell transplant to be at least partially exposed in order to permit removal of the cell transplant therefrom. The carrier housing includes a carrier plate opening leading to an inner compartment configured to removably receive the carrier plate.

公开(公告)号：US20240238421A1

公开(公告)日：2024-07-18

申请号：US18392543

申请日：2023-12-21

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  COLORADO SCHOOL OF MINES

发明人： Karin A. PAYNE ,  Melissa D. KREBS

IPC分类号： A61K47/36 ,  A61K9/00 ,  A61K9/06 ,  A61K47/22 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61P19/00 ,  C07K16/22 ,  C08J3/075 ,  A61B17/16

CPC分类号： A61K47/36 ,  A61K9/0019 ,  A61K9/06 ,  A61K47/22 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61P19/00 ,  C07K16/22 ,  C08J3/075 ,  A61B17/16 ,  A61L2300/256 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/62 ,  A61L2430/06 ,  C08J2305/04 ,  C08J2305/08

摘要： The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of “bony bars” at the site of growth plate injury, thereby preventing growth arrest and/or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation.

公开(公告)号：US20240238301A1

公开(公告)日：2024-07-18

申请号：US18622525

申请日：2024-03-29

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Michael R. VERNERIS ,  Laura Michelle MCLAUGHLIN

IPC分类号： A61K31/519 ,  A61K35/28 ,  A61P37/06

CPC分类号： A61K31/519 ,  A61K35/28 ,  A61P37/06

摘要： Embodiments of the instant disclosure generally relate to compositions and methods for improving engraftment, reducing the risk of cellular implantation or transplantation rejection, reducing toxicities due to radiation and chemotherapy treatments and/or treating a malignant or non-malignant condition or a subject having a solid organ transplantation using stem cell implantation in combination with compositions disclosed herein. In certain embodiments, compositions and methods disclosed herein concern administering a composition including, but not limited to, at least one Janus kinase (JAK) inhibitor. In some embodiments, compositions and methods disclosed herein can be administered in combination with and/or before, during and/or after hematopoietic cell transplantation (HCT) to treat a health condition in a subject.

公开(公告)号：US20240229072A9

公开(公告)日：2024-07-11

申请号：US18547348

申请日：2022-02-22

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： Ram H. NAGARAJ ,  Rooban B. NAHOMI

IPC分类号： C12N15/86 ,  A61K9/00 ,  A61K48/00 ,  A61P27/06 ,  C07K14/47

CPC分类号： C12N15/86 ,  A61K9/0048 ,  A61K48/0075 ,  A61P27/06 ,  C07K14/47 ,  C12N2750/14143

摘要： Gene therapy for a retinal disease, injury, or condition in a subject involves administering to the subject a pharmaceutical composition containing a recombinant adeno-associated viral vector encoding at least one heat shock protein, such as Hsp27. A recombinant adeno-associated viral vector can include a promoter sequence that induces production of a heat shock protein specifically in retinal ganglion cells. The loss of such cells causes retinal damage and loss of eyesight in patients afflicted with an ocular condition. The disclosed viral vector may be included in pharmaceutical compositions that may be administered intravitreally using an administration device. A single injection 10 may be therapeutically sufficient for treating various ocular conditions.

公开(公告)号：US12029732B2

公开(公告)日：2024-07-09

申请号：US17604858

申请日：2020-04-20

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Tamara Terzian ,  Neil Box

IPC分类号： A61K31/428 ,  A61K31/429 ,  A61P7/10

CPC分类号： A61K31/428 ,  A61K31/429 ,  A61P7/10

摘要： Disclosed herein are compositions, methods, and systems useful in the prevention, management, or treatment of various conditions associated the lymphatic vasculature, including, but not limited to lymphedema. The disclosed methods and compositions are useful in reducing the activity of p53 in a subject at risk for or suffering from a disease or condition associated with lymphatic vasculature, including adults, children, infants, and embryos. Reduction in p53 activity may be achieve through reduction in one or more of p53 gene expression, p53 transcriptional activity, p53 DNA-binding affinity, etc. In many embodiments, the disease or condition is lymphedema, for example lymphedema associated with Milroy's disease, Klippel-Trenaunay and Cloves Syndromes. In many embodiments, treatment may involve administering a compound or pharmaceutically acceptable salt thereof to a subject in need thereof, exemplary compounds include, anti-p53 compounds, PFT, and PFT-β.

公开(公告)号：US12029687B2

公开(公告)日：2024-07-09

申请号：US17741170

申请日：2022-05-10

申请人： The Regents of the University of Colorado, a body corporate ,  New World Medical, Inc.

发明人： Malik Y. Kahook ,  Khalid Mansour ,  Suhail Abdullah ,  Eric Porteous ,  Vijay R. Balan

IPC分类号： A61F9/013 ,  A61B17/32 ,  A61F9/007 ,  A61B17/00 ,  A61B17/3211

CPC分类号： A61F9/0133 ,  A61B17/320068 ,  A61F9/00745 ,  A61F9/00781 ,  A61B2017/00867 ,  A61B2017/320082 ,  A61B17/3211 ,  A61B2217/005 ,  A61F9/00736

摘要： The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

公开(公告)号：US20240221188A1

公开(公告)日：2024-07-04

申请号：US18402003

申请日：2024-01-02

申请人： The Regents of the University of Colorado, a body corporate

发明人： Min-Hyung Choi ,  Shane Transue

IPC分类号： G06T7/292 ,  G16H50/50

CPC分类号： G06T7/292 ,  G16H50/50 ,  G06T2207/10016 ,  G06T2207/10028 ,  G06T2207/20024

摘要： Systems and methods for contagion mapping are disclosed herein. An implementation of the contagion modeling system based on a thermal depth video capture is disclosed. The modelling system includes two CO2 thermal depth imaging cameras connected to a processor. The CO2 thermal depth imaging cameras are configured so that they have fields of view within a modeling area. The modeling area includes a stationary object, a moving object and a gaseous fluid source, which is a contagion source.

公开(公告)号：US20240219549A1

公开(公告)日：2024-07-04

申请号：US18557369

申请日：2022-04-26

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  UNIVERSITY OF WASHINGTON ,  ALLIANCE FOR SUSTAINABLE ENERGY LLC

发明人： Gregor P. HENZE ,  Joshua R. SMITH ,  Soumik SARKAR ,  Anthony J. FLORITA ,  Margarite JACOBY ,  Mohamadtaghi Katanbaf NEZHAD ,  Ali SAFFARI ,  Sin Yong TAN

IPC分类号： G01S13/04 ,  G01S13/86

CPC分类号： G01S13/04 ,  G01S13/86

摘要： An integrated occupancy sensing system includes one or more radio frequency identification (RFID) sensor nodes and one or more base station units. Each of the one or more RFID sensor nodes includes at least one of (1) an image sensor, (2) an acoustic energy sensor, (3) a temperature sensor, (4) an illuminance sensor, or (5) a relative humidity sensor. Each of the one or more base station units is configured to be connected to a power source to emit a continuous wave carrier signal and to receive a reflected signal. Each of the one or more RFID sensor nodes is configured to receive and reflect the continuous wave carrier signal. In response to receiving the reflected signal from the one or more RFID sensor nodes, at least one of the base station units is configured to infer the likelihood of human occupancy in the building.

公开(公告)号：US20240207477A1

公开(公告)日：2024-06-27

申请号：US18573907

申请日：2022-06-27

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Mark HERNANDEZ ,  Emmalee BIESIADA

IPC分类号： A61L9/04 ,  A61L2/20 ,  A61L9/12 ,  A61L9/20

CPC分类号： A61L9/046 ,  A61L2/208 ,  A61L9/12 ,  A61L9/20 ,  A61L2202/11 ,  A61L2209/12 ,  A61L2209/16 ,  A61L2209/211

摘要： Described herein are systems and methods for treatment of various airborne or surface-associated contaminants in which UV aerosol technology is combined with the use of hydrogen peroxide vapor or aerosol to create potent airborne concentrations of reactive oxygen-containing radicals that react with the airborne or surface-associated contaminants to inactivate, disinfect, oxidize, rearrange, ablate and/or otherwise treat these materials and thereby achieve disinfection of indoor air and/or surfaces. This technology is referred to herein as peroxide-enhanced germicidal irradiation (PEGI).