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公开(公告)号：US09689786B2
公开(公告)日：2017-06-27
申请号：US14410019
申请日：2013-06-26
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , UNIVERSITE MONTPELLIER I , UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES
CPC分类号： G01N15/0205 , G01N15/02 , G01N15/0211 , G01N35/085
摘要： A method for determining the size distribution of a mixture of molecule or particle species including the steps of: injecting a sample of the mixture to be analyzed inside a capillary in which an eluent is flowing; transporting the sample injected along the capillary from an injection section to a detection section thereof, in experimental conditions suitable to generate a Taylor dispersion phenomenon that is measurable at the level of the detection section; generating, by a suitable sensor included in the detection section, a signal characteristic of the Taylor dispersion of the transported sample; processing the detection signal in order to obtain an experimental Taylor signal S(t); and analyzing the experimental Taylor signal Ŝ(t), wherein the step of analyzing an experimental Taylor signal Ŝ(t) of a sample of the mixture consists of searching an amplitude distribution P(G(c)) that allows the experimental Taylor signal Ŝ(t)′ to be broken down into a sum of Gaussian functions.
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2.发明申请SUGAR-ANALOG PHOSPHORUS-CONTAINING HETEROCYCLES HAVING AN ANTI-METASTATIC ACTIVITY 审中-公开具有抗细胞活性的含糖类含磷的杂环化合物公开(公告)号：US20150376216A1
公开(公告)日：2015-12-31
申请号：US14769928
申请日：2014-02-25
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIRIQUE , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIE , UNIVERSITE MONTPELLIER 1 , UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES , UNIVERSITE PARIS-NORD 13 , UNIVERSITE PARIS-SUD 11
发明人： Norbert BAKALARA , Marcel DELAFORGE , Marc LECOUVEY , Jean-Philippe HUGNOT , Philippe LEGRAND , Jean-Luc PIRAT , David VIRIEUX , Jean-Noel VOLLE
IPC分类号： C07F9/6571 , A61K45/06 , A61K31/665
CPC分类号： C07F9/657172 , A61K9/0019 , A61K9/08 , A61K31/665 , A61K31/67 , A61K31/675 , A61K45/06 , A61K47/14 , C07D493/04 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要： The use of compounds of formula (1) as defined in the description, for reducing or preventing the onset of metastases in a patient suffering from cancer. Pharmaceutical compositions for using in human or veterinary medicine, including at least one compound of formula (1) are also described.
摘要翻译： 使用描述中定义的式（1）化合物，用于减少或预防患有癌症的患者的转移发生。 还描述了用于人或兽医学包括至少一种式（1）化合物的药物组合物。
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3.发明申请METHOD FOR DETERMINING THE SIZE DISTRIBUTION OF A MIXTURE OF PARTICLES USING TAYLOR DISPERSION, AND ASSOCIATED SYSTEM 有权用于确定使用TAYLOR DISPERSION和相关系统的颗粒混合物的尺寸分布的方法公开(公告)号：US20150192507A1
公开(公告)日：2015-07-09
申请号：US14410019
申请日：2013-06-26
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIOUE (C.N.R.S) , UNIVERSITE MONTPELLIER I , UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHBIQUES
IPC分类号： G01N15/02
CPC分类号： G01N15/0205 , G01N15/02 , G01N15/0211 , G01N35/085
摘要： The method comprises the following steps: injecting (100) a sample into a capillary; transporting (110) the sample along the capillary in experimental conditions suited to generate a Taylor dispersion phenomenon; generating (120) a signal characteristic of the Taylor dispersion; processing (130) the signal in order to obtain the experimental Taylor signal Ŝ(t); and analysing (200) the experimental Taylor signal Ŝ(t), The analysis step consists of seeking an amplitude distribution P(G(c)) that allows the experimental Taylor signal Ŝ(t) to be broken down into a sum of Gaussian functions by implementing a constrained regularization algorithm consisting of minimising a cost function Hα including at least one constraint term associated with a constraint that must observe the amplitude distribution P(G(c)) , whereby the minimization is carried out on an interval of interest of the values of the parameter G(c) that is characteristic of the Gaussian amplitude function P(G(c)).
摘要翻译： 该方法包括以下步骤：将样品注入（100）到毛细管中; 在适于产生泰勒色散现象的实验条件下沿着毛细管传送（110）样品; 产生（120）泰勒分散的信号特征; 处理（130）信号以获得实验泰勒信号Ŝ（t）; 并分析（200）实验泰勒信号Ŝ（t），分析步骤包括寻求允许将实验泰勒信号Ŝ（t）分解为高斯函数之和的幅度分布P（G（c）） 通过实现包含最小化成本函数Hα的约束正则化算法，该成本函数包括至少一个与必须遵守幅度分布P（G（c））的约束相关联的约束项，由此最小化在 作为高斯振幅函数P（G（c））的特征的参数G（c）的值。
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公开(公告)号：US20220029172A1
公开(公告)日：2022-01-27
申请号：US17496200
申请日：2021-10-07
申请人： JOHNSON MATTHEY FUEL CELLS LIMITED , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE MONTPELLIER
发明人： Marie Josephe Vanessa ARMEL , Stephen Charles BENNETT , Frederic Christophe JAQUEN , Deborah JONES , Sheena HINDOCHA , Fabrice SALLES
IPC分类号： H01M4/90 , H01M4/88 , B01J23/78 , B01J23/80 , B01J35/10 , B01J37/08 , B01J35/00 , B01J23/89 , H01M4/86
摘要： A method for the manufacture of an oxygen reduction reaction (ORR) catalyst, the method comprising; providing a metal organic framework (MOF) material having a specific internal pore volume of 0.7 cm3g−1 or greater; providing a source of iron and/or cobalt; pyrolysing the MOF material together with the source of iron and/or cobalt to form the catalyst, wherein the MOF material comprises nitrogen and/or the MOF material is pyrolysed together with a source of nitrogen and the source of iron and/or cobalt is disclosed.
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5.发明授权公开(公告)号：US10702860B2
公开(公告)日：2020-07-07
申请号：US14416404
申请日：2013-07-23
发明人： Claude Grison , Vincent Escande
IPC分类号： B01J31/22 , B01J37/06 , B01J37/08 , B01J37/00 , B01J23/34 , B01J37/36 , B09C1/10 , B01J23/889 , B01J37/14 , B01J37/30 , B01J37/34 , C07C1/20 , C07C5/367 , C07C45/29 , C07C49/807 , C07C67/307 , C07C211/50 , C07C245/08 , C07D213/80 , C07D307/30 , C07D307/68 , C07D401/04 , C07D403/14 , C07D407/04
摘要： The use, after heat treatment, of manganese accumulating plants for carrying out chemical reactions.
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公开(公告)号：US10463901B2
公开(公告)日：2019-11-05
申请号：US15661232
申请日：2017-07-27
发明人： Claude Grison , Jose Escarre
IPC分类号： A62D3/35 , B01J23/06 , B01J23/72 , B01J23/755 , C07C29/62 , C07C2/86 , C07C17/16 , C07C41/30 , C07C45/00 , C07C67/02 , C07C67/347 , C07C209/32 , C07D239/22 , C07F1/08 , A62D101/04
摘要： A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.
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公开(公告)号：US10179816B2
公开(公告)日：2019-01-15
申请号：US15333519
申请日：2016-10-25
申请人： LABORATOIRE FRANCAIS DU FRACTIONNEMENT DES BIOTECHNOLOGIES , CENTRE REGIONAL DE LUTTE CONTRE LE CANCER , I.N.S.E.R.M. (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE MONTPELLIER 1
IPC分类号： A61K39/395 , C07K16/28 , A61K31/282 , A61K31/337 , A61K45/06 , A61K33/24 , A61K9/00 , C07K16/30 , A61K39/00
摘要： The invention relates to novel pharmaceutical compositions including, as active ingredient, an antibody binding the human anti-Müllerian hormone type II receptor (AMHR-II) and an anticancer agent, as well as the therapeutic applications of these compositions.
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公开(公告)号：US09744391B2
公开(公告)日：2017-08-29
申请号：US14831987
申请日：2015-08-21
发明人： Claude Grison , Jose Escarre
IPC分类号： C07C321/00 , A62D3/35 , B01J23/06 , B01J23/72 , B01J23/755 , C07C29/62 , C07C2/86 , C07C17/16 , C07C41/30 , C07C45/00 , C07C67/02 , C07C67/347 , C07C209/32 , C07D239/22 , C07F1/08 , A62D101/04
CPC分类号： A62D3/35 , A62D2101/04 , B01J23/06 , B01J23/72 , B01J23/755 , C07C2/861 , C07C17/16 , C07C29/62 , C07C41/30 , C07C45/00 , C07C67/02 , C07C67/347 , C07C209/32 , C07C2523/04 , C07C2527/122 , C07C2527/128 , C07C2527/138 , C07D239/22 , C07F1/08 , C07C31/36
摘要： A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.
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公开(公告)号：US09656947B2
公开(公告)日：2017-05-23
申请号：US14406065
申请日：2013-06-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) , UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
发明人： Marc Taillefer , Florian Monnier , Anis Tlili , Grégory Danoun
IPC分类号： C07C213/04 , C07C37/20 , C07B37/04 , C07C213/06 , C07C45/68
CPC分类号： C07C213/04 , C07B37/04 , C07C37/20 , C07C45/68 , C07C213/06 , C07C39/21 , C07C217/18 , C07C49/784 , C07C49/84 , C07C49/813 , C07C49/83
摘要： The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.
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公开(公告)号：US09637544B2
公开(公告)日：2017-05-02
申请号：US14658785
申请日：2015-03-16
申请人： LFB BIOTECHNOLOGIES , UNIVERSITE MONTPELLIER I , CENTRE NATIONAL DE LUTTE CONTRE LE CANCER , I.N.S.E.R.M. (Institut National de la Sante et de la Recherche Medicale)
IPC分类号： C07K16/28 , G01N33/574 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2863 , A61K31/282 , A61K31/337 , A61K31/7088 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2869 , C07K16/46 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/92 , G01N33/57449 , G01N2333/72
摘要： Novel mutated humanized 12G4 antibodies, and fragments thereof, directed against the anti-Müllerian hormone type II receptor.
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