公开(公告)号：US10888529B2

公开(公告)日：2021-01-12

申请号：US16091071

申请日：2017-04-04

申请人： UNIVERSIDAD DEL PAIS VASCO-EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU)

发明人： Alejandro Sänchez Barreiro ,  Inés Fernändez Piñeiro ,  Iker Badiola ,  Joana Märquez

IPC分类号： A61K9/51 ,  A61K31/7105 ,  B82B3/00 ,  A61K47/18 ,  B82Y5/00 ,  B82B1/00

摘要： The invention relates to a nanoparticle comprising: (i) between 60 wt.-% and 99 wt.-% sorbitan ester, relative to the total weight of the nanoparticle; (ii) a positively charged substance; and (iii) a miRNA. The invention also relates to the methods for producing same and to the uses thereof, particularly for therapeutic uses, such as cancer treatment.

公开(公告)号：US20160113995A1

公开(公告)日：2016-04-28

申请号：US14985532

申请日：2015-12-31

申请人： BIOPRAXIS RESEARCH AIE ,  PRAXIS PHARMACEUTICAL, S.A. ,  FUNDACIO D'INVESTIGACIO SANITARIA DE LES ILLES BALEARS ,  UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  UNIVERSIDAD DE BARCELONA ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

发明人： Eusebio GAINZA LAFUENTE ,  Angel DEL POZO PEREZ ,  Garazi GAINZA LUCEA ,  Oihane IBARROLA MORENO ,  Silvia VILLULLAS RINCON ,  Raul FERNANDEZ PLAGARO ,  Daniel BACHILLER PEREZ ,  Jose Luis PEDRAZ MUNOZ ,  Amaya ESQUISABEL ALEGRIA ,  Marta PASTOR NAVARRO ,  Ester FUSTE DOMINGUEZ ,  Eulalia SANS SERRAMIT JANA ,  Iraida GIL MARTIN

IPC分类号： A61K38/12 ,  A61K9/51 ,  A61K9/00

CPC分类号： A61K38/12 ,  A61K9/0073 ,  A61K9/5123

摘要： A lipid nanoparticle that includes at least one antibiotic from the polymyxin family, a lipid fraction, and one or more surfactants. The lipid nanoparticle is useful in the prevention and/or treatment of respiratory tree infections.

摘要翻译： 包含来自多粘菌素家族的至少一种抗生素，脂质部分和一种或多种表面活性剂的脂质纳米颗粒。 脂质纳米颗粒可用于预防和/或治疗呼吸道感染。

公开(公告)号：US20160053042A1

公开(公告)日：2016-02-25

申请号：US14758157

申请日：2013-12-26

申请人： UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  CENTRO DE INVESTIGACIÓN BIOMEDICA EN RED ,  FUNDACION TECNALIA RESEARCH & INNOVATION

发明人： Jesús María Aizpurua Iparraguirre ,  Maialen Sagartzazu Aizpurua ,  Iñigo Braceras Izaguirre ,  Francisco Javier Azpiroz Dorronsoro ,  Joseba Oyarbide Vicuña

IPC分类号： C08G8/28 ,  C09K11/06 ,  C08J9/36

CPC分类号： C08G8/28 ,  A61L27/18 ,  A61L27/56 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2400/18 ,  A61L2430/02 ,  A61L2430/24 ,  A61L2430/38 ,  C08G65/48 ,  C08G2650/40 ,  C08J9/36 ,  C08J2361/16 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1466 ,  C08L71/00

摘要： The present invention relates to a modified polyaryletherketone polymer (PAEK) with chemically modified surfaces with azides, alkynes, thiols, maleimides, sulfonylazides or thio acids, suitable for “click” reactions and to a process to obtain it. It also relates to the conjugated biomaterials derived thereof, PAEK type materials with surfaces modified with a RGD (Arg-Gly-Asp) and/or OGP10-14 (Tyr-Gly-Phe-Gly-Gly) peptidomimetics and to a process to obtain it. These materials are particularly useful for manufacturing medical devices. Finally, the present invention also relates to a fluorescent PAEK material.

摘要翻译： 本发明涉及具有化学修饰表面的改性聚芳醚酮聚合物（PAEK），其具有适用于“点击”反应的叠氮化物，炔，硫醇，马来酰亚胺，磺酰基叠氮化物或硫代酸，以及获得该反应的方法。 它还涉及其衍生的共轭生物材料，具有用RGD（Arg-Gly-Asp）和/或OGP10-14（Tyr-Gly-Phe-Gly-Gly）肽模拟物修饰的表面的PAEK型材料，以及获得 它。 这些材料对于制造医疗装置特别有用。 最后，本发明还涉及一种荧光PAEK材料。

公开(公告)号：US20150157723A1

公开(公告)日：2015-06-11

申请号：US14097488

申请日：2013-12-05

申请人： International Business Machines Corporation ,  Universidad del Pais Vasco/Euskal Herriko Unibertsitatea ,  Agency For Science, Technology and Research

发明人： Julian M. W. Chan ,  Amanda C. Engler ,  James L. Hedrick ,  Xiyu Ke ,  Victor W.L. Ng ,  Haritz Sardon ,  Jeremy P. K. Tan ,  Yi Yan Yang

IPC分类号： A61K47/34 ,  A61K31/713 ,  A61K31/704 ,  A61K38/16

CPC分类号： A61K47/34 ,  A61K9/5146 ,  A61K31/704 ,  A61K31/713 ,  A61K38/00 ,  A61K38/16 ,  C08G64/0241 ,  C08G64/183 ,  C08L69/00

摘要： Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

摘要翻译： 纳米颗粒包含药物，第一嵌段聚合物和第二嵌段聚合物。 第一嵌段聚合物具有聚（环氧乙烷）（PEO）嵌段和带有侧链芳香族含氮杂环（N-杂环）的聚碳酸酯嵌段）。 N-杂环可以是碱的形式，碱的氢盐，碱的磺基甜菜碱加合物或其组合。 第二嵌段聚合物具有PEO嵌段和带有侧链儿茶酚基团的聚碳酸酯嵌段，其可以儿茶酚，氧化形式的儿茶酚和/或邻苯二酚的聚合形式存在。 纳米颗粒可以分散在水中并且能够控制释放药物。

公开(公告)号：US20190111002A1

公开(公告)日：2019-04-18

申请号：US16091071

申请日：2017-04-04

申请人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA ,  UNIVERSIDAD DEL PAIS VASCO - EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU)

发明人： Alejandro SÁNCHEZ BARREIRO ,  Inés FERNÁNDEZ PIÑEIRO ,  Iker BADIOLA ,  Joana MÁRQUEZ

IPC分类号： A61K9/51 ,  A61K31/7105

摘要： The invention relates to a nanoparticle comprising: (i) between 60 wt.-% and 99 wt.-% sorbitan ester, relative to the total weight of the nanoparticle; (ii) a positively charged substance; and (iii) a miRNA. The invention also relates to the methods for producing same and to the uses thereof, particularly for therapeutic uses, such as cancer treatment.

公开(公告)号：US20180258473A1

公开(公告)日：2018-09-13

申请号：US15755485

申请日：2016-10-10

申请人： ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI ,  UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  BASQUE CENTER FOR MACROMOLECULAR DESIGN AND ENGINEERING, POLYMAT FUNDAZIOA

发明人： Charles Henderson Lawrie ,  Lourdes Basabe-Desmonts ,  Thomas Schäfer ,  Luis Manuel Liz Marzán ,  Wolfgang Johann Parak

IPC分类号： C12Q1/6823 ,  B01L3/00 ,  C12Q1/6827

CPC分类号： C12Q1/6823 ,  B01L3/502707 ,  B01L3/502761 ,  B82Y30/00 ,  C12Q1/6827 ,  C12Q2523/313 ,  C12Q2527/101 ,  C12Q2527/107 ,  C12Q2537/125 ,  C12Q2563/155 ,  C12Q2563/159 ,  C12Q2565/113 ,  C12Q2565/519 ,  C12Q2600/156 ,  G01N33/542 ,  G01N33/54346 ,  C12Q2547/107

摘要： The present invention provides a method for detecting the presence or absence of a target analyte in a test sample, comprising the steps: i) providing a plurality of detector nanoparticles comprising a first detector nanoparticle functionalised with a first probe specific for a first region of a target analyte and a second detector nanoparticle functionalised with a second probe specific for a second region of said target analyte; and ii) contacting said detector nanoparticles with a test sample under conditions suitable for the binding of the specific probes to the target analyte, wherein target analyte-induced agglomeration of the detector nanoparticles permits the release of a detectable signal means from a signal reservoir. Also provided are related devices and systems for performing the method of the invention.

公开(公告)号：US20180050908A1

公开(公告)日：2018-02-22

申请号：US15553058

申请日：2016-02-19

申请人： UNIVERSIDAD DEL PAIS VASCO - EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU)

发明人： Alexander LÓPEZ URIONABARRENECHEA ,  Isabel DE MARCO RODRÍGUEZ ,  Blanca María CABALLERO IGLESIAS ,  Naia GASTELU OTAZUA ,  Ainhoa HERNÁNDEZ SÁINZ ,  Aitziber ADRADOS LÓPEZ DE VIÑASPRE ,  Jon SOLAR IRAZABAL

IPC分类号： C01B3/40 ,  B29B17/04 ,  C10B53/07 ,  C01B3/26

CPC分类号： C01B3/40 ,  B01D53/002 ,  B01D53/8668 ,  B01D2255/20753 ,  B01D2255/50 ,  B01J23/40 ,  B01J23/58 ,  B01J23/60 ,  B01J23/63 ,  B01J23/755 ,  B01J29/068 ,  B01J29/072 ,  B01J29/46 ,  B01J35/04 ,  B01J37/0201 ,  B01J37/0215 ,  B01J37/0246 ,  B01J37/0248 ,  B01J37/18 ,  B01J2229/186 ,  B29B17/02 ,  B29B17/04 ,  B29B2017/0496 ,  B29K2307/04 ,  C01B3/26 ,  C01B2203/0227 ,  C01B2203/0277 ,  C01B2203/1023 ,  C01B2203/1058 ,  C01B2203/1082 ,  C10B53/07 ,  C10K1/20 ,  C10K1/32 ,  C10K1/34

摘要： A method for treating vapours generated during the pyrolysis of carbon fibre composites, such as production waste generated by the producers or composites of carbon fibre at the end of the service life thereof, includes, passing the vapours through a reactor which is at a high temperature and contains a solid material filler (solid bed), for example CSi, and optionally also a solid catalyst having an acid and/or reforming function, preferably both, for example a transition metal supported on an acid substrate, such as Ni on zeolite. Following the condensation of the vapours resulting from the treatment, an improved aqueous liquid phase, a minimum or non-existent organic fraction and a gaseous phase of increased added value are obtained.

公开(公告)号：US09062160B1

公开(公告)日：2015-06-23

申请号：US14162222

申请日：2014-01-23

申请人： International Business Machines Corporation ,  Agency For Science, Technology and Research ,  Universidad del Pais Vasco/Euskal Herriko Unibertsitatea

发明人： Julian M. W. Chan ,  Daniel J. Coady ,  Amanda C. Engler ,  Jeannette M. Garcia ,  James L. Hedrick ,  Zhan Yuin Ong ,  Haritz Sardon ,  Yi Yan Yang

IPC分类号： C08G73/24 ,  C08G71/04 ,  C08G65/00 ,  C08G73/02

CPC分类号： C08G71/04 ,  C08G65/007 ,  C08G73/02 ,  C08G73/0206

摘要： One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.

摘要翻译： 形成聚氨酯的一种无催化剂的方法包括形成包含第一单体，表面活性剂，与水不混溶的有机溶剂和水的第一乳液。 第一单体包含两个或多个五氟苯基碳酸酯基团。 将第一乳液与含有包含两个或多个亲核胺基团的第二单体的含水混合物组合，从而形成第二乳液。 通过界面聚合使第二乳液的第一和第二单体反应，由此形成聚氨酯。 聚氨酯的数均分子量（Mn）可以为约30000至约80000.该方法与通过环状碳酸酯前体向第一单体引入侧链官能团相容。

公开(公告)号：US11977254B2

公开(公告)日：2024-05-07

申请号：US17620187

申请日：2020-06-24

申请人： UNIVERSIDAD DEL PAIS VASCO—EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU)

发明人： Agustín Joel Villatoro Bernardo ,  Joseba Andoni Zubia Zaballa

IPC分类号： G02B6/02 ,  G01B11/16 ,  G01D5/353

CPC分类号： G02B6/02042 ,  G01B11/161 ,  G01D5/35306

摘要： A composed multicore optical fiber (MCF) device includes a first segment (MCF1) of a MCF having three coupled identical cores and having a first length (L1) and a second segment (MCF2) of the same MCF having a second length (L2). L1 and L2 are different from each other. One of the three coupled cores is located in a geometrical centre of the MCF. The first segment (MCF1) and the second segment (MCF2) of the MCF are rotated 180° relative to each other and spliced together. The first segment (MCF1) is spliced to a first segment (SMF1) of a single mode fiber (SMF) and the second segment (MCF2) is spliced to a second segment (SMF2) of the SMF. The free end of the second segment (SMF2) of the SMF is coupled to a mirror (M) to reflect an optical signal coming from the first segment (SMF1) of the SMF.

公开(公告)号：US11951579B2

公开(公告)日：2024-04-09

申请号：US16305006

申请日：2017-05-11

申请人： UNIVERSIDAD DEL PAIS VASCO—EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU) ,  FUNDACIÓN TECNALIA RESEARCH & INNOVATION

发明人： Octavio Manuel Pereira Neto ,  Adrián Rodríguez Ezquerro ,  López De Lacalle Marcaide Luis ,  Franck Andrés Girot Mata ,  Mariluz Penalva Oscoz ,  Rivero Rastrero Maria Asunción

IPC分类号： B23Q11/10 ,  F16N7/32 ,  F16N13/22

CPC分类号： B23Q11/1046 ,  B23Q11/1061 ,  B23Q11/1084 ,  F16N7/32 ,  F16N13/22 ,  F16N2270/70 ,  Y02P70/10

摘要： A device for cooling and lubricating a tool during a chip removal machining process, which includes: a first subsystem for cryogenic cooling that includes: a first entry configured to introduce CO2 in liquid state in a first conduit of the device; a first exit configured to supply CO2 in liquid state from a second conduit of the device; a third conduit located between the first and second conduit; and means for preventing the formation of dry ice in the first, second and third conduits; and a second subsystem for lubrication that includes means for supplying micro-particles of a cutting oil in liquid state; wherein the first subsystem and second subsystem are independent from each other, and wherein the first subsystem and second subsystem are configured to act either simultaneously or either one alone. Method of operation of the device.